Jason Sello, PhD
Professor
Pharmaceutical Chemistry
School of Pharmacy

Education & Training

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• Bacterial Genetics John Innes Centre 07/2006
• Enzymology Harvard Medical School 4/2004
• Biophysics Harvard University 06/2002
• B.S. Biology Morehouse College 05/1997

Grants and Projects

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• Maximizing Opportunities for Research Excellence, NIH, 1998-2024
• Studies of the antibacterial activity of and resistance to molecules targeting the ClpP peptidase, NIH, 2017-2022

Publications (52)

Top publication keywords:
Bacterial ProteinsStreptomycesMycobacterium tuberculosisProteasome InhibitorsDrug Resistance, BacterialTryptophan-tRNA LigaseScandiumMesylatesDepsipeptidesGene Expression Regulation, BacterialStreptomyces coelicolorPeptides, CyclicEndopeptidase ClpParabensAnti-Bacterial Agents

• Small molecules restore azole activity against drug-tolerant and drug-resistant Candida isolates.
  mBio 2023 Alabi PE, Gautier C, Murphy TP, Gu X, Lepas M, Aimanianda V, Sello JK, Ene IV
• Hydroxyl-Rich Hydrophilic Endocytosis-Promoting Peptide with No Positive Charge.
  Journal of the American Chemical Society 2022 Wang S, Li Z, Aispuro D, Guevara N, Van Valkenburgh J, Chen B, Zhou X, McCarroll MN, Ji F, Cong X, Sarkar P, Chaudhuri R, Guo Z, Perkins NP, Shao S, Sello JK, Chen K, Xue M
• Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb Mycobacterium tuberculosis ClpXP1P2 Activity in Vitro.
  ACS chemical biology 2022 Schmitz KR, Handy EL, Compton CL, Gupta S, Bishai WR, Sauer RT, Sello JK
• Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections.
  Frontiers in cellular and infection microbiology 2021 Craig E, Calarco A, Conte R, Ambrogi V, d'Ayala GG, Alabi P, Sello JK, Cerruti P, Kima PE
• Discovery of Retro-1 Analogs Exhibiting Enhanced Anti-vaccinia Virus Activity.
  Frontiers in microbiology 2020 Priyamvada L, Alabi P, Leon A, Kumar A, Sambhara S, Olson VA, Sello JK, Satheshkumar PS

