Jacob Young, MD
Resident Physician
Neurological Surgery
School of Medicine

He works closely with mentors Manish Aghi MD PhD, Shawn Hervey-Jumper MD, Hideho Okada MD PhD, David Raleigh MD PhD, and Mitchel Berger MD on projects exploring these topics. Jacob’s research accomplishments have been recognized at the institutional, regional, and national levels and include receiving the Peter Huttenlocher & Douglas Buchanan Prize and the Brain Research Foundation Award from the University of Chicago, the Harold Rosegay Award from the San Francisco Neurosurgical Society, and the Donald O. Quest award from the American Association of Neurological Surgeons. His work has been funded by the American Association of Neurological Surgeons and the Neurosurgery Research Education Fund. His clinical performance was recognized with the Krevan’s Award for Excellence in Patient Care at the Zuckerberg San Francisco General Hospital, the Howard Naffziger Award for Outstanding Clinical Service and Care to Neurosurgical Patients at UCSF, and the Exceptional Physician Award from UCSF.

• "De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.
  Acta neuropathologica 2023 Hadad S, Gupta R, Oberheim Bush NA, Taylor JW, Villanueva-Meyer JE, Young JS, Wu J, Ravindranathan A, Zhang Y, Warrier G, McCoy L, Shai A, Pekmezci M, Perry A, Bollen AW, Phillips JJ, Braunstein SE, …
• The surgical management of diffuse gliomas: Current state of neurosurgical management and future directions.
  Neuro-oncology 2023 Young JS, Morshed RA, Hervey-Jumper SL, Berger MS
• Advances in Intraoperative Glioma Tissue Sampling and Infiltration Assessment.
  Brain sciences 2023 Al-Adli NN, Young JS, Scotford K, Sibih YE, Payne J, Berger MS
• Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses.
  Nature medicine 2023 Chen WC, Choudhury A, Youngblood MW, Polley MC, Lucas CG, Mirchia K, Maas SLN, Suwala AK, Won M, Bayley JC, Harmanci AS, Harmanci AO, Klisch TJ, Nguyen MP, Vasudevan HN, McCortney K, Yu TJ, Bhave V, …
• Insular Gliomas: A Review of Surgical Anatomy and Operative Considerations.
  Functional Anatomy of the Brain: A View from the Surgeon’s Eye 2023 Ramin A. Morshed, Jacob S. Young, Alexander F. Haddad, Mitchel S. Berger
• Asleep triple-modality motor mapping for perirolandic gliomas: an update on outcomes.
  Journal of neurosurgery 2023 Morshed RA, Cummins DD, Clark JP, Young JS, Haddad AF, Gogos AJ, Hervey-Jumper SL, Berger MS
• Adjuvant Chemoradiotherapy within One Year of Resection for Molecularly Defined Astrocytoma.
  International Journal of Radiation Oncology • Biology • Physics 2023 S.J. Liu, W.C. Chen, Y. Zhang, J.S. Young, R.A. Morshed, M.P. Nguyen, J. Villanueva-Meyer, J. Phillips, N.A. Oberheim, M.K. Aghi, P.K. Sneed, S.E. Braunstein, J. de Groot, M.S. Berger, A.M. Molinaro, …
• JS05.7.A SURGICAL RE-RESECTION FOR RECURRENT GLIOBLASTOMA: PROGNOSTIC EVALUATION USING THE NOVEL RANO CLASSIFICATION FOR EXTENT OF RESECTION FROM THE RANORESECT GROUP.
  Neuro-Oncology 2023 P Karschnia, A Dono, J S Young, S T Juenger, N Teske, L Häni, T Sciortino, C Y Mau, F Bruno, L Nunez, R A Morshed, A F Haddad, M Weller, M van den Bent, J Beck, S Hervey-Jumper, A M Molinaro, N Tandon…
• Prognostic evaluation of re-resection for recurrent glioblastoma using the novel RANO classification for extent of resection: A report of the RANO resect group.
  Neuro-oncology 2023 Karschnia P, Dono A, Young JS, Juenger ST, Teske N, Häni L, Sciortino T, Mau CY, Bruno F, Nunez L, Morshed RA, Haddad AF, Weller M, van den Bent M, Beck J, Hervey-Jumper S, Molinaro AM, Tandon N, Rudà…
• Glioma-neuronal circuit remodeling induces regional immunosuppression.
  bioRxiv : the preprint server for biology 2023 Nejo T, Krishna S, Jimenez C, Yamamichi A, Young JS, Lakshmanachetty S, Chen T, Phyu SSS, Ogino H, Watchmaker P, Diebold D, Choudhury A, Daniel AGS, Raleigh DR, Hervey-Jumper SL, Okada H
• Analysis of upfront resection or stereotactic radiosurgery for local control of solid and cystic cerebellar hemangioblastomas.
