Jean-Marc Schwarz, PhD
Adjunct Professor
Medicine
School of Medicine

Publications (56)

Top publication keywords:
LipogenesisBlood GlucoseDietary CarbohydratesHeterocyclic Compounds, 3-RingHIV Integrase InhibitorsDiabetes Mellitus, Type 2ChylomicronsInsulinDietMetabolic SyndromeInsulin ResistancePediatric ObesityFructoseDietary SugarsTriglycerides

• Effect of weight gain on blood pressure in Ugandan persons with HIV on dolutegravir/lamivudine/ tenofovir disoproxil fumarate over 48 weeks.
  PloS one 2025 Amutuhaire W, Castelnuovo B, Brusselaers N, Nabwana M, Muhammad L, Maloney B, Nixon B, Schwarz JM, Mulindwa F
• Leukocyte telomere length change in children with obesity in the context of an isocaloric fructose restriction intervention.
  Diabetology & metabolic syndrome 2025 Wojcicki JM, Epel E, Lin J, Tai V, Schwarz JM, Noworolski SM, Erkin-Cakmak A, Mulligan K, Gugliucci A, Lustig RH
• Blood glucose outcomes of anti-retroviral therapy naïve Ugandan people with HIV with pre-diabetes mellitus initiated on dolutegravir for 48 weeks.
  BMC infectious diseases 2024 Mulindwa F, Schwarz JM, Brusselaers N, Nabwana M, Bollinger R, Buzibye A, Amutuhaire W, Yendewa G, Odongpiny ELA, Kiguba R, Castelnuovo B
• Effects of Consuming Beverages Sweetened with Fructose, Glucose, High-Fructose Corn Syrup, Sucrose, or Aspartame on OGTT-Derived Indices of Insulin Sensitivity in Young Adults.
  Nutrients 2024 Hieronimus B, Medici V, Lee V, Nunez MV, Sigala DM, Bremer AA, Cox CL, Keim NL, Schwarz JM, Pacini G, Tura A, Havel PJ, Stanhope KL
• Should dolutegravir always be withheld in people with HIV on dolutegravir with incident diabetes mellitus? a case report.
  BMC infectious diseases 2023 Mulindwa F, Castelnuovo B, Brusselaers N, Bollinger R, Yendewa G, Amutuhaire W, Mukashaka C, Schwarz JM

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• Dolutegravir use over 48 weeks is not associated with worsening insulin resistance and pancreatic beta cell function in a cohort of HIV-infected Ugandan adults.
  AIDS research and therapy 2023 Mulindwa F, Castelnuovo B, Brusselaers N, Nabwana M, Bollinger R, Buzibye A, Agnes Odongpiny EL, Kiguba R, Schwarz JM
• Dolutegravir use over 48 weeks is not associated with worsening insulin resistance and pancreatic beta cell function in a cohort of HIV-infected Ugandan adults.
  Research square 2023 Mulindwa F, Castelnuovo B, Brusselaers N, Nabwana M, Bollinger R, Laker E, Kiguba R, Schwarz JM
• Prevalence of Cardiometabolic Disease Risk Factors in People With HIV Initiating Antiretroviral Therapy at a High-Volume HIV Clinic in Kampala, Uganda.
  Open forum infectious diseases 2023 Amutuhaire W, Mulindwa F, Castelnuovo B, Brusselaers N, Schwarz JM, Edrisa M, Dujanga S, Salata RA, Yendewa GA
• Implementation of longitudinal insulin kinetic studies in busy field settings in Uganda: experience from the "glucose metabolism changes in Ugandan HIV patients on dolutegravir based anti-retroviral therapy" (GLUMED study).
  The Pan African medical journal 2023 Mulindwa F, Schwarz JM, Brusselaers N, Dujanga S, Yendewa G, Castelnuovo B
• Blood glucose trajectories and incidence of diabetes mellitus in Ugandan people living with HIV initiated on dolutegravir.
  AIDS research and therapy 2023 Mulindwa F, Castelnuovo B, Brusselaers N, Bollinger R, Rhein J, Edrisa M, Buzibye A, Amutuhaire W, Yendewa G, Nabaggala S, Odongpiny ELA, Kiguba R, Nakawooza A, Dujanga S, Nabwana M, Schwarz JM
• Association between integrase strand transfer inhibitor use with insulin resistance and incident diabetes mellitus in persons living with HIV: a systematic review and meta-analysis.
