Jim Wells, PhD
Professor
Pharmaceutical Chemistry
School of Pharmacy

He is especially interested in the inter-protein circuitry of pathways involved in cell death and inflammation, and the intra-protein allosteric circuitry that governs how distant functional sites in one protein communicate.

• Covalent inhibition of pro-apoptotic BAX.
  Nature chemical biology 2024 McHenry MW, Shi P, Camara CM, Cohen DT, Rettenmaier TJ, Adhikary U, Gygi MA, Yang K, Gygi SP, Wales TE, Engen JR, Wells JA, Walensky LD
• Photoproximity Labeling from Single Catalyst Sites Allows Calibration and Increased Resolution for Carbene Labeling of Protein Partners In Vitro and on Cells.
  ACS central science 2023 Bartholow TG, Burroughs PWW, Elledge SK, Byrnes JR, Kirkemo LL, Garda V, Leung KK, Wells JA
• Secreted HLA-Fc fusion profiles immunopeptidome in hypoxic PDAC and cellular senescence.
  PNAS nexus 2023 Rettko NJ, Kirkemo LL, Wells JA
• Extracellular targeted protein degradation: an emerging modality for drug discovery.
  Nature reviews. Drug discovery 2023 Wells JA, Kumru K
• Author Correction: Changing the public perception of human embryology.
  Nature cell biology 2023 Rivron NC, Martinez-Arias A, Sermon K, Mummery C, Schöler HR, Wells J, Nichols J, Hadjantonakis AK, Lancaster MA, Moris N, Fu J, Sturmey RG, Niakan K, Rossant J, Kato K
• Changing the public perception of human embryology.
  Nature cell biology 2023 Rivron NC, Martinez-Arias A, Sermon K, Mummery C, Schöler HR, Wells J, Nichols J, Hadjantonakis AK, Lancaster MA, Moris N, Fu J, Sturmey RG, Niakan K, Rossant J, Kato K
• Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma.
  bioRxiv : the preprint server for biology 2023 Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker P, Naik A, Shai A, Phillips JJ, Chang …
• Multi-scale photocatalytic proximity labeling reveals cell surface neighbors on and between cells.
  bioRxiv : the preprint server for biology 2023 Lin Z, Schaefer K, Lui I, Yao Z, Fossati A, Swaney DL, Palar A, Sali A, Wells JA
• Site-specific proximity labeling at single residue resolution for identification of protein partners in vitro and on cells.
  bioRxiv : the preprint server for biology 2023 Bartholow TG, Burroughs P, Elledge SK, Byrnes JR, Kirkemo LL, Garda V, Leung KK, Wells JA
• Discovery of VH domains that allosterically inhibit ENPP1.
  Nature chemical biology 2023 Solomon PE, Bracken CJ, Carozza JA, Wang H, Young EP, Wellner A, Liu CC, Sweet-Cordero EA, Li L, Wells JA
• Secreted HLA Fc-Fusion Profiles Immunopeptidome in Hypoxic PDAC and Cellular Senescence.
  bioRxiv : the preprint server for biology 2023 Rettko NJ, Kirkemo LL, Wells JA
• Theranostic Targeting of CUB Domain-Containing Protein 1 (CDCP1) in Multiple Subtypes of Bladder Cancer.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Chopra S, Trepka K, Sakhamuri S, Carretero-González A, Zhu J, Egusa E, Zhou J, Leung K, Zhao N, Hooshdaran N, Feng FY, Wells JA, Chou J, Evans MJ
• Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps.
  Structure (London, England : 1993) 2023 Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Mehmood H, Pawar KI, Pourmal S, Smith AM, Zhou F, QCRG …
• MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Stopfer LE, Rettko NJ, Leddy O, Mesfin JM, Brown E, Winski S, Bryson B, Wells JA, White FM
• Direct Identification of Proteolytic Cleavages on Living Cells Using a Glycan-Tethered Peptide Ligase.
  ACS central science 2022 Schaefer K, Lui I, Byrnes JR, Kang E, Zhou J, Weeks AM, Wells JA
• Using Split Luminescent Biosensors for SARS-CoV-2 Antibody Detection in Serum, Plasma, and Blood Samples.
  Current protocols 2022 Elledge SK, Eigl I, Phelps M, McClinton K, Zhou XX, Leung KK, Tato CM, Wells JA
• Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins.
  Nature biotechnology 2022 Pance K, Gramespacher JA, Byrnes JR, Salangsang F, Serrano JC, Cotton AD, Steri V, Wells JA
• Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps.
  bioRxiv : the preprint server for biology 2022 Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Pawar KI, Pourmal S, Smith AM, Zhou F, QCRG Structural …
• CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, including PSMA Null Disease.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2022 Zhao N, Chopra S, Trepka K, Wang YH, Sakhamuri S, Hooshdaran N, Kim H, Zhou J, Lim SA, Leung KK, Egusa EA, Zhu J, Zhang L, Foye A, Sriram R, Chan E, Seo Y, Feng FY, Small EJ, Chou J, Wells JA, …
• The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance.
  Nature communications 2022 Ferguson ID, Patiño-Escobar B, Tuomivaara ST, Lin YT, Nix MA, Leung KK, Kasap C, Ramos E, Nieves Vasquez W, Talbot A, Hale M, Naik A, Kishishita A, Choudhry P, Lopez-Girona A, Miao W, Wong SW, Wolf JL…
• Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein-Protein Interactions.
  Journal of the American Chemical Society 2022 Jiang Z, Kuo YH, Zhong M, Zhang J, Zhou XX, Xing L, Wells JA, Wang Y, Arkin MR
• Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability.
  Nature chemical biology 2022 Li Z, Ferguson L, Deol KK, Roberts MA, Magtanong L, Hendricks JM, Mousa GA, Kilinc S, Schaefer K, Wells JA, Bassik MC, Goga A, Dixon SJ, Ingolia NT, Olzmann JA
• Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation.
  Molecular & cellular proteomics : MCP 2022 Solomon PE, Kirkemo LL, Wilson GM, Leung KK, Almond MH, Sayles LC, Sweet-Cordero EA, Rosenberg OS, Coon JJ, Wells JA
• Roadmap for Optimizing and Broadening Antibody-Based PROTACs for Degradation of Cell Surface Proteins.
  ACS chemical biology 2022 Gramespacher JA, Cotton AD, Burroughs PWW, Seiple IB, Wells JA
• Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells.
  eLife 2022 Kirkemo LL, Elledge SK, Yang J, Byrnes JR, Glasgow JE, Blelloch R, Wells JA
• Switchable assembly and function of antibody complexes in vivo using a small molecule.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Martinko AJ, Simonds EF, Prasad S, Ponce A, Bracken CJ, Wei J, Wang YH, Chow TL, Huang Z, Evans MJ, Wells JA, Hill ZB
• Engineering Antibodies Targeting p16 MHC-Peptide Complexes.
  ACS chemical biology 2022 Rettko NJ, Campisi J, Wells JA
• Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression.
  Molecular & cellular proteomics : MCP 2022 Byrnes JR, Weeks AM, Shifrut E, Carnevale J, Kirkemo L, Ashworth A, Marson A, Wells JA
• Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.
  The Journal of clinical investigation 2022 Lim SA, Zhou J, Martinko AJ, Wang YH, Filippova EV, Steri V, Wang D, Remesh SG, Liu J, Hann B, Kossiakoff AA, Evans MJ, Leung KK, Wells JA
• Identifying and antagonizing the interactions between layilin and glycosylated collagens.
  Cell chemical biology 2022 Glasgow JE, Byrnes JR, Barbee SD, Moreau JM, Rosenblum MD, Wells JA
• Response to Vaccination Against SARS-CoV-2 in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis With Renal Involvement.