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• Principles of Information Storage in Small-Molecule Mixtures.
  IEEE transactions on nanobioscience 2020 Rosenstein JK, Rose C, Reda S, Weber PM, Kim E, Sello J, Geiser J, Kennedy E, Arcadia C, Dombroski A, Oakley K, Chen SL, Tann H, Rubenstein BM
• Multicomponent molecular memory.
  Nature communications 2020 Arcadia CE, Kennedy E, Geiser J, Dombroski A, Oakley K, Chen SL, Sprague L, Ozmen M, Sello J, Weber PM, Reda S, Rose C, Kim E, Rubenstein BM, Rosenstein JK
• Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins.
  eLife 2019 Morgens DW, Chan C, Kane AJ, Weir NR, Li A, Dubreuil MM, Tsui CK, Hess GT, Lavertu A, Han K, Polyakov N, Zhou J, Handy EL, Alabi P, Dombroski A, Yao D, Altman RB, Sello JK, Denic V, Bassik MC
• Analysis of vertebrate vision in a 384-well imaging system.
  Scientific reports 2019 Thorn RJ, Dombroski A, Eller K, Dominguez-Gonzalez TM, Clift DE, Baek P, Seto RJ, Kahn ES, Tucker SK, Colwill RM, Sello JK, Creton R
• Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation.
  Nature communications 2019 McCarroll MN, Gendelev L, Kinser R, Taylor J, Bruni G, Myers-Turnbull D, Helsell C, Carbajal A, Rinaldi C, Kang HJ, Gong JH, Sello JK, Tomita S, Peterson RT, Keiser MJ, Kokel D
• A peculiar IclR family transcription factor regulates para-hydroxybenzoate catabolism in Streptomyces coelicolor.
  Nucleic acids research 2018 Zhang R, Lord DM, Bajaj R, Peti W, Page R, Sello JK
• Structurally optimized analogs of the retrograde trafficking inhibitor Retro-2cycl limit Leishmania infections.
  PLoS neglected tropical diseases 2017 Craig E, Huyghues-Despointes CE, Yu C, Handy EL, Sello JK, Kima PE
• Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.
  ACS infectious diseases 2016 Totaro KA, Barthelme D, Simpson PT, Jiang X, Lin G, Nathan CF, Sauer RT, Sello JK
• A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus.
  PloS one 2016 Arvanitis M, Li G, Li DD, Cotnoir D, Ganley-Leal L, Carney DW, Sello JK, Mylonakis E
• Highly Dynamic Interactions Maintain Kinetic Stability of the ClpXP Protease During the ATP-Fueled Mechanical Cycle.
  ACS chemical biology 2016 Amor AJ, Schmitz KR, Sello JK, Baker TA, Sauer RT
• Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in Their Interaction with the ClpP Peptidase.
  Chembiochem : a European journal of chemical biology 2015 Carney DW, Schmitz KR, Scruse AC, Sauer RT, Sello JK
• Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines.
  Bioorganic & medicinal chemistry 2015 Totaro KA, Barthelme D, Simpson PT, Sauer RT, Sello JK
• Genetic and Proteomic Analyses of Pupylation in Streptomyces coelicolor.
  Journal of bacteriology 2015 Compton CL, Fernandopulle MS, Nagari RT, Sello JK
• Fragment-Based Strategy for Investigating and Suppressing the Efflux of Bioactive Small Molecules.
  ACS infectious diseases 2014 Compton CL, Carney DW, Groomes PV, Sello JK
• Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Schmitz KR, Carney DW, Sello JK, Sauer RT
• A simple fragment of cyclic acyldepsipeptides is necessary and sufficient for ClpP activation and antibacterial activity.
  Chembiochem : a European journal of chemical biology 2014 Carney DW, Compton CL, Schmitz KR, Stevens JP, Sauer RT, Sello JK
• Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses.
  Bioorganic & medicinal chemistry 2014 Carney DW, Nelson CD, Ferris BD, Stevens JP, Lipovsky A, Kazakov T, DiMaio D, Atwood WJ, Sello JK
• Efficient and regiospecific syntheses of peptides with piperazic and dehydropiperazic acids via a multicomponent reaction.
  Organic letters 2014 Handy EL, Totaro KA, Lin CP, Sello JK
• Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity.
  Journal of the American Chemical Society 2014 Carney DW, Schmitz KR, Truong JV, Sauer RT, Sello JK
• A retrograde trafficking inhibitor of ricin and Shiga-like toxins inhibits infection of cells by human and monkey polyomaviruses.
  mBio 2013 Nelson CD, Carney DW, Derdowski A, Lipovsky A, Gee GV, O'Hara B, Williard P, DiMaio D, Sello JK, Atwood WJ
• Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase.
  ACS chemical biology 2013 Compton CL, Schmitz KR, Sauer RT, Sello JK
• Genome Sequence of Streptomyces viridosporus Strain T7A ATCC 39115, a Lignin-Degrading Actinomycete.