  Journal of neurosurgery 2023 Carrete LR, Morshed RA, Young JS, Avalos LN, Sneed PK, Aghi MK, McDermott MW, Theodosopoulos PV
• Molecular Features of Resected Melanoma Brain Metastases, Clinical Outcomes, and Responses to Immunotherapy.
  JAMA network open 2023 Vasudevan HN, Delley C, Chen WC, Mirchia K, Pan S, Shukla P, Aabedi AA, Nguyen MP, Morshed RA, Young JS, Boreta L, Fogh SE, Nakamura JL, Theodosopoulos PV, Phillips J, Hervey-Jumper SL, Daras M, Pike …
• High-volume facilities are not always low risk: comparing risk-standardized mortality rates versus facility volume as quality measures in surgical neuro-oncology.
  Journal of neurosurgery 2023 Chalif EJ, Young JS, Villa GR, Aghi MK, Lenzi J, Berger MS
• Does waiting for surgery matter? How time from diagnostic MRI to resection affects outcomes in newly diagnosed glioblastoma.
  Journal of neurosurgery 2023 Young JS, Al-Adli NN, Muster R, Chandra A, Morshed RA, Pereira MP, Chalif EJ, Hervey-Jumper SL, Theodosopoulos PV, McDermott MW, Berger MS, Aghi MK
• Prognostic evaluation of surgical re-resection for recurrent glioblastoma using the novel RANO classification for extent of resection: A report of the RANO resect group.
  Journal of Clinical Oncology 2023 Philipp Karschnia, Antonio Dono, Jacob S Young, Stephanie T. Jünger, Nico Teske, Levin Häni, Tommaso Sciortino, Christine Y. Mau, Francesco Bruno, Michael Weller, Roberta Ruda, Michael A. Vogelbaum, …
• Prognostic validation of a new classification system for extent of resection in glioblastoma: A report of the RANO resect group.
  Neuro-oncology 2023 Karschnia P, Young JS, Dono A, Häni L, Sciortino T, Bruno F, Juenger ST, Teske N, Morshed RA, Haddad AF, Zhang Y, Stoecklein S, Weller M, Vogelbaum MA, Beck J, Tandon N, Hervey-Jumper S, Molinaro AM, …
• Technical Aspects of Motor and Language Mapping in Glioma Patients.
  Cancers 2023 Al-Adli NN, Young JS, Sibih YE, Berger MS
• A Preoperative Scoring System to Predict Function-Based Resection Limitation Due to Insufficient Participation During Awake Surgery.
  Neurosurgery 2023 Elia A, Young JS, Simboli GA, Roux A, Moiraghi A, Trancart B, Al-Adli N, Aboubakr O, Bedioui A, Leclerc A, Planet M, Parraga E, Benevello C, Oppenheim C, Chretien F, Dezamis E, Berger MS, Zanello M, …
• Abstract 2497: Glioma-induced neuronal remodeling promotes regional immunosuppression.
  Cancer Research 2023 Takahide Nejo, Saritha Krishna, Christian Jimenez, Akane Yamamichi, Jacob S. Young, Tiffany Chen, Senthilnath Lakshmanachetty, Payal Watchmaker, Abrar Choudhury, Hirokazu Ogino, David R. Raleigh, …
• Glioblastoma induces the recruitment and differentiation of hybrid neutrophils from skull bone marrow.
  bioRxiv : the preprint server for biology 2023 Lad BM, Beniwal AS, Jain S, Shukla P, Jung J, Shah SS, Yagnik G, Babikir H, Nguyen AT, Gill S, Young JS, Lui A, Salha D, Diaz A, Aghi MK
• Pseudoprogression versus true progression in glioblastoma: what neurosurgeons need to know.
  Journal of neurosurgery 2023 Young JS, Al-Adli N, Scotford K, Cha S, Berger MS
• CDKN2A/B co-deletion is associated with increased risk of local and distant intracranial recurrence after surgical resection of brain metastases.
  Neuro-oncology advances 2023 Morshed RA, Nguyen MP, Cummins DD, Saggi S, Young JS, Haddad AF, Goldschmidt E, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Hervey-Jumper SL, Daras M, Aghi MK
• Identification of risk factors associated with leptomeningeal disease after resection of brain metastases.
