James Allison, MD
Professor Emeritus
Medicine
School of Medicine
james.allison@ucsf.edu 510-891-3250
Dr. Allison received a BA with honors from the University of Pennsylvania, and, in 1969, his MD from the University of Rochester. His entire post graduate training was at the University of California Los Angeles (UCLA) and the University of California San Francisco (UCSF). He began his medical career at Kaiser San Rafael in 1974 where he was that groups’ first gastroenterologist.
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In 1977 he transferred to Kaiser Oakland Medical Center where he was a full-time gastroenterologist and educator (Assistant Program Director – Internal Medicine) and where he devoted the majority of his time to patient care, administration, clinical research and teaching. In 1996 he received the Lowell Beal MD Award “in appreciation of his example of academic excellence combined with warm humanity.” He retired as a clinician from Kaiser in 1998.
After his retirement from Kaiser, Dr. Allison was invited to be a member of the University of California San Francisco (UCSF) faculty and an Emeritus Investigator at Kaiser Permanente’s Division of Research.
He is Clinical Professor of Medicine Emeritus at UCSF and is a member of the Division of Gastroenterology at UCSF and the San Francisco General Hospital. In 2003, he received the Bay Area Chapter of the Crohn’s and Colitis Foundation’s Premier Physician Award, and in 2004, the American Gastroenterological Association‘s (AGA) Distinguished Clinician Award. He is a fellow of the American College of Physicians and of the American Gastroenterological Association.
Dr. Allison is a national and international expert on screening tests for colon cancer. In a publication in The New England Journal of Medicine in 1996, he was the first person in the U.S. to show that the fecal immunochemical test (FIT) was superior to the standard guaiac fecal occult blood test for screening for colorectal cancer. Since 2000 Dr. Allison has been an ad hoc consultant to the Centers for Disease Control, National Cancer Institute and the Agency for Healthcare Research and Quality (AHRQ) on issues concerned with screening for colorectal cancer. Currently he is working with the California Colorectal Cancer Coalition (C4), California and San Francisco Departments of Public Health to increase screening rates in the uninsured/underserved population by instituting a FIT based screening program in clinics served by safety net hospitals. The screening model this group has developed is being exported to other parts of the San Francisco Bay Area and state of California and has support from both the CDC and the American Gastroenterological Association.
In addition to expertise in colorectal cancer screening tests, Dr. Allison has been a dedicated researcher in inflammatory bowel disease (IBD). In 2005 he helped establish an Inflammatory Bowel Disease (Crohn’s Disease and Ulcerative Colitis) registry of over 25000 patients at Kaiser’s Division of Research. In the past 7 years, close to 20 peer reviewed publications have been published from information contained in the registry.
Dr. Allison’s screening and IBD research has been published in the Annals of Internal Medicine, The New England Journal of Medicine, Gastroenterology, Clinical Gastroenterology and Hepatology, the Journal of the National Cancer Institute and other peer reviewed journals. He has been quoted in Prevention Magazine, the Ladies’ Home Journal, the Wall Street Journal, the San Francisco Chronicle and the New York Times.
Awards
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- 2017 Achievement Award, American Cancer Society, 2017
- Distinguished Clinician Award, American Gastroenterological Association (AGA), 2004
- Crohn’s and Colitis Foundation’s Premier Physician Award, Bay Area Chapter Crohn's and Colitis Foundation, 2003
- Lowell Beal MD Award, Kaiser Oakland Medical Center, 1996
Education & Training
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- PGY 3 and Fellowship in Gastroenterology Internal Medicine/Gastroenterology UCSF 06/1974
- PGY 1&2 Internal Medicine UCLA 05/1971
- MD Medicine University of Rochester 05/1969
- AB French University of Pennsylvania 05/1964
Publications (55)
Top publication keywords:
FecesHemoglobin SubunitsOccult BloodAdenomatous PolypsColorectal NeoplasmsColonoscopyGuaiacInflammatory Bowel DiseasesAdenomaMercaptopurineColitis, UlcerativeMass ScreeningEarly Detection of CancerImmunochemistryHemoglobins
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An efficient strategy for evaluating new non-invasive screening tests for colorectal cancer: the guiding principles.