  Genome announcements 2013 Davis JR, Goodwin L, Teshima H, Detter C, Tapia R, Han C, Huntemann M, Wei CL, Han J, Chen A, Kyrpides N, Mavrommatis K, Szeto E, Markowitz V, Ivanova N, Mikhailova N, Ovchinnikova G, Pagani I, Pati A…
• Study of PcaV from Streptomyces coelicolor yields new insights into ligand-responsive MarR family transcription factors.
  Nucleic acids research 2013 Davis JR, Brown BL, Page R, Sello JK
• Mining the antibiotic resistome.
  Chemistry & biology 2012 Sello JK
• Genome sequence of Amycolatopsis sp. strain ATCC 39116, a plant biomass-degrading actinomycete.
  Journal of bacteriology 2012 Davis JR, Goodwin LA, Woyke T, Teshima H, Bruce D, Detter C, Tapia R, Han S, Han J, Pitluck S, Nolan M, Mikhailova N, Land ML, Sello JK
• Use of a multicomponent reaction for chemoselective derivatization of multiple classes of metabolites.
  Chembiochem : a European journal of chemical biology 2012 Totaro KA, Okandeji BO, Sello JK
• Replication of biosynthetic reactions enables efficient synthesis of A-factor, a γ-butyrolactone autoinducer from Streptomyces griseus.
  Organic & biomolecular chemistry 2012 Morin JB, Adams KL, Sello JK
• Investigation of the configurational stabilities of chiral isocyanoacetates in multicomponent reactions.
  The Journal of organic chemistry 2011 Carney DW, Truong JV, Sello JK
• Synthesis and evaluation of inhibitors of bacterial drug efflux pumps of the major facilitator superfamily.
  Bioorganic & medicinal chemistry 2011 Okandeji BO, Greenwald DM, Wroten J, Sello JK
• Deletion of the elongation factor 4 gene (lepA) in Streptomyces coelicolor enhances the production of the calcium-dependent antibiotic.
  FEMS microbiology letters 2010 Badu-Nkansah A, Sello JK
• Diversity-oriented synthesis of cyclic acyldepsipeptides leads to the discovery of a potent antibacterial agent.
  Bioorganic & medicinal chemistry 2010 Socha AM, Tan NY, LaPlante KL, Sello JK
• Efficient conversion of triacylglycerols and fatty acids to biodiesel in a microwave reactor using metal triflate catalysts.
  Organic & biomolecular chemistry 2010 Socha AM, Sello JK
• Efficient synthesis of a peculiar vicinal diamine semiochemical from Streptomyces natalensis.
  Organic letters 2010 Morin JB, Sello JK
• Regulation of an auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene via ribosome-mediated transcriptional attenuation.
  Journal of bacteriology 2010 Vecchione JJ, Sello JK
• Regulation of genes in Streptomyces bacteria required for catabolism of lignin-derived aromatic compounds.
  Applied microbiology and biotechnology 2009 Davis JR, Sello JK
• Two distinct major facilitator superfamily drug efflux pumps mediate chloramphenicol resistance in Streptomyces coelicolor.
  Antimicrobial agents and chemotherapy 2009 Vecchione JJ, Alexander B, Sello JK
• Brønsted acidity of substrates influences the outcome of passerini three-component reactions.
  The Journal of organic chemistry 2009 Okandeji BO, Sello JK
• Biomimetic synthesis of a new class of bacterial signaling molecules.
  Organic letters 2009 Davis JB, Bailey JD, Sello JK
• A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
  Antimicrobial agents and chemotherapy 2009 Vecchione JJ, Sello JK
• The oligoribonuclease gene in Streptomyces coelicolor is not transcriptionally or translationally coupled to adpA, a key bldA target.
  FEMS microbiology letters 2008 Sello JK, Buttner MJ
• Characterization of an inducible, antibiotic-resistant aminoacyl-tRNA synthetase gene in Streptomyces coelicolor.
  Journal of bacteriology 2008 Vecchione JJ, Sello JK
• Catalysis of Ugi four component coupling reactions by rare earth metal triflates.
  The Journal of organic chemistry 2008 Okandeji BO, Gordon JR, Sello JK
• The gene encoding RNase III in Streptomyces coelicolor is transcribed during exponential phase and is required for antibiotic production and for proper sporulation.
  Journal of bacteriology 2008 Sello JK, Buttner MJ
• Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol.
  Organic & biomolecular chemistry 2007 Pacholec M, Sello JK, Walsh CT, Thomas MG
• Stereochemical control of skeletal diversity.
  Organic letters 2003 Sello JK, Andreana PR, Lee D, Schreiber SL
• Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis.
  Organic letters 2000 Lee D, Sello JK, Schreiber SL
• Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin.
  Chemistry & biology 1998 Quadri LE, Sello J, Keating TA, Weinreb PH, Walsh CT