Jacquelyn Maher, MD
Professor
Medicine
School of Medicine

Ongoing work in her group concentrates on the mechanism by which metabolic stresses kill liver cells. She is also using induced pluripotent stem cells (iPSCs) from patients with NAFLD to study the disorder directly in humans. Her research team has recently found that NAFLD iPSCs, when converted in the laboratory to hepatocytes (iPSC-Heps), display characteristics of NAFLD. The group is currently expanding their work with NAFLD iPSC-Heps to encompass larger populations from a variety of ethnic backgrounds.

• Mouse liver injury induces hepatic macrophage FGF23 production.
  PloS one 2022 Kumar P, Liu Y, Shen Y, Maher JJ, Cingolani F, Czaja MJ
• Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation.
  Hepatology (Baltimore, Md.) 2021 Peaslee C, Esteva-Font C, Su T, Munoz-Howell A, Duwaerts CC, Liu Z, Rao S, Liu K, Medina M, Sneddon JB, Maher JJ, Mattis AN
• Visceral Adipose Tissue Inflammation and Radiographic Visceral-to-Subcutaneous Adipose Tissue Ratio in Patients with Cirrhosis.
  Digestive diseases and sciences 2021 Ha NB, Cho SJ, Mohamad Y, Kent D, Jun G, Wong R, Swarnakar V, Lin S, Maher JJ, Lai JC
• Induced Pluripotent Stem Cell-derived Hepatocytes From Patients With Nonalcoholic Fatty Liver Disease Display a Disease-specific Gene Expression Profile.
  Gastroenterology 2021 Duwaerts CC, Le Guillou D, Her CL, Phillips NJ, Willenbring H, Mattis AN, Maher JJ
• Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α.
  Cell death and differentiation 2020 Duwaerts CC, Siao K, Soon RK, Her C, Iwawaki T, Kohno K, Mattis AN, Maher JJ
• Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.
  Scientific reports 2020 Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A
• Nonalcoholic Fatty Liver Disease in 2020.
  Gastroenterology 2020 Maher JJ, Schattenberg JM
• Macronutrients and the Adipose-Liver Axis in Obesity and Fatty Liver.
  Cellular and molecular gastroenterology and hepatology 2019 Duwaerts CC, Maher JJ
• Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration.
  The American journal of pathology 2018 Greenhalgh SN, Matchett KP, Taylor RS, Huang K, Li JT, Saeteurn K, Donnelly MC, Simpson EEM, Pollack JL, Atakilit A, Simpson KJ, Maher JJ, Iredale JP, Sheppard D, Henderson NC
• Macrophages Steal STING From the Infectious Disease Playbook to Promote Nonalcoholic Fatty Liver Disease.
  Gastroenterology 2018 Maher JJ
• Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved.
  Autoimmunity 2018 Lee B, Holt EW, Wong RJ, Sewell JL, Somsouk M, Khalili M, Maher JJ, Tana MM
• Hospitalizations for Autoimmune Hepatitis Disproportionately Affect Black and Latino Americans.
  The American journal of gastroenterology 2018 Wen JW, Kohn MA, Wong R, Somsouk M, Khalili M, Maher J, Tana MM
• CD18 deficiency improves liver injury in the MCD model of steatohepatitis.
  PloS one 2017 Pierce AA, Duwaerts CC, Siao K, Mattis AN, Goodsell A, Baron JL, Maher JJ
• Specific Macronutrients Exert Unique Influences on the Adipose-Liver Axis to Promote Hepatic Steatosis in Mice.
  Cellular and molecular gastroenterology and hepatology 2017 Duwaerts CC, Amin AM, Siao K, Her C, Fitch M, Beysen C, Turner SM, Goodsell A, Baron JL, Grenert JP, Cho SJ, Maher JJ
• Modeling fatty liver disease in animals: Is there an optimal approach, and is the effort worthwhile?
  Hepatology (Baltimore, Md.) 2016 Maher JJ
• Pathogenesis of NAFLD and NASH.
  Alcoholic and Non-Alcoholic Fatty Liver Disease 2016 Jacquelyn J. Maher
• Nonalcoholic fatty liver disease.
  Nature reviews. Disease primers 2015 Brunt EM, Wong VW, Nobili V, Day CP, Sookoian S, Maher JJ, Bugianesi E, Sirlin CB, Neuschwander-Tetri BA, Rinella ME
• Isocaloric manipulation of macronutrients within a high-carbohydrate/moderate-fat diet induces unique effects on hepatic lipogenesis, steatosis and liver injury.
  The Journal of nutritional biochemistry 2015 Pierce AA, Duwaerts CC, Soon RK, Siao K, Grenert JP, Fitch M, Hellerstein MK, Beysen C, Turner SM, Maher JJ
• Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis.
  BMC gastroenterology 2015 Pierce AA, Pickens MK, Siao K, Grenert JP, Maher JJ
• A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.
  Hepatology (Baltimore, Md.) 2014 Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H
• Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis.
  Current hepatology reports 2014 Duwaerts CC, Maher JJ
• Circulating interleukin-8 levels explain breast cancer osteolysis in mice and humans.
  Bone 2014 Kamalakar A, Bendre MS, Washam CL, Fowler TW, Carver A, Dilley JD, Bracey JW, Akel NS, Margulies AG, Skinner RA, Swain FL, Hogue WR, Montgomery CO, Lahiji P, Maher JJ, Leitzel KE, Ali SM, Lipton A, …
• Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.
  Nature medicine 2013 Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH…
• A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.
  Nature medicine 2013 Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton L, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes J, McGuinness …
• Retinol binding protein 4 and fatty liver: A direct link?
  Hepatology (Baltimore, Md.) 2013 Maher JJ
• Hepatic fibrosis: evaluation with semiquantitative contrast-enhanced CT.
  Radiology 2012 Varenika V, Fu Y, Maher JJ, Gao D, Kakar S, Cabarrus MC, Yeh BM
• Insulin sensitivity and variability in hepatitis C virus infection using direct measurement.
  Digestive diseases and sciences 2012 Mukhtar NA, Bacchetti P, Ayala CE, Melgar J, Christensen S, Maher JJ, Khalili M
• The basic helix-loop-helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: analysis of stellate cell entry into the developing liver.
  Hepatology (Baltimore, Md.) 2012 Yin C, Evason KJ, Maher JJ, Stainier DY
• Specific bile acids inhibit hepatic fatty acid uptake in mice.
  Hepatology (Baltimore, Md.) 2012 Nie B, Park HM, Kazantzis M, Lin M, Henkin A, Ng S, Song S, Chen Y, Tran H, Lai R, Her C, Maher JJ, Forman BM, Stahl A
• Impact of insulin resistance on HCV treatment response and impact of HCV treatment on insulin sensitivity using direct measurements of insulin action.
  Diabetes care 2012 Brandman D, Bacchetti P, Ayala CE, Maher JJ, Khalili M
• Assessment of factors associated with pre-diabetes in HCV infection including direct and dynamic measurements of insulin action.
  Journal of viral hepatitis 2011 Mukhtar NA, Ayala C, Maher JJ, Khalili M
• Lipids in liver disease: looking beyond steatosis.
  Gastroenterology 2011 Schwabe RF, Maher JJ
• New insights from rodent models of fatty liver disease.
  Antioxidants & redox signaling 2011 Maher JJ
• Stress signaling in the methionine-choline-deficient model of murine fatty liver disease.
  Gastroenterology 2010 Soon RK, Yan JS, Grenert JP, Maher JJ
• Comparison of surrogate and direct measurement of insulin resistance in chronic hepatitis C virus infection: impact of obesity and ethnicity.
  Hepatology (Baltimore, Md.) 2010 Lam KD, Bacchetti P, Abbasi F, Ayala CE, Loeb SM, Shah V, Wen MJ, Reaven GM, Maher JJ, Khalili M
• Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity.
  Journal of theoretical biology 2010 Sheikh-Bahaei S, Maher JJ, Anthony Hunt C
• Dietary fructose exacerbates hepatocellular injury when incorporated into a methionine-choline-deficient diet.
  Liver international : official journal of the International Association for the Study of the Liver 2010 Pickens MK, Ogata H, Soon RK, Grenert JP, Maher JJ
• Trunk fat as a determinant of liver disease.
  Gastroenterology 2010 Maher JJ
• Short passive cooling protects rats during hepatectomy by inducing heat shock proteins and limiting the induction of pro-inflammatory cytokines.
  The Journal of surgical research 2010 Niemann CU, Xu F, Choi S, Behrends M, Park Y, Hirose R, Maher JJ
• Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis.
  Journal of lipid research 2009 Pickens MK, Yan JS, Ng RK, Ogata H, Grenert JP, Beysen C, Turner SM, Maher JJ
• DAMPs ramp up drug toxicity.
  The Journal of clinical investigation 2009 Maher JJ
• Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis.
  Hepatology (Baltimore, Md.) 2008 Maher JJ, Leon P, Ryan JC
• Impaired dexamethasone-mediated induction of tryptophan 2,3-dioxygenase in heme-deficient rat hepatocytes: translational control by a hepatic eIF2alpha kinase, the heme-regulated inhibitor.