Gut 2023 Bresalier RS, Senore C, Young GP, Allison J, Benamouzig R, Benton S, Bossuyt PMM, Caro L, Carvalho B, Chiu HM, Coupé VMH, de Klaver W, de Klerk CM, Dekker E, Dolwani S, Fraser CG, Grady W, Guittet L, … -
A phase 2 study of nivolumab combined with ibrutinib in patients with diffuse large B-cell Richter transformation of CLL.
Blood advances 2023 Jain N, Senapati J, Thakral B, Ferrajoli A, Thompson P, Burger J, Basu S, Kadia T, Daver N, Borthakur G, Konopleva M, Pemmaraju N, Parry E, Wu CJ, Khoury J, Bueso-Ramos C, Garg N, Wang X, Lopez W, … -
Rising Use of Multitarget Stool DNA Testing for Colorectal Cancer.
JAMA network open 2021 Hoffman RM, Levy BT, Allison JE -
Why What You May Not Know About Fecal Immunochemical Testing Matters.
Annals of internal medicine 2019 Allison J -
Why What You May Not Know About Fecal Immunochemical Testing Matters.
Annals of internal medicine 2019 Allison J
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Publisher Correction: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.
Nature medicine 2018 Amaria RN, Reddy SM, Tawbi HA, Davies MA, Ross MI, Glitza IC, Cormier JN, Lewis C, Hwu WJ, Hanna E, Diab A, Wong MK, Royal R, Gross N, Weber R, Lai SY, Ehlers R, Blando J, Milton DR, Woodman S, … -
Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.
Nature medicine 2018 Amaria RN, Reddy SM, Tawbi HA, Davies MA, Ross MI, Glitza IC, Cormier JN, Lewis C, Hwu WJ, Hanna E, Diab A, Wong MK, Royal R, Gross N, Weber R, Lai SY, Ehlers R, Blando J, Milton DR, Woodman S, … -
Potential Intended and Unintended Consequences of Recommending Initiation of Colorectal Cancer Screening at Age 45 Years.
Gastroenterology 2018 Liang PS, Allison J, Ladabaum U, Martinez ME, Murphy CC, Schoen RE, Shaukat A, Tinmouth J, Gupta S -
Yield of Colonoscopy After a Positive Result From a Fecal Immunochemical Test OC-Light.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2018 Alsayid M, Singh MH, Issaka R, Laleau V, Day L, Lee J, Allison J, Somsouk M -
Colonoscopy vs. Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM): Rationale for Study Design.
The American journal of gastroenterology 2017 Dominitz JA, Robertson DJ, Ahnen DJ, Allison JE, Antonelli M, Boardman KD, Ciarleglio M, Del Curto BJ, Huang GD, Imperiale TF, Larson MF, Lieberman D, O'Connor T, O'Leary TJ, Peduzzi P, Provenzale D, … -
Replacing the Guaiac Fecal Occult Blood Test With the Fecal Immunochemical Test Increases Proportion of Individuals Screened in a Large Healthcare Setting.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2017 Akram A, Juang D, Bustamante R, Liu L, Earles A, Ho SB, Wang-Rodriguez J, Allison JE, Gupta S -
Recommendations for a step-wise comparative approach to the evaluation of new screening tests for colorectal cancer.
Cancer 2016 Young GP, Senore C, Mandel JS, Allison JE, Atkin WS, Benamouzig R, Bossuyt PM, Silva MD, Guittet L, Halloran SP, Haug U, Hoff G, Itzkowitz SH, Leja M, Levin B, Meijer GA, O'Morain CA, Parry S, … -
Faecal immunochemical tests versus guaiac faecal occult blood tests: what clinicians and colorectal cancer screening programme organisers need to know.
Gut 2015 Tinmouth J, Lansdorp-Vogelaar I, Allison JE -
Improving the reporting of evaluations of faecal immunochemical tests for haemoglobin: the FITTER standard and checklist.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2015 Fraser CG, Allison JE, Young GP, Halloran SP, Seaman HE -
Advances in Fecal Occult Blood Tests: the FIT revolution.
Digestive diseases and sciences 2014 Young GP, Symonds EL, Allison JE, Cole SR, Fraser CG, Halloran SP, Kuipers EJ, Seaman HE -
Navigating the murky waters of colorectal cancer screening and health reform.
American journal of public health 2014 Green BB, Coronado GD, Devoe JE, Allison J -
Challenges and possible solutions to colorectal cancer screening for the underserved.
Journal of the National Cancer Institute 2014 Gupta S, Sussman DA, Doubeni CA, Anderson DS, Day L, Deshpande AR, Elmunzer BJ, Laiyemo AO, Mendez J, Somsouk M, Allison J, Bhuket T, Geng Z, Green BB, Itzkowitz SH, Martinez ME -
Population screening for colorectal cancer means getting FIT: the past, present, and future of colorectal cancer screening using the fecal immunochemical test for hemoglobin (FIT).
Gut and liver 2014 Allison JE, Fraser CG, Halloran SP, Young GP -
A standard for Faecal Immunochemical TesTs for haemoglobin evaluation reporting (FITTER).
Annals of clinical biochemistry 2013 Fraser CG, Allison JE, Young GP, Halloran SP, Seaman H -
FIT testing: an overview.
Current gastroenterology reports 2013 Day LW, Bhuket T, Allison J -
Making colorectal cancer screening FITTER for purpose with quantitative faecal immunochemical tests for haemoglobin (FIT).
Clinical chemistry and laboratory medicine 2013 Fraser CG, Halloran SP, Allison JE, Young GP -
Racial and ethnic differences in health care utilization and outcomes among ulcerative colitis patients in an integrated health-care organization.
Digestive diseases and sciences 2013 Li D, Collins B, Velayos FS, Liu L, Lewis JD, Allison JE, Flowers NT, Hutfless S, Abramson O, Herrinton LJ -
Quantitation of hemoglobin improves fecal immunochemical tests for noninvasive screening.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2013 Fraser CG, Allison JE, Young GP, Halloran SP -
Measurement of colorectal cancer test use with medical claims data in a safety-net health system.
The American journal of the medical sciences 2013 Gupta S, Tong L, Anderson P, Rose B, Carter E, Koch M, Argenbright K, Ahn C, Allison J, Skinner CS -
Colorectal-cancer screening.
The New England journal of medicine 2012 Allison JE -
Incidence and mortality of colorectal adenocarcinoma in persons with inflammatory bowel disease from 1998 to 2010.
Gastroenterology 2012 Herrinton LJ, Liu L, Levin TR, Allison JE, Lewis JD, Velayos F -
A proposal to standardize reporting units for fecal immunochemical tests for hemoglobin.
Journal of the National Cancer Institute 2012 Fraser CG, Allison JE, Halloran SP, Young GP, Expert Working Group on Fecal Immunochemical Tests for Hemoglobin, Colorectal Cancer Screening Commi -
Newer fecal tests: opportunities for professionals in laboratory medicine.
Clinical chemistry 2012 Fraser CG, Allison JE, Young GP, Halloran SP -
Comparing fecal immunochemical tests: improved standardization is needed.
Gastroenterology 2012 Allison JE, Fraser CG, Halloran SP, Young GP -
Role of thiopurine and anti-TNF therapy in lymphoma in inflammatory bowel disease.
The American journal of gastroenterology 2011 Herrinton LJ, Liu L, Weng X, Lewis JD, Hutfless S, Allison JE -
ACP Journal Club. Fecal immunochemical tests had better sensitivity for detecting colorectal neoplasia in aspirin users than in nonusers.
Annals of internal medicine 2011 Allison JE, Fraser CG -
FIT: a valuable but underutilized screening test for colorectal cancer-it's time for a change.
The American journal of gastroenterology 2010 Allison JE -
Prevalence of colorectal cancer surveillance for ulcerative colitis in an integrated health care delivery system.
Gastroenterology 2010 Velayos FS, Liu L, Lewis JD, Allison JE, Flowers N, Hutfless S, Abramson O, Perry GS, Herrinton LJ -
Incidence, prevalence, and time trends of pediatric inflammatory bowel disease in Northern California, 1996 to 2006.
The Journal of pediatrics 2010 Abramson O, Durant M, Mow W, Finley A, Kodali P, Wong A, Tavares V, McCroskey E, Liu L, Lewis JD, Allison JE, Flowers N, Hutfless S, Velayos FS, Perry GS, Cannon R, Herrinton LJ -
Colorectal cancer screening guidelines: the importance of evidence and transparency.
Gastroenterology 2010 Allison JE -
The best screening test for colorectal cancer is the one that gets done well.