  Journal of neurosurgery 2023 Morshed RA, Saggi S, Cummins DD, Molinaro AM, Young JS, Viner JA, Villanueva-Meyer JE, Goldschmidt E, Boreta L, Braunstein SE, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Hervey-Jumper SL, …
• Interactive Effects of Molecular, Therapeutic, and Patient Factors on Outcome of Diffuse Low-Grade Glioma.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2023 Hervey-Jumper SL, Zhang Y, Phillips JJ, Morshed RA, Young JS, McCoy L, Lafontaine M, Luks T, Ammanuel S, Kakaizada S, Egladyous A, Gogos A, Villanueva-Meyer J, Shai A, Warrier G, Rice T, Crane J, …
• Recent advances in the molecular prognostication of meningiomas.
  Frontiers in oncology 2023 Wang EJ, Haddad AF, Young JS, Morshed RA, Wu JPH, Salha DM, Butowski N, Aghi MK
• Evaluation Of Surgical Resection for Recurrent Glioblastoma Using The RANO Classification For Extent Of Resection: A Report Of The RANO Resect Group.
  Brain and Spine 2023 Philipp Karschnia, Antonio Dono, Jacob S. Young, Stephanie T. Jünger, Nico Teske, Levin Häni, Tommaso Sciortino, Christine Y. Mau, Francesco Bruno, Michael Weller, Roberta Rudà, Michael A. Vogelbaum, …
• BIOM-02. MUTATIONAL ANALYSIS AND SINGLE CELL SEQUENCING OF MELANOMA BRAIN METASTASES REVEALS BRAF STATUS CORRELATES WITH CLINICAL OUTCOME AND DIFFERENTIAL IMMUNE POPULATIONS.
  Neuro-Oncology 2022 Harish Vasudevan, Cyrille Delley, Alexander Aabedi, Poojan Shukla, Minh Nguyen, Ramin A Morshed, Jacob S Young, Ben Demaree, Devan Diwanji, Shawn L Hervey-Jumper, Lauren Boreta, Shannon Fogh, Jean …
• CNSC-05. ELECTROPHYSIOLOGICAL PATTERNS OF GLIOMA-INDUCED NEURONAL NETWORK REMODELING ARE CONSERVED ACROSS TUMOR SUBTYPE.
  Neuro-Oncology 2022 Alexander Aabedi, Benjamin Lipkin, Jacob S Young, Leighton Hinkley, Anne Findlay, Andy Daniel, Saritha Krishna, Gray Umbach, Jasleen Kaur, Mitchel S Berger, Annette Molinaro, David Brang, Srikantan …
• CNSC-19. GLIOMA-INDUCED NEURONAL REMODELING PROMOTES REGIONAL IMMUNOSUPPRESSION.
  Neuro-Oncology 2022 Takahide Nejo, Saritha Krishna, Jacob S Young, Akane Yamamichi, Christian Jimenez, Tiffany Chen, Payal Watchmaker, Abrar Choudhury, David Diebold, Hirokazu Ogino, David Raleigh, Shawn L Hervey-Jumper,…
• SURG-04. CDK2NA/B, SMAD4, AND PIK3R1 MUTATIONS ARE ASSOCIATED WITH INCREASED RISK OF LOCAL RECURRENCE AFTER SURGICAL RESECTION OF BRAIN METASTASES.
  Neuro-Oncology 2022 Ramin A Morshed, Daniel Cummins, Minh Nguyen, Jacob S Young, Philip Theodospoulos, Shawn L Hervey-Jumper, Manish Aghi, Mariza Daras
• SURG-05. SUPERVISED MACHINE LEARNING IDENTIFIES RISK FACTORS ASSOCIATED WITH LEPTOMENINGEAL DISEASE AFTER SURGICAL RESECTION OF BRAIN METASTASES.
  Neuro-Oncology 2022 Ramin A Morshed, Satvir Saggi, Daniel Cummins, Jacob S Young, Jennifer Viner, Javier Villanueva-Meyer, Ezequiel Goldschmidt, Lauren Boreta, Steve Braunstein, Edward Chang, Michael McDermott, Mitchel S…
• Transsphenoidal Surgery for Acromegaly.
  Acromegaly 2022 Ryan R. L. Phelps, Jacob S. Young, José Gurrola, Manish K. Aghi
• Recognizing the psychological impact of a glioma diagnosis on mental and behavioral health: a systematic review of what neurosurgeons need to know.
  Journal of neurosurgery 2022 Young JS, Al-Adli N, Sibih YE, Scotford KL, Casey M, James S, Berger MS
• Mutational Analysis and Single Cell Sequencing of Melanoma Brain Metastases.