  The Journal of pharmacology and experimental therapeutics 2007 Liao M, Pabarcus MK, Wang Y, Hefner C, Maltby DA, Medzihradszky KF, Salas-Castillo SP, Yan J, Maher JJ, Correia MA
• Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97?
  Biochemistry 2007 Faouzi S, Medzihradszky KF, Hefner C, Maher JJ, Correia MA
• Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury.
  Journal of lipid research 2007 Lee GS, Yan JS, Ng RK, Kakar S, Maher JJ
• Alcoholic steatohepatitis: management and prognosis.
  Current gastroenterology reports 2007 Maher JJ
• Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion.
  Surgery 2006 Niemann CU, Choi S, Behrends M, Hirose R, Noh J, Coatney JL, Roberts JP, Serkova NJ, Maher JJ
• Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1.
  Journal of lipid research 2006 Rizki G, Arnaboldi L, Gabrielli B, Yan J, Lee GS, Ng RK, Turner SM, Badger TM, Pitas RE, Maher JJ
• VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis.
  Nature medicine 2006 Tam BY, Wei K, Rudge JS, Hoffman J, Holash J, Park SK, Yuan J, Hefner C, Chartier C, Lee JS, Jiang S, Nayak NR, Niyak NR, Kuypers FA, Ma L, Sundram U, Wu G, Garcia JA, Schrier SL, Maher JJ, Johnson RS…
• ANIT toxicity toward mouse hepatocytes in vivo is mediated primarily by neutrophils via CD18.
  American journal of physiology. Gastrointestinal and liver physiology 2006 Kodali P, Wu P, Lahiji PA, Brown EJ, Maher JJ
• Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats.
  Molecular & cellular proteomics : MCP 2006 Hirsch J, Hansen KC, Choi S, Noh J, Hirose R, Roberts JP, Matthay MA, Burlingame AL, Maher JJ, Niemann CU
• Metabolic profiling of livers and blood from obese Zucker rats.
  Journal of hepatology 2005 Serkova NJ, Jackman M, Brown JL, Liu T, Hirose R, Roberts JP, Maher JJ, Niemann CU
• Transgenic overexpression of interleukin-8 in mouse liver protects against galactosamine/endotoxin toxicity.
  Journal of hepatology 2005 Hanson JC, Bostick MK, Campe CB, Kodali P, Lee G, Yan J, Maher JJ
• Heme-reversible impairment of CYP2B1/2 induction in heme-depleted rat hepatocytes in primary culture: translational control by a hepatic alpha-subunit of the eukaryotic initiation factor kinase?
  The Journal of pharmacology and experimental therapeutics 2005 Han XM, Lee G, Hefner C, Maher JJ, Correia MA
• Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injury.
  American journal of physiology. Gastrointestinal and liver physiology 2004 Xu J, Lee G, Wang H, Vierling JM, Maher JJ
• What doesn't kill you makes you stronger: how hepatocytes survive prolonged cholestasis.
  Hepatology (Baltimore, Md.) 2004 Maher JJ
• Infiltrating neutrophils in bile duct-ligated livers do not promote hepatic fibrosis.
  Hepatology research : the official journal of the Japan Society of Hepatology 2003 Saito JM, Bostick MK, Campe CB, Xu J, Maher JJ
• Treatment of alcoholic hepatitis.
  Journal of gastroenterology and hepatology 2002 Maher JJ
• Alcoholic steatosis and steatohepatitis.
  Seminars in gastrointestinal disease 2002 Maher JJ
• Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury.
  The Journal of biological chemistry 2001 Björkegren J, Beigneux A, Bergo MO, Maher JJ, Young SG
• Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway.
  The Journal of biological chemistry 2001 Faouzi S, Burckhardt BE, Hanson JC, Campe CB, Schrum LW, Rippe RA, Maher JJ
• Interactions between hepatic stellate cells and the immune system.
  Seminars in liver disease 2001 Maher JJ
• Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii.
  The Journal of biological chemistry 2001 Sonda S, Ting LM, Novak S, Kim K, Maher JJ, Farese RV, Ernst JD
• Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice.
  The Journal of cell biology 2001 Wang R, Ferrell LD, Faouzi S, Maher JJ, Bishop JM
• Antidiabetic treatment for NASH?
  Hepatology (Baltimore, Md.) 2001 Maher J
• The CYP2E1 knockout delivers another punch: first ASH, now NASH. Alcoholic steatohepatitis. Nonalcoholic steatohepatitis.