  Frontiers in medicine 2022 Carruthers JE, Wells J, Gupta A, Kallon D, Cox A, Pina N, Yaqoob MM, Rajakariar R
• BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.
  Nature cell biology 2022 Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Kain AM, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nuñez JK, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman…
• Cleavage of talin by calpain promotes platelet-mediated fibrin clot contraction.
  Blood advances 2021 Fong KP, Molnar KS, Agard N, Litvinov RI, Kim OV, Wells JA, Weisel JW, DeGrado WF, Bennett JS
• Phage-Based Profiling of Rare Single Cells Using Nanoparticle-Directed Capture.
  ACS nano 2021 Ma Y, Chen K, Xia F, Atwal R, Wang H, Ahmed SU, Cardarelli L, Lui I, Duong B, Wang Z, Wells JA, Sidhu SS, Kelley SO
• BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.
  bioRxiv : the preprint server for biology 2021 Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Mac Kain A, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nunez J, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, …
• Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance.
  Frontiers in immunology 2021 Muller YD, Ferreira LMR, Ronin E, Ho P, Nguyen V, Faleo G, Zhou Y, Lee K, Leung KK, Skartsis N, Kaul AM, Mulder A, Claas FHJ, Wells JA, Bluestone JA, Tang Q
• Biotin as a Reactive Handle to Selectively Label Proteins and DNA with Small Molecules.
  ACS chemical biology 2021 Cotton AD, Wells JA, Seiple IB
• A functional mammalian display screen identifies rare antibodies that stimulate NK cell-mediated cytotoxicity.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Kang E, Kadoch C, Rubenstein JL, Lanier LL, Wells JA
• SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay.
  Science advances 2021 Peluso MJ, Takahashi S, Hakim J, Kelly JD, Torres L, Iyer NS, Turcios K, Janson O, Munter SE, Thanh C, Donatelli J, Nixon CC, Hoh R, Tai V, Fehrman EA, Hernandez Y, Spinelli MA, Gandhi M, Palafox MA, …
• Real world utilization of REGEN-COV2 at a community hospital.
  The American journal of emergency medicine 2021 Ash J, Leavitt R, Dietrich T, Schritter S, Wells J, Santarelli A, Ashurst J
• Inhibition of Cancer Cell Adhesion, Migration and Proliferation by a Bispecific Antibody that Targets two Distinct Epitopes on αv Integrins.
  Journal of molecular biology 2021 Gallo E, Kelil A, Haughey M, Cazares-Olivera M, Yates BP, Zhang M, Wang NY, Blazer L, Carderelli L, Adams JJ, Kossiakoff AA, Wells JA, Xie W, Sidhu SS
• Reply to Liu et al.: Specific mutations matter in specificity and catalysis in ACE2.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Glasgow J, Glasgow A, Kortemme T, Wells JA
• Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection.
  Nature biotechnology 2021 Elledge SK, Zhou XX, Byrnes JR, Martinko AJ, Lui I, Pance K, Lim SA, Glasgow JE, Glasgow AA, Turcios K, Iyer NS, Torres L, Peluso MJ, Henrich TJ, Wang TT, Tato CM, Leung KK, Greenhouse B, Wells JA
• The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28.
  Frontiers in immunology 2021 Muller YD, Nguyen DP, Ferreira LMR, Ho P, Raffin C, Valencia RVB, Congrave-Wilson Z, Roth TL, Eyquem J, Van Gool F, Marson A, Perez L, Wells JA, Bluestone JA, Tang Q
• SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay.
  medRxiv : the preprint server for health sciences 2021 Peluso MJ, Takahashi S, Hakim J, Kelly JD, Torres L, Iyer NS, Turcios K, Janson O, Munter SE, Thanh C, Nixon CC, Hoh R, Tai V, Fehrman EA, Hernandez Y, Spinelli MA, Gandhi M, Palafox MA, Vallari A, …
• Mapping proteolytic neo-N termini at the surface of living cells.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Weeks AM, Byrnes JR, Lui I, Wells JA
• The seroprevalence of SARS-CoV-2 in a rural southwest community.
  Journal of osteopathic medicine 2021 Santarelli A, Lalitsasivimol D, Bartholomew N, Reid S, Reid J, Lyon C, Wells J, Ashurst J
• Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Chen W, Mou KY, Solomon P, Aggarwal R, Leung KK, Wells JA
• Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1.
  Journal of the American Chemical Society 2021 Cotton AD, Nguyen DP, Gramespacher JA, Seiple IB, Wells JA
• Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2.
  mAbs 2021 Lim SA, Gramespacher JA, Pance K, Rettko NJ, Solomon P, Jin J, Lui I, Elledge SK, Liu J, Bracken CJ, Simmons G, Zhou XX, Leung KK, Wells JA
• Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA
• Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2.
  Nature chemical biology 2020 Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, QCRG Structural Biology Consortium, Zhou XX, Leung KK, Wells JA
• Targeting Phosphotyrosine in Native Proteins with Conditional, Bispecific Antibody Traps.
  Journal of the American Chemical Society 2020 Zhou XX, Bracken CJ, Zhang K, Zhou J, Mou Y, Wang L, Cheng Y, Leung KK, Wells JA
• Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Zhou J, Li S, Leung KK, O'Donovan B, Zou JY, DeRisi JL, Wells JA
• ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens.
  Cell reports. Medicine 2020 Zamecnik CR, Rajan JV, Yamauchi KA, Mann SA, Loudermilk RP, Sowa GM, Zorn KC, Alvarenga BD, Gaebler C, Caskey M, Stone M, Norris PJ, Gu W, Chiu CY, Ng D, Byrnes JR, Zhou XX, Wells JA, Robbiani DF, …
• Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding.
  mSphere 2020 Byrnes JR, Zhou XX, Lui I, Elledge SK, Glasgow JE, Lim SA, Loudermilk RP, Chiu CY, Wang TT, Wilson MR, Leung KK, Wells JA
• Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection.
  medRxiv : the preprint server for health sciences 2020 Elledge SK, Zhou XX, Byrnes JR, Martinko AJ, Lui I, Pance K, Lim SA, Glasgow JE, Glasgow AA, Turcios K, Iyer N, Torres L, Peluso MJ, Henrich TJ, Wang TT, Tato CM, Leung KK, Greenhouse B, Wells JA
• Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike.
  bioRxiv : the preprint server for biology 2020 Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, QCRG Structural Biology Consortium, Zhou XX, Leung KK, Wells JA
• Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
  bioRxiv : the preprint server for biology 2020 Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Lim SA, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Zhou XX, Hobman TC, Kortemme T, Wells JA
• ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork.
  Nucleic acids research 2020 Kim S, Kang N, Park SH, Wells J, Hwang T, Ryu E, Kim BG, Hwang S, Kim SJ, Kang S, Lee S, Stirling P, Myung K, Lee KY
• Redox priming promotes Aurora A activation during mitosis.
  Science signaling 2020 Lim DC, Joukov V, Rettenmaier TJ, Kumagai A, Dunphy WG, Wells JA, Yaffe MB
• Split enzymes: Design principles and strategy.
  Methods in enzymology 2020 Lim SA, Wells JA
• A SARS-CoV-2 serological assay to determine the presence of blocking antibodies that compete for human ACE2 binding.
  medRxiv : the preprint server for health sciences 2020 Byrnes JR, Zhou XX, Lui I, Elledge SK, Glasgow JE, Lim SA, Loudermilk R, Chiu CY, Wilson MR, Leung KK, Wells JA
• Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering.
