Janice Schwartz, MD
Recalled Professor in Residence
Medicine
School of Medicine

I have studied models of aging from in vitro models of cardiac changes with aging to physiologic and pharmacokinetic investigations of healthy humans to population studies of community dwelling elderly, and frail elderly adults.

My current work focuses on improving medication use in the very oldest people, in optimizing outcomes in older people receiving polypharmacy, and the translation and optimization of new therapeutic agents such as anticoagulants during clinical use to benefit the very oldest and frailest patients. I recently completed a ORISE visiting Professorship in the Office of Clinical Pharmacology at the FDA to stimulate initiatives to improve the drug evaluation and monitoring process for older adults and incorporate patient-centered outcomes into the drug evaluation process.

• "Unjustified Partiality or Impartial Bias? Reckoning with Age and Disability Discrimination in Cancer Clinical Trials".
  The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics 2024 Schwartz JB, Covinsky K
• Navigating the Path to Inclusion: Understanding Barriers and Facilitators to Clinical Trial Participation Among Chinese Older Adults in the United States with Multimorbidity.
  Journal of general internal medicine 2024 Tarn DM, Liu RY, Pun T, Schwartz JB
• Prevalence and proportion by age and sex of chronic health conditions in a large healthcare system.
  PloS one 2024 Gronich N, Saliba W, Schwartz JB
• Reasons for Nonadherence to the Direct Oral Anticoagulant Apixaban: A Cross-Sectional Survey of Atrial Fibrillation Patients.
  JACC. Advances 2023 Tarn DM, Shih K, Tseng CH, Thomas A, Schwartz JB
• Polypharmacy in Older Heart Failure Patients: a Multidisciplinary Approach.
  Current heart failure reports 2022 Sukumar S, Orkaby AR, Schwartz JB, Marcum Z, Januzzi JL, Vaduganathan M, Warraich HJ
• Apixaban Concentrations in Routine Clinical Care of Older Adults with Non-valvular Atrial Fibrillation
  JACC ADV 2022 Thomas A, Fang MC, Kogan S, Hubbard CC, Friedman PN, Gong L, Klein, TE, Nutescu, EA, O’Brien, TJ, Tuck M, Perera M.A., Schwartz, JB
• Apixaban Concentrations in Routine Clinical Care of Older Adults With Nonvalvular Atrial Fibrillation.
  JACC. Advances 2022 Thomas A, Fang MC, Kogan S, Hubbard CC, Friedman PN, Gong L, Klein TE, Nutescu EA, O'Brien TJ, Tuck M, Perera MA, Schwartz JB
• Reasons for nonadherence to the direct oral anticoagulant apixaban for atrial fibrillation.
  Journal of the American Geriatrics Society 2021 Tarn DM, Shih KJ, Schwartz JB
• Development, evaluation and use of COVID-19 vaccines in older adults: Preliminary principles for the pandemic and beyond.
  British journal of clinical pharmacology 2021 Hilmer SN, Petrovic M, Le Couteur DG, Schwartz JB, Thuermann P
• A challenge: The American Geriatric Society needs to address the lack of inclusion of older adults in new drug evaluation.
  Journal of the American Geriatrics Society 2021 Slattum PW, Schwartz JB
• Anti-factor Xa activity assays of direct-acting oral anticoagulants during clinical care: An observational study.
  Research and practice in thrombosis and haemostasis 2021 Sukumar S, Cabero M, Tiu S, Fang MC, Kogan SC, Schwartz JB
• Primary nonadherence to statin medications: Survey of patient perspectives.
  Preventive medicine reports 2021 Tarn DM, Pletcher MJ, Tosqui R, Fernandez A, Tseng CH, Moriconi R, Bell DS, Barrientos M, Turner JA, Schwartz JB
• Something Old and Something New: The Time Is Right for Geriatric Engineering Programs.
  Journal of the American Geriatrics Society 2021 Herr AE, Schwartz JB
• Perceptions of Patients with Primary Nonadherence to Statin Medications.
  Journal of the American Board of Family Medicine : JABFM 2021 Tarn DM, Barrientos M, Pletcher MJ, Cox K, Turner J, Fernandez A, Schwartz JB
• Polypharmacy: A Five-Step Call to Action for Family Physicians.
