James Rubenstein, MD, PhD
Professor
Medicine
School of Medicine

In his research, Rubenstein investigates immunologic tools to improve tumor response to chemotherapy and radiation treatment, and to minimize toxicity from treatment. He is also interested in developing tumor biomarkers to diagnose brain tumors.

Rubenstein earned his medical degree at Weill Cornell Medicine and completed a residency in internal medicine at Stanford Medicine. He earned a doctorate in molecular and cellular neurosciences at the Rockefeller University. He completed a fellowship in hematology and oncology at UCSF, which included training in neuro-oncology.

Rubenstein has won research awards from the Leukemia & Lymphoma Society and the National Cancer Institute. He is a member of the American Society of Hematology, American Society of Clinical Oncology and American Association for Cancer Research.

• EBV-positive PCNSL in older patients: incidence, characteristics, tumor pathology, and outcomes across a large multicenter cohort.
  Leukemia & lymphoma 2023 Agrawal P, David KA, Chen Z, Sundaram S, Kim SH, Vaca R, Lin Y, Singer S, Malecek MK, Carter J, Zayac A, Kim MS, Reddy N, Ney D, Habib A, Strouse C, Graber J, Bachanova V, Salman S, Vendiola JA, …
• Stereotactic Radiosurgery for Primary Central Nervous System Lymphoma.
  Cureus 2023 Wu SY, Braunstein SE, Rubenstein JL, Sneed PK
• Tafasitamab at the blood-brain barrier.
  British journal of haematology 2023 Rauschecker AM, Mo SS, Randall M, Shen-Sampas J, Rubenstein JL
• Primary CNS lymphoma: update on molecular pathogenesis and therapy.
  Leukemia & lymphoma 2022 Mo SS, Cleveland J, Rubenstein JL
• Primary CNS Lymphoma: Progress With Dose-Intensive Consolidation.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2022 Rubenstein JL
• Acquired factor VII inhibitor associated with primary central nervous system Lymphoma: A case report.
  EJHaem 2022 Goyal V, Salmasi G, Leavitt AD, Rubenstein JL, Banerjee R
• A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome.
  Blood advances 2022 Güney E, Lucas CG, Qi Z, Yu J, Zhang R, Ohgami RS, Rubenstein JL, Boué DR, Schafernak K, Wertheim GB, Dahiya S, Giulino-Roth L, Attarbaschi A, Barth MJ, Kothari S, Abla O, Cohen AL, Mendez JS, Bollen …
• Regulation of CNS Lymphoma Progression By the Myeloid Microenvironment.
  Blood 2021 Hua-Xin Gao, Eleanor Fraser, Mario Merlini, Huimin Geng, Lingjing Chen, Ming Lu, Yasmin Moshfegh, Joseph Cleveland, Jae Ryu, Jigyasa Sharma, David A. Solomon, Katerina Akassoglou, Clifford Lowell, …
• Tumor metabolism and neurocognition in CNS lymphoma.
  Neuro-oncology 2021 Geng H, Tsang M, Subbaraj L, Cleveland J, Chen L, Lu M, Sharma J, Vigneron DB, Kurhanewicz J, LaFontaine M, Luks T, Barshop BA, Gangoiti J, Villanueva-Meyer JE, Rubenstein JL
• Primary central nervous system lymphoma in older adults and the rationale for maintenance strategies: a narrative review.
  Annals of lymphoma 2021 Tsang M, Rubenstein JL, Pulczynski EJ
• A functional mammalian display screen identifies rare antibodies that stimulate NK cell-mediated cytotoxicity.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Kang E, Kadoch C, Rubenstein JL, Lanier LL, Wells JA
• Consensus recommendations for MRI and PET imaging of primary central nervous system lymphoma: guideline statement from the International Primary CNS Lymphoma Collaborative Group (IPCG).