  Cell chemical biology 2020 Harvey EP, Hauseman ZJ, Cohen DT, Rettenmaier TJ, Lee S, Huhn AJ, Wales TE, Seo HS, Luccarelli J, Newman CE, Guerra RM, Bird GH, Dhe-Paganon S, Engen JR, Wells JA, Walensky LD
• Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Moroz A, Wang YH, Sharib JM, Wei J, Zhao N, Huang Y, Chen Z, Martinko AJ, Zhuo J, Lim SA, Zhang LH, Seo Y, Carlin S, Leung KK, Collisson EA, Kirkwood KS, Wells JA, Evans MJ
• National Cancer Institute Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions.
  Journal of proteome research 2020 Kagan J, Moritz RL, Mazurchuk R, Lee JH, Kharchenko PV, Rozenblatt-Rosen O, Ruppin E, Edfors F, Ginty F, Goltsev Y, Wells JA, LaCava J, Riesterer JL, Germain RN, Shi T, Chee MS, Budnik BA, Yates JR, …
• Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Leung KK, Wilson GM, Kirkemo LL, Riley NM, Coon JJ, Wells JA
• Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Elledge SK, Tran HL, Christian AH, Steri V, Hann B, Toste FD, Chang CJ, Wells JA
• N-Terminal Modification of Proteins with Subtiligase Specificity Variants.
  Current protocols in chemical biology 2020 Weeks AM, Wells JA
• Profiling the Surfaceome Identifies Therapeutic Targets for Cells with Hyperactive mTORC1 Signaling.
  Molecular & cellular proteomics : MCP 2019 Wei J, Leung K, Truillet C, Ruggero D, Wells JA, Evans MJ
• Subtiligase-Catalyzed Peptide Ligation.
  Chemical reviews 2019 Weeks AM, Wells JA
• Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases.
  Journal of medicinal chemistry 2019 Yueh C, Rettenmaier J, Xia B, Hall DR, Alekseenko A, Porter KA, Barkovich K, Keseru G, Whitty A, Wells JA, Vajda S, Kozakov D
• Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration.
  Neuron 2019 Hertz NT, Adams EL, Weber RA, Shen RJ, O'Rourke MK, Simon DJ, Zebroski H, Olsen O, Morgan CW, Mileur TR, Hitchcock AM, Sinnott Armstrong NA, Wainberg M, Bassik MC, Molina H, Wells JA, Tessier-Lavigne …
• Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Leung KK, Nguyen A, Shi T, Tang L, Ni X, Escoubet L, MacBeth KJ, DiMartino J, Wells JA
• Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif.
  Journal of the American Chemical Society 2018 Mou Y, Zhou XX, Leung K, Martinko AJ, Yu JY, Chen W, Wells JA
• Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Henderson AR, Henley MJ, Foster NJ, Peiffer AL, Beyersdorf MS, Stanford KD, Sturlis SM, Linhares BM, Hill ZB, Wells JA, Cierpicki T, Brooks CL, Fierke CA, Mapp AK
• The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins.
  ACS chemical biology 2018 Hill ME, Kumar A, Wells JA, Hobman TC, Julien O, Hardy JA
• An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.
  eLife 2018 Keedy DA, Hill ZB, Biel JT, Kang E, Rettenmaier TJ, Brandão-Neto J, Pearce NM, von Delft F, Wells JA, Fraser JS
• Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates.
  Molecular pharmaceutics 2018 Spangler B, Kline T, Hanson J, Li X, Zhou S, Wells JA, Sato AK, Renslo AR
• Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Pollock SB, Hu A, Mou Y, Martinko AJ, Julien O, Hornsby M, Ploder L, Adams JJ, Geng H, Müschen M, Sidhu SS, Moffat J, Wells JA
• Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
  Cell death and differentiation 2018 Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, …
• Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins.
  eLife 2018 Martinko AJ, Truillet C, Julien O, Diaz JE, Horlbeck MA, Whiteley G, Blonder J, Weissman JS, Bandyopadhyay S, Evans MJ, Wells JA
• Human antibody-based chemically induced dimerizers for cell therapeutic applications.
  Nature chemical biology 2017 Hill ZB, Martinko AJ, Nguyen DP, Wells JA
• Engineering peptide ligase specificity by proteomic identification of ligation sites.
  Nature chemical biology 2017 Weeks AM, Wells JA
• Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades.
  Molecular cancer research : MCR 2017 Srinivasan SR, Cesa LC, Li X, Julien O, Zhuang M, Shao H, Chung J, Maillard I, Wells JA, Duckett CS, Gestwicki JE
• A Split-Abl Kinase for Direct Activation in Cells.
  Cell chemical biology 2017 Diaz JE, Morgan CW, Minogue CE, Hebert AS, Coon JJ, Wells JA
• Engineering a light-activated caspase-3 for precise ablation of neurons in vivo.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Smart AD, Pache RA, Thomsen ND, Kortemme T, Davis GW, Wells JA
• Time-Resolved Proteomics Extends Ribosome Profiling-Based Measurements of Protein Synthesis Dynamics.
  Cell systems 2017 Liu TY, Huang HH, Wheeler D, Xu Y, Wells JA, Song YS, Wiita AP
• Caspases and their substrates.
  Cell death and differentiation 2017 Julien O, Wells JA
• Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product.
  Journal of the American Chemical Society 2017 Tran HL, Lexa KW, Julien O, Young TS, Walsh CT, Jacobson MP, Wells JA
• Redox-based reagents for chemoselective methionine bioconjugation.
  Science (New York, N.Y.) 2017 Lin S, Yang X, Jia S, Weeks AM, Hornsby M, Lee PS, Nichiporuk RV, Iavarone AT, Wells JA, Toste FD, Chang CJ
• Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast.
  Molecular & cellular proteomics : MCP 2017 Calvo SE, Julien O, Clauser KR, Shen H, Kamer KJ, Wells JA, Mootha VK
• Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface.
  Oncotarget 2016 Ye X, Chan KC, Waters AM, Bess M, Harned A, Wei BR, Loncarek J, Luke BT, Orsburn BC, Hollinger BD, Stephens RM, Bagni R, Martinko A, Wells JA, Nissley DV, McCormick F, Whiteley G, Blonder J
• A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models.
  Journal of medicinal chemistry 2016 Spangler B, Fontaine SD, Shi Y, Sambucetti L, Mattis AN, Hann B, Wells JA, Renslo AR
• Direct Proximity Tagging of Small Molecule Protein Targets Using an Engineered NEDD8 Ligase.
  Journal of the American Chemical Society 2016 Hill ZB, Pollock SB, Zhuang M, Wells JA
• Enzyme-catalyzed expressed protein ligation.
  Nature methods 2016 Henager SH, Chu N, Chen Z, Bolduc D, Dempsey DR, Hwang Y, Wells J, Cole PA
• Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Wang W, Nguyen LT, Burlak C, Chegini F, Guo F, Chataway T, Ju S, Fisher OS, Miller DW, Datta D, Wu F, Wu CX, Landeru A, Wells JA, Cookson MR, Boxer MB, Thomas CJ, Gai WP, Ringe D, Petsko GA, Hoang QQ
• Stem Cells and Regeneration in the Digestive System: Keystone Meeting.
  Gastroenterology 2016 Soffers JH, Hansen D, Sinagoga KL, Li B, Martin MG, Wells J, Grompe M, Li L
• A reactivity-based probe of the intracellular labile ferrous iron pool.
  Nature chemical biology 2016 Spangler B, Morgan CW, Fontaine SD, Vander Wal MN, Chang CJ, Wells JA, Renslo AR
• Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity.
  Nature communications 2016 Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA
• Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.
  ACS chemical biology 2016 Hill ME, MacPherson DJ, Wu P, Julien O, Wells JA, Hardy JA
• Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA
• Initial Results from the Survey of Organizational Research Climates (SOuRCe) in the U.S. Department of Veterans Affairs Healthcare System.
  PloS one 2016 Martinson BC, Nelson D, Hagel-Campbell E, Mohr D, Charns MP, Bangerter A, Thrush CR, Ghilardi JR, Bloomfield H, Owen R, Wells JA
• CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites.
