Jacqueline Leung, MD, MPH
Professor
Anesthesia
School of Medicine

Dr. Leung is the director of the Perioperative Medicine Research Group based at UCSF Medical Center. The group conducts outcomes research in older surgical patients. Our recent work focuses on identifying the pathophysiology of postoperative delirium and cognitive decline, and also the mechanism between sleep disruption and ICU delirium.

Education & Training

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• M.D. School of Medicine Stanford University 1984
• Residency University of California, San Francisco
• Clinical Fellowship Cardiology University of California, San Francisco

Interests

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• delirium
• postoperative
• aging
• cognitive function
• geriatrics
• anesthesia

Websites

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• Clinical Profile at UCSF Medical Center (ucsfhealth.org)
• Leung research (leung.ucsf.edu)

Grants and Projects

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• The role of genomics in postoperative delirium and sedation, NIH, 2019-2022
• Acute preoperative sleep disruption and postoperative delirium, NIH, 2017-2020
• The Effects of Light vs Deep Anesthesia on Postoperative Cognitive Outcomes, NIH, 2015-2018
• Pathophysiology of postoperative delirium in older patients, NIH, 2009-2015
• Aging and Perioperative Outcomes, NIH, 2001-2006

Publications (102)

Top publication keywords:
Postoperative ComplicationsCognition DisordersIntraoperative ComplicationsSleep Initiation and Maintenance DisordersPerioperative CareAnesthesia, GeneralEmergence DeliriumCoronary Artery BypassDeliriumSurgical Procedures, OperativeMonitoring, IntraoperativeElectroencephalographyCyclohexanecarboxylic AcidsConsciousness MonitorsPain, Postoperative

• Plasma SOMAmer proteomics of postoperative delirium.
  Brain and behavior 2024 Leung JM, Rojas JC, Sands LP, Chan B, Rajbanshi B, Du Z, Du P, Perioperative Medicine Research group
• Early immune factors associated with the development of post-acute sequelae of SARS-CoV-2 infection in hospitalized and non-hospitalized individuals.
  Frontiers in immunology 2024 Leung JM, Wu MJ, Kheradpour P, Chen C, Drake KA, Tong G, Ridaura VK, Zisser HC, Conrad WA, Hudson N, Allen J, Welberry C, Parsy-Kowalska C, Macdonald I, Tapson VF, Moy JN, deFilippi CR, Rosas IO, …
• Assessing patterns of delirium symptoms reveals a novel subtype among elective surgical patients with postoperative delirium.
  International journal of geriatric psychiatry 2024 Yang L, Do Q, Zhu X, Leung JM, Perioperative Medicine Research Group, Sands LP
• Distinct temporal trajectories and risk factors for Post-acute sequelae of SARS-CoV-2 infection.
  Frontiers in medicine 2023 Chen C, Parthasarathy S, Leung JM, Wu MJ, Drake KA, Ridaura VK, Zisser HC, Conrad WA, Tapson VF, Moy JN, deFilippi CR, Rosas IO, Prabhakar BS, Basit M, Salvatore M, Krishnan JA, Kim CC
• Multi-omic profiling reveals early immunological indicators for identifying COVID-19 Progressors.
  Clinical immunology (Orlando, Fla.) 2023 Drake KA, Talantov D, Tong GJ, Lin JT, Verheijden S, Katz S, Leung JM, Yuen B, Krishna V, Wu MJ, Sutherland AM, Short SA, Kheradpour P, Mumbach MR, Franz KM, Trifonov V, Lucas MV, Merson J, Kim CC, …