  Neuro-oncology 2021 Barajas RF, Politi LS, Anzalone N, Schöder H, Fox CP, Boxerman JL, Kaufmann TJ, Quarles CC, Ellingson BM, Auer D, Andronesi OC, Ferreri AJM, Mrugala MM, Grommes C, Neuwelt EA, Ambady P, Rubenstein JL,…
• Myeloablative versus non-myeloablative consolidative chemotherapy for newly diagnosed primary central nervous system lymphoma: Results of CALGB 51101 (Alliance).
  Journal of Clinical Oncology 2021 Tracy Batchelor, Sharmila Giri, Amy S. Ruppert, Nancy L. Bartlett, Eric D. Hsi, Bruce D. Cheson, Lakshmi Nayak, John Paul Leonard, James L. Rubenstein
• Blood Coagulation Factor Fibrinogen in Tumor Pathogenesis of Central Nervous System B-Cell Lymphoma.
  The American journal of pathology 2021 Chan JP, Merlini M, Gao HX, Mendiola AS, Akassoglou K, Rubenstein JL, Ryu JK
• Survival and Patient-Reported Outcomes of Older Adults with Primary Central Nervous System Lymphoma on Low-Dose Lenalidomide.
  Blood 2020 Mazie Tsang, Joseph Cleveland, Miguel Carlos Cerejo, Huimin Geng, James L. Rubenstein
• On point in primary CNS lymphoma.
  Hematological oncology 2020 Tsang M, Cleveland J, Rubenstein JL
• Cutaneous T-Cell Lymphoma PDX Drug Screening Platform Identifies Cooperation between Inhibitions of PI3Kα/δ and HDAC.
  The Journal of investigative dermatology 2020 Wu CH, Yang CY, Wang L, Gao HX, Rakhshandehroo T, Afghani S, Pincus L, Balassanian R, Rubenstein J, Gill R, Bandyopadhyay S, McCormick F, Moasser M, Ai WZ
• Myeloablative versus non-myeloablative consolidative chemotherapy for newly diagnosed primary central nervous system lymphoma: Results of induction therapy in Alliance 51101.
  Journal of Clinical Oncology 2020 Tracy Batchelor, Sharmila Giri, Amy S. Ruppert, Nancy L. Bartlett, Eric D. Hsi, Bruce D. Cheson, Lakshmi Nayak, John Paul Leonard, James L. Rubenstein
• THERAPEUTIC VITRECTOMY AS AN ADJUNCT TREATMENT TO SYSTEMIC CHEMOTHERAPY FOR INTRAOCULAR LYMPHOMA.
  Retinal cases & brief reports 2020 Bever GJ, Kim DJ, Afshar AR, Rubenstein JL, Damato BE
• Development of a Pathway-Directed Drug Screen Platform for Cutaneous T Cell Lymphoma Using Patient-Derived Xenograft Models.
  Blood 2019 CHI-HENG WU, Chen-Yen Yang, Linlin Wang, Hua-Xin Gao, Rakhshandehroo Taha, Shervin Afghani, Laura Pincus, Ronald Balassanian, James Rubenstein, Ryan Gill, Sourav Bandyopadhyay, Frank McCormick, Mark …
• Potential Genetic and Immunologic Mechanisms of Therapeutic Resistance and Disease Progression in CNS Lymphoma Elucidated Via Whole Brain Autopsy Studies.
  Blood 2019 David A. Solomon, Huimin Geng, Raymond A. Sobel, Lakshmi Subbaraj, Mazie Tsang, James L. Rubenstein
• Maintenance lenalidomide in primary CNS lymphoma.
  Annals of oncology : official journal of the European Society for Medical Oncology 2019 Rubenstein JL, Geng H, Vu K, Mannis G, Formaker P, Hwang J, Munster PN, Damato B
• An audit of retinal lymphoma treatment at the University of California San Francisco.
  Eye (London, England) 2019 Damato B, Bever GJ, Kim DJ, Afshar AR, Rubenstein JL
• Evolving Treatments for Primary Central Nervous System Lymphoma.