  Journal of molecular biology 2016 Cimermancic P, Weinkam P, Rettenmaier TJ, Bichmann L, Keedy DA, Woldeyes RA, Schneidman-Duhovny D, Demerdash ON, Mitchell JC, Wells JA, Fraser JS, Sali A
• Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based Docking.
  Journal of medicinal chemistry 2015 Rettenmaier TJ, Fan H, Karpiak J, Doak A, Sali A, Shoichet BK, Wells JA
• A High Through-put Platform for Recombinant Antibodies to Folded Proteins.
  Molecular & cellular proteomics : MCP 2015 Hornsby M, Paduch M, Miersch S, Sääf A, Matsuguchi T, Lee B, Wypisniak K, Doak A, King D, Usatyuk S, Perry K, Lu V, Thomas W, Luke J, Goodman J, Hoey RJ, Lai D, Griffin C, Li Z, Vizeacoumar FJ, Dong D…
• Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Morgan CW, Diaz JE, Zeitlin SG, Gray DC, Wells JA
• A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA
• An improved single-chain Fab platform for efficient display and recombinant expression.
  Journal of molecular biology 2014 Koerber JT, Hornsby MJ, Wells JA
• In amnio MRI of mouse embryos.
  PloS one 2014 Roberts TA, Norris FC, Carnaghan H, Savery D, Wells JA, Siow B, Scambler PJ, Pierro A, De Coppi P, Eaton S, Lythgoe MF
• Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.
  Molecular cell 2014 Ordureau A, Sarraf SA, Duda DM, Heo JM, Jedrychowski MP, Sviderskiy VO, Olszewski JL, Koerber JT, Xie T, Beausoleil SA, Wells JA, Gygi SP, Schulman BA, Harper JW
• Unraveling the mechanism of cell death induced by chemical fibrils.
  Nature chemical biology 2014 Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA
• Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.
  Chemistry & biology 2014 Arkin MR, Tang Y, Wells JA
• Cell biology. New tricks for an old dimer.
  Science (New York, N.Y.) 2014 Wells JA, Kossiakoff AA
• Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Wiita AP, Hsu GW, Lu CM, Esensten JH, Wells JA
• FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions.
  MedChemComm 2014 Lodge JM, Rettenmaier TJ, Wells JA, Pomerantz WC, Mapp AK
• Global analysis of cellular proteolysis by selective enzymatic labeling of protein N-termini.
  Methods in enzymology 2014 Wiita AP, Seaman JE, Wells JA
• Methods in Enzymology. Regulated cell death part B--necroptotic, autophagic and other non-apoptotic mechanisms. Preface.
  Methods in enzymology 2014 Ashkenazi A, Wells JA, Yuan J
• Regulated cell death part A: apoptotic mechanisms. Preface.
  Methods in enzymology 2014 Ashkenazi A, Yuan J, Wells JA
• Turning on caspases with genetics and small molecules.
  Methods in enzymology 2014 Morgan CW, Julien O, Unger EK, Shah NM, Wells JA
• K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
  Nature 2013 Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM
• Global cellular response to chemotherapy-induced apoptosis.
  eLife 2013 Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA
• Nature-inspired design of motif-specific antibody scaffolds.
  Nature biotechnology 2013 Koerber JT, Thomsen ND, Hannigan BT, Degrado WF, Wells JA
• Next generation therapeutics.
  Current opinion in chemical biology 2013 Carter PJ, Hazuda D, Wells JA
• Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Thomsen ND, Koerber JT, Wells JA
• Ordering a dynamic protein via a small-molecule stabilizer.
  Journal of the American Chemical Society 2013 Wang N, Majmudar CY, Pomerantz WC, Gagnon JK, Sadowsky JD, Meagher JL, Johnson TK, Stuckey JA, Brooks CL, Wells JA, Mapp AK
• Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3.
  The Journal of biological chemistry 2013 Datta D, McClendon CL, Jacobson MP, Wells JA
• The DegraBase: a database of proteolysis in healthy and apoptotic human cells.
  Molecular & cellular proteomics : MCP 2012 Crawford ED, Seaman JE, Agard N, Hsu GW, Julien O, Mahrus S, Nguyen H, Shimbo K, Yoshihara HA, Zhuang M, Chalkley RJ, Wells JA
• Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator.
  Molecular cell 2012 Zhuang M, Guan S, Wang H, Burlingame AL, Wells JA
• Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis.
  Cell death and differentiation 2012 Crawford ED, Seaman JE, Barber AE, David DC, Babbitt PC, Burlingame AL, Wells JA
• Fibrils colocalize caspase-3 with procaspase-3 to foster maturation.
  The Journal of biological chemistry 2012 Zorn JA, Wolan DW, Agard NJ, Wells JA
• Quantitative profiling of caspase-cleaved substrates reveals different drug-induced and cell-type patterns in apoptosis.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Shimbo K, Hsu GW, Nguyen H, Mahrus S, Trinidad JC, Burlingame AL, Wells JA
• Global kinetic analysis of proteolysis via quantitative targeted proteomics.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Agard NJ, Mahrus S, Trinidad JC, Lynn A, Burlingame AL, Wells JA
• Evaluation of BMP-2 gene-activated muscle grafts for cranial defect repair.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2011 Liu F, Porter RM, Wells J, Glatt V, Pilapil C, Evans CH
• Identification of specific tethered inhibitors for caspase-5.
  Chemical biology & drug design 2011 Gao J, Wells JA
• Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation.
  Journal of the American Chemical Society 2011 Zorn JA, Wille H, Wolan DW, Wells JA
• Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis.
  The Journal of biological chemistry 2011 Tang Y, Wells JA, Arkin MR
• Turning a protein kinase on or off from a single allosteric site via disulfide trapping.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Sadowsky JD, Burlingame MA, Wolan DW, McClendon CL, Jacobson MP, Wells JA
• Caspase substrates and cellular remodeling.
  Annual review of biochemistry 2011 Crawford ED, Wells JA
• Activation of specific apoptotic caspases with an engineered small-molecule-activated protease.
  Cell 2010 Gray DC, Mahrus S, Wells JA
• Prediction of protease substrates using sequence and structure features.
  Bioinformatics (Oxford, England) 2010 Barkan DT, Hostetter DR, Mahrus S, Pieper U, Wells JA, Craik CS, Sali A
• Turning enzymes ON with small molecules.
  Nature chemical biology 2010 Zorn JA, Wells JA
• Inflammatory stimuli regulate caspase substrate profiles.
  Molecular & cellular proteomics : MCP 2010 Agard NJ, Maltby D, Wells JA
• Sampling the N-terminal proteome of human blood.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Wildes D, Wells JA
• Molecules that modulate Apaf-1 activity.
  Medicinal research reviews 2010 Pérez-Payá E, Orzáez M, Mondragón L, Wolan D, Wells JA, Messeguer A, Vicent MJ
• Warren L. DeLano 21 June 1972-3 November 2009.
  Nature structural & molecular biology 2009 Brunger AT, Wells JA
• Small-molecule activators of a proenzyme.
  Science (New York, N.Y.) 2009 Wolan DW, Zorn JA, Gray DC, Wells JA
• Methods for the proteomic identification of protease substrates.
  Current opinion in chemical biology 2009 Agard NJ, Wells JA
• Dissecting an allosteric switch in caspase-7 using chemical and mutational probes.
  The Journal of biological chemistry 2009 Hardy JA, Wells JA
• Two-state selection of conformation-specific antibodies.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Gao J, Sidhu SS, Wells JA
• Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini.
  Cell 2008 Mahrus S, Trinidad JC, Barkan DT, Sali A, Burlingame AL, Wells JA
• Tags for labeling protein N-termini with subtiligase for proteomics.
