James Smith, MD, MS
Professor in Residence
Urology
School of Medicine

He and his partners conduct basic science investigations of sperm physiology, sperm stem cells, and semen physiology; translational research focused on fertility restoration by means of testicular and stem cell transplantation; and clinical research into reproductive effects of targeted cancer therapies such as tyrosine kinase inhibitors and MTOR inhibitors., Clinically, Dr. Smith treats men with fertility problems, need for fertility preservation, erectile dysfunction, orchalgia, and hypogonadism in the Center for Reproductive Health. Dr. Smith specializes in the use of minimally invasive vasectomy, microsurgical vasovasostomy, vasoepididymostomy, sperm retrieval techniques, spermatic cord denervation, and varicocelectomy.

• Factors Influencing the Decision for Fresh vs Cryopreserved Microdissection Testicular Sperm Extraction for Non-Obstructive Azoospermia.
  Urology 2021 Asanad K, Matthew Coward R, Mehta A, Smith JF, Vij SC, Nusbaum DJ, Rodman JCS, Samplaski MK
• One size does not fit all: variations by ethnicity in demographic characteristics of men seeking fertility treatment across North America.
  Fertility and sterility 2021 Chen AB, Jarvi KA, Lajkosz K, Smith JF, Lo KC, Grober ED, Lau S, Bieniek JM, Brannigan RE, Chow VDW, Domes T, Dupree JM, Goldstein M, Hedges JC, Hotaling JM, Ko EY, Kolettis PN, Nangia AK, Sandlow JI,…
• Male vitamin D status and male factor infertility.
  Fertility and sterility 2021 Banks N, Sun F, Krawetz SA, Coward RM, Masson P, Smith JF, Trussell JC, Santoro N, Zhang H, Steiner AZ
• Sperm deoxyribonucleic acid fragmentation: predictors, fertility outcomes, and assays among infertile males.
  F&S reports 2021 Rios JS, Coward RM, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Sun F, Wild R, Smith JF, Santoro N, Zhang H, Steiner AZ
• Ex vivo human testes as a practical model to simulate ultrasound-guided testicular cell transplantation for human fertility restoration.
  F&S science 2021 Yang H, Lindsey JP, Gillis-Buck EM, Srirangapatanam S, Rosen JE, Hussein AA, Smith JF
• The Impact of Physician Productivity Models on Access to Subspecialty Care: A White Paper From the Society for the Study of Male Reproduction and the Society for Male Reproduction and Urology.
  Urology 2021 Dupree JM, Coward RM, Hsieh TC, Tanrikut C, Shin P, Mehta A, Hotaling JM, Pastuszak AW, Williams D, Alukal J, Lipshultz LI, Schlegel P, Walsh TJ, Eisenberg ML, Shin D, Honig S, Nagler HM, Samplaski M,…
• Development and validation of a novel mail-in semen analysis system and the correlation between one hour and delayed semen analysis testing.
  Fertility and sterility 2021 Samplaski MK, Falk O, Honig S, Shin D, Matthews W, Smith JF
• A View from the past into our collective future: the oncofertility consortium vision statement.
  Journal of assisted reproduction and genetics 2021 Woodruff TK, Ataman-Millhouse L, Acharya KS, Almeida-Santos T, Anazodo A, Anderson RA, Appiah L, Bader J, Becktell K, Brannigan RE, Breech L, Bourlon MT, Bumbuliene Ž, Burns K, Campo-Engelstein L, …
• Disparities in fertility knowledge among women from low and high resource settings presenting for fertility care in two United States metropolitan centers.
  Fertility research and practice 2020 Hoffman JR, Delaney MA, Valdes CT, Herrera D, Washington SL, Aghajanova L, Smith JF, Herndon CN
• The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial.
  Fertility and sterility 2020 Steiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Coward RM, Huang H, Wild R, Masson P, Smith JF, Santoro N, Eisenberg E, Zhang H, Reproductive …
• Reproductive endocrinologists are the gatekeepers for male infertility care in North America: results of a North American survey on the referral patterns and characteristics of men presenting to male infertility specialists for infertility investigations.
  Fertility and sterility 2019 Samplaski MK, Smith JF, Lo KC, Hotaling JM, Lau S, Grober ED, Trussell JC, Walsh TJ, Kolettis PN, Chow VDW, Zini AS, Spitz A, Fischer MA, Domes T, Zeitlin SI, Fuchs EF, Hedges JC, Sandlow JI, …
• Fertility Related Quality of Life, Gonadal Function and Erectile Dysfunction in Male Partners of Couples with Unexplained Infertility.