  BMJ open diabetes research & care 2023 Mulindwa F, Kamal H, Castelnuovo B, Byonanebye DM, Schwarz JM, Bollinger R, Brusselaers N
• Effects of Isocaloric Fructose Restriction on Ceramide Levels in Children with Obesity and Cardiometabolic Risk: Relation to Hepatic De Novo Lipogenesis and Insulin Sensitivity.
  Nutrients 2022 Olson E, Suh JH, Schwarz JM, Noworolski SM, Jones GM, Barber JR, Erkin-Cakmak A, Mulligan K, Lustig RH, Mietus-Snyder M
• Association between integrase strand transfer inhibitor (INSTIs) use with insulin resistance and incident diabetes mellitus in persons living with HIV: A systematic review and meta-analysis protocol.
  PloS one 2022 Mulindwa F, Kamal H, Castelnuovo B, Bollinger RC, Schwarz JM, Brussealers N
• Separation of postprandial lipoproteins: improved purification of chylomicrons using an ApoB100 immunoaffinity method.
  Journal of lipid research 2019 Jones GM, Caccavello R, Palii SP, Pullinger CR, Kane JP, Mulligan K, Gugliucci A, Schwarz JM
• Isocaloric Fructose Restriction Reduces Serum d-Lactate Concentration in Children With Obesity and Metabolic Syndrome.
  The Journal of clinical endocrinology and metabolism 2019 Erkin-Cakmak A, Bains Y, Caccavello R, Noworolski SM, Schwarz JM, Mulligan K, Lustig RH, Gugliucci A
• An ethanolic extract of Artemisia scoparia inhibits lipolysis in vivo and has antilipolytic effects on murine adipocytes in vitro.
  American journal of physiology. Endocrinology and metabolism 2018 Boudreau A, Richard AJ, Burrell JA, King WT, Dunn R, Schwarz JM, Ribnicky DM, Rood J, Salbaum JM, Stephens JM
• Dietary carbohydrates and fatty liver disease: de novo lipogenesis.
  Current opinion in clinical nutrition and metabolic care 2018 Chiu S, Mulligan K, Schwarz JM
• Conversion of Sugar to Fat: Is Hepatic de Novo Lipogenesis Leading to Metabolic Syndrome and Associated Chronic Diseases?
  The Journal of the American Osteopathic Association 2017 Schwarz JM, Clearfield M, Mulligan K
• Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity.
  Gastroenterology 2017 Schwarz JM, Noworolski SM, Erkin-Cakmak A, Korn NJ, Wen MJ, Tai VW, Jones GM, Palii SP, Velasco-Alin M, Pan K, Patterson BW, Gugliucci A, Lustig RH, Mulligan K
• Short-term isocaloric fructose restriction lowers apoC-III levels and yields less atherogenic lipoprotein profiles in children with obesity and metabolic syndrome.
  Atherosclerosis 2016 Gugliucci A, Lustig RH, Caccavello R, Erkin-Cakmak A, Noworolski SM, Tai VW, Wen MJ, Mulligan K, Schwarz JM
• In vivo triglyceride synthesis in subcutaneous adipose tissue of humans correlates with plasma HDL parameters.
  Atherosclerosis 2016 Tuvdendorj D, Munoz AO, Ruiz-Barros V, Schwarz JM, Montalto G, Chandalia M, Sowers LC, Rizzo M, Murphy EJ, Abate N
• Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome.
  Obesity (Silver Spring, Md.) 2015 Lustig RH, Mulligan K, Noworolski SM, Tai VW, Wen MJ, Erkin-Cakmak A, Gugliucci A, Schwarz JM
• Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat.
  The Journal of clinical endocrinology and metabolism 2015 Schwarz JM, Noworolski SM, Wen MJ, Dyachenko A, Prior JL, Weinberg ME, Herraiz LA, Tai VW, Bergeron N, Bersot TP, Rao MN, Schambelan M, Mulligan K
• Subchronic sleep restriction causes tissue-specific insulin resistance.
  The Journal of clinical endocrinology and metabolism 2015 Rao MN, Neylan TC, Grunfeld C, Mulligan K, Schambelan M, Schwarz JM
• Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function.
