Jan Christoph, PhD, MSc
Assistant Professor
Cardiovascular Research Inst
School of Medicine

Jan Christoph studies the heart from a complex and dynamical systems perspective. He is interested in arrhythmia mechanisms and the coupling between electrophysiology and tissue mechanics, as well as electromechanical feedback. He uses computational methods, artificial intelligence and high-resolution imaging to study the heart.

Awards

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• 1DP2HL168071-01, National Institutes of Health, 2022-2027

Interests

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• Biomechanics
• Imaging
• Physiology
• Bioelectricity
• Computational Biology
• Computational Cardiology
• Electrophysiology
• Biophysics
• Computational Modeling
• Echocardiography
• Cardiac Arrhythmias
• Artificial Intelligence

Websites

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• Cardiac Vision Laboratory (cardiacvision.ucsf.edu)

Publications (20)

Top publication keywords:
Models, CardiovascularVoltage-Sensitive Dye ImagingArtifactsMyocardial ContractionComputer SimulationMyocytes, CardiacRomano-Ward SyndromeMyocardiumElectrophysiological PhenomenaMechanical PhenomenaArrhythmias, CardiacHeterocyclic Compounds, 4 or More RingsHeartHeart VentriclesERG1 Potassium Channel

• AI-enabled motion artifact correction to replace emission- and excitation-ratiometry in cardiac optical mapping: A proof-of-concept study.
  Cardiovascular research 2026 Hua Z, Patlatzoglou K, Kappadan V, Sun X, Lebert J, Efstathiou P, Tonko JB, Lee IE, Sohi A, Agha-Jaffar D, Mohamed N, Abdelghani Y, Onslow O, Baranwal T, Pyman E, Guichard JB, Ripplinger CM, Luther S,…
• Panoramic voltage-sensitive optical mapping of contracting hearts using cooperative multiview motion tracking with 12 cameras.
  The Journal of physiology 2026 Chowdhary S, Lebert J, Dickman S, Manetta M, Gordon C, Christoph J
• AAV9-mediated KCNH2 suppression-replacement gene therapy in a transgenic rabbit model of type 1 short QT syndrome.
  European heart journal 2026 Nimani S, Bains S, Alerni N, Ördög B, Horváth A, Matas L, Louradour J, Giammarino L, Tester DJ, Beslac O, Lopez R, Meier S, Egle M, Christoforou N, Barbieri M, Vashanthakumar V, Perez-Feliz S, Parodi …
• Differential response to acute ischemia between isolated contracting hearts and hearts perfused with excitation-contraction uncouplers.
  American journal of physiology. Heart and circulatory physiology 2025 Kappadan V, Hua Z, Efstathiou P, Lebert J, Sohi A, Agha-Jaffar D, Tonko JB, Sun X, Mohamed N, Abdelghani Y, Peters NS, Christoph J, Ng FS
• Dreaming of electrical waves: Generative modeling of cardiac excitation waves using diffusion models.
  APL machine learning 2024 Baranwal T, Lebert J, Christoph J

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• Paralysis by analysis: Overcoming cardiac contraction with computer vision.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Christoph J, Ripplinger CM
• Optical mapping of contracting hearts.
  The Journal of physiology 2023 Kappadan V, Sohi A, Parlitz U, Luther S, Uzelac I, Fenton F, Peters NS, Christoph J, Ng FS
• Repolarization indicates electrical instability in ventricular arrhythmia originating from papillary muscle.
  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2023 Münkler P, Klatt N, Scherschel K, Kuklik P, Jungen C, Cavus E, Eickholt C, Christoph J, Lemoine MD, Christ T, Willems S, Riedel R, Kirchhof P, Meyer C
• Reconstruction of three-dimensional scroll waves in excitable media from two-dimensional observations using deep neural networks.
  Physical review. E 2023 Lebert J, Mittal M, Christoph J
• Real-Time Optical Mapping of Contracting Cardiac Tissues With GPU-Accelerated Numerical Motion Tracking.
  Frontiers in cardiovascular medicine 2022 Lebert J, Ravi N, Kensah G, Christoph J
• Rotor Localization and Phase Mapping of Cardiac Excitation Waves Using Deep Neural Networks.
  Frontiers in physiology 2021 Lebert J, Ravi N, Fenton FH, Christoph J
• Direct optogenetic stimulation of smooth muscle cells to control gastric contractility.
  Theranostics 2021 Vogt M, Schulz B, Wagdi A, Lebert J, van Belle GJ, Christoph J, Bruegmann T, Patejdl R
• Inverse mechano-electrical reconstruction of cardiac excitation wave patterns from mechanical deformation using deep learning.
  Chaos (Woodbury, N.Y.) 2020 Christoph J, Lebert J
• High-Resolution Optical Measurement of Cardiac Restitution, Contraction, and Fibrillation Dynamics in Beating vs. Blebbistatin-Uncoupled Isolated Rabbit Hearts.
  Frontiers in physiology 2020 Kappadan V, Telele S, Uzelac I, Fenton F, Parlitz U, Luther S, Christoph J
• Synchronization-based reconstruction of electromechanical wave dynamics in elastic excitable media.
  Chaos (Woodbury, N.Y.) 2019 Lebert J, Christoph J
• Marker-Free Tracking for Motion Artifact Compensation and Deformation Measurements in Optical Mapping Videos of Contracting Hearts.
  Frontiers in physiology 2018 Christoph J, Luther S
• Electromechanical vortex filaments during cardiac fibrillation.
  Nature 2018 Christoph J, Chebbok M, Richter C, Schröder-Schetelig J, Bittihn P, Stein S, Uzelac I, Fenton FH, Hasenfuß G, Gilmour RF, Luther S
• Electromechanical optical mapping.
  Progress in biophysics and molecular biology 2017 Christoph J, Schröder-Schetelig J, Luther S
• Features of Chaotic Transients in Excitable Media Governed by Spiral and Scroll Waves.
  Physical review letters 2017 Lilienkamp T, Christoph J, Parlitz U
• Optogenetic Light Crafting Tools for the Control of Cardiac Arrhythmias.
  Methods in molecular biology (Clifton, N.J.) 2016 Richter C, Christoph J, Lehnart SE, Luther S