James Huang, MD
Professor
Pediatrics
School of Medicine

Education & Training

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• Pediatric Hematology/Oncology Fellowship Boston Children's Hospital and Dana Farber Cancer Institute 06/1997
• Pediatrics Residency Johns Hopkins Hospital 06/1994
• MD Medicine Baylor College of Medicine 05/1991
• AB Biochemical Sciences Harvard College 06/1986

Interests

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• hemostasis and thrombosis
• immune cytopenia
• bone marrow failure

Websites

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• Clinical Profile at UCSF Benioff Children's Hospital (ucsfbenioffchildrens.org)

Publications (30)

Top publication keywords:
Hemophilia ALipomatosisAnemia, AplasticBone Marrow DiseasesExocrine Pancreatic InsufficiencyThalassemiaAnemiaHemorrhageLigasesFactor VFactor V DeficiencyPolydeoxyribonucleotidesThrombotic MicroangiopathiesAntilymphocyte SerumUbiquitin-Protein Ligase Complexes

• A pilot trial of prophylactic defibrotide to prevent serious thrombotic microangiopathy in high-risk pediatric patients.
  Pediatric blood & cancer 2022 Higham CS, Shimano KA, Melton A, Kharbanda S, Chu J, Dara J, Winestone LE, Hermiston ML, Huang JN, Dvorak CC
• Diagnostic work-up for severe aplastic anemia in children: Consensus of the North American Pediatric Aplastic Anemia Consortium.
  American journal of hematology 2021 Shimano KA, Narla A, Rose MJ, Gloude NJ, Allen SW, Bergstrom K, Broglie L, Carella BA, Castillo P, de Jong JLO, Dror Y, Geddis AE, Huang JN, Lau BW, McGuinn C, Nakano TA, Overholt K, Rothman JA, …
• Plasma-derived factor X concentrate compassionate use for hereditary factor X deficiency: Long-term safety and efficacy in a retrospective data-collection study.
  Research and practice in thrombosis and haemostasis 2021 Huang JN, Liesner R, Austin SK, Kavakli K, Akanezi C
• Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome.
  Nature communications 2021 Kennedy AL, Myers KC, Bowman J, Gibson CJ, Camarda ND, Furutani E, Muscato GM, Klein RH, Ballotti K, Liu S, Harris CE, Galvin A, Malsch M, Dale D, Gansner JM, Nakano TA, Bertuch A, Vlachos A, Lipton …
• A study assessing the feasibility of randomization of pediatric and young adult patients between matched unrelated donor bone marrow transplantation and immune-suppressive therapy for newly diagnosed severe aplastic anemia: A joint pilot trial of the North American Pediatric Aplastic Anemia Consortium and the Pediatric Transplantation and Cellular Therapy Consortium.
  Pediatric blood & cancer 2020 Pulsipher MA, Lehmann LE, Bertuch AA, Sasa G, Olson T, Nakano T, Gilio A, Burroughs LM, Lipton JM, Huang JN, Dickerson K, Bertaina A, Zhuang C, Malsch M, Fleming M, Weller E, Shimamura A, Williams DA