  Bioorganic & medicinal chemistry letters 2008 Yoshihara HA, Mahrus S, Wells JA
• An allosteric circuit in caspase-1.
  Journal of molecular biology 2008 Datta D, Scheer JM, Romanowski MJ, Wells JA
• Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.
  Nature 2007 Wells JA, McClendon CL
• Computational approach to site-directed ligand discovery.
  Proteins 2007 Tóth G, Mukhyala K, Wells JA
• Evaluation of technical approaches to tele-electromyography via internet protocol networks.
  Telemedicine journal and e-health : the official journal of the American Telemedicine Association 2007 Simmons SC, Moore DP, Wells J
• Diurnal variation in retinal thickening measurement by optical coherence tomography in center-involved diabetic macular edema.
  Archives of ophthalmology (Chicago, Ill. : 1960) 2006 Diabetic Retinopathy Clinical Research Network, Danis RP, Glassman AR, Aiello LP, Antoszyk AN, Beck RW, Browning DJ, Ciardella AP, Kinyoun JL, Murtha TJ, Topping TM, Shami M, Sharuk GS, Wells JA
• Hot-spot mimicry of a cytokine receptor by a small molecule.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Thanos CD, DeLano WL, Wells JA
• Positive pressure ventilation with the laryngeal mask airway in the operating room and prehospital: a practical review.
  The Journal of trauma 2006 Matioc AA, Wells JA
• A common allosteric site and mechanism in caspases.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Scheer JM, Romanowski MJ, Wells JA
• Malonate-assisted purification of human caspases.
  Protein expression and purification 2005 Scheer JM, Wells JA, Romanowski MJ
• Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Buck E, Wells JA
• Searching for new allosteric sites in enzymes.
  Current opinion in structural biology 2004 Hardy JA, Wells JA
• Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor.
  The Journal of biological chemistry 2004 Buck E, Bourne H, Wells JA
• Discovery of an allosteric site in the caspases.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Hardy JA, Lam J, Nguyen JT, O'Brien T, Wells JA
• Apo cytochrome c inhibits caspases by preventing apoptosome formation.
  Biochemical and biophysical research communications 2004 Martin AG, Nguyen J, Wells JA, Fearnhead HO
• Mechanistic diversity of cytokine receptor signaling across cell membranes.
  Science's STKE : signal transduction knowledge environment 2004 Stroud RM, Wells JA
• Small-molecule inhibitors of protein-protein interactions: progressing towards the dream.
  Nature reviews. Drug discovery 2004 Arkin MR, Wells JA
• Tethering: fragment-based drug discovery.
  Annual review of biophysics and biomolecular structure 2004 Erlanson DA, Wells JA, Braisted AC
• Potent small-molecule binding to a dynamic hot spot on IL-2.
  Journal of the American Chemical Society 2003 Thanos CD, Randal M, Wells JA
• Propylene glycol-associated renal toxicity from lorazepam infusion.
  Pharmacotherapy 2003 Yaucher NE, Fish JT, Smith HW, Wells JA
• Direct activation of the apoptosis machinery as a mechanism to target cancer cells.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Nguyen JT, Wells JA
• Binding of small molecules to an adaptive protein-protein interface.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC
• Drug discovery at signaling interfaces.
  Ernst Schering Research Foundation workshop 2003 Wells J, Arkin M, Braisted A, DeLano W, McDowell B, Oslob J, Raimundo B, Randal M
• BVA governance.
  The Veterinary record 2002 Johnson B, Gorman NT, Hird JF, Wadsworth DE, Wells JA, Dyson SJ, Bleby J
• Nocturnal polyuria in type 2 diabetes: a symptom of obstructive sleep apnea.
  The Diabetes educator 2002 Chasens ER, Umlauf MG, Pillion DJ, Wells JA
• The LMA-unique in a prehospital trauma patient: interaction with a semirigid cervical collar: a case report.
  The Journal of trauma 2002 Matioc AA, Wells JA
• Acute barium poisoning treated with hemodialysis.
  The American journal of emergency medicine 2001 Wells JA, Wood KE
• Metabolic databases - what next?
  Trends in biochemical sciences 2001 Gerrard JA, Sparrow AD, Wells JA
• Site-directed ligand discovery.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Erlanson DA, Braisted AC, Raphael DR, Randal M, Stroud RM, Gordon EM, Wells JA
• Mutational analysis of the major coat protein of M13 identifies residues that control protein display.
  Protein science : a publication of the Protein Society 2000 Weiss GA, Wells JA, Sidhu SS
• Convergent solutions to binding at a protein-protein interface.
  Science (New York, N.Y.) 2000 DeLano WL, Ultsch MH, de Vos AM, Wells JA
• High copy display of large proteins on phage for functional selections.
  Journal of molecular biology 2000 Sidhu SS, Weiss GA, Wells JA
• Phage display for selection of novel binding peptides.
  Methods in enzymology 2000 Sidhu SS, Lowman HB, Cunningham BC, Wells JA
• Urinary incontinence in a geriatric patient with a complex neurologic history.
  Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society 1999 Wells JA, Ouslander JG, Meadows E, Johnson VY
• Selection for improved subtiligases by phage display.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Atwell S, Wells JA
• Growth hormone binding affinity for its receptor surpasses the requirements for cellular activity.
  Biochemistry 1999 Pearce KH, Cunningham BC, Fuh G, Teeri T, Wells JA
• Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site.
  Biochemistry 1998 Fairbrother WJ, Christinger HW, Cochran AG, Fuh G, Keenan CJ, Quan C, Shriver SK, Tom JY, Wells JA, Cunningham BC
• Probing the importance of second sphere residues in an esterolytic antibody by phage display.
  Journal of molecular biology 1998 Arkin MR, Wells JA
• Will any dimer do?
  Nature structural biology 1998 Ballinger MD, Wells JA
• Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis.
  The Journal of biological chemistry 1998 Jones JT, Ballinger MD, Pisacane PI, Lofgren JA, Fitzpatrick VD, Fairbrother WJ, Wells JA, Sliwkowski MX
• Selection of heregulin variants having higher affinity for the ErbB3 receptor by monovalent phage display.
  The Journal of biological chemistry 1998 Ballinger MD, Jones JT, Lofgren JA, Fairbrother WJ, Akita RW, Sliwkowski MX, Wells JA
• Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor.
  The Journal of biological chemistry 1998 Fuh G, Li B, Crowley C, Cunningham B, Wells JA
• Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.
  Journal of molecular biology 1998 Clackson T, Ultsch MH, Wells JA, de Vos AM
• Incidence of idiopathic full-thickness macular holes in fellow eyes. A 5-year prospective natural history study.
  Ophthalmology 1998 Ezra E, Wells JA, Gray RH, Kinsella FM, Orr GM, Grego J, Arden GB, Gregor ZJ
• Interface pressure, wound healing, and satisfaction in the evaluation of a non-powered fluid mattress.
  Ostomy/wound management 1998 Wells JA, Karr D
• Surgical removal of non-age-related subfoveal choroidal neovascular membranes.
  Eye (London, England) 1998 Eckstein M, Wells JA, Aylward B, Gregor Z
• Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.
  Cell 1997 Wiesmann C, Fuh G, Christinger HW, Eigenbrot C, Wells JA, de Vos AM
• Structural plasticity in a remodeled protein-protein interface.
  Science (New York, N.Y.) 1997 Atwell S, Ultsch M, De Vos AM, Wells JA
• Phage display of a catalytic antibody to optimize affinity for transition-state analog binding.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Baca M, Scanlan TS, Stephenson RC, Wells JA
• Structural mimicry of a native protein by a minimized binding domain.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Starovasnik MA, Braisted AC, Wells JA
• Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
  Protein science : a publication of the Protein Society 1997 Scheidig AJ, Hynes TR, Pelletier LA, Wells JA, Kossiakoff AA
• Mutational analysis of thrombopoietin for identification of receptor and neutralizing antibody sites.
