Janet Finer-Moore, PhD
RES-FY
Biochemistry and Biophysics
School of Medicine

Publications (79)

Top publication keywords:
QuinazolinesModels, MoleculartRNA MethyltransferasesCrystallography, X-RayFolic AcidHydro-LyasesThymidylate SynthaseDeoxyuracil NucleotidesRNA, TransferEscherichia coli ProteinsEscherichia coliProtein ConformationMonosaccharide Transport ProteinsBinding SitesSubstrate Specificity

• Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.
  Nature structural & molecular biology 2023 Kim SK, Dickinson MS, Finer-Moore J, Guan Z, Kaake RM, Echeverria I, Chen J, Pulido EH, Sali A, Krogan NJ, Rosenberg OS, Stroud RM
• Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.
  bioRxiv : the preprint server for biology 2023 Kim SK, Dickinson MS, Finer-Moore J, Guan Z, Kaake RM, Echeverria I, Chen J, Pulido EH, Sali A, Krogan NJ, Rosenberg OS, Stroud RM
• Diversity of function and mechanism in a family of organic anion transporters.
  Current opinion in structural biology 2022 Li F, Eriksen J, Finer-Moore J, Stroud RM, Edwards RH
• Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog.
  Biochemistry 2021 Kholodar SA, Finer-Moore JS, Swiderek K, Arafet K, Moliner V, Stroud RM, Kohen A
• Ion transport and regulation in a synaptic vesicle glutamate transporter.
  Science (New York, N.Y.) 2020 Li F, Eriksen J, Finer-Moore J, Chang R, Nguyen P, Bowen A, Myasnikov A, Yu Z, Bulkley D, Cheng Y, Edwards RH, Stroud RM

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• Diversity in kinetics correlated with structure in nano body-stabilized LacY.
  PloS one 2020 Kumar H, Finer-Moore J, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM
• Crystal Structure of a ligand-bound LacY-Nanobody Complex.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Kumar H, Finer-Moore JS, Jiang X, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM
• A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer.
  Biochemistry 2018 Finer-Moore JS, Lee TT, Stroud RM
• Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Kapoor K, Finer-Moore JS, Pedersen BP, Caboni L, Waight A, Hillig RC, Bringmann P, Heisler I, Müller T, Siebeneicher H, Stroud RM
• Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.
  Journal of molecular biology 2015 Finer-Moore J, Czudnochowski N, O'Connell JD, Wang AL, Stroud RM
• Structure of LacY with an α-substituted galactoside: Connecting the binding site to the protonation site.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Kumar H, Finer-Moore JS, Kaback HR, Stroud RM
• Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion.
  Cell 2015 Rosenberg OS, Dovala D, Li X, Connolly L, Bendebury A, Finer-Moore J, Holton J, Cheng Y, Stroud RM, Cox JS
• Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides.
  Journal of medicinal chemistry 2014 Tochowicz A, Santucci M, Saxena P, Guaitoli G, Trande M, Finer-Moore J, Stroud RM, Costi MP
• Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Lohse MB, Rosenberg OS, Cox JS, Stroud RM, Finer-Moore JS, Johnson AD
• Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Monk BC, Tomasiak TM, Keniya MV, Huschmann FU, Tyndall JD, O'Connell JD, Cannon RD, McDonald JG, Rodriguez A, Finer-Moore JS, Stroud RM
• Structure of sugar-bound LacY.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Kumar H, Kasho V, Smirnova I, Finer-Moore JS, Kaback HR, Stroud RM
• The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.
  Nucleic acids research 2013 Czudnochowski N, Ashley GW, Santi DV, Alian A, Finer-Moore J, Stroud RM
• Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells.
  Journal of medicinal chemistry 2013 Tochowicz A, Dalziel S, Eidam O, O'Connell JD, Griner S, Finer-Moore JS, Stroud RM
• In human pseudouridine synthase 1 (hPus1), a C-terminal helical insert blocks tRNA from binding in the same orientation as in the Pus1 bacterial homologue TruA, consistent with their different target selectivities.
  Journal of molecular biology 2013 Czudnochowski N, Wang AL, Finer-Moore J, Stroud RM
• Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site.
  Journal of the American Chemical Society 2013 Wang Z, Sapienza PJ, Abeysinghe T, Luzum C, Lee AL, Finer-Moore JS, Stroud RM, Kohen A
• Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase.
  Journal of medicinal chemistry 2012 Carosati E, Tochowicz A, Marverti G, Guaitoli G, Benedetti P, Ferrari S, Stroud RM, Finer-Moore J, Luciani R, Farina D, Cruciani G, Costi MP
• A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase.
  Journal of the American Chemical Society 2012 Wang Z, Abeysinghe T, Finer-Moore JS, Stroud RM, Kohen A
• LpxI structures reveal how a lipid A precursor is synthesized.