  American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting 2019 Ferreri AJM, Holdhoff M, Nayak L, Rubenstein JL
• Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma.
  Neuro-oncology 2019 Grommes C, Rubenstein JL, DeAngelis LM, Ferreri AJM, Batchelor TT
• Low-dose lenalidomide maintenance after induction therapy in older patients with primary central nervous system lymphoma.
  British journal of haematology 2019 Vu K, Mannis G, Hwang J, Geng H, Rubenstein JL
• Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NFkB Activation in Preclinical Patient-Derived Models of CNS Lymphoma.
  Blood 2018 Huimin Geng, Brice Tiret, Hua-Xin Gao, Cigall Kadoch, Ming Lu, Lingjing Chen, Ilwoo Park, Gerd Melkus, Adam Elkhaled, John Kurhanewicz, Lisa Drew, Sebastien Degorce, Michele Mayo, Keith Dillman, Rana …
• Low-Dose Lenalidomide Maintenance after Induction Therapy in Older Patients with Primary CNS Lymphoma.
  Blood 2018 Khoan Vu, James Rubenstein, Gabriel N. Mannis, Jimmy Hwang, Huimin Geng
• RTHP-31. STEREOTACTIC RADIOSURGERY FOR PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA.
  Neuro-Oncology 2018 Susan Wu, Steve Braunstein, James Rubenstein, Penny Sneed
• Can rituximab unlock the innate potential of checkpoint blockade in the CNS?
  Leukemia & lymphoma 2018 Rubenstein JL
• Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma.
  Blood advances 2018 Rubenstein JL, Geng H, Fraser EJ, Formaker P, Chen L, Sharma J, Killea P, Choi K, Ventura J, Kurhanewicz J, Lowell C, Hwang J, Treseler P, Sneed PK, Li J, Wang X, Chen N, Gangoiti J, Munster PN, …
• Abstract 4975: Tumor metabolism and cognitive dysfunction in CNS lymphoma.
  Cancer Research 2018 Lakshmi Subbaraj, Huimin Geng, Jigyasa Sharma, Marisa LaFontaine, James L. Rubenstein
• Insights from a Case of Vitreoretinal Lymphoma.
  Ocular oncology and pathology 2018 Damato BE, Bever GJ, Afshar AR, Rubenstein JL
• Biology of CNS lymphoma and the potential of novel agents.
  Hematology. American Society of Hematology. Education Program 2017 Rubenstein JL
• EXTH-71. HYPERPOLARIZED [1-13C] PYRUVATE AS A BIOMARKER FOR TREATMENT MONITORING IN LYMPHOMA MURINE MODELS.
  Neuro-Oncology 2017 Brice Tiret, Adam Autry, Ilwoo Park, Ming Lu, Rana Anjum, Liza Drew, Sebastien Degorce, Michele Mayo, Keith Dillman, James Rubenstein, Myriam M Chaumeil
• CHECKMATE 647: A PHASE 2, OPEN-LABEL STUDY OF NIVOLUMAB IN RELAPSED/REFRACTORY PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA OR RELAPSED/REFRACTORY PRIMARY TESTICULAR LYMPHOMA.
  Hematological Oncology 2017 L. Nayak, F.M. Iwamoto, A.J. Ferreri, A. Santoro, S. Singer, C. Batlevi, T. Batchelor, J. Rubenstein, P. Johnston, R. Ramchandren, C. Soussain, J. Drappatz, K. Becker, M. Witzens-Harig, G. Illerhaus, …
• Preliminary analysis of lenalidomide maintenance after methotrexate-temozolomide-rituximab induction in older patients with PCNSL.
  Hematological Oncology 2017 J.L. Rubenstein, J. Hwang, G. Mannis
• Regression of methotrexate-resistant AIDS-related primary central nervous system lymphoma with lenalidomide plus combination anti-retroviral therapy.
  Leukemia & lymphoma 2017 Gupta NK, Wang CC, Mannis GN, Yu JJ, Rubenstein JL
• Targeting NF-KB Activation in Novel Intracranial Models of CNS Lymphoma.