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• Presence of Preoperative Neurodegeneration Biofluid Markers in Patients with Postoperative Delirium.
  Anesthesiology 2023 Leung JM, Rojas JC, Tang C, Chan B, Lario-Lago A, Boxer AL, Do Q, Kramer JH, Du Z, Du P, Sands LP, Perioperative Medicine Research Group
• Fine structure and molecular characterization of two new parabasalid species that naturally colonize laboratory mice, Tritrichomonas musculus and Tritrichomonas casperi.
  The Journal of eukaryotic microbiology 2023 Tuzlak L, Alves-Ferreira EVC, Schwartz CL, Kennard A, Leung JM, Shehata C, Grigg ME
• Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19.
  Nature communications 2023 Robertson SJ, Bedard O, McNally KL, Shaia C, Clancy CS, Lewis M, Broeckel RM, Chiramel AI, Shannon JG, Sturdevant GL, Rosenke R, Anzick SL, Forte E, Preuss C, Baker CN, Harder JM, Brunton C, Munger S,…
• Multi-omic Profiling Reveals Early Immunological Indicators for Identifying COVID-19 Progressors.
  bioRxiv : the preprint server for biology 2023 Drake KA, Talantov D, Tong GJ, Lin JT, Verheijden S, Katz S, Leung JM, Yuen B, Krishna V, Wu MJ, Sutherland A, Short SA, Kheradpour P, Mumbach M, Franz K, Trifonov V, Lucas MV, Merson J, Kim CC, …
• Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19.
  bioRxiv : the preprint server for biology 2023 Robertson S, Bedard O, McNally K, Shaia C, Clancy C, Lewis M, Broeckel R, Chiramel A, Shannon JG, Sturdevant G, Rosenke R, Anzick SL, Forte E, Preuss C, Baker C, Harder J, Brunton C, Munger SC, Bruno …
• Sleep Loss the night before surgery and incidence of postoperative delirium in adults 65-95 years of age.
  Sleep medicine 2023 Leung JM, Tang C, Do Q, Sands LP, Tran D, Lee KA, Perioperative Medicine Research Group
• Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge.
  EBioMedicine 2022 Leventhal SS, Meade-White K, Rao D, Haddock E, Leung J, Scott D, Archer J, Randall S, Erasmus JH, Feldmann H, Hawman DW
• Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial.
  BMJ open 2022 Buren MA, Theologis A, Zuraek A, Behrends M, Clark AJ, Leung JM
• KIBRA, MTNR1B, and FKBP5 genotypes are associated with decreased odds of incident delirium in elderly post-surgical patients.
  Scientific reports 2022 Terrelonge M, LaHue SC, Tang C, Movsesyan I, Pullinger CR, Dubal DB, Leung J, Douglas VC
• Postoperative delirium prediction using machine learning models and preoperative electronic health record data.
  BMC anesthesiology 2022 Bishara A, Chiu C, Whitlock EL, Douglas VC, Lee S, Butte AJ, Leung JM, Donovan AL
• A pigtailed macaque model of Kyasanur Forest disease virus and Alkhurma hemorrhagic disease virus pathogenesis.
  PLoS pathogens 2021 Broeckel RM, Feldmann F, McNally KL, Chiramel AI, Sturdevant GL, Leung JM, Hanley PW, Lovaglio J, Rosenke R, Scott DP, Saturday G, Bouamr F, Rasmussen AL, Robertson SJ, Best SM
• Further Insight into the Mechanism of Human PMN Lysis following Phagocytosis of Staphylococcus aureus.
  Microbiology spectrum 2021 Rungelrath V, Porter AR, Malachowa N, Freedman BA, Leung JM, Voyich JM, Otto M, Kobayashi SD, DeLeo FR
• Rottlerin inhibits La Crosse virus-induced encephalitis in mice and blocks release of replicating virus from the Golgi body in neurons.
  Nature microbiology 2021 Ojha D, Winkler CW, Leung JM, Woods TA, Chen CZ, Nair V, Taylor K, Yeh CD, Tawa GJ, Larson CL, Zheng W, Haigh CL, Peterson KE
• Midazolam Premedication Immediately Before Surgery Is Not Associated With Early Postoperative Delirium.
  Anesthesia and analgesia 2021 Wang ML, Min J, Sands LP, Leung JM, the Perioperative Medicine Research Group
• The Impact of Surgery duration and Surgery End Time on Postoperative Sleep in Older Adults.
  Journal of sleep disorders and management 2021 Tran D, Tang C, Tabatabai S, Pleasants D, Choukalas C, Min J, Do Q, Sands L, Lee K, Leung JM
• Obesity and perioperative outcomes in older surgical patients undergoing elective spine and major arthroplasty surgery.
  Journal of clinical anesthesia 2021 Tabatabai S, Do Q, Min J, Tang CJ, Pleasants D, Sands LP, Du P, Leung JM
• Prion-induced photoreceptor degeneration begins with misfolded prion protein accumulation in cones at two distinct sites: cilia and ribbon synapses.
