Jason Maynard, PhD
Associate Researcher
Pharmaceutical Chemistry
School of Pharmacy

Publications (21)

Top publication keywords:
AlarminsProtein Processing, Post-TranslationalN-AcetylglucosaminyltransferasesSciatic NerveCysteineAcetylglucosamineMolecular ChaperonesGlycopeptidesGlycoproteinsArabidopsis ProteinsApoferritinsDrosophilaGlycosylationMannosyl-Glycoprotein Endo-beta-N-AcetylglucosaminidaseIntestinal Mucosa

• Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment.
  Nature aging 2025 Remesal L, Sucharov-Costa J, Wu Y, Pratt KJB, Bieri G, Philp A, Phan M, Aghayev T, White CW, Wheatley EG, Zou B, Desousa BR, Couthouis J, Jian IH, Xie XS, Lu Y, Maynard JC, Burlingame AL, Villeda SA
• SPINDLY mediates O-fucosylation of hundreds of proteins and sugar-dependent growth in Arabidopsis.
  The Plant cell 2023 Bi Y, Shrestha R, Zhang Z, Hsu CC, Reyes AV, Karunadasa S, Baker PR, Maynard JC, Liu Y, Hakimi A, Lopez-Ferrer D, Hassan T, Chalkley RJ, Xu SL, Wang ZY
• O-GlcNAc glycosylation orchestrates fate decision and niche function of bone marrow stromal progenitors.
  eLife 2023 Zhang Z, Huang Z, Awad M, Elsalanty M, Cray J, Ball LE, Maynard JC, Burlingame AL, Zeng H, Mansky KC, Ruan HB
• Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C.
  Immunity 2022 Zhao M, Ren K, Xiong X, Xin Y, Zou Y, Maynard JC, Kim A, Battist AP, Koneripalli N, Wang Y, Chen Q, Xin R, Yang C, Huang R, Yu J, Huang Z, Zhang Z, Wang H, Wang D, Xiao Y, Salgado OC, Jarjour NN, …
• Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C.
  Immunity 2022 Zhao M, Ren K, Xiong X, Xin Y, Zou Y, Maynard JC, Kim A, Battist AP, Koneripalli N, Wang Y, Chen Q, Xin R, Yang C, Huang R, Yu J, Huang Z, Zhang Z, Wang H, Wang D, Xiao Y, Salgado OC, Jarjour NN, …

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• Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.
  Molecular neurodegeneration 2021 Mohan S, Sampognaro PJ, Argouarch AR, Maynard JC, Welch M, Patwardhan A, Courtney EC, Zhang J, Mason A, Li KH, Huang EJ, Seeley WW, Miller BL, Burlingame A, Jacobson MP, Kao AW
• Methods for Enrichment and Assignment of N-Acetylglucosamine Modification Sites.
  Molecular & cellular proteomics : MCP 2021 Maynard JC, Chalkley RJ
• Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation.
  Proceedings of the National Academy of Sciences of the United States of America 2020 White CW, Fan X, Maynard JC, Wheatley EG, Bieri G, Couthouis J, Burlingame AL, Villeda SA
• Cytosolic N-GlcNAc proteins are formed by the action of endo-β-N-acetylglucosaminidase.
  Biochemical and biophysical research communications 2020 Maynard JC, Fujihira H, Dolgonos GE, Suzuki T, Burlingame AL
• The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation.
  Nature communications 2019 Liu B, Salgado OC, Singh S, Hippen KL, Maynard JC, Burlingame AL, Ball LE, Blazar BR, Farrar MA, Hogquist KA, Ruan HB
• Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Kim S, Maynard JC, Strickland A, Burlingame AL, Milbrandt J
• Proteomic analysis reveals O-GlcNAc modification on proteins with key regulatory functions in Arabidopsis.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Xu SL, Chalkley RJ, Maynard JC, Wang W, Ni W, Jiang X, Shin K, Cheng L, Savage D, Hühmer AF, Burlingame AL, Wang ZY
• Schwann Cell O-GlcNAc Glycosylation Is Required for Myelin Maintenance and Axon Integrity.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Kim S, Maynard JC, Sasaki Y, Strickland A, Sherman DL, Brophy PJ, Burlingame AL, Milbrandt J
• Cysteine S-linked N-acetylglucosamine (S-GlcNAcylation), A New Post-translational Modification in Mammals.
  Molecular & cellular proteomics : MCP 2016 Maynard JC, Burlingame AL, Medzihradszky KF
• SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells.
  eLife 2016 Myers SA, Peddada S, Chatterjee N, Friedrich T, Tomoda K, Krings G, Thomas S, Maynard J, Broeker M, Thomson M, Pollard K, Yamanaka S, Burlingame AL, Panning B
• Development of a Grp94 inhibitor.
  Journal of the American Chemical Society 2012 Duerfeldt AS, Peterson LB, Maynard JC, Ng CL, Eletto D, Ostrovsky O, Shinogle HE, Moore DS, Argon Y, Nicchitta CV, Blagg BS
• Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control.
  Developmental biology 2010 Maynard JC, Pham T, Zheng T, Jockheck-Clark A, Rankin HB, Newgard CB, Spana EP, Nicchitta CV
• Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Lev A, Dimberu P, Das SR, Maynard JC, Nicchitta CV, Bennink JR, Yewdell JW
• The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation.
  Immunity 2008 Lev A, Takeda K, Zanker D, Maynard JC, Dimberu P, Waffarn E, Gibbs J, Netzer N, Princiotta MF, Neckers L, Picard D, Nicchitta CV, Chen W, Reiter Y, Bennink JR, Yewdell JW
• Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo.
  Immunology 2008 Tewalt EF, Maynard JC, Walters JJ, Schell AM, Berwin BL, Nicchitta CV, Norbury CC
• Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94.
  Protein science : a publication of the Protein Society 2006 Chu F, Maynard JC, Chiosis G, Nicchitta CV, Burlingame AL