  The Journal of urology 2019 Coward RM, Stetter C, Kunselman A, Trussell JC, Lindgren MC, Alvero RR, Casson P, Christman GM, Coutifaris C, Diamond MP, Hansen KR, Krawetz SA, Legro RS, Robinson RD, Smith JF, Steiner AZ, Wild RA, …
• The National Physicians Cooperative: transforming fertility management in the cancer setting and beyond.
  Future oncology (London, England) 2018 Smith BM, Duncan FE, Ataman L, Smith K, Quinn GP, Chang RJ, Finlayson C, Orwig K, Valli-Pulaski H, Moravek MB, Zelinski MB, Irene Su H, Vitek W, Smith JF, Jeruss JS, Gracia C, Coutifaris C, Shah D, …
• Large Differences in Small RNA Composition Between Human Biofluids.
  Cell reports 2018 Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ
• Semen Parameters Among Transgender Women With a History of Hormonal Treatment.
  Urology 2018 Adeleye AJ, Reid G, Kao CN, Mok-Lin E, Smith JF
• Fertility preservation for men with testicular cancer: Is sperm cryopreservation cost effective in the era of assisted reproductive technology?
  Urologic oncology 2017 Gilbert K, Nangia AK, Dupree JM, Smith JF, Mehta A
• Tyrosine Kinase Inhibitors and Male Reproductive Health.
  Clinical pharmacology and therapeutics 2017 Ramstein JJ, Tsai KK, Smith JF
• Semen amyloids participate in spermatozoa selection and clearance.
  eLife 2017 Roan NR, Sandi-Monroy N, Kohgadai N, Usmani SM, Hamil KG, Neidleman J, Montano M, Ständker L, Röcker A, Cavrois M, Rosen J, Marson K, Smith JF, Pilcher CD, Gagsteiger F, Sakk O, O'Rand M, Lishko PV, …
• Demographic analysis of a low resource, socioculturally diverse urban community presenting for infertility care in a United States public hospital.
  Contraception and reproductive medicine 2017 Ho JR, Hoffman JR, Aghajanova L, Smith JF, Cardenas M, Herndon CN
• Maternal fetal medicine.
  Current opinion in obstetrics & gynecology 2017 Smith JF
• Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells.
  PLoS pathogens 2017 Neidleman JA, Chen JC, Kohgadai N, Müller JA, Laustsen A, Thavachelvam K, Jang KS, Stürzel CM, Jones JJ, Ochsenbauer C, Chitre A, Somsouk M, Garcia MM, Smith JF, Greenblatt RM, Münch J, Jakobsen MR, …
• Fertility preservation options for prepubertal boys facing gonadotoxic therapies.
  Minerva ginecologica 2016 Hussein AA, Yango P, Ezz Y, Smith JF, Tran ND
• The Sexual Impact of Infertility Among Women Seeking Fertility Care.
  Sexual medicine 2016 Winkelman WD, Katz PP, Smith JF, Rowen TS, Infertility Outcomes Program Project Group
• Out-of-Pocket Costs for Men Undergoing Infertility Care and Associated Financial Strain.
  Urology practice 2016 Elliott PA, Hoffman J, Abad-Santos M, Herndon C, Katz PP, Smith JF
• Limitations and barriers in access to care for male factor infertility.
  Fertility and sterility 2016 Mehta A, Nangia AK, Dupree JM, Smith JF
• The continuing threat of syphilis in pregnancy.
  Current opinion in obstetrics & gynecology 2016 Moline HR, Smith JF
• Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone.
  Science (New York, N.Y.) 2016 Miller MR, Mannowetz N, Iavarone AT, Safavi R, Gracheva EO, Smith JF, Hill RZ, Bautista DM, Kirichok Y, Lishko PV
• Freezing and thawing testicular cells may not affect growth of cultured testicular cells.
  Fertility and sterility 2015 Smith JF, Tran ND
• Fertility preservation for boys and adolescents facing sterilizing medical therapy.
  Translational andrology and urology 2014 Hussein AA, Tran ND, Smith JF
• Optimizing cryopreservation of human spermatogonial stem cells: comparing the effectiveness of testicular tissue and single cell suspension cryopreservation.
  Fertility and sterility 2014 Yango P, Altman E, Smith JF, Klatsky PC, Tran ND
• Testicular niche required for human spermatogonial stem cell expansion.
  Stem cells translational medicine 2014 Smith JF, Yango P, Altman E, Choudhry S, Poelzl A, Zamah AM, Rosen M, Klatsky PC, Tran ND
• Characterization of human spermatogonial stem cell markers in fetal, pediatric, and adult testicular tissues.
  Reproduction (Cambridge, England) 2014 Altman E, Yango P, Moustafa R, Smith JF, Klatsky PC, Tran ND
• Temporal and geospatial trends in male factor infertility with assisted reproductive technology in the United States from 1999-2010.
  Fertility and sterility 2014 Odisho AY, Nangia AK, Katz PP, Smith JF
• Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection.