  Blood 2016 Huimin Geng, Huaxin Gao, Cigall Kadoch, Ming Lu, Lingjing Chen, Rana Anjum, Lisa Drew, Sebastien Degorce, Keith Dillman, Michele Mayo, Shawn Anderson, Colin Collins, Clifford A. Lowell, James L. …
• The Challenge of Primary Central Nervous System Lymphoma.
  Hematology/oncology clinics of North America 2016 Carnevale J, Rubenstein JL
• ATIM-27. PHASE I INVESTIGATION OF LENALIDOMIDE PLUS RITUXIMAB AND OUTCOMES OF LENALIDOMIDE MAINTENANCE IN RECURRENT CNS LYMPHOMA.
  Neuro-Oncology 2016 James Rubenstein, Eleanor Fraser, Paul Formaker, James Chi-Chiang Lee, Nianhang Chen, Mallory Kock, Wesley Cheung, Phoebe Killea, Kee-Hyun Choi, Xiaomin Wang, Pamela Munster, Bertil Damato
• Long-term survival in AIDS-related primary central nervous system lymphoma.
  Neuro-oncology 2016 Gupta NK, Nolan A, Omuro A, Reid EG, Wang CC, Mannis G, Jaglal M, Chavez JC, Rubinstein PG, Griffin A, Abrams DI, Hwang J, Kaplan LD, Luce JA, Volberding P, Treseler PA, Rubenstein JL
• Abstract A06: Development of a drug discovery platform using clinically relevant patient-derived xenograft models for cutaneous T cell lymphomas.
  Clinical Cancer Research 2016 Wei Ai, Yen-Chen Yang Yang, Shervin Afghani, Huaxin Gao, Laura Pincus Pincus, Linlin Wang Wang, Taha Rakhshandhroo, Ronald Balassanian, James Rubenstein, Ryan Gill, Frank McCormick
• Phase I investigation of lenalidomide plus rituximab and outcomes of lenalidomide maintenance in recurrent CNS lymphoma.
  Journal of Clinical Oncology 2016 James L. Rubenstein, Eleanor Fraser, Paul Formaker, James Chi-Chiang Lee, Nianhang Chen, Mallory Kock, Wesley Cheung, Xiaomin Wang, Pamela N. Munster, Bertil Damato
• The role of whole brain radiation in primary CNS lymphoma.
  Blood 2016 Kasenda B, Loeffler J, Illerhaus G, Ferreri AJ, Rubenstein J, Batchelor TT
• Therapy for Secondary CNS Involvement in Malignant Lymphomas: No Standard Yet!
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2016 Korfel A, Chamberlain M, Neuwelt E, Thiel E, Doolittle N, Schlegel U, Dreyling M, Rubenstein J, Fischer L, Björkholm M, Martus P, Weller M, Glantz M
• Expression of B and T Lymphocyte Attenuator (BTLA) Correlates with CNS Metastasis and Adverse Prognosis in Activated B-Cell Lymphoma and Acute Lymphoblastic Leukemia.
  Blood 2015 Huimin Geng, Zhengshan Chen, Shawn Anderson, Eleanor Fraser, Ming Lu, Chen Lingjing, Colin Collins, Muschen Markus, James L. Rubenstein
• Performance of Apparent Diffusion Coefficient Values and Conventional MRI Features in Differentiating Tumefactive Demyelinating Lesions From Primary Brain Neoplasms.
  AJR. American journal of roentgenology 2015 Mabray MC, Cohen BA, Villanueva-Meyer JE, Valles FE, Barajas RF, Rubenstein JL, Cha S
• Prolonged Complete Response in a Pediatric Patient With Primary Peripheral T-Cell Lymphoma of the Central Nervous System.
  Pediatric hematology and oncology 2015 Shalabi H, Angiolillo A, Vezina G, Rubenstein JL, Pittaluga S, Raffeld M, Marcus L
• New approaches in primary central nervous system lymphoma.