  JAMA neurology 2014 Mak AC, Pullinger CR, Tang LF, Wong JS, Deo RC, Schwarz JM, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Duncan JL, …
• Thermogenic changes after gastric bypass, adjustable gastric banding or diet alone.
  Surgery 2014 Rabl C, Rao MN, Schwarz JM, Mulligan K, Campos GM
• Effect of 8 weeks of overfeeding on ectopic fat deposition and insulin sensitivity: testing the "adipose tissue expandability" hypothesis.
  Diabetes care 2014 Johannsen DL, Tchoukalova Y, Tam CS, Covington JD, Xie W, Schwarz JM, Bajpeyi S, Ravussin E
• Response to comment on Lecoultre et al. Ten nights of moderate hypoxia improves insulin sensitivity in obese humans. Diabetes care 2013;36:e197-e198.
  Diabetes care 2014 Peterson CM, Lecoultre V, Schwarz JM, Ravussin E
• Effects of Artemisia species on de novo lipogenesis in vivo.
  Nutrition (Burbank, Los Angeles County, Calif.) 2014 Rood JC, Schwarz JM, Gettys T, Mynatt RL, Mendoza T, Johnson WD, Cefalu WT
• Ten nights of moderate hypoxia improves insulin sensitivity in obese humans.
  Diabetes care 2013 Lecoultre V, Peterson CM, Covington JD, Ebenezer PJ, Frost EA, Schwarz JM, Ravussin E
• Changes in post-prandial glucose and pancreatic hormones, and steady-state insulin and free fatty acids after gastric bypass surgery.
  Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2013 Campos GM, Rabl C, Havel PJ, Rao M, Schwarz JM, Schambelan M, Mulligan K
• Adverse metabolic effects of dietary fructose: results from the recent epidemiological, clinical, and mechanistic studies.
  Current opinion in lipidology 2013 Stanhope KL, Schwarz JM, Havel PJ
• Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans.
  Nutrition & metabolism 2012 Cox CL, Stanhope KL, Schwarz JM, Graham JL, Hatcher B, Griffen SC, Bremer AA, Berglund L, McGahan JP, Keim NL, Havel PJ
• Circulating concentrations of monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, and soluble leukocyte adhesion molecule-1 in overweight/obese men and women consuming fructose- or glucose-sweetened beverages for 10 weeks.
  The Journal of clinical endocrinology and metabolism 2011 Cox CL, Stanhope KL, Schwarz JM, Graham JL, Hatcher B, Griffen SC, Bremer AA, Berglund L, McGahan JP, Keim NL, Havel PJ
• Metabolic responses to prolonged consumption of glucose- and fructose-sweetened beverages are not associated with postprandial or 24-h glucose and insulin excursions.
  The American journal of clinical nutrition 2011 Stanhope KL, Griffen SC, Bremer AA, Vink RG, Schaefer EJ, Nakajima K, Schwarz JM, Beysen C, Berglund L, Keim NL, Havel PJ
• Boosting dose ritonavir does not alter peripheral insulin sensitivity in healthy HIV-seronegative volunteers.
  Journal of acquired immune deficiency syndromes (1999) 2010 Taylor SA, Lee GA, Pao VY, Anthonypillai J, Aweeka FT, Schwarz JM, Mulligan K, Schambelan M, Grunfeld C
• Effects of insulin-like growth factor (IGF)-I/IGF-binding protein-3 treatment on glucose metabolism and fat distribution in human immunodeficiency virus-infected patients with abdominal obesity and insulin resistance.
  The Journal of clinical endocrinology and metabolism 2010 Rao MN, Mulligan K, Tai V, Wen MJ, Dyachenko A, Weinberg M, Li X, Lang T, Grunfeld C, Schwarz JM, Schambelan M
• Reduced oxygenation in human obese adipose tissue is associated with impaired insulin suppression of lipolysis.
  The Journal of clinical endocrinology and metabolism 2010 Pasarica M, Rood J, Ravussin E, Schwarz JM, Smith SR, Redman LM
• The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome.
  Nature reviews. Gastroenterology & hepatology 2010 Lim JS, Mietus-Snyder M, Valente A, Schwarz JM, Lustig RH
• The protease inhibitor combination lopinavir/ritonavir does not decrease insulin secretion in healthy, HIV-seronegative volunteers.