  Nature structural & molecular biology 2012 Metzger LE, Lee JK, Finer-Moore JS, Raetz CR, Stroud RM
• EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Rosenberg OS, Dovey C, Tempesta M, Robbins RA, Finer-Moore JS, Stroud RM, Cox JS
• Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1.
  BMC biology 2011 Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P
• Structural and functional basis for RNA cleavage by Ire1.
  BMC biology 2011 Korennykh AV, Korostelev AA, Egea PF, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P
• Structural context shapes the aquaporin selectivity filter.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Savage DF, O'Connell JD, Miercke LJ, Finer-Moore J, Stroud RM
• Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome.
  Journal of molecular biology 2009 Alian A, DeGiovanni A, Griner SL, Finer-Moore JS, Stroud RM
• The unfolded protein response signals through high-order assembly of Ire1.
  Nature 2008 Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P
• Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Alian A, Lee TT, Griner SL, Stroud RM, Finer-Moore J
• The crystal structure of E. coli rRNA pseudouridine synthase RluE.
  Journal of molecular biology 2007 Pan H, Ho JD, Stroud RM, Finer-Moore J
• Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective.
  The Journal of biological chemistry 2006 Hur S, Stroud RM, Finer-Moore J
• The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261.
  Biochemistry 2006 Newby Z, Lee TT, Morse RJ, Liu Y, Liu L, Venkatraman P, Santi DV, Finer-Moore JS, Stroud RM
• On the mechanism of sensing unfolded protein in the endoplasmic reticulum.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P
• The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition.
  Acta crystallographica. Section D, Biological crystallography 2005 Finer-Moore JS, Anderson AC, O'Neil RH, Costi MP, Ferrari S, Krucinski J, Stroud RM
• Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Pan H, Agarwalla S, Moustakas DT, Finer-Moore J, Stroud RM
• The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase.
  Protein engineering 2003 Gonzalez-Pacanowska D, Ruiz-Perez LM, Carreras-Gómez MA, Costi MP, Stroud RM, Finer-Moore J, Santi DV
• The only active mutant of thymidylate synthase D169, a residue far from the site of methyl transfer, demonstrates the exquisite nature of enzyme specificity.
  Protein engineering 2003 Birdsall DL, Finer-Moore J, Stroud RM
• Conformational dynamics along an enzymatic reaction pathway: thymidylate synthase, "the movie".
  Biochemistry 2003 Stroud RM, Finer-Moore JS
• Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure.
  Biochemistry 2003 Finer-Moore JS, Santi DV, Stroud RM
• Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access.
  Biochemistry 2002 Fritz TA, Liu L, Finer-Moore JS, Stroud RM
• Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.
  Journal of molecular biology 2001 Sayre PH, Finer-Moore JS, Fritz TA, Biermann D, Gates SB, MacKellar WC, Patel VF, Stroud RM
• Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.
  Chemistry & biology 2001 Fritz TA, Tondi D, Finer-Moore JS, Costi MP, Stroud RM
• Replacement set mutagenesis of the four phosphate-binding arginine residues of thymidylate synthase.
  Protein engineering 2000 Kawase S, Cho SW, Rozelle J, Stroud RM, Finer-Moore J, Santi DV
• Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Chen JC, Krucinski J, Miercke LJ, Finer-Moore JS, Tang AH, Leavitt AD, Stroud RM
• Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
  Biochemistry 2000 Morse RJ, Kawase S, Santi DV, Finer-Moore J, Stroud RM
• Inactivity of N229A thymidylate synthase due to water-mediated effects: isolating a late stage in methyl transfer.
  Journal of molecular biology 1998 Reyes CL, Sage CR, Rutenber EE, Nissen RM, Finer-Moore JS, Stroud RM
• Efficiency of signalling through cytokine receptors depends critically on receptor orientation.
  Nature 1998 Syed RS, Reid SW, Li C, Cheetham JC, Aoki KH, Liu B, Zhan H, Osslund TD, Chirino AJ, Zhang J, Finer-Moore J, Elliott S, Sitney K, Katz BA, Matthews DJ, Wendoloski JJ, Egrie J, Stroud RM
• D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
  Biochemistry 1998 Sage CR, Michelitsch MD, Stout TJ, Biermann D, Nissen R, Finer-Moore J, Stroud RM
• The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis.
  Protein engineering 1998 Birdsall DL, Huang W, Santi DV, Stroud RM, Finer-Moore J
• Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.
  Journal of molecular biology 1998 Finer-Moore JS, Liu L, Birdsall DL, Brem R, Apfeld J, Santi DV, Stroud RM
• Design of potent selective zinc-mediated serine protease inhibitors.
  Nature 1998 Katz BA, Clark JM, Finer-Moore JS, Jenkins TE, Johnson CR, Ross MJ, Luong C, Moore WR, Stroud RM
• A novel dCMP methylase by engineering thymidylate synthase.