  Chinese clinical oncology 2015 Fraser E, Gruenberg K, Rubenstein JL
• 77-year-old woman with a dural-based mass. Marginal zone B-cell lymphoma (MZBCL).
  Brain pathology (Zurich, Switzerland) 2015 Okimoto RA, Perry A, Rubenstein JL
• Interim Results of a Phase I Study of Lenalidomide (CC-5013) Plus Intraventricular/Intravenous Rituximab for Recurrent/Refractory CNS and Intraocular Lymphoma.
  Blood 2014 James L. Rubenstein, Paul Formaker, Xiaomin Wang, Nianhang Chen, Michael Seider, Pamela Munster, Bertil Damato
• Progress in central nervous system lymphomas.
  British journal of haematology 2014 Wang CC, Carnevale J, Rubenstein JL
• Reply to M.C. Chamberlain.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2014 Rubenstein JL, Cheson BD, Jung SH, Kaplan LD
• 50 Brain Metastases and Neoplastic Meningitis.
  2014 Penny K. Sneed, Norbert Kased, James L. Rubenstein
• CNS Lymphoma.
  Rare Lymphomas 2014 Agnieszka Korfel, James Rubenstein, German Ott, Eric D. Hsi
• High-Dose Methotrexate Is Effective, Safe, and Leads To Durable Responses In Patients With AIDS-Related Primary Central Nervous System Lymphoma Treated During The Era Of Combined Anti-Retroviral Therapy.
  Blood 2013 Neel K. Gupta, Jimmy Hwang, James L. Rubenstein
• Novel Intracranial Xenografts Of CNS Lymphoma Implicate a Role For Cereblon As a Mediator Of Lenalidomide Efficacy.
  Blood 2013 Hua-Xin Gao, Shawn Anderson, Cigall Kadoch, Mekhala Maiti, Lingjing Chen, Dong-Han Yao, Gerd Melkus, Maria Wang, Yan Ren, Michael Breider, Carla Heise, Clifford A. Lowell, Colin Collins, James L. …
• Obesity and Hepatitis B Infection and Risk Of Primary CNS Lymphoma.
  Blood 2013 Chia-Ching J. Wang, Paige M Bracci, James L. Rubenstein
• Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Kadoch C, Li J, Wong VS, Chen L, Cha S, Munster P, Lowell CA, Shuman MA, Rubenstein JL
• How I treat CNS lymphomas.
  Blood 2013 Rubenstein JL, Gupta NK, Mannis GN, Lamarre AK, Treseler P
• The roles of tumor associated macrophages and interferon gamma in immune surveillance in CNS lymphoma (P2211).
  The Journal of Immunology 2013 Hua-Xin Gao, Valerie Wong, Lingjing Chen, Richard Locksley, Clifford Lowell, James Rubenstein
• CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma.
  Blood 2013 Rubenstein JL, Wong VS, Kadoch C, Gao HX, Barajas R, Chen L, Josephson SA, Scott B, Douglas V, Maiti M, Kaplan LD, Treseler PA, Cha S, Hwang JH, Cinque P, Cyster JG, Lowell C
• Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202).
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013 Rubenstein JL, Hsi ED, Johnson JL, Jung SH, Nakashima MO, Grant B, Cheson BD, Kaplan LD
• A systematic approach to the diagnosis of suspected central nervous system lymphoma.
  JAMA neurology 2013 Scott BJ, Douglas VC, Tihan T, Rubenstein JL, Josephson SA
• Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma.
  Blood 2012 Rubenstein JL, Li J, Chen L, Advani R, Drappatz J, Gerstner E, Batchelor T, Krouwer H, Hwang J, Auerback G, Kadoch C, Lowell C, Munster P, Cha S, Shuman MA, Damon LE
• BCL6 Expression and Treatment Delay Correlate with Adverse Outcome in Newly Diagnosed Primary CNS Lymphoma: Final Report of CALGB 50202 (Alliance).