  Acta neuropathologica communications 2021 Striebel JF, Race B, Leung JM, Schwartz C, Chesebro B
• Does postoperative delirium following elective noncardiac surgery predict long-term mortality?
  Age and ageing 2020 Ziman N, Sands LP, Tang C, Zhu J, Leung JM
• ADAPT-2: A Randomized Clinical Trial to Reduce Intraoperative EEG Suppression in Older Surgical Patients Undergoing Major Noncardiac Surgery.
  Anesthesia and analgesia 2020 Tang CJ, Jin Z, Sands LP, Pleasants D, Tabatabai S, Hong Y, Leung JM
• American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Postoperative Delirium Prevention.
  Anesthesia and analgesia 2020 Hughes CG, Boncyk CS, Culley DJ, Fleisher LA, Leung JM, McDonagh DL, Gan TJ, McEvoy MD, Miller TE, Perioperative Quality Initiative (POQI) 6 Workgroup
• ADAPT-2: A Randomized Clinical Trial to Reduce Intraoperative EEG Suppression in Older Surgical Patients Undergoing Major Noncardiac Surgery.
  Anesthesia and analgesia 2020 Tang CJ, Jin Z, Sands LP, Pleasants D, Tabatabai S, Hong Y, Leung JM
• Adherence to recommended practices for perioperative anesthesia care for older adults among US anesthesiologists: results from the ASA Committee on Geriatric Anesthesia-Perioperative Brain Health Initiative ASA member survey.
  Perioperative medicine (London, England) 2020 Deiner S, Fleisher LA, Leung JM, Peden C, Miller T, Neuman MD, ASA Committee on Geriatric Anesthesia and the ASA Perioperative Brain Health Initiative
• Processed Electroencephalogram Monitoring and Postoperative Delirium: A Systematic Review and Meta-analysis.
  Anesthesiology 2018 MacKenzie KK, Britt-Spells AM, Sands LP, Leung JM
• Volatile anaesthetics and postoperative delirium in older surgical patients-A secondary analysis of prospective cohort studies.
  Acta anaesthesiologica Scandinavica 2018 Kinjo S, Lim E, Magsaysay MV, Sands LP, Leung JM, Perioperative Medicine Research Group
• Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial.
  Anesthesiology 2017 Leung JM, Sands LP, Chen N, Ames C, Berven S, Bozic K, Burch S, Chou D, Covinsky K, Deviren V, Kinjo S, Kramer JH, Ries M, Tay B, Vail T, Weinstein P, Chang S, Meckler G, Newman S, Tsai T, Voss V, …
• Validation of a Nurse-Based Delirium-Screening Tool for Hospitalized Patients.
  Psychosomatics 2017 Hargrave A, Bastiaens J, Bourgeois JA, Neuhaus J, Josephson SA, Chinn J, Lee M, Leung J, Douglas V
• Burst-suppression ratio underestimates absolute duration of electroencephalogram suppression compared with visual analysis of intraoperative electroencephalogram.
  British journal of anaesthesia 2017 Muhlhofer WG, Zak R, Kamal T, Rizvi B, Sands LP, Yuan M, Zhang X, Leung JM
• The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor.
  Anesthesia and analgesia 2016 Vacas S, McInrue E, Gropper MA, Maze M, Zak R, Lim E, Leung JM
• Preoperative Sleep Disruption and Postoperative Delirium.
  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2015 Leung JM, Sands LP, Newman S, Meckler G, Xie Y, Gay C, Lee K
• Prognostic Significance of Postoperative Subsyndromal Delirium.
  Psychosomatics 2015 Shim J, DePalma G, Sands LP, Leung JM
• Impact of intraoperative hypotension and blood pressure fluctuations on early postoperative delirium after non-cardiac surgery.
  British journal of anaesthesia 2015 Hirsch J, DePalma G, Tsai TT, Sands LP, Leung JM
• Sensitivity and specificity of the animal fluency test for predicting postoperative delirium.
  Canadian journal of anaesthesia = Journal canadien d'anesthesie 2014 Long LS, Wolpaw JT, Leung JM
• American Geriatrics Society abstracted clinical practice guideline for postoperative delirium in older adults.
  Journal of the American Geriatrics Society 2014 American Geriatrics Society Expert Panel on Postoperative Delirium in Older Adults
• Postoperative delirium in older adults: best practice statement from the American Geriatrics Society.
  Journal of the American College of Surgeons 2014 American Geriatrics Society Expert Panel on Postoperative Delirium in Older Adults
• The temporal relationship between early postoperative delirium and postoperative cognitive dysfunction in older patients: a prospective cohort study.
