Jane Symington, MD, PhD
Assistant Professor
Pediatrics
School of Medicine

Dr. Jane Symington is a pediatric physician scientist investigating the pathogenesis of Coccidioides, the fungus that causes Coccidioidomycosis, more commonly known as Valley Fever. Her current work focuses on dissecting the interactions between Coccidioides and innate immune cells to identify and target pathways important for fungal virulence or protective host responses.

Education & Training

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• Pediatric Infectious Diseases Fellowship University of California San Francisco 2022
• Pediatric Residency University of California San Francisco 2019
• MD, PhD Molecular Microbiology and Microbial Pathogenesis Washington University in St. Louis 2016
• BS Biology Yale University 2007

Publications (6)

Top publication keywords:
HistoplasmosisEscherichia coli InfectionsAutophagy-Related ProteinsFlow CytometryOvariectomyMacrophagesUropathogenic Escherichia coliUrotheliumActinsAutophagyBlotting, WesternEnzyme-Linked Immunosorbent AssayInterleukin-1betaUrinary Tract InfectionsCarrier Proteins

• Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages.
  PLoS pathogens 2022 Cohen A, Jeng EE, Voorhies M, Symington J, Ali N, Rodriguez RA, Bassik MC, Sil A
• A non-canonical autophagy-dependent role of the ATG16L1T300A variant in urothelial vesicular trafficking and uropathogenic Escherichia coli persistence.
  Autophagy 2018 Wang C, Bauckman KA, Ross ASB, Symington JW, Ligon MM, Scholtes G, Kumar A, Chang HW, Twentyman J, Fashemi BE, Xavier RJ, Mysorekar IU
• ATG16L1 deficiency in macrophages drives clearance of uropathogenic E. coli in an IL-1β-dependent manner.
  Mucosal immunology 2015 Symington JW, Wang C, Twentyman J, Owusu-Boaitey N, Schwendener R, Núñez G, Schilling JD, Mysorekar IU
• Estrogenic modulation of uropathogenic Escherichia coli infection pathogenesis in a murine menopause model.
  Infection and immunity 2012 Wang C, Symington JW, Ma E, Cao B, Mysorekar IU
• ATG16L1 and pathogenesis of urinary tract infections.
  Autophagy 2012 Wang C, Symington JW, Mysorekar IU
• Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Wang C, Mendonsa GR, Symington JW, Zhang Q, Cadwell K, Virgin HW, Mysorekar IU