  Blood 2012 James L. Rubenstein, Eric D. Hsi, Jeffrey L. Johnson, Sin-Ho Jung, Barbara Grant, Bruce D. Cheson, Lawrence D. Kaplan
• Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Wieduwilt MJ, Valles F, Issa S, Behler CM, Hwang J, McDermott M, Treseler P, O'Brien J, Shuman MA, Cha S, Damon LE, Rubenstein JL
• Biology of Primary Central Nervous System Lymphoma.
  Lymphoma and Leukemia of the Nervous System 2012 James L. Rubenstein
• Combined Diffusion and Perfusion MRI As Biomarkers of Prognosis in Immunocompetent Patients with Primary CNS Lymphoma.
  Blood 2011 Francisco Valles, Samuel Regalado, James L. Rubenstein, Soonmee Cha
• Dynamic Changes in Macrophage Polarization Correlate with Progression and Response in CNS Lymphoma: Insights Into the Transcriptome of Lymphoma-Associated M2 Macrophages,.
  Blood 2011 Cigall Kadoch, Valerie Wong, Lingjing Chen, Anna Bet-Lachin, Ritu Roy, William Hyun, Caroline Behler, Clifford Lowell, James L. Rubenstein
• Genomic and Molecular Properties of Relapsed CNS Lymphoma Using Novel Primary Meningeal Lymphoma Cell Lines and Intracranial Xenografts,.
  Blood 2011 Hua-Xin Gao, Shawn Anderson, Lingjing Chen, Cigall Kadoch, Byron C Hann, Clifford Lowell, Colin Collins, James L. Rubenstein
• Metabolic Profiling of CNS Lymphoma and Its Microenvironment.
  Blood 2011 Anna Bet-Lachin, Frank Jiang, Lingjing Chen, Keyvan Keshari, David Wilson, John Kurhanewicz, James L. Rubenstein
• Multicenter Phase I Trial of Intraventricular Immuno-Chemotherapy in Recurrent CNS Lymphoma.
  Blood 2011 James L. Rubenstein, Lingjing Chen, Ranjana Advani, Jan Drappatz, Elizabeth Gerstner, Tracy Batchelor, Hendrikus Krouwer, Cigall Kadoch, Pamela Munster, Soonmee Cha, Marc A Shuman, Lloyd E. Damon
• Primary vitreoretinal lymphoma: a report from an International Primary Central Nervous System Lymphoma Collaborative Group symposium.
  The oncologist 2011 Chan CC, Rubenstein JL, Coupland SE, Davis JL, Harbour JW, Johnston PB, Cassoux N, Touitou V, Smith JR, Batchelor TT, Pulido JS
• Regression of refractory intraocular large B-cell lymphoma with lenalidomide monotherapy.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011 Rubenstein JL, Treseler PA, Stewart PJ
• Intensive Chemotherapy and Immunotherapy, without Brain Irradiation, In Newly Diagnosed Patients with Primary CNS Lymphoma: Results of CALGB 50202.
  Blood 2010 James L. Rubenstein, Jeffrey L. Johnson, Sin-Ho Jung, Bruce D. Cheson, Lawrence D. Kaplan
• Interim results of a phase I trial of intraventricular rituximab plus methotrexate in recurrent CNS lymphoma: Macrophage polarization and acquired resistance to therapy.
  Journal of Clinical Oncology 2010 J. L. Rubenstein, C. Kadoch, V. S. Wong, W. Hyun, C. Lowell
• Abstract 2728: Multivariate analysis of cerebrospinal fluid protein biomarkers in central nervous system lymphoma patients and controls.
  Clinical Research 2010 Valerie S. Wong, Lingjing Chen, Cigall Kadoch, Anly Tsang, Lisa Siu, Clifford Lowell, James L. Rubenstein
• Abstract 5580: Macrophage polarization and acquired resistance to rituximab in CNS lymphoma.
