Jan Christoph, PhD, MSc
Assistant Professor
Cardiovascular Research Inst
School of Medicine

Jan Christoph studies the heart from a complex and dynamical systems perspective. He is interested in arrhythmia mechanisms and the coupling between electrophysiology and tissue mechanics, as well as electromechanical feedback. He uses computational methods, artificial intelligence and high-resolution imaging to study the heart.

Awards

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• 1DP2HL168071-01, National Institutes of Health, 2022-2027

Interests

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• Biomechanics
• Imaging
• Physiology
• Bioelectricity
• Computational Biology
• Computational Cardiology
• Electrophysiology
• Biophysics
• Computational Modeling
• Echocardiography
• Cardiac Arrhythmias
• Artificial Intelligence

Websites

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• Posts on X JChristophUCSF (X.com)
• Cardiac Vision Laboratory (cardiacvision.ucsf.edu)

Publications (34)

Top publication keywords:
Decision Support Systems, ClinicalModels, CardiovascularVoltage-Sensitive Dye ImagingNeoplasmsUser-Computer InterfacePrecision MedicineArtifactsMyocardial ContractionElectrophysiological PhenomenaGenomicsMechanical PhenomenaArrhythmias, CardiacInformed ConsentHeartInformation Storage and Retrieval

• Utilization of Broad Consent as an Effective Instrument for Study Recruitment.
  Studies in health technology and informatics 2025 Apfelbacher T, Koçman SE, Negash S, Manuilova I, Mang JM, Papon H, Mikolajczyk R, Prokosch HU, Christoph J
• AAV9-mediated KCNH2 suppression-replacement gene therapy in a transgenic rabbit model of type 1 short QT syndrome.
  European heart journal 2025 Nimani S, Bains S, Alerni N, Ördög B, Horváth A, Matas L, Louradour J, Giammarino L, Tester DJ, Beslac O, Lopez R, Meier S, Egle M, Christoforou N, Barbieri M, Vashanthakumar V, Perez-Feliz S, Parodi …
• Uncovering the Understanding of the Concept of Patient Similarity in Cancer Research and Treatment: Scoping Review.
  Journal of medical Internet research 2025 Manuilova I, Bossenz J, Weise AB, Boehm D, Döbel M, Werle SD, Ustjanzew A, Reimer N, Strantz C, Unberath P, Metzger P, Pauli T, Schulze S, Hiemer S, Oguztürk I, Kamkar L, Kestler HA, Busch H, Brors B,…
• Building a Knowledge Base for Variant Annotation Using Therapy Recommendations in cBioPortal.
  Studies in health technology and informatics 2025 Boehm D, Reimer N, Christoph J, Scheiter A, Unberath P
• Prototypical Visualization of Patient Similarities in cBioPortal to Enhance Decision-Making in Molecular Tumor Boards.
  Studies in health technology and informatics 2025 Bossenz J, Manuilova I, Weise AB, Schulze S, Hiemer S, Eszlinger M, Boerries M, Busch H, Boehm D, Unberath P, Reimer N, Strantz C, Christoph J