  International Journal of Radiation Oncology • Biology • Physics 2022 H. Vasudevan, C. Delley, A. Aabedi, M.P. Nguyen, R.A. Morshed, J.S. Young, B. Demaree, D. Diwanji, S. Hervey-Jumper, L. Boreta, S.E. Fogh, J.L. Nakamura, P.V. Theodosopoulos, J. Phillips, M. Daras, K.…
• Timing of Adjuvant Radiotherapy and Survival Analysis for Molecularly Defined Low Grade Glioma.
  International Journal of Radiation Oncology • Biology • Physics 2022 S.J. Liu, W.C. Chen, Y. Zhang, J.S. Young, R.A. Morshed, J. Villanueva-Meyer, J. Phillips, N.A. Oberheim, M.K. Aghi, P.K. Sneed, S.E. Braunstein, M.S. Berger, A.M. Molinaro, S. Hervey-Jumper, D. …
• Chronic convection-enhanced intratumoural delivery of chemotherapy for glioblastoma.
  The Lancet. Oncology 2022 Young JS, Aghi MK
• A case (report) for mechanistic validation of meningioma molecular therapies.
  Neuro-oncology advances 2022 Nguyen MP, Seo K, Eaton CD, Lucas CG, Chen WC, Choudhury A, Young JS, Raleigh DR
• Prospective genomically guided identification of "early/evolving" and "undersampled" IDH-wildtype glioblastoma leads to improved clinical outcomes.
  Neuro-oncology 2022 Zhang Y, Lucas CG, Young JS, Morshed RA, McCoy L, Oberheim Bush NA, Taylor JW, Daras M, Butowski NA, Villanueva-Meyer JE, Cha S, Wrensch M, Wiencke JK, Lee JC, Pekmezci M, Phillips JJ, Perry A, Bollen…
• TERT promotor status does not add prognostic information in IDH-wildtype glioblastomas fulfilling other diagnostic WHO criteria: A report of the RANO resect group.
  Neuro-oncology advances 2022 Karschnia P, Young JS, Dono A, Häni L, Juenger ST, Sciortino T, Bruno F, Teske N, Morshed RA, Haddad AF, Zhang Y, Stoecklein S, Vogelbaum MA, Beck J, Tandon N, Hervey-Jumper S, Molinaro AM, Rudà R, …
• OS07.6.A Extent of resection in glioblastoma: refinement and prognostic validation of a classification system from the RANO resect group.
  Neuro-Oncology 2022 P Karschnia, J S Young, A Dono, L Häni, T Sciortino, F Bruno, S T Jünger, N Teske, M Weller, R Rudà, L Bello, O Schnell, Y Esquenazi, S J Grau, A M Molinaro, M S Berger, S M Chang, M van den Bent, J …
• CDK 4/6 inhibitors for the treatment of meningioma.
  Frontiers in oncology 2022 Young JS, Kidwell RL, Zheng A, Haddad AF, Aghi MK, Raleigh DR, Schulte JD, Butowski NA
• Involvement of White Matter Language Tracts in Glioma: Clinical Implications, Operative Management, and Functional Recovery After Injury.
  Frontiers in neuroscience 2022 Aabedi AA, Young JS, Chang EF, Berger MS, Hervey-Jumper SL
• Machine learning for predicting hemorrhage in pediatric patients with brain arteriovenous malformation.
  Journal of neurosurgery. Pediatrics 2022 Saggi S, Winkler EA, Ammanuel SG, Morshed RA, Garcia JH, Young JS, Semonche A, Fullerton HJ, Kim H, Cooke DL, Hetts SW, Abla A, Lawton MT, Gupta N
• A targeted gene expression biomarker and association with meningioma outcomes and radiotherapy.
  Journal of Clinical Oncology 2022 William Cheng Chen, Abrar Choudhury, Harish Vasudevan, Calixto-Hope C. Lucas, Minh P. Nguyen, Jacob S Young, Theresa Yu, Jason Chan, Nancy Ann Oberheim Bush, Jessica Schulte, Javier Villanueva-Meyer, …
• Convection-delivered adenoviral gene therapy reprograms the immunosuppressive glioblastoma microenvironment.
  Journal of Clinical Oncology 2022 Jacob S Young, Nam Woo Cho, Ti Casey-Clyde, Raquel Santos, Kyounghee Seo, Joanna J. Phillips, Mitchel S. Berger, Tomoko Ozawa, David R. Raleigh
• Prognostic validation and refinement of a classification system for extent of resection in glioblastoma: A report of the RANO resect group.