  Clinical Research 2010 Cigall Kadoch, Valerie S. Wong, Tara C. Rambaldo, William C. Hyun, Hua Xin Gao, Clifford A. Lowell, James L. Rubenstein
• Macrophage Polarization and Acquired Resistance to Rituximab in CNS Lymphoma.
  Blood 2009 Cigall Kadoch, Valerie D. Wong, Tara Rambaldo, William Hyun, Clifford Lowell, James Rubenstein
• Biology and treatment of primary central nervous system lymphoma.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2009 Algazi AP, Kadoch C, Rubenstein JL
• Reply to H. Zetterberg et al.
  Journal of Clinical Oncology 2009 James L. Rubenstein, Lingjing Chen, Cigall Kadoch, Sushmita Roy, Chris Becker, Howard Schulman
• Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Kadoch C, Dinca EB, Voicu R, Chen L, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, James CD, Rubenstein JL
• Differential gene expression in central nervous system lymphoma.
  Blood 2009 Rubenstein JL, Shen A, Batchelor TT, Kadoch C, Treseler P, Shuman MA
• Insights into the biology of primary central nervous system lymphoma.
  Current oncology reports 2009 Mrugala MM, Rubenstein JL, Ponzoni M, Batchelor TT
• Sarcoidosis of the pineal gland: an unusual presentation of neurosarcoidosis.
  Journal of neuro-oncology 2008 Yang I, Delpolyi A, Sughrue ME, Rubenstein J, Bollen AW, Parsa AT
• Chapter 56 Brain Metastases and Neoplastic Meningitis.
  Abeloff\u0027s Clinical Oncology 2008 Penny K. Sneed, Norbert Kased, Kim Huang, James L. Rubenstein
• Primary lymphoma of the central nervous system: epidemiology, pathology and current approaches to diagnosis, prognosis and treatment.
  Leukemia & lymphoma 2008 Rubenstein J, Ferreri AJ, Pittaluga S
• Protein biomarker identification in the CSF of patients with CNS lymphoma.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007 Roy S, Josephson SA, Fridlyand J, Karch J, Kadoch C, Karrim J, Damon L, Treseler P, Kunwar S, Shuman MA, Jones T, Becker CH, Schulman H, Rubenstein JL
• Complement Activation and Resistance within the Cerebrospinal Fluid Following Intraventricular Administration of Anti-CD20 in the Treatment of Recurrent CNS Lymphoma.
  Blood 2007 Cigall Kadoch, Marc A. Shuman, James L. Rubenstein
• Treatment of Primary CNS Lymphoma with Induction High-Dose Methotrexate, Temozolomide, Rituximab Followed by Consolidation Cytarabine/Etoposide: A Pilot Study with Biomarker Analysis.
  Blood 2007 Samar Issa, Arthur Shen, Jon Karch, Cigall Kadoch, Marc Shuman, Lloyd Damon, James Rubenstein
• In Reply.
  Journal of Clinical Oncology 2007 James Rubenstein, Lauren Abrey, Ranjana Advani, Marc Shuman, Tony Tsai, Joan O'Brien
• Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007 Rubenstein JL, Fridlyand J, Abrey L, Shen A, Karch J, Wang E, Issa S, Damon L, Prados M, McDermott M, O'Brien J, Haqq C, Shuman M
• Molecular pathogenesis of primary central nervous system lymphoma.
  Neurosurgical focus 2006 Kadoch C, Treseler P, Rubenstein JL
• Identification of CSF Biomarkers for the Diagnosis of CNS Lymphoma.
  Blood 2006 James L. Rubenstein, Cigall Kadoch, Jon Karch, Andrew Josephson, Samar Issa, Chris Becker, Howard Schulman, Lloyd Damon, Marc A. Shuman, Sushmita Roy
• Treatment of primary CNS lymphoma with induction high-dose methotrexate, temozolomide, rituximab followed by consolidation cytarabine/etoposide: A pilot study with biomarker analysis.