  Canadian journal of anaesthesia = Journal canadien d'anesthesie 2014 Youngblom E, DePalma G, Sands L, Leung J
• Does preoperative risk for delirium moderate the effects of postoperative pain and opiate use on postoperative delirium?
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2013 Leung JM, Sands LP, Lim E, Tsai TL, Kinjo S
• Association between intraoperative blood transfusions and early postoperative delirium in older adults.
  Journal of the American Geriatrics Society 2013 Behrends M, DePalma G, Sands L, Leung J
• Impact of missing data on analysis of postoperative cognitive decline (POCD).
  Applied nursing research : ANR 2013 DeCrane SK, Sands LP, Young KM, DePalma G, Leung JM
• An update on delirium in the postoperative setting: prevention, diagnosis and management.
  Best practice & research. Clinical anaesthesiology 2012 Shim JJ, Leung JM
• A brief review of practical preoperative cognitive screening tools.
  Canadian journal of anaesthesia = Journal canadien d'anesthesie 2012 Long LS, Shapiro WA, Leung JM
• Does using a femoral nerve block for total knee replacement decrease postoperative delirium?
  BMC anesthesiology 2012 Kinjo S, Lim E, Sands LP, Bozic KJ, Leung JM
• Prediction of postoperative pain using path analysis in older patients.
  Journal of anesthesia 2011 Kinjo S, Sands LP, Lim E, Paul S, Leung JM
• Perioperative cognitive decline in the aging population.
  Mayo Clinic proceedings 2011 Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung JM, Miller BL, Seeley WW, Vacas S, Weiner MW, Yaffe K, Young WL, Xie Z, Maze M
• Factors associated with recovery from early postoperative delirium.
  Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 2011 DeCrane SK, Sands L, Ashland M, Lim E, Tsai TL, Paul S, Leung JM
• Brief report: preoperative frailty in older surgical patients is associated with early postoperative delirium.
  Anesthesia and analgesia 2011 Leung JM, Tsai TL, Sands LP
• Postoperative delirium: are there modifiable risk factors?
  European journal of anaesthesiology 2010 Leung JM
• Long-term cognitive decline: is there a link to surgery and anesthesia?
  Anesthesiology 2009 Leung JM, Sands LP
• Does postoperative delirium limit the use of patient-controlled analgesia in older surgical patients?
  Anesthesiology 2009 Leung JM, Sands LP, Paul S, Joseph T, Kinjo S, Tsai T
• Apolipoprotein E e4 allele increases the risk of early postoperative delirium in older patients undergoing noncardiac surgery.
  Anesthesiology 2007 Leung JM, Sands LP, Wang Y, Poon A, Kwok PY, Kane JP, Pullinger CR
• The effects of postoperative pain and its management on postoperative cognitive dysfunction.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2007 Wang Y, Sands LP, Vaurio L, Mullen EA, Leung JM
• Histologic assessment of right atrial appendage myocardium in patients with atrial fibrillation after coronary artery bypass graft surgery.
  Cardiology 2006 Nakai T, Chandy J, Nakai K, Bellows WH, Flachsbart K, Lee RJ, Leung JM
• Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients.
  Neurology 2006 Leung JM, Sands LP, Rico M, Petersen KL, Rowbotham MC, Dahl JB, Ames C, Chou D, Weinstein P
• Nitrous oxide does not change the incidence of postoperative delirium or cognitive decline in elderly surgical patients.
  British journal of anaesthesia 2006 Leung JM, Sands LP, Vaurio LE, Wang Y
• Postoperative delirium: the importance of pain and pain management.
  Anesthesia and analgesia 2006 Vaurio LE, Sands LP, Wang Y, Mullen EA, Leung JM
• The role of postoperative analgesia in delirium and cognitive decline in elderly patients: a systematic review.
  Anesthesia and analgesia 2006 Fong HK, Sands LP, Leung JM
• Are preoperative depressive symptoms associated with postoperative delirium in geriatric surgical patients?
  The journals of gerontology. Series A, Biological sciences and medical sciences 2005 Leung JM, Sands LP, Mullen EA, Wang Y, Vaurio L
• Post-CABG dobutamine stress echocardiography.
  Anesthesia and analgesia 2005 Leung JM, Bellows WH
• Impairment of left atrial function predicts post-operative atrial fibrillation after coronary artery bypass graft surgery.
  European heart journal 2004 Leung JM, Bellows WH, Schiller NB