  Family medicine 2020 Tarn DM, Schwartz JB
• Prevalence and Knowledge of Potential Interactions Between Over-the-Counter Products and Apixaban.
  Journal of the American Geriatrics Society 2019 Tarn DM, Barrientos M, Wang AY, Ramaprasad A, Fang MC, Schwartz JB
• Apixaban Concentrations with Lower than Recommended Dosing in Older Adults with Atrial Fibrillation.
  Journal of the American Geriatrics Society 2019 Sukumar S, Gulilat M, Linton B, Gryn SE, Dresser GK, Alfonsi JE, Schwarz UI, Kim RB, Schwartz JB
• Pharmacotherapy Research Priorities in Older Adults With Cardiovascular Disease in Nursing Homes, Assisted Living, and Home Care: Report From a Satellite Symposium of the ACC, AGS, NIA Workshop.
  Journal of the American Medical Directors Association 2019 Zarowitz BJ, Nace DA, Brandt N, Schwartz JB
• Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2019 Winston CN, Goetzl EJ, Schwartz JB, Elahi FM, Rissman RA
• Pharmacotherapy in Older Adults with Cardiovascular Disease: Report from an American College of Cardiology, American Geriatrics Society, and National Institute on Aging Workshop.
  Journal of the American Geriatrics Society 2018 Schwartz JB, Schmader KE, Hanlon JT, Abernethy DR, Gray S, Dunbar-Jacob J, Holmes HM, Murray MD, Roberts R, Joyner M, Peterson J, Lindeman D, Tai-Seale M, Downey L, Rich MW
• Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations.
  The Journal of clinical endocrinology and metabolism 2018 Schwartz JB, Gallagher JC, Jorde R, Berg V, Walsh J, Eastell R, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, Holick M, Orwoll E, Nielson C, Kaufmann M, Jones G, Bouillon R, Lai J, Verotta …
• Editorial Commentary: Blood pressure and cognition in the elderly.
  Trends in cardiovascular medicine 2018 Schwartz JB
• Deficient neurotrophic factors of CSPG4-type neural cell exosomes in Alzheimer disease.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Goetzl EJ, Nogueras-Ortiz C, Mustapic M, Mullins RJ, Abner EL, Schwartz JB, Kapogiannis D
• Medication burden attributable to chronic co-morbid conditions in the very old and vulnerable.
  PloS one 2018 Moore KL, Patel K, Boscardin WJ, Steinman MA, Ritchie C, Schwartz JB
• High complement levels in astrocyte-derived exosomes of Alzheimer disease.
  Annals of neurology 2018 Goetzl EJ, Schwartz JB, Abner EL, Jicha GA, Kapogiannis D
• Farewell to Our Good Friend, Outstanding Mentor, and Colleague Darrell R. Abernethy (1949-2017).
  Clinical pharmacology and therapeutics 2018 Schwartz JB, Woosley RL, Peck CC
• Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer's disease.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Goetzl EJ, Abner EL, Jicha GA, Kapogiannis D, Schwartz JB
• Authors Have Incorrectly Calculated Need for Renal Dose Adjustments for NOACs.
  Journal of the American College of Cardiology 2017 Schwartz JB
• Dosing Accuracy of Direct Oral Anticoagulants in an Academic Medical Center.
  Journal of hospital medicine 2017 Schwartz J, Merrill S, de Leon N, Thompson A, Fang M
• Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Goetzl EJ, Schwartz JB, Mustapic M, Lobach IV, Daneman R, Abner EL, Jicha GA
• Dabigatran Compared With Rivaroxaban vs Warfarin.
  JAMA internal medicine 2017 Schwartz JB
• Letter to the Editor: "Effects of Testosterone Replacement on Electrocardiographic Parameters in Men: Findings From Two Randomized Trials".
  The Journal of clinical endocrinology and metabolism 2017 Schwartz JB, Rosano G, Channer KS
• Pharmacokinetics and Saturable Absorption of Gabapentin in Nursing Home Elderly Patients.
  The AAPS journal 2017 Ahmed GF, Bathena SP, Brundage RC, Leppik IE, Conway JM, Schwartz JB, Birnbaum AK
• Potential impact of substituting estimated Glomerular Filtration Rate for estimated Creatinine Clearance for dosing of Direct Oral Anticoagulants
  J Am Geriatr Soc 2016 Schwartz, JB
• Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Goetzl EJ, Kapogiannis D, Schwartz JB, Lobach IV, Goetzl L, Abner EL, Jicha GA, Karydas AM, Boxer A, Miller BL
• Potential Effect of Substituting Estimated Glomerular Filtration Rate for Estimated Creatinine Clearance for Dosing of Direct Oral Anticoagulants.
