James Frank, MD
Professor
Medicine
School of Medicine

He also directs the medical student critical care immersion experience and ICU acting internship at the site. Dr. Frank is the program director for the UCSF Pulmonary and Critical Care Fellowship Program, and is the president of the Association for Pulmonary and Critical Care Medicine Program Directors (APCCMPD), which represents 95% of pulmonary and critical care fellowship training programs in the US. His clinical work includes critical care medicine, co-leading the pulmonary embolism response team, thoracentesis service and neuromuscular/amyotrophic lateral sclerosis respiratory clinic at the SFVA. His current academic interests include education leadership, teaching quality improvement and communication skills, professional coaching, and curriculum development and implementation.

• A single center evaluation of applicant experiences in virtual interviews across eight internal medicine subspecialty fellowship programs.
  Medical education online 2021 Huppert LA, Hsu G, Elnachef N, Flint L, Frank JA, Gensler LS, Hsiao EC, Khanna RR, Qasim A, Schwartz BS, Widera E, Zapata C, Babik JM
• Virtual Interviews at Graduate Medical Education Training Programs: Determining Evidence-Based Best Practices.
  Academic medicine : journal of the Association of American Medical Colleges 2020 Huppert LA, Hsiao EC, Cho KC, Marquez C, Chaudhry RI, Frank J, Goglin SE, Hsu G, Kathpalia P, Khanna R, Kompala T, Rao MN, Bower BA, Trafas V, Santhosh L, Schwartz BS, Babik JM
• When to rule out COVID-19: How many negative RT-PCR tests are needed?
  Respiratory medicine case reports 2020 Isikbay M, Henry TS, Frank JA, Hope MD
• Marijuana Use, Respiratory Symptoms, and Pulmonary Function: A Systematic Review and Meta-analysis.
  Annals of internal medicine 2018 Ghasemiesfe M, Ravi D, Vali M, Korenstein D, Arjomandi M, Frank J, Austin PC, Keyhani S
• Imaging of Acute Lung Injury.
  Radiologic clinics of North America 2016 Elicker BM, Jones KT, Naeger DM, Frank JA
• Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma.
  The Journal of allergy and clinical immunology 2016 Sweerus K, Lachowicz-Scroggins M, Gordon E, LaFemina M, Huang X, Parikh M, Kanegai C, Fahy JV, Frank JA
• Pulmonary epithelial barrier function: some new players and mechanisms.
  American journal of physiology. Lung cellular and molecular physiology 2015 Brune K, Frank J, Schwingshackl A, Finigan J, Sidhaye VK
• Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice.
  American journal of respiratory cell and molecular biology 2014 LaFemina MJ, Sutherland KM, Bentley T, Gonzales LW, Allen L, Chapin CJ, Rokkam D, Sweerus KA, Dobbs LG, Ballard PL, Frank JA
• Double impact of cigarette smoke and mechanical ventilation on the alveolar epithelial type II cell.
  Critical care (London, England) 2014 Hirsch J, Chalkley RJ, Bentley T, Burlingame AL, Frank JA
• TGF-β and lung fluid balance in ARDS.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Frank JA, Matthay MA
• Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteins.
  The American journal of pathology 2013 Yang J, Wheeler SE, Velikoff M, Kleaveland KR, LaFemina MJ, Frank JA, Chapman HA, Christensen PJ, Kim KK
• Claudin-4 promotes epithelial repair and restoration of barrier function via interactions with the small GTPase Rap1.
  The FASEB Journal 2013 Katherine Sutherland, Trevor Bentley, Michael LaFemina, James Frank
• Claudins and alveolar epithelial barrier function in the lung.
  Annals of the New York Academy of Sciences 2012 Frank JA
• Claudin-4 interacts with the small GTPase Rap1 and accelerates epithelial repair.
  The FASEB Journal 2012 Katherine Marie Sutherland, Trevor Bentley, Michael LaFemina, Gwen Ho, Jan Hirsch, James Frank
• Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs.
  The American journal of pathology 2011 Rokkam D, Lafemina MJ, Lee JW, Matthay MA, Frank JA
• Claudin-4 promotes repair and barrier function in lung epithelia.
  The FASEB Journal 2011 Deepti Rokkam, Jan Hirsch, Gwen Ho, Chris Griffin, Michael J LaFemina, James A Frank
• Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells.
  American journal of physiology. Lung cellular and molecular physiology 2010 LaFemina MJ, Rokkam D, Chandrasena A, Pan J, Bajaj A, Johnson M, Frank JA
• Claudin-4 is required for EGFR-mediated alveolar epithelial migration.
