Javid Moslehi, MD
Professor
Medicine
School of Medicine

javid.moslehi@ucsf.edu 415-502-3119

CLINICAL INTERESTS:

Cardio-Oncology, Cardio-Immunology

RESEARCH INTERESTS: I am a cardiologist and myocyte biologist. My clinical focus is cardio-oncology and cardio-immunology. My clinical interests overlap with my laboratory focus, where we are investigating the mechanistic underpinnings of cardiovascular sequelae of novel targeted and immune-based cancer therapies.

Since 2016, a major focus of my clinical and research program has been the interaction between the cardiovascular and immune systems. Our group initially described a novel clinical syndrome of fulminant myocarditis that arises from (ICI) immune checkpoint inhibitors (Johnson et al, NEJM, 2016). We further defined the clinical characteristics of ICI-associated myocarditis (Moslehi et al, Lancet, 2018) and showed that cardiovascular sequelae of ICI include pericarditis, vasculitis and arrhythmias (Salem et al, Lancet Oncology, 2018). My laboratory has generated mouse models that recapitulate these novel immune-based clinical syndromes which have provided insights into new diagnostic and treatment strategies for these complications (Bonaca et al, Circulation, 2019; Salem et al, NEJM, 2019; Wei et al, Cancer Discovery, 2021). My interest in this space has recently expanded to other inflammatory cardiomyopathies, including giant cell myocarditis, acute cellular rejection (ACR) following cardiac transplantation, and other forms of myocarditis. Our group is further investigating the how the immune system can be harnessed to treat heart disease.

Awards

Show all (6) Hide

  • Elected Member, Association of American Physicians (AAP), 2024
  • Inaugural Holder of the William Grossman Distinguished Professorship in Cardiology, UCSF, 2021
  • Elected Member, American Society of Clinical Investigation (ASCI), 2020
  • Alumni Achievement Award, Stanley J. Sarnoff Cardiovascular Research Foundation, 2016
  • Biomedical Science Impact Award, Vanderbilt University, 2016
  • Thomas Smith Award in Heart Failure Research, Brigham and Women's Hospital, Harvard Medical School, 2009

Education & Training

  • Post-Doctoral Fellowship, Oncology Dana-Farber Cancer Institute 05/2014
  • Fellowship, Cardiology Brigham and Women's Hospital 06/2007
  • Residency, Internal Medicine Johns Hopkins Hospital 06/2004
  • MD Medicine University of Connecticut 06/2001
  • BA Biology Johns Hopkins University 06/1996

Interests

Show all (3) Hide

  • Myocyte Biology
  • Cardio-Oncology
  • Cardio-Immunology

Grants and Projects

Publications (279)

Top publication keywords:
Antineoplastic AgentsNeoplasmsProgrammed Cell Death 1 ReceptorMyocarditisPharmacovigilanceCardiovascular DiseasesHeart DiseasesImmunotherapyAnthracyclinesProtein Kinase InhibitorsMedical OncologyAdverse Drug Reaction Reporting SystemsCardiovascular SystemAntineoplastic Agents, ImmunologicalCardiotoxicity