James Bayrer, MD, PhD
Associate Professor
Pediatrics
School of Medicine
As a pediatric gastroenterologist and physician scientist, I am keenly aware of the challenges faced by our pediatric population. The intestinal epithelium comprises the human body’s greatest environmentally exposed surface and is the largest sensory and endocrine organ.
Show full bio (49 words) Hide full bio
My research utilizes human intestinal organoids and animal models to understand how the intestine senses and responds to both regular and inflammatory stimuli. By investigating the molecular pathways involved, we aim to discover new ways to promote intestinal wound healing and modulate the signals contributing to visceral pain syndromes.
Awards
Show all (13) Hide
- Best of DDW, ACG-CCFA IBD Circle Spotlight, 2015
- Poster of Distinction, American Gastroenterological Association, DDW, 2015
- Poster Award, Kenneth Rainin Foundation Innovations Symposium, 2015
- Young Faculty Investigator Research Award, NASPGHAN, 2015
- Poster of Distinction, American Gastroenterological Association, DDW, 2014
- Teaching and Tomorrow Travel Award, NASPGHAN, 2008
- Outstanding Poster Presentation Award, Lepow Research Day, CWRU, 2005
- Sigma Xi Award for Poster Presentation, ShowCase, CWRU, 2004
- President's Award for Outstanding Poster Presentation, Graduate Student Symposium, CWRU, 2003
- Honors in Chemistry, Claremont McKenna College, 1998
- Honors in Literature, Claremont McKenna College, 1998
- Magna cum Laude, Claremont McKenna College, 1998
- Top Thesis in the Sciences, Joint Science Program, Claremont McKenna College, 1998
Education & Training
Show all (2) Hide
- M.D. School of Medicine Case Western Reserve University 2007
- Ph.D. Pharmacology Case Western Reserve University 2005
Websites
Show all (2) Hide
- Profile at msg.ucsf.edu (msg.ucsf.edu)
- Bayrer Lab Website (bayrerlab.ucsf.edu)
Grants and Projects
Show all (5) Hide
- Decoding LRH-1 Activity in Gut Regeneration and Differentiation, NIH, 2021-2026
- Uncovering the role of LRH-1 in enteroendocrine cell development and ?gut-brain? communication, NIH, 2019-2021
- Targeting Intestinal Epithelium to Promote Healing in Inflammatory Bowel Disease, NIH, 2016-2019
- Creating a Pediatric Inflammatory Bowel Disease Intestinal Organoid Biorepository for Personalized Therapeutic Discovery, RAP Pilot Award for Junior Investigators, 2016-2017
- LRH-1: Structure-based Approach to Drug Design for Gastrointestinal Tumors, NIH, 2012-2015
Publications (17)
Top publication keywords:
EpitheliumEnterochromaffin CellsBiomedical ResearchHomeostasisInflammatory Bowel DiseasesDrosophila ProteinsVisceral PainGene SilencingColonic NeoplasmsOrganoidsReceptors, Cytoplasmic and NuclearDigestive SystemIntestinal DiseasesAnxietyColitis
-
Advances in Enteric Neurobiology: The "Brain" in the Gut in Health and Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Kulkarni S, Ganz J, Bayrer J, Becker L, Bogunovic M, Rao M -
LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.
Nature communications 2018 Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA -
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways.
Cell 2017 Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O'Donnell TA, Brierley SM, Ingraham HA, Julius D -
Gut enterochromaffin cells drive visceral pain and anxiety.
Nature 2023 Bayrer JR, Castro J, Venkataraman A, Touhara KK, Rossen ND, Morrie RD, Maddern J, Hendry A, Braverman KN, Garcia-Caraballo S, Schober G, Brizuela M, Castro Navarro FM, Bueno-Silva C, Ingraham HA, … -
A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance.
Proceedings of the National Academy of Sciences of the United States of America 2020 Man K, Bowman C, Braverman KN, Escalante V, Tian Y, Bisanz JE, Ganeshan K, Wang B, Patterson A, Bayrer JR, Turnbaugh PJ, Chawla A
Show all (12 more) Hide
-
SPARC - Mapping Gut-Spinal Cord Connections in Visceral Pain.
The FASEB Journal 2020 Ryan David Morrie, James Bayrer, Stuart Brierley, Holly Ingraham, David Julius -
Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.
2019 Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA -
948 – Nuclear Receptor Liver Receptor Homolog-1 Promotes Intestinal Notch Signaling and Enteroendocrine Cell Development.
Gastroenterology 2019 Pervinder K. Choksi, Holly A. Ingraham, James Bayrer -
Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.
Nature communications 2019 Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA -
273 - Nuclear Receptor LRH-1 Mitigates Intestinal Inflammatory Disease by Promoting Stem Cell Survival and Directing Normal Epithelial Composition.
Gastroenterology 2018 James Bayrer, Hazel Escusa, Ophir D. Kein, Holly Ingraham -
Intestinal Organoids: New Frontiers in the Study of Intestinal Disease and Physiology.
Journal of pediatric gastroenterology and nutrition 2017 Wallach TE, Bayrer JR -
Tu1824 Targeting Intestinal Stem Cells to Promote Healing in Inflammatory Bowel Disease.
Gastroenterology 2015 James R. Bayrer, Robert Fletterick, Holly Ingraham -
Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs.
Proceedings of the National Academy of Sciences of the United States of America 2015 Bayrer JR, Mukkamala S, Sablin EP, Webb P, Fletterick RJ -
Sa1803 Dissecting the Oncogenic Activity of the Nuclear Receptor LRH-1 in the Colon.
Gastroenterology 2014 James R. Bayrer, Sridevi Mukkamala, Elena Sablin, Robert Fletterick -
Doublesex and the regulation of sexual dimorphism in Drosophila melanogaster: structure, function, and mutagenesis of a female-specific domain.
The Journal of biological chemistry 2008 Yang Y, Zhang W, Bayrer JR, Weiss MA -
Dimerization of doublesex is mediated by a cryptic ubiquitin-associated domain fold: implications for sex-specific gene regulation.
The Journal of biological chemistry 2005 Bayrer JR, Zhang W, Weiss MA -
Expression, crystallization and preliminary X-ray characterization of the Drosophila transcription factor Doublesex.
Acta crystallographica. Section D, Biological crystallography 2004 Bayrer J, Wan Z, Li B, Weiss MA