  AIDS (London, England) 2010 Pao VY, Lee GA, Taylor S, Aweeka FT, Schwarz JM, Mulligan K, Schambelan M, Grunfeld C
• Improvement in peripheral glucose uptake after gastric bypass surgery is observed only after substantial weight loss has occurred and correlates with the magnitude of weight lost.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2009 Campos GM, Rabl C, Peeva S, Ciovica R, Rao M, Schwarz JM, Havel P, Schambelan M, Mulligan K
• The acute effects of HIV protease inhibitors on insulin suppression of glucose production in healthy HIV-negative men.
  Journal of acquired immune deficiency syndromes (1999) 2009 Lee GA, Schwarz JM, Patzek S, Kim S, Dyachenko A, Wen M, Mulligan K, Schambelan M, Grunfeld C
• Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.
  The Journal of clinical investigation 2009 Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, Hatcher B, Cox CL, Dyachenko A, Zhang W, McGahan JP, Seibert A, Krauss RM, Chiu S, Schaefer EJ, Ai M, Otokozawa S, Nakajima K, …
• The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia.
  The Journal of clinical endocrinology and metabolism 2009 Mulligan K, Khatami H, Schwarz JM, Sakkas GK, DePaoli AM, Tai VW, Wen MJ, Lee GA, Grunfeld C, Schambelan M
• Effects of ritonavir and amprenavir on insulin sensitivity in healthy volunteers.
  AIDS (London, England) 2007 Lee GA, Rao M, Mulligan K, Lo JC, Aweeka F, Schwarz JM, Schambelan M, Grunfeld C
• Single-dose lopinavir-ritonavir acutely inhibits insulin-mediated glucose disposal in healthy volunteers.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006 Lee GA, Lo JC, Aweeka F, Schwarz JM, Mulligan K, Schambelan M, Grunfeld C
• Metabolic effects of parenteral nutrition enriched with n-3 polyunsaturated fatty acids in critically ill patients.
  Clinical nutrition (Edinburgh, Scotland) 2006 Tappy L, Berger MM, Schwarz JM, Schneiter P, Kim S, Revelly JP, Chioléro R
• Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men.
  Diabetes 2005 Faeh D, Minehira K, Schwarz JM, Periasamy R, Periasami R, Park S, Seongsu P, Tappy L
• Indinavir increases glucose production in healthy HIV-negative men.
  AIDS (London, England) 2004 Schwarz JM, Lee GA, Park S, Noor MA, Lee J, Wen M, Lo JC, Mulligan K, Schambelan M, Grunfeld C
• The effects of low-dose growth hormone in HIV-infected men with fat accumulation: a pilot study.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004 Lo JC, Mulligan K, Noor MA, Lee GA, Schwarz JM, Grunfeld C, Schambelan M
• HIV protease inhibitors increase adiponectin levels in HIV-negative men.
  Journal of acquired immune deficiency syndromes (1999) 2004 Lee GA, Mafong DD, Noor MA, Lo JC, Mulligan K, Schwarz JM, Schambelan M, Grunfeld C
• The metabolic effects of lopinavir/ritonavir in HIV-negative men.
  AIDS (London, England) 2004 Lee GA, Seneviratne T, Noor MA, Lo JC, Schwarz JM, Aweeka FT, Mulligan K, Schambelan M, Grunfeld C
• Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets.
  The American journal of clinical nutrition 2003 Schwarz JM, Linfoot P, Dare D, Aghajanian K
• Measurement of gluconeogenesis in exercising men by mass isotopomer distribution analysis.
  Journal of applied physiology (Bethesda, Md. : 1985) 2002 Trimmer JK, Schwarz JM, Casazza GA, Horning MA, Rodriguez N, Brooks GA
• Indinavir acutely inhibits insulin-stimulated glucose disposal in humans: a randomized, placebo-controlled study.
  AIDS (London, England) 2002 Noor MA, Seneviratne T, Aweeka FT, Lo JC, Schwarz JM, Mulligan K, Schambelan M, Grunfeld C
• Effects of recombinant human growth hormone on hepatic lipid and carbohydrate metabolism in HIV-infected patients with fat accumulation.
  The Journal of clinical endocrinology and metabolism 2002 Schwarz JM, Mulligan K, Lee J, Lo JC, Wen M, Noor MA, Grunfeld C, Schambelan M