  Journal of Clinical Oncology 2006 S. Issa, J. Hwang, J. Karch, J. Fridlyand, M. Prados, T. Batchelor, K. Aldape, C. Haqq, L. Damon, J. Rubenstein
• Gene expression and angiotropism in primary CNS lymphoma.
  Blood 2006 Rubenstein JL, Fridlyand J, Shen A, Aldape K, Ginzinger D, Batchelor T, Treseler P, Berger M, McDermott M, Prados M, Karch J, Okada C, Hyun W, Parikh S, Haqq C, Shuman M
• Surgically (laparotomy/laparoscopy) guided placement of high dose rate interstitial irradiation catheters (LG-HDRT): technique and outcome.
  Gynecologic oncology 2005 Orr JW, Dosoretz DD, Mahoney D, Roland PY, Kelly FJ, Blitzer P, Nakfoor B, Katin M, Rubenstein J, Boothby RR
• Pathology and genetics of primary central nervous system and intraocular lymphoma.
  Hematology/oncology clinics of North America 2005 Rubenstein JL, Treseler P, O'Brien JM
• Primary CNS lymphoma of T-cell origin: a descriptive analysis from the international primary CNS lymphoma collaborative group.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005 Shenkier TN, Blay JY, O'Neill BP, Poortmans P, Thiel E, Jahnke K, Abrey LE, Neuwelt E, Tsang R, Batchelor T, Harris N, Ferreri AJ, Ponzoni M, O'Brien P, Rubenstein J, Connors JM
• Primary Central Nervous System Lymphoma of T Cell Origin: A Descriptive Analysis of 45 Cases from the International PCNSL Collaborative Group.
  Blood 2004 Tamara Shenkier, Jean-Yves Blay, Brian P. O’Neill, Philip Poortmans, Kristoph Janke, Lauren E. Abrey, Edward Neuwelt, Richard Tsang, Tracy Batchelor, Nancy Harris, Andres J. Ferreri, Maurilio Ponzoni,…
• Results from a phase I study of intraventricular administration of rituximab in patients with recurrent lymphomatous meningitis.
  Journal of Clinical Oncology 2004 J. L. Rubenstein, A. Shen, L. Abrey, D. Combs, C. Haqq, L. Damon, J. O'Brien, P. O'Connor, M. Prados, M. Shuman
• Results from a phase I study of intraventricular administration of rituximab in patients with recurrent lymphomatous meningitis.
  Journal of Clinical Oncology 2004 J. L. Rubenstein, A. Shen, L. Abrey, D. Combs, C. Haqq, L. Damon, J. O'Brien, P. O'Connor, M. Prados, M. Shuman
• Brain Metastases from Genitourinary Cancer: Germ Cell, Testicular, Prostate and Bladder Cancer.
  Intracranial Metastases 2004 Philip V. Theodosopoulos, James L. Rubenstein, Michael W. McDermott
• Hemorrhage and VEGF expression in a case of primary CNS lymphoma.
  Journal of neuro-oncology 2002 Rubenstein J, Fischbein N, Aldape K, Burton E, Shuman M
• Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions.
  Science (New York, N.Y.) 2001 Marín O, Yaron A, Bagri A, Tessier-Lavigne M, Rubenstein JL
• Tbr1 regulates differentiation of the preplate and layer 6.
  Neuron 2001 Hevner RF, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, Bulfone A, Goffinet AM, Campagnoni AT, Rubenstein JL
• Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons.
  Neuron 2000 Pleasure SJ, Anderson S, Hevner R, Bagri A, Marin O, Lowenstein DH, Rubenstein JL
• Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption.
  Neoplasia (New York, N.Y.) 2000 Rubenstein JL, Kim J, Ozawa T, Zhang M, Westphal M, Deen DF, Shuman MA
• Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1.
  Development (Cambridge, England) 2000 Galceran J, Miyashita-Lin EM, Devaney E, Rubenstein JL, Grosschedl R
• Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
  Development (Cambridge, England) 1998 Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS