Jae Kyu Ryu, PhD
Assistant Professor
Neurology
School of Medicine

Awards

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• Scientist Development Grant, American Heart Association, 2016-2019
• Young Investigator Award, A Race to Erase MS, 2016-2018
• Postdoctoral Fellowship, National Multiple Sclerosis Society, 2011-2014
• Postdoctoral Fellowship, American Heart Association, 2009-2011

Education & Training

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• Postdoctoral Neuroimmunology Gladstone Institute of Neurological Disease 2013
• Ph.D. Pharmacology University of British Columbia 2008

Publications (66)

Top publication keywords:
NeuronsNeuroprotective AgentsCorpus StriatumNeurotoxinsAmyloid beta-PeptidesAlzheimer DiseaseFibrinogenAvian ProteinsBlood-Brain BarrierNerve DegenerationEncephalomyelitis, Autoimmune, ExperimentalReceptors, Purinergic P2Quinolinic AcidGliosisMicroglia

• Defining blood-induced microglia functions in neurodegeneration through multiomic profiling.
  Nature immunology 2023 Mendiola AS, Yan Z, Dixit K, Johnson JR, Bouhaddou M, Meyer-Franke A, Shin MG, Yong Y, Agrawal A, MacDonald E, Muthukumar G, Pearce C, Arun N, Cabriga B, Meza-Acevedo R, Alzamora MDPS, Zamvil SS, Pico…
• SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy.
  bioRxiv : the preprint server for biology 2021 Ryu JK, Sozmen EG, Dixit K, Montano M, Matsui Y, Liu Y, Helmy E, Deerinck TJ, Yan Z, Schuck R, Acevedo RM, Spencer CM, Thomas R, Pico AR, Zamvil SS, Lynch KL, Ellisman MH, Greene WC, Akassoglou K
• BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis.
  Brain : a journal of neurology 2021 Petersen MA, Tognatta R, Meyer-Franke A, Bushong EA, Mendiola AS, Yan Z, Muthusamy A, Merlini M, Meza-Acevedo R, Cabriga B, Zhou Y, Thomas R, Ryu JK, Lassmann H, Ellisman MH, Akassoglou K
• Blood Coagulation Factor Fibrinogen in Tumor Pathogenesis of Central Nervous System B-Cell Lymphoma.
  The American journal of pathology 2021 Chan JP, Merlini M, Gao HX, Mendiola AS, Akassoglou K, Rubenstein JL, Ryu JK
• Microglial Gi-dependent dynamics regulate brain network hyperexcitability.
  Nature neuroscience 2020 Merlini M, Rafalski VA, Ma K, Kim KY, Bushong EA, Rios Coronado PE, Yan Z, Mendiola AS, Sozmen EG, Ryu JK, Haberl MG, Madany M, Sampson DN, Petersen MA, Bardehle S, Tognatta R, Dean T, Acevedo RM, …

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• Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.
  Nature immunology 2020 Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff …
• A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling.
  Translational psychiatry 2019 Vagena E, Ryu JK, Baeza-Raja B, Walsh NM, Syme C, Day JP, Houslay MD, Baillie GS
• Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Willis CM, Nicaise AM, Menoret A, Ryu JK, Mendiola AS, Jellison ER, Givogri MI, Han DK, Bongarzone ER, Akassoglou K, Vella AT, Crocker SJ
• Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.
  Neuron 2019 Merlini M, Rafalski VA, Rios Coronado PE, Gill TM, Ellisman M, Muthukumar G, Subramanian KS, Ryu JK, Syme CA, Davalos D, Seeley WW, Mucke L, Nelson RB, Akassoglou K
• Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.
  Nature immunology 2018 Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, …
• Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination.
  Brain : a journal of neurology 2018 Lee NJ, Ha SK, Sati P, Absinta M, Luciano NJ, Lefeuvre JA, Schindler MK, Leibovitch EC, Ryu JK, Petersen MA, Silva AC, Jacobson S, Akassoglou K, Reich DS
• Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics.
  Nature reviews. Neuroscience 2018 Petersen MA, Ryu JK, Akassoglou K
• Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.
  Neuron 2017 Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee…
• Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.
  Nature 2017 Xu T, Stewart KM, Wang X, Liu K, Xie M, Ryu JK, Li K, Ma T, Wang H, Ni L, Zhu S, Cao N, Zhu D, Zhang Y, Akassoglou K, Dong C, Driggers EM, Ding S
• Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity.
  The Journal of experimental medicine 2017 Czirr E, Castello NA, Mosher KI, Castellano JM, Hinkson IV, Lucin KM, Baeza-Raja B, Ryu JK, Li L, Farina SN, Belichenko NP, Longo FM, Akassoglou K, Britschgi M, Cirrito JR, Wyss-Coray T
• Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Shaw MA, Gao Z, McElhinney KE, Thornton S, Flick MJ, Lane A, Degen JL, Ryu JK, Akassoglou K, Mullins ES
• p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.
  Cell reports 2015 Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K
• Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation.
  Nature communications 2015 Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K
• Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer's disease.
  Journal of neuroinflammation 2015 Ryu JK, Cho T, Choi HB, Jantaratnotai N, McLarnon JG
• Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions.
  Nature neuroscience 2015 Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, …
• SIRT1 deacetylates RORγt and enhances Th17 cell generation.
  The Journal of experimental medicine 2015 Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E
• Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.
  Molecular medicine (Cambridge, Mass.) 2015 Terrando N, Yang T, Ryu JK, Newton PT, Monaco C, Feldmann M, Ma D, Akassoglou K, Maze M
• Hypoxia Inducible Factor-1α in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease
  eNeuro 2015 Le Moan N, Baeten KM, Rafalski VA, Ryu JK, Rios Coronado PE, Bedard C, Syme C, Davalos D, Akassoglou K
• Early detection of thrombin activity in neuroinflammatory disease.
  Annals of neurology 2014 Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K
• Long-term potentiation promotes proliferation/survival and neuronal differentiation of neural stem/progenitor cells.
  PloS one 2013 Cho T, Ryu JK, Taghibiglou C, Ge Y, Chan AW, Liu L, Lu J, McLarnon JG, Wang YT
• Actions of the anti-angiogenic compound angiostatin in an animal model of Alzheimer's disease.
  Current Alzheimer research 2013 Ryu JK, Little JP, Klegeris A, Jantaratnotai N, McLarnon JG
• Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase.
  Neuron 2012 Choi HB, Gordon GR, Zhou N, Tai C, Rungta RL, Martinez J, Milner TA, Ryu JK, McLarnon JG, Tresguerres M, Levin LR, Buck J, MacVicar BA
• Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation.
  Nature communications 2012 Davalos D, Ryu JK, Merlini M, Baeten KM, Le Moan N, Petersen MA, Deerinck TJ, Smirnoff DS, Bedard C, Hakozaki H, Gonias Murray S, Ling JB, Lassmann H, Degen JL, Ellisman MH, Akassoglou K
• Resolving postoperative neuroinflammation and cognitive decline.
  Annals of neurology 2011 Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M
• Comparison of Vascular Perturbations in an Aβ-Injected Animal Model and in AD Brain.
  International journal of Alzheimer's disease 2011 Jantaratnotai N, Ryu JK, Schwab C, McGeer PL, McLarnon JG
• Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease.
  Neurobiology of disease 2011 Franciosi S, Ryu JK, Shim Y, Hill A, Connolly C, Hayden MR, McLarnon JG, Leavitt BR
• Block of purinergic P2X7R inhibits tumor growth in a C6 glioma brain tumor animal model.
  Journal of neuropathology and experimental neurology 2011 Ryu JK, Jantaratnotai N, Serrano-Perez MC, McGeer PL, McLarnon JG
• Pyrazole compound 2-MBAPA as a novel inhibitor of microglial activation and neurotoxicity in vitro and in vivo.
  Journal of Alzheimer's disease : JAD 2011 Hashioka S, McLarnon JG, Ryu JK, Youssef AM, Abd-El-Aziz AS, Neeland EG, Klegeris A
• Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Schachtrup C, Ryu JK, Helmrick MJ, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K
• Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus.
  BMC neuroscience 2010 Kim YB, Ryu JK, Lee HJ, Lim IJ, Park D, Lee MC, Kim SU
• Neural progenitor cells attenuate inflammatory reactivity and neuronal loss in an animal model of inflamed AD brain.
  Journal of neuroinflammation 2009 Ryu JK, Cho T, Wang YT, McLarnon JG
• Lysophosphatidylcholine induces glial cell activation: role of rho kinase.
  Glia 2009 Sheikh AM, Nagai A, Ryu JK, McLarnon JG, Kim SU, Masuda J
• Microglial VEGF receptor response is an integral chemotactic component in Alzheimer's disease pathology.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Ryu JK, Cho T, Choi HB, Wang YT, McLarnon JG
• Block of purinergic P2X(7) receptor is neuroprotective in an animal model of Alzheimer's disease.
  Neuroreport 2008 Ryu JK, McLarnon JG
• A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain.
  Journal of cellular and molecular medicine 2008 Ryu JK, McLarnon JG
• VEGF receptor antagonist Cyclo-VEGI reduces inflammatory reactivity and vascular leakiness and is neuroprotective against acute excitotoxic striatal insult.
  Journal of neuroinflammation 2008 Ryu JK, McLarnon JG
• Expression and function of the P2X(7) receptor in rat C6 glioma cells.
  Cancer letters 2007 Wei W, Ryu JK, Choi HB, McLarnon JG
• Thalidomide inhibition of perturbed vasculature and glial-derived tumor necrosis factor-alpha in an animal model of inflamed Alzheimer's disease brain.
  Neurobiology of disease 2007 Ryu JK, McLarnon JG
• Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Choi HB, Ryu JK, Kim SU, McLarnon JG
• Depletion of neutrophils reduces neuronal degeneration and inflammatory responses induced by quinolinic acid in vivo.
  Glia 2007 Ryu JK, Tran KC, McLarnon JG
• Broad-spectrum effects of 4-aminopyridine to modulate amyloid beta1-42-induced cell signaling and functional responses in human microglia.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Franciosi S, Ryu JK, Choi HB, Radov L, Kim SU, McLarnon JG
• Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus.
  Journal of neuropathology and experimental neurology 2006 McLarnon JG, Ryu JK, Walker DG, Choi HB
• Minocycline or iNOS inhibition block 3-nitrotyrosine increases and blood-brain barrier leakiness in amyloid beta-peptide-injected rat hippocampus.
  Experimental neurology 2006 Ryu JK, McLarnon JG
• Neuronal cell death induced by cystatin C in vivo and in cultured human CNS neurons is inhibited with cathepsin B.
  Brain research 2005 Nagai A, Ryu JK, Terashima M, Tanigawa Y, Wakabayashi K, McLarnon JG, Kobayashi S, Masuda J, Kim SU
• Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum.
  Neurobiology of disease 2005 Ryu JK, Choi HB, McLarnon JG
• Induction of angiogenesis by platelet-activating factor in the rat striatum.
  Neuroreport 2005 Tran KC, Ryu JK, McLarnon JG
• Induction of angiogenesis in the beta-amyloid peptide-injected rat hippocampus.
  Neuroreport 2005 Zand L, Ryu JK, McLarnon JG
• Minocycline inhibits neuronal death and glial activation induced by beta-amyloid peptide in rat hippocampus.
  Glia 2004 Ryu JK, Franciosi S, Sattayaprasert P, Kim SU, McLarnon JG
• Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease.
  Neurobiology of disease 2004 Ryu JK, Kim J, Cho SJ, Hatori K, Nagai A, Choi HB, Lee MC, McLarnon JG, Kim SU
• Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease.
  Experimental neurology 2004 Ryu JK, Kim SU, McLarnon JG
• Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins.
  Neurobiology of disease 2003 Choi SH, Lee DY, Ryu JK, Kim J, Joe EH, Jin BK
• Neuroprotective effects of pyruvate in the quinolinic acid rat model of Huntington's disease.
  Experimental neurology 2003 Ryu JK, Kim SU, McLarnon JG
• Amyloid beta peptide-induced corpus callosum damage and glial activation in vivo.
  Neuroreport 2003 Jantaratnotai N, Ryu JK, Kim SU, McLarnon JG
• Differential activation of subtype purinergic receptors modulates Ca(2+) mobilization and COX-2 in human microglia.
  Glia 2003 Choi HB, Hong SH, Ryu JK, Kim SU, McLarnon JG
• Adenosine triphosphate induces proliferation of human neural stem cells: Role of calcium and p70 ribosomal protein S6 kinase.
  Journal of neuroscience research 2003 Ryu JK, Choi HB, Hatori K, Heisel RL, Pelech SL, McLarnon JG, Kim SU
• Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies.
  Neurobiology of disease 2003 Ryu JK, Nagai A, Kim J, Lee MC, McLarnon JG, Kim SU
• Cystatin C induces neuronal cell death in vivo.
  Annals of the New York Academy of Sciences 2002 Nagai A, Ryu JK, Kobayash S, Kim SU
• Inhibition of lipopolysaccharide-induced cyclooxygenase-2, tumor necrosis factor-alpha and [Ca2+]i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195.
  Journal of neurochemistry 2002 Choi HB, Khoo C, Ryu JK, van Breemen E, Kim SU, McLarnon JG
• ATP-induced in vivo neurotoxicity in the rat striatum via P2 receptors.
  Neuroreport 2002 Ryu JK, Kim J, Choi SH, Oh YJ, Lee YB, Kim SU, Jin BK
• Fractalkine and fractalkine receptors in human neurons and glial cells.
  Journal of neuroscience research 2002 Hatori K, Nagai A, Heisel R, Ryu JK, Kim SU
• Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia.
  Glia 2002 Ryu JK, Shin WH, Kim J, Joe EH, Lee YB, Cho KG, Oh YJ, Kim SU, Jin BK