  Hepatology (Baltimore, Md.) 2001 Maher J
• Bile duct ligation in rats induces biliary expression of cytokine-induced neutrophil chemoattractant.
  Gastroenterology 2000 Saito JM, Maher JJ
• Leukocytes as modulators of stellate cell activation.
  Alcoholism, clinical and experimental research 1999 Maher JJ
• Cytokines: overview.
  Seminars in liver disease 1999 Maher JJ
• How does estrogen enhance endotoxin toxicity? Let me count the ways.
  Hepatology (Baltimore, Md.) 1998 Maher JJ
• Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivo.
  The American journal of physiology 1998 Maher JJ, Lozier JS, Scott MK
• CHEMOKINES AND ALCOHOLIC LIVER DISEASE.
  Alcoholism Clinical and Experimental Research 1998 Jacquelyn J. Maher
• The extracellular matrix in liver regeneration.
  Liver Growth and Repair 1998 Jacquelyn J. Maher
• Manipulation of glutathione stores in rat hepatic stellate cells does not alter collagen synthesis.
  Hepatology (Baltimore, Md.) 1997 Maher JJ, Neuschwander-Tetri BA
• Glutathione regulation in rat hepatic stellate cells. Comparative studies in primary culture and in liver injury in vivo.
  Biochemical pharmacology 1997 Maher JJ, Saito JM, Neuschwander-Tetri BA
• Adenovirus-mediated expression of cytokine-induced neutrophil chemoattractant in rat liver induces a neutrophilic hepatitis.
  Hepatology (Baltimore, Md.) 1997 Maher JJ, Scott MK, Saito JM, Burton MC
• Exploring alcohol's effects on liver function.
  Alcohol health and research world 1997 Maher JJ
• Rat hepatocytes and Kupffer cells interact to produce interleukin-8 (CINC) in the setting of ethanol.
  The American journal of physiology 1995 Maher JJ
• Malondialdehyde stimulates collagen production by hepatic lipocytes only upon activation in primary culture.
  Alcohol and alcoholism (Oxford, Oxfordshire) 1994 Maher JJ, Tzagarakis C, Giménez A
• Acetaldehyde-induced stimulation of collagen synthesis and gene expression is dependent on conditions of cell culture: studies with rat lipocytes and fibroblasts.
  Alcoholism, clinical and experimental research 1994 Maher JJ, Zia S, Tzagarakis C
• Partial cloning of the M subunit of laminin from adult rat lipocytes: expression of the M subunit by cells isolated from normal and injured liver.
  Hepatology (Baltimore, Md.) 1994 Maher JJ, Tzagarakis C
• Cell-matrix interactions in liver.
  Seminars in cell biology 1993 Maher JJ, Bissell DM
• Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride.
  The Journal of clinical investigation 1993 Maher JJ
• Parenchymal and nonparenchymal cell interactions in the liver.
  Seminars in liver disease 1993 Maher JJ, Friedman SL
• Inhibition of rat hepatic lipocyte activation in culture by interferon-gamma.
  Hepatology (Baltimore, Md.) 1992 Rockey DC, Maher JJ, Jarnagin WR, Gabbiani G, Friedman SL
• Isolated hepatic lipocytes and Kupffer cells from normal human liver: morphological and functional characteristics in primary culture.
  Hepatology (Baltimore, Md.) 1992 Friedman SL, Rockey DC, McGuire RF, Maher JJ, Boyles JK, Yamasaki G
• Yet another role for the "good" matrix protein: laminin in regenerating liver.
  Hepatology (Baltimore, Md.) 1992 Maher JJ
• Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo.
  The Journal of clinical investigation 1990 Maher JJ, McGuire RF
• Connective tissue biology and hepatic fibrosis: report of a conference.
  Hepatology (Baltimore, Md.) 1990 Bissell DM, Friedman SL, Maher JJ, Roll FJ
• Hepatic fibrosis caused by alcohol.
  Seminars in liver disease 1990 Maher JJ
• Fat-storing cells and myofibroblasts: one cell or two?
  Hepatology (Baltimore, Md.) 1989 Maher JJ
• Primary hepatocyte culture: is it home away from home?
  Hepatology (Baltimore, Md.) 1988 Maher JJ
• Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer.
  The Journal of clinical investigation 1988 Maher JJ, Bissell DM, Friedman SL, Roll FJ
• Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture.
  Gastroenterology 1988 Maher JJ, Friedman SL, Roll FJ, Bissell DM
• Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver.
  The Journal of clinical investigation 1987 Bissell DM, Arenson DM, Maher JJ, Roll FJ