• Does intraoperative evaluation of left ventricular contractile reserve predict myocardial viability? A clinical study using dobutamine stress echocardiography in patients undergoing coronary artery bypass graft surgery.
  Anesthesia and analgesia 2004 Leung JM, Bellows WH, Pastor D
• Increases in P-wave dispersion predict postoperative atrial fibrillation after coronary artery bypass graft surgery.
  Anesthesia and analgesia 2004 Chandy J, Nakai T, Lee RJ, Bellows WH, Dzankic S, Leung JM
• The prevalence of preoperative diastolic filling abnormalities in geriatric surgical patients.
  Anesthesia and analgesia 2003 Phillip B, Pastor D, Bellows W, Leung JM
• Prognostic significance of postoperative in-hospital complications in elderly patients. I. Long-term survival.
  Anesthesia and analgesia 2003 Manku K, Bacchetti P, Leung JM
• Prognostic significance of postoperative in-hospital complications in elderly patients. II. Long-term quality of life.
  Anesthesia and analgesia 2003 Manku K, Leung JM
• Preoperative electrocardiogram abnormalities do not predict postoperative cardiac complications in geriatric surgical patients.
  Journal of the American Geriatrics Society 2002 Liu LL, Dzankic S, Leung JM
• Comparison of left atrial dimensions by transesophageal and transthoracic echocardiography.
  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2002 Block M, Hourigan L, Bellows WH, Reeves J, Romson JL, Tran M, Pastor D, Schiller NB, Leung JM
• The relative importance of left atrial function versus dimension in predicting atrial fibrillation after coronary artery bypass graft surgery.
  American heart journal 2002 Nakai T, Lee RJ, Schiller NB, Bellows WH, Dzankic S, Reeves J, Romson J, Ferguson S, Leung JM
• The prevalence and predictors of the use of alternative medicine in presurgical patients in five California hospitals.
  Anesthesia and analgesia 2001 Leung JM, Dzankic S, Manku K, Yuan S
• Relative importance of preoperative health status versus intraoperative factors in predicting postoperative adverse outcomes in geriatric surgical patients.
  Journal of the American Geriatrics Society 2001 Leung JM, Dzankic S
• The prevalence and predictive value of abnormal preoperative laboratory tests in elderly surgical patients.
  Anesthesia and analgesia 2001 Dzankic S, Pastor D, Gonzalez C, Leung JM
• Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans.
  Anesthesiology 2000 Leung JM, Weiskopf RB, Feiner J, Hopf HW, Kelley S, Viele M, Lieberman J, Watson J, Noorani M, Pastor D, Yeap H, Ho R, Toy P
• Predicting adverse postoperative outcomes in patients aged 80 years or older.
  Journal of the American Geriatrics Society 2000 Liu LL, Leung JM
• Critical oxygen delivery in conscious humans is less than 7.3 ml O2 x kg(-1) x min(-1).
  Anesthesiology 2000 Lieberman JA, Weiskopf RB, Kelley SD, Feiner J, Noorani M, Leung J, Toy P, Viele M
• Effects of dobutamine on hemodynamics and left ventricular performance after cardiopulmonary bypass in cardiac surgical patients.
  Anesthesiology 1999 Romson JL, Leung JM, Bellows WH, Bronstein M, Keith F, Moores W, Flachsbart K, Richter R, Pastor D, Fisher DM
• Automated electrocardiograph ST segment trending monitors: accuracy in detecting myocardial ischemia.
  Anesthesia and analgesia 1998 Leung JM, Voskanian A, Bellows WH, Pastor D
• Dissociation between haemodynamics and sympathetic activation during anaesthetic induction with desfluranes.
  Canadian journal of anaesthesia = Journal canadien d'anesthesie 1998 Leung JM, Pastor DA
• Human cardiovascular and metabolic response to acute, severe isovolemic anemia.
  JAMA 1998 Weiskopf RB, Viele MK, Feiner J, Kelley S, Lieberman J, Noorani M, Leung JM, Fisher DM, Murray WR, Toy P, Moore MA
• Transesophageal echocardiography in myocardial revascularization: I. Accuracy of intraoperative real-time interpretation.
  Anesthesia and analgesia 1996 Bergquist BD, Leung JM, Bellows WH
• Transesophageal echocardiography in myocardial revascularization: II. Influence on intraoperative decision making.
  Anesthesia and analgesia 1996 Bergquist BD, Bellows WH, Leung JM