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• Empowering personalized oncology: evolution of digital support and visualization tools for molecular tumor boards.
  BMC medical informatics and decision making 2025 Strantz C, Böhm D, Ganslandt T, Börries M, Metzger P, Pauli T, Blaumeiser A, Scheiter A, Jung IC, Christoph J, Manuilova I, Strauch K, Ustjanzew A, Reimer N, Busch H, Unberath P
• Identifications of Similarity Metrics for Patients With Cancer: Protocol for a Scoping Review.
  JMIR research protocols 2024 Manuilova I, Bossenz J, Weise AB, Boehm D, Strantz C, Unberath P, Reimer N, Metzger P, Pauli T, Werle SD, Schulze S, Hiemer S, Ustjanzew A, Kestler HA, Busch H, Brors B, Christoph J
• Dreaming of electrical waves: Generative modeling of cardiac excitation waves using diffusion models.
  APL machine learning 2024 Baranwal T, Lebert J, Christoph J
• Dreaming of Electrical Waves: Generative Modeling of Cardiac Excitation Waves using Diffusion Models.
  ArXiv 2024 Baranwal T, Lebert J, Christoph J
• Data Visualization Support for Tumor Boards and Clinical Oncology: Protocol for a Scoping Review.
  JMIR research protocols 2024 Boehm D, Strantz C, Christoph J, Busch H, Ganslandt T, Unberath P
• Extending cBioPortal for Therapy Recommendation Documentation in Molecular Tumor Boards: Development and Usability Study.
  JMIR medical informatics 2023 Renner C, Reimer N, Christoph J, Busch H, Metzger P, Boerries M, Ustjanzew A, Boehm D, Unberath P
• Paralysis by analysis: Overcoming cardiac contraction with computer vision.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Christoph J, Ripplinger CM
• MIRACUM-Pipe: An Adaptable Pipeline for Next-Generation Sequencing Analysis, Reporting, and Visualization for Clinical Decision Making.
  Cancers 2023 Metzger P, Hess ME, Blaumeiser A, Pauli T, Schipperges V, Mertes R, Christoph J, Unberath P, Reimer N, Scheible R, Illert AL, Busch H, Andrieux G, Boerries M
• Optical mapping of contracting hearts.
  The Journal of physiology 2023 Kappadan V, Sohi A, Parlitz U, Luther S, Uzelac I, Fenton F, Peters NS, Christoph J, Ng FS
• Repolarization indicates electrical instability in ventricular arrhythmia originating from papillary muscle.
  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2023 Münkler P, Klatt N, Scherschel K, Kuklik P, Jungen C, Cavus E, Eickholt C, Christoph J, Lemoine MD, Christ T, Willems S, Riedel R, Kirchhof P, Meyer C
• Reconstruction of three-dimensional scroll waves in excitable media from two-dimensional observations using deep neural networks.
  Physical review. E 2023 Lebert J, Mittal M, Christoph J
• N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy.
  Gastroenterology 2022 Krug J, Rodrian G, Petter K, Yang H, Khoziainova S, Guo W, Bénard A, Merkel S, Gellert S, Maschauer S, Spermann M, Waldner M, Bailey P, Pilarsky C, Liebl A, Tripal P, Christoph J, Naschberger E, …
• Real-Time Optical Mapping of Contracting Cardiac Tissues With GPU-Accelerated Numerical Motion Tracking.
  Frontiers in cardiovascular medicine 2022 Lebert J, Ravi N, Kensah G, Christoph J
• Searching of Clinical Trials Made Easier in cBioPortal Using Patients' Genetic and Clinical Profiles.
  Applied clinical informatics 2022 Unberath P, Mahlmeister L, Reimer N, Busch H, Boerries M, Christoph J
• cbpManager: a web application to streamline the integration of clinical and genomic data in cBioPortal to support the Molecular Tumor Board.
  BMC medical informatics and decision making 2021 Ustjanzew A, Desuki A, Ritzel C, Dolezilek AC, Wagner DC, Christoph J, Unberath P, Kindler T, Faber J, Marini F, Panholzer T, Paret C
• Rotor Localization and Phase Mapping of Cardiac Excitation Waves Using Deep Neural Networks.
  Frontiers in physiology 2021 Lebert J, Ravi N, Fenton FH, Christoph J
• Challenges and Experiences Extending the cBioPortal for Cancer Genomics to a Molecular Tumor Board Platform.
  Studies in health technology and informatics 2021 Reimer N, Unberath P, Busch H, Börries M, Metzger P, Ustjanzew A, Renner C, Prokosch HU, Christoph J
• Direct optogenetic stimulation of smooth muscle cells to control gastric contractility.
  Theranostics 2021 Vogt M, Schulz B, Wagdi A, Lebert J, van Belle GJ, Christoph J, Bruegmann T, Patejdl R
• Inverse mechano-electrical reconstruction of cardiac excitation wave patterns from mechanical deformation using deep learning.
  Chaos (Woodbury, N.Y.) 2020 Christoph J, Lebert J
• High-Resolution Optical Measurement of Cardiac Restitution, Contraction, and Fibrillation Dynamics in Beating vs. Blebbistatin-Uncoupled Isolated Rabbit Hearts.
  Frontiers in physiology 2020 Kappadan V, Telele S, Uzelac I, Fenton F, Parlitz U, Luther S, Christoph J
• In silico signaling modeling to understand cancer pathways and treatment responses.
  Briefings in bioinformatics 2020 Kunz M, Jeromin J, Fuchs M, Christoph J, Veronesi G, Flentje M, Nietzer S, Dandekar G, Dandekar T
• Requirements Analysis and Specification for a Molecular Tumor Board Platform Based on cBioPortal.
  Diagnostics (Basel, Switzerland) 2020 Buechner P, Hinderer M, Unberath P, Metzger P, Boeker M, Acker T, Haller F, Mack E, Nowak D, Paret C, Schanze D, von Bubnoff N, Wagner S, Busch H, Boerries M, Christoph J
• Synchronization-based reconstruction of electromechanical wave dynamics in elastic excitable media.
  Chaos (Woodbury, N.Y.) 2019 Lebert J, Christoph J
• β6 -integrin serves as a novel serum tumor marker for colorectal carcinoma.
  International journal of cancer 2019 Bengs S, Becker E, Busenhart P, Spalinger MR, Raselli T, Kasper S, Lang S, Atrott K, Mamie C, Vavricka SR, von Boehmer L, Knuth A, Tuomisto A, Mäkinen MJ, Hruz P, Turina M, Rickenbacher A, Petrowsky H…
• Marker-Free Tracking for Motion Artifact Compensation and Deformation Measurements in Optical Mapping Videos of Contracting Hearts.
  Frontiers in physiology 2018 Christoph J, Luther S
• Electromechanical vortex filaments during cardiac fibrillation.
  Nature 2018 Christoph J, Chebbok M, Richter C, Schröder-Schetelig J, Bittihn P, Stein S, Uzelac I, Fenton FH, Hasenfuß G, Gilmour RF, Luther S
• Electromechanical optical mapping.
  Progress in biophysics and molecular biology 2017 Christoph J, Schröder-Schetelig J, Luther S
• Features of Chaotic Transients in Excitable Media Governed by Spiral and Scroll Waves.
  Physical review letters 2017 Lilienkamp T, Christoph J, Parlitz U
• Optogenetic Light Crafting Tools for the Control of Cardiac Arrhythmias.
  Methods in molecular biology (Clifton, N.J.) 2016 Richter C, Christoph J, Lehnart SE, Luther S