  Journal of virology 2014 Roan NR, Liu H, Usmani SM, Neidleman J, Müller JA, Avila-Herrera A, Gawanbacht A, Zirafi O, Chu S, Dong M, Kumar ST, Smith JF, Pollard KS, Fändrich M, Kirchhoff F, Münch J, Witkowska HE, Greene WC
• Slo1 is the principal potassium channel of human spermatozoa.
  eLife 2013 Mannowetz N, Naidoo NM, Choo SA, Smith JF, Lishko PV
• Out-of-pocket fertility patient expense: data from a multicenter prospective infertility cohort.
  The Journal of urology 2013 Wu AK, Odisho AY, Washington SL, Katz PP, Smith JF
• Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Smith JF, Syritsyna O, Fellous M, Serres C, Mannowetz N, Kirichok Y, Lishko PV
• Time costs of fertility care: the hidden hardship of building a family.
  Fertility and sterility 2013 Wu AK, Elliott P, Katz PP, Smith JF
• Racial, socioeconomic, and demographic disparities in access to fertility preservation in young women diagnosed with cancer.
  Cancer 2012 Letourneau JM, Smith JF, Ebbel EE, Craig A, Katz PP, Cedars MI, Rosen MP
• Predictors of sexual bother in a population of male North American medical students.
  The journal of sexual medicine 2011 Smith JF, Breyer BN, Shindel AW
• National study of factors influencing assisted reproductive technology outcomes with male factor infertility.
  Fertility and sterility 2011 Nangia AK, Luke B, Smith JF, Mak W, Stern JE, SART Writing Group
• The use of complementary and alternative fertility treatments.
  Current opinion in obstetrics & gynecology 2011 Weiss DA, Harris CR, Smith JF
• Socioeconomic disparities in the use and success of fertility treatments: analysis of data from a prospective cohort in the United States.
  Fertility and sterility 2011 Smith JF, Eisenberg ML, Glidden D, Millstein SG, Cedars M, Walsh TJ, Showstack J, Pasch LA, Adler N, Katz PP
• Sexual dysfunction, HIV, and AIDS in men who have sex with men.
  AIDS patient care and STDs 2011 Shindel AW, Horberg MA, Smith JF, Breyer BN
• HIV status is an independent risk factor for reporting lower urinary tract symptoms.
  The Journal of urology 2011 Breyer BN, Van den Eeden SK, Horberg MA, Eisenberg ML, Deng DY, Smith JF, Shindel AW
• Costs of infertility treatment: results from an 18-month prospective cohort study.
  Fertility and sterility 2010 Katz P, Showstack J, Smith JF, Nachtigall RD, Millstein SG, Wing H, Eisenberg ML, Pasch LA, Croughan MS, Adler N
• Pentoxifylline treatment and penile calcifications in men with Peyronie's disease.
  Asian journal of andrology 2010 Smith JF, Shindel AW, Huang YC, Clavijo RI, Flechner L, Breyer BN, Eisenberg ML, Lue TF
• Contraceptive usage patterns in North American medical students.
  Contraception 2010 Rowen TS, Smith JF, Eisenberg ML, Breyer BN, Drey EA, Shindel AW
• Sexual function and depressive symptoms among male North American medical students.
  The journal of sexual medicine 2010 Smith JF, Breyer BN, Eisenberg ML, Sharlip ID, Shindel AW
• Sexual function and depressive symptoms among female North American medical students.
  The journal of sexual medicine 2010 Shindel AW, Eisenberg ML, Breyer BN, Sharlip ID, Smith JF
• The relationship between isolated teratozoospermia and clinical pregnancy after in vitro fertilization with or without intracytoplasmic sperm injection: a systematic review and meta-analysis.
  Fertility and sterility 2010 Hotaling JM, Smith JF, Rosen M, Muller CH, Walsh TJ
• Male athletic activities and their effects on semen and hormonal parameters.
  The Physician and sportsmedicine 2010 Brant WO, Myers JB, Carrell DT, Smith JF
• Tunica-sparing ossified Peyronie's plaque excision.
  BJU international 2010 Eisenberg ML, Smith JF, Shindel AW, Lue TF
• The professional imperative for obstetrician-gynecologists to discontinue newborn male circumcision.
  American journal of perinatology 2010 Smith JF
• Medical student sexuality: how sexual experience and sexuality training impact U.S. and Canadian medical students' comfort in dealing with patients' sexuality in clinical practice.
  Academic medicine : journal of the Association of American Medical Colleges 2010 Shindel AW, Ando KA, Nelson CJ, Breyer BN, Lue TF, Smith JF
• Fertility treatments and outcomes among couples seeking fertility care: data from a prospective fertility cohort in the United States.