  The Journal of biological chemistry 1997 Pearce KH, Potts BJ, Presta LG, Bald LN, Fendly BM, Wells JA
• Minimized proteins.
  Current opinion in structural biology 1997 Cunningham BC, Wells JA
• Song development by grey catbirds
  Animal behaviour 1997 Kroodsma DE, Houlihan PW, Fallon PA, Wells JA
• Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Muller YA, Li B, Christinger HW, Wells JA, Cunningham BC, de Vos AM
• Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library.
  Journal of molecular biology 1997 Atwell S, Ridgway JB, Wells JA, Carter P
• Antibody humanization using monovalent phage display.
  The Journal of biological chemistry 1997 Baca M, Presta LG, O'Connor SJ, Wells JA
• Synthesis of proteins by subtiligase.
  Methods in enzymology 1997 Braisted AC, Judice JK, Wells JA
• Furilisin: a variant of subtilisin BPN' engineered for cleaving tribasic substrates.
  Biochemistry 1996 Ballinger MD, Tom J, Wells JA
• Long-acting growth hormones produced by conjugation with polyethylene glycol.
  The Journal of biological chemistry 1996 Clark R, Olson K, Fuh G, Marian M, Mortensen D, Teshima G, Chang S, Chu H, Mukku V, Canova-Davis E, Somers T, Cronin M, Winkler M, Wells JA
• Structural and mutational analysis of affinity-inert contact residues at the growth hormone-receptor interface.
  Biochemistry 1996 Pearce KH, Ultsch MH, Kelley RF, de Vos AM, Wells JA
• Hormone mimicry.
  Science (New York, N.Y.) 1996 Wells JA
• Minimizing a binding domain from protein A.
  Proceedings of the National Academy of Sciences of the United States of America 1996 Braisted AC, Wells JA
• Levels of vascular endothelial growth factor are elevated in the vitreous of patients with subretinal neovascularisation.
  The British journal of ophthalmology 1996 Wells JA, Murthy R, Chibber R, Nunn A, Molinatti PA, Kohner EM, Gregor ZJ
• Binding in the growth hormone receptor complex.
  Proceedings of the National Academy of Sciences of the United States of America 1996 Wells JA
• Hematopoietic receptor complexes.
  Annual review of biochemistry 1996 Wells JA, de Vos AM
• Surgical treatment of full-thickness macular holes using autologous serum.
  Eye (London, England) 1996 Wells JA, Gregor ZJ
• Minimization of a polypeptide hormone.
  Science (New York, N.Y.) 1995 Li B, Tom JY, Oare D, Yen R, Fairbrother WJ, Wells JA, Cunningham BC
• Mutations of the growth hormone receptor in children with idiopathic short stature. The Growth Hormone Insensitivity Study Group.
  The New England journal of medicine 1995 Goddard AD, Covello R, Luoh SM, Clackson T, Attie KM, Gesundheit N, Rundle AC, Wells JA, Carlsson LM
• Designing subtilisin BPN' to cleave substrates containing dibasic residues.
  Biochemistry 1995 Ballinger MD, Tom J, Wells JA
• Structural and functional epitopes in the growth hormone receptor complex.
  Bio/technology (Nature Publishing Company) 1995 Wells JA
• Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines.
  The Journal of biological chemistry 1995 Fuh G, Wells JA
• The prevalence of homosexual behavior and attraction in the United States, the United Kingdom and France: results of national population-based samples.
  Archives of sexual behavior 1995 Sell RL, Wells JA, Wypij D
• A hot spot of binding energy in a hormone-receptor interface.
  Science (New York, N.Y.) 1995 Clackson T, Wells JA
• Subtiligase: a tool for semisynthesis of proteins.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Chang TK, Jackson DY, Burnier JP, Wells JA
• Dissecting the energetics of an antibody-antigen interface by alanine shaving and molecular grafting.
  Protein science : a publication of the Protein Society 1994 Jin L, Wells JA
• Readability of HIV/AIDS educational materials: the role of the medium of communication, target audience, and producer characteristics.
  Patient education and counseling 1994 Wells JA
• Ocular findings associated with a 3 base pair deletion in the peripherin-RDS gene in autosomal dominant retinitis pigmentosa.
  The British journal of ophthalmology 1994 Wroblewski JJ, Wells JA, Eckstein A, Fitzke FW, Jubb C, Keen TJ, Inglehearn CF, Bhattacharya SS, Arden GB, Jay MR
• A designed peptide ligase for total synthesis of ribonuclease A with unnatural catalytic residues.
  Science (New York, N.Y.) 1994 Jackson DY, Burnier J, Quan C, Stanley M, Tom J, Wells JA
• Bilateral macular drusen in age-related macular degeneration. Prognosis and risk factors.
  Ophthalmology 1994 Holz FG, Wolfensberger TJ, Piguet B, Gross-Jendroska M, Wells JA, Minassian DC, Chisholm IH, Bird AC
• Engineering an interfacial zinc site to increase hormone-receptor affinity.
  Chemistry & biology 1994 Matthews DJ, Wells JA
• A survey of furin substrate specificity using substrate phage display.
  Protein science : a publication of the Protein Society 1994 Matthews DJ, Goodman LJ, Gorman CM, Wells JA
• Pouching principles and products.
  Ostomy/wound management 1994 Wells JA, Doughty DB
• Production of an atrial natriuretic peptide variant that is specific for type A receptor.
  The EMBO journal 1994 Cunningham BC, Lowe DG, Li B, Bennett BD, Wells JA
• Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes.
  Endocrinology 1994 Ilondo MM, Damholt AB, Cunningham BA, Wells JA, De Meyts P, Shymko RM
• In vitro selection of zinc fingers with altered DNA-binding specificity.
  Biochemistry 1994 Jamieson AC, Kim SH, Wells JA
• A reinvestigation of a synthetic peptide (TrPepz) designed to mimic trypsin.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Wells JA, Fairbrother WJ, Otlewski J, Laskowski M, Burnier J
• A second-generation study of 427 probands with congenital heart defects and their 837 children.
  Journal of the American College of Cardiology 1994 Whittemore R, Wells JA, Castellsague X
• Corneal opacities in spondyloepiphyseal dysplasia tarda.
  Cornea 1994 Wells JA, Ellerine NP, Fernhoff PM, Waring GO
• In vitro selection from protein and peptide libraries.
  Trends in biotechnology 1994 Clackson T, Wells JA
• Literacy of women attending family planning clinics in Virginia and reading levels of brochures on HIV prevention.
  Family planning perspectives 1994 Wells JA, Ruscavage D, Parker B, McArthur L
• The stoichiometry of growth hormone-binding protein complexes in human plasma: comparison with cell surface receptors.
  The Journal of clinical endocrinology and metabolism 1994 Baumann G, Lowman HB, Mercado M, Wells JA
• Structural and functional basis for hormone binding and receptor oligomerization.
  Current opinion in cell biology 1994 Wells JA
• Structure from function: screening structural models with functional data.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Jin L, Cohen FE, Wells JA
• Macular dystrophy associated with mutations at codon 172 in the human retinal degeneration slow gene.
  Ophthalmology 1994 Wroblewski JJ, Wells JA, Eckstein A, Fitzke F, Jubb C, Keen TJ, Inglehearn C, Bhattacharya S, Arden GB, Jay M
• Affinity maturation of human growth hormone by monovalent phage display.
  Journal of molecular biology 1993 Lowman HB, Wells JA
• Comparison of a structural and a functional epitope.
  Journal of molecular biology 1993 Cunningham BC, Wells JA
• Evidence that the growth hormone receptor mediates differentiation and development of the mammary gland.