  Journal of the American Geriatrics Society 2016 Schwartz JB
• Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Goetzl EJ, Mustapic M, Kapogiannis D, Eitan E, Lobach IV, Goetzl L, Schwartz JB, Miller BL
• Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial.
  Journal of the American Geriatrics Society 2016 Schwartz JB, Kane L, Bikle D
• Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease.
  Neurology 2015 Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, Kapogiannis D
• Low neural exosomal levels of cellular survival factors in Alzheimer's disease.
  Annals of clinical and translational neurology 2015 Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, Carlson OD, Mustapic M, Kapogiannis D
• Cardiovascular physiology in the older adults.
  Journal of geriatric cardiology : JGC 2015 Dai X, Hummel SL, Salazar JB, Taffet GE, Zieman S, Schwartz JB
• Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction.
  Liver international : official journal of the International Association for the Study of the Liver 2015 Lai JC, Bikle DD, Lizaola B, Hayssen H, Terrault NA, Schwartz JB
• Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Kapogiannis D, Boxer A, Schwartz JB, Abner EL, Biragyn A, Masharani U, Frassetto L, Petersen RC, Miller BL, Goetzl EJ
• Primary prevention: do the very elderly require a different approach?
  Trends in cardiovascular medicine 2014 Schwartz JB
• Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2014 Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, Abner EL, Petersen RC, Federoff HJ, Miller BL, Goetzl EJ
• Prescribing quality in older veterans: a multifocal approach.
  Journal of general internal medicine 2014 Steinman MA, Miao Y, Boscardin WJ, Komaiko KD, Schwartz JB
• Patterns of chronic co-morbid medical conditions in older residents of U.S. nursing homes: differences between the sexes and across the agespan.
  The journal of nutrition, health & aging 2014 Moore KL, Boscardin WJ, Steinman MA, Schwartz JB
• Relationship of vitamin D, HIV, HIV treatment, and lipid levels in the Women's Interagency HIV Study of HIV-infected and uninfected women in the United States.
  Journal of the International Association of Providers of AIDS Care 2014 Schwartz JB, Moore KL, Yin M, Sharma A, Merenstein D, Islam T, Golub ET, Tien PC, Adeyemi OM
• Variability in free 25(OH) vitamin D levels in clinical populations.
  The Journal of steroid biochemistry and molecular biology 2013 Schwartz JB, Lai J, Lizaola B, Kane L, Weyland P, Terrault NA, Stotland N, Bikle D
• Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships.
  The Journal of clinical endocrinology and metabolism 2013 Kane L, Moore K, Lütjohann D, Bikle D, Schwartz JB
• Aging enhances release of exosomal cytokine mRNAs by Aβ1-42-stimulated macrophages.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Mitsuhashi M, Taub DD, Kapogiannis D, Eitan E, Zukley L, Mattson MP, Ferrucci L, Schwartz JB, Goetzl EJ
• Patterns of multimorbidity in elderly veterans.
  Journal of the American Geriatrics Society 2012 Steinman MA, Lee SJ, John Boscardin W, Miao Y, Fung KZ, Moore KL, Schwartz JB
• Distinct energy requirements for human memory CD4 T-cell homeostatic functions.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Taub DD, Hesdorffer CS, Ferrucci L, Madara K, Schwartz JB, Goetzl EJ
• Age and sex variation in prevalence of chronic medical conditions in older residents of U.S. nursing homes.
  Journal of the American Geriatrics Society 2012 Moore KL, Boscardin WJ, Steinman MA, Schwartz JB
• Distinctive immunoregulatory effects of adenosine on T cells of older humans.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Hesdorffer CS, Malchinkhuu E, Biragyn A, Mabrouk OS, Kennedy RT, Madara K, Taub DD, Longo DL, Schwartz JB, Ferrucci L, Goetzl EJ
• Defective T cell chemotaxis to sphingosine 1-phosphate and chemokine CCL21 in idiopathic T lymphocytopenia.
  Journal of clinical immunology 2011 Goetzl EJ, Schwartz JB, Huang MC
• Effects of testosterone on the Q-T interval in older men and older women with chronic heart failure.
