Jana Mike, MD, PhD
Assistant Professor
Pediatrics
School of Medicine

I study neonatal brain hypoxic-ischemic injury. Specifically I focus on the role of Arginase-1 in microglial efferocytosis and brain fibrosis.

Education & Training

Show all (3) Hide

• Fellowship Pediatric Critical Care University of California San Francisco 2020
• Residency Pediatrics Maimonides Infants and Children's Hospital 2016
• MD/PhD Pediatrics Commenius University Bratislava 2012

Publications (10)

Top publication keywords:
SheepArginaseGene Expression RegulationMicrogliaBrain InjuriesGliosisNeuroprotectionCitratesHypothermia, InducedCaffeineHippocampusAnimals, NewbornApoptosisDisease Models, AnimalHypoxia-Ischemia, Brain

• Hypoxanthine-early biomarker of outcomes in an ovine model of neonatal hypoxic ischemic encephalopathy.
  Pediatric research 2026 Mike JK, Natarajan E, Ha J, White Y, Iranmahboub A, Hutchings RS, Vento C, Manzoor H, Wang A, Goudy BD, Lakshminrusimha S, Smith MA, Steurer MA, Fineman JR, Ferriero DM, Maltepe E
• ARG1 inhibition after Neonatal Hypoxic-Ischemic Brain Injury.
  Developmental neuroscience 2026 Natarajan E, Fineman JR, Ferriero DM, Maltepe E, Mike JK
• Temporal and Spatial Gene Expression Dynamics in Neonatal HI Hippocampus with Focus on Arginase.
  Cells 2026 Smith MA, Natarajan E, Lizama-Valenzuela C, Arnold T, Stroud D, Larpthaveesarp A, Alvira C, Fineman JR, Ferriero DM, Maltepe E, Gonzalez F, Mike JK
• Perinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia.
  Stroke 2024 Mike JK, White Y, Ha J, Iranmahboub A, Hawkins C, Hutchings RS, Vento C, Manzoor H, Wang A, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Fineman JR, Ferriero DM, Maltepe E
• Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy.
  Children (Basel, Switzerland) 2023 Mike JK, White Y, Hutchings RS, Vento C, Ha J, Iranmahboub A, Manzoor H, Gunewardena A, Cheah C, Wang A, Goudy BD, Lakshminrusimha S, Long-Boyle J, Fineman JR, Ferriero DM, Maltepe E

Show all (5 more) Hide

• Perinatal Azithromycin Provides Limited Neuroprotection in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy.
  Stroke 2023 Mike JK, White Y, Hutchings RS, Vento C, Ha J, Manzoor H, Lee D, Losser C, Arellano K, Vanhatalo O, Seifert E, Gunewardena A, Wen B, Wang L, Wang A, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, …
• Defining Longer-Term Outcomes in an Ovine Model of Moderate Perinatal Hypoxia-Ischemia.
  Developmental neuroscience 2022 Mike JK, Wu KY, White Y, Pathipati P, Ndjamen B, Hutchings RS, Losser C, Vento C, Arellano K, Vanhatalo O, Ostrin S, Windsor C, Ha J, Alhassen Z, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long…
• Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia.
  Cells 2021 Mike JK, Ferriero DM
• Changes in arginase isoforms in a murine model of neonatal brain hypoxia-ischemia.
  Pediatric research 2020 Mike JK, Pathipati P, Sheldon RA, Ferriero DM
• The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia.
  Developmental neuroscience 2019 Krystofova J, Pathipati P, Russ J, Sheldon A, Ferriero D