  Fertility and sterility 2010 Smith JF, Eisenberg ML, Millstein SG, Nachtigall RD, Sadetsky N, Cedars MI, Katz PP, Infertility Outcomes Program Project Group
• The impact of infertility on family size in the USA: data from the National Survey of Family Growth.
  Human reproduction (Oxford, England) 2010 Breyer BN, Smith JF, Shindel AW, Sharlip ID, Eisenberg ML
• Predictors of not pursuing infertility treatment after an infertility diagnosis: examination of a prospective U.S. cohort.
  Fertility and sterility 2010 Eisenberg ML, Smith JF, Millstein SG, Nachtigall RD, Adler NE, Pasch LA, Katz PP, Infertility Outcomes Program Project Group
• Increased risk of high-grade prostate cancer among infertile men.
  Cancer 2010 Walsh TJ, Schembri M, Turek PJ, Chan JM, Carroll PR, Smith JF, Eisenberg ML, Van Den Eeden SK, Croughan MS
• The impact of sexual orientation on sexuality and sexual practices in North American medical students.
  The journal of sexual medicine 2010 Breyer BN, Smith JF, Eisenberg ML, Ando KA, Rowen TS, Shindel AW
• The use of complementary and alternative fertility treatment in couples seeking fertility care: data from a prospective cohort in the United States.
  Fertility and sterility 2010 Smith JF, Eisenberg ML, Millstein SG, Nachtigall RD, Shindel AW, Wing H, Cedars M, Pasch L, Katz PP, Infertility Outcomes Program Project Group
• Are sonographic characteristics associated with progression to surgery in men with Peyronie's disease?
  The Journal of urology 2010 Breyer BN, Shindel AW, Huang YC, Eisenberg ML, Weiss DA, Lue TF, Smith JF
• Racial disparities in erectile dysfunction among participants in the California Men's Health Study.
  The journal of sexual medicine 2009 Smith JF, Caan BJ, Sternfeld B, Haque R, Quesenberry CP, Quinn VP, Shan J, Walsh TJ, Lue TF, Jacobsen SJ, Van den Eeden SK
• Socioeconomic, anthropomorphic, and demographic predictors of adult sexual activity in the United States: data from the national survey of family growth.
  The journal of sexual medicine 2009 Eisenberg ML, Shindel AW, Smith JF, Breyer BN, Lipshultz LI
• Racial differences in vasectomy utilization in the United States: data from the national survey of family growth.
  Urology 2009 Eisenberg ML, Henderson JT, Amory JK, Smith JF, Walsh TJ
• Penile sonographic and clinical characteristics in men with Peyronie's disease.
  The journal of sexual medicine 2009 Smith JF, Brant WO, Fradet V, Shindel AW, Vittinghoff E, Chi T, Huang YC, Davis CB, Conti S, Lue TF
• Sexual, marital, and social impact of a man's perceived infertility diagnosis.
  The journal of sexual medicine 2009 Smith JF, Walsh TJ, Shindel AW, Turek PJ, Wing H, Pasch L, Katz PP, Infertility Outcomes Program Project Group
• Perceived negative consequences of donor gametes from male and female members of infertile couples.
  Fertility and sterility 2009 Eisenberg ML, Smith JF, Millstein SG, Walsh TJ, Breyer BN, Katz PP, Infertility Outcomes Program Project Group
• Who is the 40-year-old virgin and where did he/she come from? Data from the National Survey of Family Growth.
  The journal of sexual medicine 2009 Eisenberg ML, Shindel AW, Smith JF, Lue TF, Walsh TJ
• Does bicycling contribute to erectile dysfunction? Examining the evidence.
  The Physician and sportsmedicine 2009 Brant WO, Lue TF, Smith JF
• Meta-analysis: does lidocaine gel before flexible cystoscopy provide pain relief?
  BJU international 2009 Aaronson DS, Walsh TJ, Smith JF, Davies BJ, Hsieh MH, Konety BR
• Endoscopic subureteral injection is not less expensive than outpatient open reimplantation for unilateral vesicoureteral reflux.
  The Journal of urology 2008 Saperston K, Smith J, Putman S, Matern R, Foot L, Wallis C, deVries C, Snow B, Cartwright P
• Risk factors for emotional and relationship problems in Peyronie's disease.
  The journal of sexual medicine 2008 Smith JF, Walsh TJ, Conti SL, Turek P, Lue T
• Ejaculatory duct obstruction.
  The Urologic clinics of North America 2008 Smith JF, Walsh TJ, Turek PJ
• The FG syndromes (Online Mendelian Inheritance in Man 305450): perspective in 2008.
  Advances in pediatrics 2008 Opitz JM, Smith JF, Santoro L
• Genitourinary anomalies of pediatric FG syndrome.
  The Journal of urology 2007 Smith JF, Wayment RO, Cartwright PC, Snow BW, Opitz JM