Jay Nadel, MD
Professor Emeritus
Medicine
School of Medicine

• 1968 appointed the first Chief of the Division of Pulmonary Diseases in the Department of Medicine, UCSF
• Lobbied Congress to rename the National Heart Institute to the National Heart and Lung Institute
• Co-Editor of the Murray/Nadel Textbook of Respiratory Medicine

B. Early Areas of Studies

• Chronic airway diseases, including asthma, COPD, and CF
• Air pollutants (sulfur dioxide and ozone)
• Airway epithelium
• Viruses, bacteria, air pollutants, allergens, cigarette smoke
• Na+, Cl¯ exchange mechanism in the airway epithelium

C. Later Areas of Study

• Cell and molecular biology
• Antimuscarinic Therapy of Bronchospasm
• Signaling pathways for mucin production

D. Recent Areas of Study

• EGFR Signaling Pathways
• Modulation of proinflammatory responses
• Viral infections
• CFTR and its role in inflammatory airway diseases
• Bronchiolitis Obliterans Syndrome following lung transplantation

• Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome.
  Current opinion in pulmonary medicine 2016 Gelb AF, Christenson SA, Nadel JA
• Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome.
  The Journal of allergy and clinical immunology 2015 Gelb AF, Nadel JA
• Unraveling the Pathophysiology of the Asthma-COPD Overlap Syndrome: Unsuspected Mild Centrilobular Emphysema Is Responsible for Loss of Lung Elastic Recoil in Never Smokers With Asthma With Persistent Expiratory Airflow Limitation.
  Chest 2015 Gelb AF, Yamamoto A, Verbeken EK, Nadel JA
• EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production.
  American journal of physiology. Lung cellular and molecular physiology 2014 Kalinowski A, Ueki I, Min-Oo G, Ballon-Landa E, Knoff D, Galen B, Lanier LL, Nadel JA, Koff JL
• The CFTR and EGFR relationship in airway vascular growth, and its importance in cystic fibrosis.
  The European respiratory journal 2013 Nadel JA
• Unsuspected mild emphysema in nonsmoking patients with chronic asthma with persistent airway obstruction.
  The Journal of allergy and clinical immunology 2013 Gelb AF, Yamamoto A, Mauad T, Kollin J, Schein MJ, Nadel JA
• Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium.
  The Journal of experimental medicine 2013 Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL
• Normal CFTR inhibits epidermal growth factor receptor-dependent pro-inflammatory chemokine production in human airway epithelial cells.
  PloS one 2013 Kim S, Beyer BA, Lewis C, Nadel JA
• John Widdicombe's contribution to respiratory physiology and cough: reminiscences.
  Cough (London, England) 2013 Chung KF, Nadel JA, Fontana G
• Mucous hypersecretion and relationship to cough.
  Pulmonary pharmacology & therapeutics 2013 Nadel JA
• Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells.
  Experimental cell research 2011 Kim S, Lewis C, Nadel JA
• CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells.
  Journal of immunology (Baltimore, Md. : 1950) 2011 Kim S, Lewis C, Nadel JA
• Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases.
  The European respiratory journal 2008 Burgel PR, Nadel JA
• Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium.
  American journal of physiology. Lung cellular and molecular physiology 2008 Koff JL, Shao MX, Ueki IF, Nadel JA
• Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease.
  Current opinion in allergy and clinical immunology 2007 Nadel JA
• Pseudomonas lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade.
  Journal of immunology (Baltimore, Md. : 1950) 2006 Koff JL, Shao MX, Kim S, Ueki IF, Nadel JA
• Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Shao MX, Nadel JA
• Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Shao MX, Nadel JA
• COPD
  Role of the Airway Epithelium in Defense Against Inhaled Invaders 2005 Nadel JA
• Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells.
  American journal of physiology. Lung cellular and molecular physiology 2004 Shao MX, Nakanaga T, Nadel JA
• Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Shao MX, Ueki IF, Nadel JA
• Epidermal growth factor system regulates mucin production in airways.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Takeyama K, Dabbagh K, Lee HM, Agustí C, Lausier JA, Ueki IF, Grattan KM, Nadel JA
• Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells.
  The Journal of clinical investigation 1991 Nadel JA, Conrad DJ, Ueki IF, Schuster A, Sigal E
• Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation.
  Biochemistry 1989 Vanderslice P, Craik CS, Nadel JA, Caughey GH
• Mast cell chymase. A potent secretagogue for airway gland serous cells.
  Journal of immunology (Baltimore, Md. : 1950) 1989 Sommerhoff CP, Caughey GH, Finkbeiner WE, Lazarus SC, Basbaum CB, Nadel JA
• Micropipette measurement of airway submucosal gland secretion. Autonomic effects.
  The American review of respiratory disease 1980 Ueki I, German VF, Nadel JA
• Roentgenographic study of the human trachea with powdered tantalum.
  Radiology 1970 Hinchcliffe WA, Zamel N, Fishman NH, Dedo HH, Greenspan RH, Nadel J
• Experimental exposure of human subjects to ozone.
  Journal of the Air Pollution Control Association 1969 Goldsmith JR, Nadel JA
• MONITORING HUMAN EXPOSURES TO SULFUR DIOXIDE IN A BODY PLETHYSMOGRAPH.
  Journal of the Air Pollution Control Association 1965 TOKIWA Y, TAMPLIN BR, NADEL JA
• Acute effects of inhalation of cigarette smoke on airway conductance.
  Journal of applied physiology 1961 NADEL JA, COMROE JH