Jason Northey, PhD
Specialist
Surgery
School of Medicine

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California 2021

Publications (21)

Top publication keywords:
Trans-ActivatorsExtracellular MatrixStress, MechanicalMammary Glands, HumanPhosphotyrosineShc Signaling Adaptor ProteinsCarcinogenesisMaillard ReactionOncogene ProteinsMammary Neoplasms, ExperimentalMammary Neoplasms, AnimalBreast NeoplasmsBiomechanical PhenomenaReceptors, SteroidHormones

• Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk.
  Cell stem cell 2024 Northey JJ, Hayward MK, Yui Y, Stashko C, Kai F, Mouw JK, Thakar D, Lakins JN, Ironside AJ, Samson S, Mukhtar RA, Hwang ES, Weaver VM
• Design of a mucin-selective protease for targeted degradation of cancer-associated mucins.
  Nature biotechnology 2023 Pedram K, Shon DJ, Tender GS, Mantuano NR, Northey JJ, Metcalf KJ, Wisnovsky SP, Riley NM, Forcina GC, Malaker SA, Kuo A, George BM, Miller CL, Casey KM, Vilches-Moure JG, Ferracane MJ, Weaver VM, …
• A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer.
  Nature communications 2023 Stashko C, Hayward MK, Northey JJ, Pearson N, Ironside AJ, Lakins JN, Oria R, Goyette MA, Mayo L, Russnes HG, Hwang ES, Kutys ML, Polyak K, Weaver VM
• Extracellular Matrix Glycation and Crosslinking in Mammary Tumor Progression.
  Methods in molecular biology (Clifton, N.J.) 2023 Northey JJ, Weaver VM
• Mechanosensitive Steroid Hormone Signaling and Cell Fate.
  Endocrinology 2022 Northey JJ, Weaver VM

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• ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells.
  The EMBO journal 2022 Kai F, Ou G, Tourdot RW, Stashko C, Gaietta G, Swift MF, Volkmann N, Long AF, Han Y, Huang HH, Northey JJ, Leidal AM, Viasnoff V, Bryant DM, Guo W, Wiita AP, Guo M, Dumont S, Hanein D, Radhakrishnan R…
• Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and antitumor immunity.
  Nature cancer 2022 Tsai KK, Huang SS, Northey JJ, Liao WY, Hsu CC, Cheng LH, Werner ME, Chuu CP, Chatterjee C, Lakins JN, Weaver VM
• NCI's publication affiliation conundrum: Reframing innovation to incentivize an equitable path for advocate representation.
  Translational oncology 2021 Samson S, Northey JJ, Acerbi I, Goga A, Flink CL, Weaver VM, LaBarge MA
• Mechanical Pressure Driving Proteoglycan Expression in Mammographic Density: a Self-perpetuating Cycle?
  Journal of mammary gland biology and neoplasia 2021 Reye G, Huang X, Haupt LM, Murphy RJ, Northey JJ, Thompson EW, Momot KI, Hugo HJ
• RASSF1A Suppression as a Potential Regulator of Mechano-Pathobiology Associated with Mammographic Density in BRCA Mutation Carriers.
  Cancers 2021 Reye G, Huang X, Britt KL, Meinert C, Blick T, Xu Y, Momot KI, Lloyd T, Northey JJ, Thompson EW, Hugo HJ
• Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer.
  The Journal of experimental medicine 2021 Drain AP, Zahir N, Northey JJ, Zhang H, Huang PJ, Maller O, Lakins JN, Yu X, Leight JL, Alston-Mills BP, Hwang ES, Chen YY, Park CC, Weaver VM
• Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.
  The Journal of clinical investigation 2020 Northey JJ, Barrett AS, Acerbi I, Hayward MK, Talamantes S, Dean IS, Mouw JK, Ponik SM, Lakins JN, Huang PJ, Wu J, Shi Q, Samson S, Keely PJ, Mukhtar RA, Liphardt JT, Shepherd JA, Hwang ES, Chen YY, …
• New Horizons in Advocacy Engaged Physical Sciences and Oncology Research.
  Trends in cancer 2018 Samson S, Northey JJ, Plaks V, Baas C, Dean I, LaBarge MA, Goga A, Van't Veer LJ, Weaver VM
• Tissue Force Programs Cell Fate and Tumor Aggression.
  Cancer discovery 2017 Northey JJ, Przybyla L, Weaver VM
• PGC-1α Promotes Breast Cancer Metastasis and Confers Bioenergetic Flexibility against Metabolic Drugs.
  Cell metabolism 2017 Andrzejewski S, Klimcakova E, Johnson RM, Tabariès S, Annis MG, McGuirk S, Northey JJ, Chénard V, Sriram U, Papadopoli DJ, Siegel PM, St-Pierre J
• Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion.
  Molecular and cellular biology 2016 Cyr-Depauw C, Northey JJ, Tabariès S, Annis MG, Dong Z, Cory S, Hallett M, Rennhack JP, Andrechek ER, Siegel PM
• Fighting the force: Potential of homeobox genes for tumor microenvironment regulation.
  Biochimica et biophysica acta 2015 Northcott JM, Northey JJ, Barnes JM, Weaver VM
• A complex containing LPP and α-actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells.
  Journal of cell science 2013 Ngan E, Northey JJ, Brown CM, Ursini-Siegel J, Siegel PM
• Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor β (TGFβ)-induced breast cancer cell migration, invasion, and metastasis.
  The Journal of biological chemistry 2012 Northey JJ, Dong Z, Ngan E, Kaplan A, Hardy WR, Pawson T, Siegel PM
• Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion.
  Molecular and cellular biology 2008 Northey JJ, Chmielecki J, Ngan E, Russo C, Annis MG, Muller WJ, Siegel PM
• Targeting aberrant TGF-beta signaling in pre-clinical models of cancer.
  Anti-cancer agents in medicinal chemistry 2007 Mourskaia AA, Northey JJ, Siegel PM