  International journal of andrology 2011 Schwartz JB, Volterrani M, Caminiti G, Marazzi G, Fini M, Rosano GM, Iellamo F
• Failure of pharmacogenetic-based dosing algorithms to identify older patients requiring low daily doses of warfarin.
  Journal of the American Medical Directors Association 2011 Schwartz JB, Kane L, Moore K, Wu AH
• Preferential enhancement of older human T cell cytokine generation, chemotaxis, proliferation and survival by lenalidomide.
  Clinical immunology (Orlando, Fla.) 2010 Huang MC, Greig NH, Luo W, Tweedie D, Schwartz JB, Longo DL, Ferrucci L, Ershler WB, Goetzl EJ
• Gender specificity of altered human immune cytokine profiles in aging.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Goetzl EJ, Huang MC, Kon J, Patel K, Schwartz JB, Fast K, Ferrucci L, Madara K, Taub DD, Longo DL
• Population analyses of atorvastatin clearance in patients living in the community and in nursing homes.
  Clinical pharmacology and therapeutics 2009 Schwartz JB, Verotta D
• Clin Pharmacol Ther
  Aging and medications: Past, Present, Future. 2009 Schwartz JB and Abernethy, DR. 2009; 85 (1): 3-10.
• Clin Pharmacol Ther
  Population analyses of atorvastatin in patients living in the community and nursing homes. 2009 Verotta D, Schwartz JB.
• Effects of vitamin D supplementation in atorvastatin-treated patients: a new drug interaction with an unexpected consequence.
  Clinical pharmacology and therapeutics 2008 Schwartz JB
• The current state of knowledge on age, sex, and their interactions on clinical pharmacology.
  Clinical pharmacology and therapeutics 2007 Schwartz JB
• Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative.
  Circulation 2006 Alexander KP, Chen AY, Newby LK, Schwartz JB, Redberg RF, Hochman JS, Roe MT, Gibler WB, Ohman EM, Peterson ED, CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse …
• Erythromycin breath test results in elderly, very elderly, and frail elderly persons.
  Clinical pharmacology and therapeutics 2006 Schwartz JB
• Population analyses of amlodipine in patients living in the community and patients living in nursing homes.
  Clinical pharmacology and therapeutics 2006 Kang D, Verotta D, Schwartz JB
• Sample size computations for PK/PD population models.
  Journal of pharmacokinetics and pharmacodynamics 2005 Kang D, Schwartz JB, Verotta D
• What does the Medicare prescription drug legislation mean for the American cardiologist?
  The American journal of geriatric cardiology 2005 Schwartz JB, Redberg RF
• Estrogen and progestin use and the QT interval in postmenopausal women.
  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 2004 Kadish AH, Greenland P, Limacher MC, Frishman WH, Daugherty SA, Schwartz JB
• A sample size computation method for non-linear mixed effects models with applications to pharmacokinetics models.
  Statistics in medicine 2004 Kang D, Schwartz JB, Verotta D
• Sudden cardiac death among women in the United States.
  Circulation 2003 Schwartz JB
• Gender-specific implications for cardiovascular medication use in the elderly optimizing therapy for older women.
  Cardiology in review 2003 Schwartz JB
• Population analyses of sustained-release verapamil in patients: effects of sex, race, and smoking.
  Clinical pharmacology and therapeutics 2003 Kang D, Verotta D, Krecic-Shepard ME, Modi NB, Gupta SK, Schwartz JB
• The influence of sex on pharmacokinetics.
  Clinical pharmacokinetics 2003 Schwartz JB
• Pharmacologic agents for weight reduction.
  The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 2002 Haller C, Schwartz JB
• Peripheral arterial disease: drug therapy.
  The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 2002 Schwartz JB
• Pharmacogenetics: has it reached the clinic?
  The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 2002 Schwartz JB
• Anticoagulant and thrombolytic therapies in women.
  The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 2002 Schwartz JB
• Drug Interactions in the Elderly With Coronary Artery Disease - Do These Interfere With Effective Therapy?
  The American journal of geriatric cardiology 1998 Schwartz JB
• Age-Related Pharmacodynamic Changes in the Elderly: Treatment Considerations in Heart Failure.
  The American journal of geriatric cardiology 1996 Schwartz JB