• Effects of acadesine on the incidence of myocardial infarction and adverse cardiac outcomes after coronary artery bypass graft surgery. Multicenter Study of Perioperative Ischemia (McSPI) Research Group.
  Anesthesiology 1995
• Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group.
  Anesthesiology 1995 Talke P, Li J, Jain U, Leung J, Drasner K, Hollenberg M, Mangano DT
• Left ventricular end-systolic cavity obliteration as an estimate of intraoperative hypovolemia.
  Anesthesiology 1994 Leung JM, Levine EH
• Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization.
  The Journal of thoracic and cardiovascular surgery 1994 Hennein HA, Ebba H, Rodriguez JL, Merrick SH, Keith FM, Bronstein MH, Leung JM, Mangano DT, Greenfield LJ, Rankin JS
• Safety and efficacy of intravenous Carbicarb in patients undergoing surgery: comparison with sodium bicarbonate in the treatment of mild metabolic acidosis. SPI Research Group. Study of Perioperative Ischemia.
  Critical care medicine 1994 Leung JM, Landow L, Franks M, Soja-Strzepa D, Heard SO, Arieff AI, Mangano DT
• An initial multicenter, randomized controlled trial on the safety and efficacy of acadesine in patients undergoing coronary artery bypass graft surgery. SPI Research Group.
  Anesthesia and analgesia 1994 Leung JM, Stanley T, Mathew J, Curling P, Barash P, Salmenpera M, Reves JG, Hollenberg M, Mangano DT
• Safety of low-dose intraoperative bicarbonate therapy: a prospective, double-blind, randomized study. The Study of Perioperative Ischemia (SPI) Research Group.
  Critical care medicine 1993 Mark NH, Leung JM, Arieff AI, Mangano DT
• Clinical evidence of myocardial stunning in patients undergoing CABG surgery.
  Journal of cardiac surgery 1993 Leung JM
• Effects of steal-prone anatomy on intraoperative myocardial ischemia. The SPI Research Group.
  Journal of the American College of Cardiology 1992 Leung JM, Hollenberg M, O'Kelly BF, Kao A, Mangano DT
• Monitoring for myocardial ischemia during noncardiac surgery. A technology assessment of transesophageal echocardiography and 12-lead electrocardiography. The Study of Perioperative Ischemia Research Group.
  JAMA 1992 Eisenberg MJ, London MJ, Leung JM, Browner WS, Hollenberg M, Tubau JF, Tateo IM, Schiller NB, Mangano DT
• The risk of myocardial ischemia in patients receiving desflurane versus sufentanil anesthesia for coronary artery bypass graft surgery. The S.P.I. Research Group.
  Anesthesiology 1992 Helman JD, Leung JM, Bellows WH, Pineda N, Roach GW, Reeves JD, Howse J, McEnany MT, Mangano DT
• Postoperative myocardial ischemia. Therapeutic trials using intensive analgesia following surgery. The Study of Perioperative Ischemia (SPI) Research Group.
  Anesthesiology 1992 Mangano DT, Siliciano D, Hollenberg M, Leung JM, Browner WS, Goehner P, Merrick S, Verrier E
• The role of hemodynamics in perioperative myocardial ischemia.
  International anesthesiology clinics 1992 Leung JM
• Ventricular dysrhythmias in patients undergoing coronary artery bypass graft surgery: incidence, characteristics, and prognostic importance. Study of Perioperative Ischemia (SPI) Research Group.
  American heart journal 1992 Smith RC, Leung JM, Keith FM, Merrick S, Mangano DT
• Isoflurane anesthesia and myocardial ischemia: comparative risk versus sufentanil anesthesia in patients undergoing coronary artery bypass graft surgery. The SPI (Study of Perioperative Ischemia) Research Group.
  Anesthesiology 1991 Leung JM, Goehner P, O'Kelly BF, Hollenberg M, Pineda N, Cason BA, Mangano DT
• Postoperative myocardial ischemia in patients undergoing coronary artery bypass graft surgery. S.P.I. Research Group.
  Anesthesiology 1991 Smith RC, Leung JM, Mangano DT
• Relationship of regional wall motion abnormalities to hemodynamic indices of myocardial oxygen supply and demand in patients undergoing CABG surgery.
  Anesthesiology 1990 Leung JM, O'Kelly BF, Mangano DT
• Prognostic importance of postbypass regional wall-motion abnormalities in patients undergoing coronary artery bypass graft surgery. SPI Research Group.
  Anesthesiology 1989 Leung JM, O'Kelly B, Browner WS, Tubau J, Hollenberg M, Mangano DT
• Transesophageal echocardiographic assessment of left ventricular function.
  International journal of cardiac imaging 1989 Leung JM, Schiller NB, Mangano DT