  Endocrinology 1993 Feldman M, Ruan W, Cunningham BC, Wells JA, Kleinberg DL
• Age-related Bruch's membrane change: a clinical study of the relative role of heredity and environment.
  The British journal of ophthalmology 1993 Piguet B, Wells JA, Palmvang IB, Wormald R, Chisholm IH, Bird AC
• Substrate phage: selection of protease substrates by monovalent phage display.
  Science (New York, N.Y.) 1993 Matthews DJ, Wells JA
• Mechanism-based design of prolactin receptor antagonists.
  The Journal of biological chemistry 1993 Fuh G, Colosi P, Wood WI, Wells JA
• Structure and function of human growth hormone: implications for the hematopoietins.
  Annual review of biophysics and biomolecular structure 1993 Wells JA, de Vos AM
• The molecular basis for growth hormone-receptor interactions.
  Recent progress in hormone research 1993 Wells JA, Cunningham BC, Fuh G, Lowman HB, Bass SH, Mulkerrin MG, Ultsch M, deVos AM
• Health behavior changes in the United States, the United Kingdom, and France.
  Journal of general internal medicine 1992 Retchin SM, Wells JA, Valleron AJ, Albrecht GL
• Immunodominant structures of human growth hormone identified by homolog-scanning mutagenesis.
  Molecular immunology 1992 Weber JR, Nelson C, Cunningham BC, Wells JA, Fong S
• Incorporation of a stabilizing Ca(2+)-binding loop into subtilisin BPN'.
  Biochemistry 1992 Braxton S, Wells JA
• High resolution functional analysis of antibody-antigen interactions.
  Journal of molecular biology 1992 Jin L, Fendly BM, Wells JA
• Effect of aging and exercise on GLUT-4 glucose transporters in muscle.
  The American journal of physiology 1992 Kern M, Dolan PL, Mazzeo RS, Wells JA, Dohm GL
• Prevalence of obesity: a comparative survey in France, the United Kingdom and the United States.
  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1992 Laurier D, Guiguet M, Chau NP, Wells JA, Valleron AJ
• Rapid evolution of peptide and protein binding properties in vitro.
  Current opinion in biotechnology 1992 Wells JA, Lowman HB
• Rational design of potent antagonists to the human growth hormone receptor.
  Science (New York, N.Y.) 1992 Fuh G, Cunningham BC, Fukunaga R, Nagata S, Goeddel DV, Wells JA
• Growth hormone augments superoxide anion secretion of human neutrophils by binding to the prolactin receptor.
  The Journal of clinical investigation 1992 Fu YK, Arkins S, Fuh G, Cunningham BC, Wells JA, Fong S, Cronin MJ, Dantzer R, Kelley KW
• [Prevalence of obesity in France].
  Revue d'epidemiologie et de sante publique 1992 Laurier D, Guiguet M, Chau NP, Wells JA, Valleron AJ
• Keratoconus associated with posterior polymorphous dystrophy.
  American journal of ophthalmology 1991 Bechara SJ, Grossniklaus HE, Waring GO, Wells JA
• Selecting high-affinity binding proteins by monovalent phage display.
  Biochemistry 1991 Lowman HB, Bass SH, Simpson N, Wells JA
• Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule.
  Science (New York, N.Y.) 1991 Cunningham BC, Ultsch M, De Vos AM, Mulkerrin MG, Clauser KR, Wells JA
• Dimerization of human growth hormone by zinc.
  Science (New York, N.Y.) 1991 Cunningham BC, Mulkerrin MG, Wells JA
• French intravenous drug users: knowledge and sexual behavior change.
  European journal of epidemiology 1991 Guiguet M, Cohen M, Flahault A, Wells JA, Valleron AJ
• Probing the mechanism and improving the rate of substrate-assisted catalysis in subtilisin BPN'.
  Biochemistry 1991 Carter P, Abrahmsén L, Wells JA
• The importance of a distal hydrogen bonding group in stabilizing the transition state in subtilisin BPN'.
  The Journal of biological chemistry 1991 Braxton S, Wells JA
• Mutational analysis and protein engineering of receptor-binding determinants in human placental lactogen.
  The Journal of biological chemistry 1991 Lowman HB, Cunningham BC, Wells JA
• A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor.
  Proceedings of the National Academy of Sciences of the United States of America 1991 Bass SH, Mulkerrin MG, Wells JA
• Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution.
  Biochemistry 1991 Abrahmsén L, Tom J, Burnier J, Butcher KA, Kossiakoff A, Wells JA
• Rational design of receptor-specific variants of human growth hormone.
  Proceedings of the National Academy of Sciences of the United States of America 1991 Cunningham BC, Wells JA
• Systematic mutational analyses of protein-protein interfaces.
  Methods in enzymology 1991 Wells JA
• Zinc mediation of the binding of human growth hormone to the human prolactin receptor.
  Science (New York, N.Y.) 1990 Cunningham BC, Bass S, Fuh G, Wells JA
• Additivity of mutational effects in proteins.
  Biochemistry 1990 Wells JA
• Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level.
  The Biochemical journal 1990 Kern M, Wells JA, Stephens JM, Elton CW, Friedman JE, Tapscott EB, Pekala PH, Dohm GL
• Increased glucose transporter (GLUT4) protein expression in hyperthyroidism.
  Biochemical and biophysical research communications 1990 Casla A, Rovira A, Wells JA, Dohm GL
• The role of lysine-234 in beta-lactamase catalysis probed by site-directed mutagenesis.
  Biochemistry 1990 Ellerby LM, Escobar WA, Fink AL, Mitchinson C, Wells JA
• Engineering human prolactin to bind to the human growth hormone receptor.
  Science (New York, N.Y.) 1990 Cunningham BC, Henner DJ, Wells JA
• The human growth hormone receptor. Secretion from Escherichia coli and disulfide bonding pattern of the extracellular binding domain.
  The Journal of biological chemistry 1990 Fuh G, Mulkerrin MG, Bass S, McFarland N, Brochier M, Bourell JH, Light DR, Wells JA
• The effect of fasting on the activation in vivo of the insulin receptor kinase.
  The Biochemical journal 1990 Contreras I, Dohm GL, Abdallah S, Wells JA, Mooney N, Rovira A, Caro JF
• Functional interaction among catalytic residues in subtilisin BPN'.
  Proteins 1990 Carter P, Wells JA
• Hormone phage: an enrichment method for variant proteins with altered binding properties.
  Proteins 1990 Bass S, Greene R, Wells JA
• Identification and design of binding determinants in proteins.
  Biochemical Society symposium 1990 Wells JA, Cunningham BC
• Part I: The NGRI Registry: initial analyses of data collected on Connecticut insanity acquittees.
  The Bulletin of the American Academy of Psychiatry and the Law 1990 Zonana HV, Wells JA, Getz MA, Buchanan J
• Part II: Sex differences in persons found not guilty by reason of insanity: analysis of data from the Connecticut NGRI Registry.
  The Bulletin of the American Academy of Psychiatry and the Law 1990 Zonana HV, Bartel RL, Wells JA, Buchanan JA, Getz MA
• Respiratory rate during acute asthma.
  Chest 1990 Kesten S, Maleki-Yazdi R, Sanders BR, Wells JA, McKillop SL, Chapman KR, Rebuck AS
• High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis.
  Science (New York, N.Y.) 1989 Cunningham BC, Wells JA
• Protein engineering of disulfide bonds in subtilisin BPN'.
  Biochemistry 1989 Mitchinson C, Wells JA
• Changes in glucose transporters in muscle in response to exercise.
  The American journal of physiology 1989 Fushiki T, Wells JA, Tapscott EB, Dohm GL
• Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis.
  Science (New York, N.Y.) 1989 Cunningham BC, Jhurani P, Ng P, Wells JA
• Engineering subtilisin BPN' for site-specific proteolysis.