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• Immunosuppressive therapy for pediatric aplastic anemia: a North American Pediatric Aplastic Anemia Consortium study.
  Haematologica 2019 Rogers ZR, Nakano TA, Olson TS, Bertuch AA, Wang W, Gillio A, Coates TD, Chawla A, Castillo P, Kurre P, Gamper C, Bennett CM, Joshi S, Geddis AE, Boklan J, Nalepa G, Rothman JA, Huang JN, Kupfer GM, …
• Low Exposure Busulfan Conditioning to Achieve Sufficient Multilineage Chimerism in Patients with Severe Combined Immunodeficiency.
  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2019 Dvorak CC, Long-Boyle J, Dara J, Melton A, Shimano KA, Huang JN, Puck JM, Dorsey MJ, Facchino J, Chang CK, Cowan MJ
• Investigation of Pediatric Anemia in the Commonwealth of the Northern Mariana Islands.
  Maternal and child health journal 2019 Lin TF, Huang JN, Cash HL
• Understanding the evolving phenotype of vascular complications in telomere biology disorders.
  Angiogenesis 2018 Higgs C, Crow YJ, Adams DM, Chang E, Hayes D, Herbig U, Huang JN, Himes R, Jajoo K, Johnson FB, Reynolds SD, Yonekawa Y, Armanios M, Boulad F, DiNardo CD, Dufour C, Goldman FD, Khan S, Kratz C, Myers …
• Comprehensive Review of Preschool Age Anemia in the Pacific Island Jurisdictions.
  Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health 2017 Lin TF, Huang JN, Cash HL
• Capacity Building for Rare Bleeding Disorders in the Remote Commonwealth of the Northern Mariana Islands.
  American journal of public health 2016 Lin TF, Carhill P, Huang JN, Baker JR
• Elevated tricuspid regurgitant jet velocity in subgroups of thalassemia patients: insight into pathophysiology and the effect of splenectomy.
  Annals of hematology 2014 Singer ST, Kuypers F, Fineman J, Gildengorin G, Larkin S, Sweeters N, Rosenfeld H, Kurio G, Higa A, Jeng M, Huang J, Vichinsky EP
• Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): an initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC).
  Pediatric blood & cancer 2013 Williams DA, Bennett C, Bertuch A, Bessler M, Coates T, Corey S, Dror Y, Huang J, Lipton J, Olson TS, Reiss UM, Rogers ZR, Sieff C, Vlachos A, Walkovich K, Wang W, Shimamura A
• Zinc supplementation improves bone density in patients with thalassemia: a double-blind, randomized, placebo-controlled trial.
  The American journal of clinical nutrition 2013 Fung EB, Kwiatkowski JL, Huang JN, Gildengorin G, King JC, Vichinsky EP
• Re: 24-year-old man with previously diagnosed hemophilia.
  Clinical chemistry 2012 Huang JN
• In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology.
  The Journal of clinical investigation 2011 Tsai M, Kita A, Leach J, Rounsevell R, Huang JN, Moake J, Ware RE, Fletcher DA, Lam WA
• Microenvironmental geometry guides platelet adhesion and spreading: a quantitative analysis at the single cell level.
  PloS one 2011 Kita A, Sakurai Y, Myers DR, Rounsevell R, Huang JN, Seok TJ, Yu K, Wu MC, Fletcher DA, Lam WA
• Functions of the mitotic B-type cyclins CLB1, CLB2, and CLB3 at mitotic exit antagonized by the CDC14 phosphatase.
  Fungal genetics and biology : FG & B 2011 Tzeng YW, Huang JN, Schuyler SC, Wu CH, Juang YL
• Pseudotumor of the mandible as first presentation of hemophilia in a 2-year-old male: a case report and review of jaw pseudotumors of hemophilia.
  Head and neck pathology 2011 Cox DP, Solar A, Huang J, Chigurupati R
• Characterization of low bone mass in young patients with thalassemia by DXA, pQCT and markers of bone turnover.
  Bone 2011 Fung EB, Vichinsky EP, Kwiatkowski JL, Huang J, Bachrach LK, Sawyer AJ, Zemel BS
• Clinical spectrum and molecular pathophysiology of Shwachman-Diamond syndrome.
  Current opinion in hematology 2011 Huang JN, Shimamura A
• Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.
  Stroke 2010 Morgenstern LB, Hemphill JC, Anderson C, Becker K, Broderick JP, Connolly ES, Greenberg SM, Huang JN, MacDonald RL, Messé SR, Mitchell PH, Selim M, Tamargo RJ, American Heart Association Stroke …
• Factor V deficiency: a concise review.
  Haemophilia : the official journal of the World Federation of Hemophilia 2008 Huang JN, Koerper MA
• Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p.
  The Journal of cell biology 2001 Huang JN, Park I, Ellingson E, Littlepage LE, Pellman D
• Low-molecular-weight heparins.
  Hematology/oncology clinics of North America 1998 Huang JN, Shimamura A
• Selection and analysis of rare second-site suppressors of Drosophila RNA polymerase II mutations.
  Molecular & general genetics : MGG 1998 Krasnoselskaya I, Huang J, Jones T, Dezan C, Mortin MA
• APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle.
  Science (New York, N.Y.) 1997 Juang YL, Huang J, Peters JM, McLaughlin ME, Tai CY, Pellman D
• Surface hydrophobicity and water transport of the toad urinary bladder: effects of vasopressin.
  The Journal of membrane biology 1988 Dial EJ, Huang J, O'Neil RG, Hills BA, Lichtenberger LM
• Antagonistic interactions between alleles of the RpII215 locus in Drosophila melanogaster.
  Genetics 1988 Mortin MA, Kim WJ, Huang J
• Monoamine oxidase: an important intracellular regulator of gastrin release in the rat.
  Gastroenterology 1986 Dial EJ, Huang J, Delansorne R, Lichtenberger LM