Gastrointestinal endoscopy 2010 Allison JE -
Validity of computerized diagnoses, procedures, and drugs for inflammatory bowel disease in a northern California managed care organization.
Pharmacoepidemiology and drug safety 2009 Liu L, Allison JE, Herrinton LJ -
New screening guidelines for colorectal cancer: a practical guide for the primary care physician.
Primary care 2009 Allison JE, Potter MB -
Screening for colorectal cancer in a safety-net health care system: access to care is critical and has implications for screening policy.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009 Gupta S, Tong L, Allison JE, Carter E, Koch M, Rockey DC, Anderson P, Ahn C, Argenbright K, Skinner CS -
The imperative of equal funding for studies that evaluate any of the evidence-based, guideline-recommended colorectal cancer screening tests.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2009 Allison JE -
Time trends in therapies and outcomes for adult inflammatory bowel disease, Northern California, 1998-2005.
Gastroenterology 2009 Herrinton LJ, Liu L, Fireman B, Lewis JD, Allison JE, Flowers N, Hutfless S, Velayos FS, Abramson O, Altschuler A, Perry GS -
Stool DNA and occult blood testing for screen detection of colorectal neoplasia.
Annals of internal medicine 2008 Ahlquist DA, Sargent DJ, Loprinzi CL, Levin TR, Rex DK, Ahnen DJ, Knigge K, Lance MP, Burgart LJ, Hamilton SR, Allison JE, Lawson MJ, Devens ME, Harrington JJ, Hillman SL -
Natural history of severe ulcerative colitis in a community-based health plan.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2008 Allison J, Herrinton LJ, Liu L, Yu J, Lowder J -
Patterns of infliximab use among Crohn's disease patients in a community setting.
Inflammatory bowel diseases 2008 Pressman AR, Hutfless S, Velayos F, Fireman B, Lewis JD, Allison J, Abramson O, Herrinton LJ -
Incidence and prevalence of inflammatory bowel disease in a Northern California managed care organization, 1996-2002.
The American journal of gastroenterology 2008 Herrinton LJ, Liu L, Lewis JD, Griffin PM, Allison J -
Gastroenterologists' attitudes and self-reported practices regarding inflammatory bowel disease.
Inflammatory bowel diseases 2008 Altschuler A, Collins B, Lewis JD, Velayos F, Allison JE, Hutfless S, Liu L, Herrinton LJ -
Mortality by medication use among patients with inflammatory bowel disease, 1996-2003.
Gastroenterology 2007 Hutfless SM, Weng X, Liu L, Allison J, Herrinton LJ -
Screening for colorectal neoplasms with new fecal occult blood tests: update on performance characteristics.
Journal of the National Cancer Institute 2007 Allison JE, Sakoda LC, Levin TR, Tucker JP, Tekawa IS, Cuff T, Pauly MP, Shlager L, Palitz AM, Zhao WK, Schwartz JS, Ransohoff DF, Selby JV -
Should recommendations for colorectal-cancer screening be changed?
Nature clinical practice. Oncology 2007 Allison JE -
Clustering of inflammatory bowel disease with immune mediated diseases among members of a northern california-managed care organization.
The American journal of gastroenterology 2007 Weng X, Liu L, Barcellos LF, Allison JE, Herrinton LJ -
Estimation of the period prevalence of inflammatory bowel disease among nine health plans using computerized diagnoses and outpatient pharmacy dispensings.
Inflammatory bowel diseases 2007 Herrinton LJ, Liu L, Lafata JE, Allison JE, Andrade SE, Korner EJ, Chan KA, Platt R, Hiatt D, O'Connor S -
Screening tests for colorectal cancer: a menu of options remains relevant.
Current oncology reports 2006 Allison JE, Lawson M -
Colon Cancer Screening Guidelines 2005: the fecal occult blood test option has become a better FIT.
Gastroenterology 2005 Allison JE -
Immunochemical fecal occult blood tests for colorectal cancer screening.
The American journal of medicine 2004 Allison JE -
A randomized controlled trial of test-and-treat strategy for Helicobacter pylori: clinical outcomes and health care costs in a managed care population receiving long-term acid suppression therapy for physician-diagnosed peptic ulcer disease.
Archives of internal medicine 2003 Allison JE, Hurley LB, Hiatt RA, Levin TR, Ackerson LM, Lieu TA