  Proteins 1989 Carter P, Nilsson B, Burnier JP, Burdick D, Wells JA
• The influence of source of insurance coverage on the health care utilization patterns of the elderly.
  Journal of health and human resources administration 1989 Dunlop BD, Wells JA, Wilensky GR
• Subtilisin--an enzyme designed to be engineered.
  Trends in biochemical sciences 1988 Wells JA, Estell DA
• Dissecting the catalytic triad of a serine protease.
  Nature 1988 Carter P, Wells JA
• GrantWatch. Foundation funding for AIDS education.
  Health affairs (Project Hope) 1988 Wells JA, Zuercher A, Clinton J
• Improvement in the alkaline stability of subtilisin using an efficient random mutagenesis and screening procedure.
  Protein engineering 1987 Cunningham BC, Wells JA
• Recruitment of substrate-specificity properties from one enzyme into a related one by protein engineering.
  Proceedings of the National Academy of Sciences of the United States of America 1987 Wells JA, Cunningham BC, Graycar TP, Estell DA
• Engineering enzyme specificity by "substrate-assisted catalysis".
  Science (New York, N.Y.) 1987 Carter P, Wells JA
• Patient age distribution in thalassemia major: changes from 1973 to 1985.
  Pediatrics 1987 Pearson HA, Guiliotis DK, Rink L, Wells JA
• Designing substrate specificity by protein engineering of electrostatic interactions.
  Proceedings of the National Academy of Sciences of the United States of America 1987 Wells JA, Powers DB, Bott RR, Graycar TP, Estell DA
• Foundation funding for AIDS programs.
  Health affairs (Project Hope) 1987 Wells JA
• On the evolution of specificity and catalysis in subtilisin.
  Cold Spring Harbor symposia on quantitative biology 1987 Wells JA, Cunningham BC, Graycar TP, Estell DA, Carter P
• Thoracoabdominal motion in response to treadmill and cycle exercise.
  The American review of respiratory disease 1986 Wells JA, Smyth RJ, Rebuck AS
• Probing steric and hydrophobic effects on enzyme-substrate interactions by protein engineering.
  Science (New York, N.Y.) 1986 Estell DA, Graycar TP, Miller JV, Powers DB, Wells JA, Burnier JP, Ng PG
• In vivo formation and stability of engineered disulfide bonds in subtilisin.
  The Journal of biological chemistry 1986 Wells JA, Powers DB
• Secretion and autoproteolytic maturation of subtilisin.
  Proceedings of the National Academy of Sciences of the United States of America 1986 Power SD, Adams RM, Wells JA
• 2-[(4-Azido-2-nitrophenyl)amino]ethyl triphosphate, a novel chromophoric and photoaffinity analogue of ATP. Synthesis, characterization, and interaction with myosin subfragment 1.
  Biochemistry 1985 Nakamaye KL, Wells JA, Bridenbaugh RL, Okamoto Y, Yount RG
• Engineering an enzyme by site-directed mutagenesis to be resistant to chemical oxidation.
  The Journal of biological chemistry 1985 Estell DA, Graycar TP, Wells JA
• Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites.
  Gene 1985 Wells JA, Vasser M, Powers DB
• Characterization of the properties of ethenoadenosine nucleotides bound or trapped at the active site of myosin subfragment 1.
  Biochemistry 1984 Perkins WJ, Wells JA, Yount RG
• An improved method for purifying 2',5'-oligoadenylate synthetases.
  The Journal of biological chemistry 1984 Wells JA, Swyryd EA, Stark GR
• Awareness by consumers and the adoption of a new service: an HMO example.
  Journal of health care marketing 1984 Griffith MJ, Wells JA
• Cloning, sequencing, and secretion of Bacillus amyloliquefaciens subtilisin in Bacillus subtilis.
  Nucleic acids research 1983 Wells JA, Ferrari E, Henner DJ, Estell DA, Chen EY
• Musculoskeletal disorders among letter carriers. A comparison of weight carrying, walking & sedentary occupations.
  Journal of occupational medicine. : official publication of the Industrial Medical Association 1983 Wells JA, Zipp JF, Schuette PT, McEleney J
• Trapping of transition metal-nucleotide complexes in myosin subfragment 1 by cross-linking thiols; divalent transition metal probes of the active site.
  Biochemistry 1983 Dalbey RE, Wells JA, Yount RG
• Physiogenic bias as invalidity in psychiatric symptom scales.
  Journal of health and social behavior 1982 Wells JA, Strickland DE
• Chemical modification of myosin by active-site trapping of metal-nucleotides with thiol crosslinking reagents.
  Methods in enzymology 1982 Wells JA, Yount RG
• Cross-linking of myosin subfragment 1. Nucleotide-enhanced modification by a variety of bifunctional reagents.
  The Journal of biological chemistry 1980 Wells JA, Knoeber C, Sheldon MC, Werber MM, Yount RG
• Mechanism of inactivation of myosin subfragment 1 by Co(III)phenATP. A reinvestigation.
  The Journal of biological chemistry 1980 Wells JA, Werber MM, Yount RG
• Reaction of 5,5'-dithiobis(2-nitrobenzoic acid) with myosin subfragment one: evidence for formation of a single protein disulfide with trapping of metal nucleotide at the active site.
  Biochemistry 1980 Wells JA, Yount RG
• Magnesium nucleotide is stoichiometrically trapped at the active site of myosin and its active proteolytic fragments by thiol cross-linking reagents.
  The Journal of biological chemistry 1980 Wells JA, Sheldon M, Yount RG
• "Magnesium nucleotide is stoichiometrically trapped at the active site of myosin and its proteolytic subfragments by thiol cross-linking reagents"
  J. Biol. Chem 1980 Wells, J.A., Sheldon, M., and Yount, R.G.
• "Reaction of 5,5'-dithiobis (2-nitrobenzoic acid) with myosin subfragment one: Evidence for formation of a single protein disulfide with trapping of metal nucleotide at the active site"
  Biochemistry 1980 Wells, J.A. and Yount, R.G.
• Inactivation of myosin subfragment one by cobalt(II)/cobalt(III) phenanthroline complexes. 2. Cobalt chelation of two critical SH groups.
  Biochemistry 1979 Wells JA, Werber MM, Yount RG
• Inactivation of myosin subfragment one by cobalt(II)/cobalt(III) phenanthroline complexes. I. Incorporation of Co(III) by in situ oxidation of Co(II).
  Biochemistry 1979 Wells JA, Werber MM, Legg JI, Yount RG
• Active site trapping of nucleotides by crosslinking two sulfhydryls in myosin subfragment 1.
  Proceedings of the National Academy of Sciences of the United States of America 1979 Wells JA, Yount RG
• Occupational stress and health among factory workers.
  Journal of health and social behavior 1979 House JS, McMichael AJ, Wells JA, Kaplan BH, Landerman LR
• "Active site trapping of nucleotides by crosslinking two sulfhydryls in myosin sub-fragment 1"
  Proc. Natl. Acad. Sci. USA 1979 Wells, J.A. and Yount, R.G.
• "Inactivation of myosin subfragment one by cobalt (II)/cobalt (III) phenanthroline complexes. 1. Incorporation of Co(III) by in situ oxidation of Co(II)"
  Biochemistry 1979 Wells, J.A., Werber, M.M. and Yount, R.G.
• "Inactivation of myosin subfragment one by cobalt (II)/cobalt (III) phenanthroline complexes. 2. Cobalt chelation of two critical SH groups"
  Biochemistry 1979 Wells, J.A., Werber, M.M., Legg, J.I., and Yount, R.G.
• Do we need a burn severity grading system.
  The Journal of trauma 1977 Fisher JC, Wells JA, Fulwider BT, Edgerton MT
• Issues in specialty certification.
  American Nurses Association Publications 1975 Wells JA