  The FASEB Journal 2010 Deepti Rokkam, Gwendolyn Ho, James A. Frank
• Neutrophil-derived IL-6 limits alveolar barrier disruption in experimental ventilator-induced lung injury.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Wolters PJ, Wray C, Sutherland RE, Kim SS, Koff J, Mao Y, Frank JA
• Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2009 Wray C, Mao Y, Pan J, Chandrasena A, Piasta F, Frank JA
• Allogeneic human mesenchymal stem cells for treatment of E. Coli endotoxin-induced acute lung injury in an ex vivo perfused human lung.
  The FASEB Journal 2009 Jae Woo Lee, Naveen Gupta, Xiaohui Fang, James A. Frank, Raphael Briot, Michael A. Matthay
• The Balance Evaluation Systems Test (BESTest) to differentiate balance deficits.
  Physical therapy 2009 Horak FB, Wrisley DM, Frank J
• Surrogate decision makers' responses to physicians' predictions of medical futility.
  Chest 2009 Zier LS, Burack JH, Micco G, Chipman AK, Frank JA, White DB
• Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis.
  The Journal of clinical investigation 2008 Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA
• Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs.
  Chest 2008 Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA
• Doubt and belief in physicians' ability to prognosticate during critical illness: the perspective of surrogate decision makers.
  Critical care medicine 2008 Zier LS, Burack JH, Micco G, Chipman AK, Frank JA, Luce JM, White DB
• Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion.
  Critical care medicine 2008 Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA
• Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.
  Circulation research 2008 Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF
• Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade.
  Thorax 2007 Frank JA, Pittet JF, Wray C, Matthay MA
• Progress toward a systems biology approach to acute lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2007 Frank JA, Erle DJ
• Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome.
  American journal of respiratory and critical care medicine 2007 Hirsch J, Hansen KC, Sapru A, Frank JA, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay MA
• Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs.
  American journal of physiology. Lung cellular and molecular physiology 2007 Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA
• Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies.
  Chest 2006 Frank JA, Parsons PE, Matthay MA
• Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function.
  American journal of respiratory cell and molecular biology 2006 Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF
• Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2006 Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay MA
• Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Godzich M, Hodnett M, Frank JA, Su G, Pespeni M, Angel A, Howard MB, Matthay MA, Pittet JF
• Leukotrienes in acute lung injury: a potential therapeutic target?
  American journal of respiratory and critical care medicine 2005 Frank JA, Matthay MA
• Effect of pharmacological inhibition of chloride transport on lung fluid balance in acute Escherichia coli pneumonia in mice.
  Critical Care 2005 L Robriquet, Y Song, H Folkesson, J Frank, A Verkman, M Matthay
• Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury.
  Critical care medicine 2005 Frank JA, McAuley DF, Gutierrez JA, Daniel BM, Dobbs L, Matthay MA
• Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury.
  Critical care medicine 2004 McAuley DF, Frank JA, Fang X, Matthay MA
• Altered proteomic patterns in rat alveolar epithelial type II cells after ventilation with high and low tidal volumes.
  Critical Care 2004 J Hirsch, K Hansen, J Frank, R Chalkley, X Fang, A Burlingame, M Matthay
• Clinically relevant concentrations of beta agonists may stimulate alveolar fluid clearance in acute respiratory distress syndrome.
  Critical Care 2004 G Perkins, D McAuley, J Frank, D Thickett, X Fang, M Matthay
• Effect of sustained inflation recruitment maneuvers on lung endothelial and alveolar epithelial injury in experimental acute lung injury.
  Critical Care 2004 J Frank, D McAuley, J Gutierrez, B Daniel, L Dobbs, M Matthay
• Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism.
  The Journal of biological chemistry 2003 Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF
• High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance.
  American journal of physiology. Lung cellular and molecular physiology 2003 Frank JA, Pittet JF, Lee H, Godzich M, Matthay MA
• Science review: mechanisms of ventilator-induced injury.
  Critical care (London, England) 2002 Frank JA, Matthay MA
• Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs.
  American journal of respiratory and critical care medicine 2002 Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA
• Pulmonary Epithelial Injury: Clinical and Experimental Evidence for a Major Role in Acute Lung Injury and Multiple Organ Dysfunction.
  Mechanisms of Organ Dysfunction in Critical Illness 2002 M. A. Matthay, L. B. Ware, J. A. Frank
• Beta-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats.
  Journal of applied physiology (Bethesda, Md. : 1985) 2000 Frank JA, Wang Y, Osorio O, Matthay MA
• Alveolar epithelial barrier. Role in lung fluid balance in clinical lung injury.
  Clinics in chest medicine 2000 Matthay MA, Fukuda N, Frank J, Kallet R, Daniel B, Sakuma T
• Diabetes mellitus: a negative predictor for the development of acute respiratory distress syndrome from septic shock.
  Critical care medicine 2000 Frank JA, Nuckton TJ, Matthay MA
• Obstructive pulmonary disease. The clinician's perspective.
  Radiologic clinics of North America 1998 Stulbarg MS, Frank JA