  Biochemistry 1997 Agarwalla S, LaPorte S, Liu L, Finer-Moore J, Stroud RM, Santi DV
• Access to phosphorylation in isocitrate dehydrogenase may occur by domain shifting.
  Biochemistry 1997 Finer-Moore J, Tsutakawa SE, Cherbavaz DR, LaPorte DC, Koshland DE, Stroud RM
• Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase.
  Biochemistry 1996 Finer-Moore JS, Liu L, Schafmeister CE, Birdsall DL, Mau T, Santi DV, Stroud RM
• Asparagine 229 mutants of thymidylate synthase catalyze the methylation of 3-methyl-2'-deoxyuridine 5'-monophosphate.
  Biochemistry 1996 Costi PM, Liu L, Finer-Moore JS, Stroud RM, Santi DV
• Entropy in bi-substrate enzymes: proposed role of an alternate site in chaperoning substrate into, and products out of, thymidylate synthase.
  Journal of molecular biology 1996 Birdsall DL, Finer-Moore J, Stroud RM
• Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.
  Protein engineering 1996 Finer-Moore JS, Fauman EB, Morse RJ, Santi DV, Stroud RM
• Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface.
  Biochemistry 1995 Katz BA, Finer-Moore J, Mortezaei R, Rich DH, Stroud RM
• Crystal structure of thymidylate synthase from T4 phage: component of a deoxynucleoside triphosphate-synthesizing complex.
  Biochemistry 1994 Finer-Moore JS, Maley GF, Maley F, Montfort WR, Stroud RM
• Mechanism-based inhibition of thymidylate synthase by 5-(trifluoromethyl)-2'-deoxyuridine 5'-monophosphate.
  Biochemistry 1994 Eckstein JW, Foster PG, Finer-Moore J, Wataya Y, Santi DV
• Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
  Journal of molecular biology 1993 Finer-Moore J, Fauman EB, Foster PG, Perry KM, Santi DV, Stroud RM
• Stereochemistry of a multistep/bipartite methyl transfer reaction: thymidylate synthase.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993 Stroud RM, Finer-Moore JS
• Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism.
  Biochemistry 1992 Kamb A, Finer-Moore JS, Stroud RM
• Structural basis for recognition of polyglutamyl folates by thymidylate synthase.
  Biochemistry 1992 Kamb A, Finer-Moore J, Calvert AH, Stroud RM
• Solvent structure in crystals of trypsin determined by X-ray and neutron diffraction.
  Proteins 1992 Finer-Moore JS, Kossiakoff AA, Hurley JH, Earnest T, Stroud RM
• Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase.
  Biochemistry 1990 Finer-Moore JS, Montfort WR, Stroud RM
• Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.
  Biochemistry 1990 Montfort WR, Perry KM, Fauman EB, Finer-Moore JS, Maley GF, Hardy L, Maley F, Stroud RM
• Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases.
  Proteins 1990 Perry KM, Fauman EB, Finer-Moore JS, Montfort WR, Maley GF, Maley F, Stroud RM
• Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis.
  Molecular and cellular biology 1988 Basson ME, Thorsness M, Finer-Moore J, Stroud RM, Rine J
• Structural studies of alpha-bungarotoxin. 3. Corrections in the primary sequence and X-ray structure and characterization of an isotoxic alpha-bungarotoxin.
  Biochemistry 1988 Kosen PA, Finer-Moore J, McCarthy MP, Basus VJ
• The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis.
  Science (New York, N.Y.) 1987 Sprang S, Standing T, Fletterick RJ, Stroud RM, Finer-Moore J, Xuong NH, Hamlin R, Rutter WJ, Craik CS
• Atomic structure of thymidylate synthase: target for rational drug design.
  Science (New York, N.Y.) 1987 Hardy LW, Finer-Moore JS, Montfort WR, Jones MO, Santi DV, Stroud RM
• Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum.
  The Journal of biological chemistry 1985 Liscum L, Finer-Moore J, Stroud RM, Luskey KL, Brown MS, Goldstein JL
• Acetylcholine receptor structure, function, and evolution.
  Annual review of cell biology 1985 Stroud RM, Finer-Moore J
• Location of an extrinsic label in the primary and tertiary structure of bacteriorhodopsin.
  Biophysical journal 1984 Katre NV, Finer-Moore J, Stroud RM, Hayward SB
• Subunit secondary structure in filamentous viruses: predictions and observations.
  Journal of biomolecular structure & dynamics 1984 Finer-Moore J, Stroud RM, Prescott B, Thomas GJ
• Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor.
  Proceedings of the National Academy of Sciences of the United States of America 1984 Finer-Moore J, Stroud RM
• Subunit organization and structure of an acetylcholine receptor.
  Cold Spring Harbor symposia on quantitative biology 1983 Fairclough RH, Finer-Moore J, Love RA, Kristofferson D, Desmeules PJ, Stroud RM