  Journal of Clinical Oncology 2022 Philipp Karschnia, Jacob S Young, Antonio Dono, Levin Häni, Tommaso Sciortino, Francesco Bruno, Stefanie T. Jünger, Nico Teske, Michael Weller, Roberta Ruda, Lorenzo Bello, Oliver Schnell, Yoshua …
• Factors associated with preoperative and postoperative seizures in patients undergoing resection of brain metastases.
  Journal of neurosurgery 2022 Garcia JH, Morshed RA, Chung J, Millares Chavez MA, Sudhakar V, Saggi S, Avalos LN, Gallagher A, Young JS, Daras M, McDermott MW, Garcia PA, Chang EF, Aghi MK
• Pituitary adenoma in the elderly: surgical outcomes and treatment trends in the United States.
  Journal of neurosurgery 2022 Chalif EJ, Morshed RA, Young JS, Haddad AF, Jain S, Aghi MK
• FLAIRectomy: Resecting beyond the Contrast Margin for Glioblastoma.
  Brain sciences 2022 Haddad AF, Young JS, Morshed RA, Berger MS
• The benefit of early surgery on overall survival in incidental low-grade glioma patients: A multicenter study.
  Neuro-oncology 2022 Ius T, Ng S, Young JS, Tomasino B, Polano M, Ben-Israel D, Kelly JJP, Skrap M, Duffau H, Berger MS
• Surgery for Control of Brain Metastases After Previous Checkpoint Inhibitor Immunotherapy.
  World neurosurgery 2022 Morshed RA, Chung JE, Cummins DD, Sudhakar V, Young JS, Daras M, Hervey-Jumper SL, Theodosopoulos PV, Aghi MK
• Resistance to immune checkpoint blockade: Mechanisms, counter-acting approaches, and future directions.
  Seminars in cancer biology 2022 Haddad AF, Young JS, Gill S, Aghi MK
• Advanced Imaging Techniques for Newly Diagnosed and Recurrent Gliomas.
  Frontiers in neuroscience 2022 Carrete LR, Young JS, Cha S
• Sarcopenia Diagnosed Using Masseter Muscle Diameter as a Survival Correlate in Elderly Patients with Glioblastoma.
  World neurosurgery 2022 Morshed RA, Young JS, Casey M, Wang EJ, Aghi MK, Berger MS, Hervey-Jumper SL
• The immunology of low-grade gliomas.
  Neurosurgical focus 2022 Haddad AF, Young JS, Oh JY, Okada H, Aghi MK
• Association of Neurological Impairment on the Relative Benefit of Maximal Extent of Resection in Chemoradiation-Treated Newly Diagnosed Isocitrate Dehydrogenase Wild-Type Glioblastoma.
  Neurosurgery 2022 Aabedi AA, Young JS, Zhang Y, Ammanuel S, Morshed RA, Dalle Ore C, Brown D, Phillips JJ, Oberheim Bush NA, Taylor JW, Butowski N, Clarke J, Chang SM, Aghi M, Molinaro AM, Berger MS, Hervey-Jumper SL
• Reducing complication rates for repeat craniotomies in glioma patients: a single-surgeon experience and comparison with the literature.
  Acta neurochirurgica 2021 Morshed RA, Young JS, Gogos AJ, Haddad AF, McMahon JT, Molinaro AM, Sudhakar V, Al-Adli N, Hervey-Jumper SL, Berger MS
• Pseudo-insular glioma syndrome: illustrative cases.
  Journal of neurosurgery. Case lessons 2021 Haddad AF, Young JS, Morshed RA, Josephson SA, Cha S, Berger MS
• Functional outcomes after resection of middle frontal gyrus diffuse gliomas.
  Journal of neurosurgery 2021 Morshed RA, Lee AT, Wang EJ, Young JS, Cha S, Hervey-Jumper SL, Berger MS
• Functional alterations in cortical processing of speech in glioma-infiltrated cortex.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Aabedi AA, Lipkin B, Kaur J, Kakaizada S, Valdivia C, Reihl S, Young JS, Lee AT, Krishna S, Berger MS, Chang EF, Brang D, Hervey-Jumper SL
• Comparing the Quality of Life after Brain Injury-Overall Scale and Satisfaction with Life Scale as Outcome Measures for Traumatic Brain Injury Research.
  Journal of neurotrauma 2021 Kreitzer N, Jain S, Young JS, Sun X, Stein MB, McCrea MA, Levin HS, Giacino JT, Markowitz AJ, Manley GT, Nelson LD, Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) …
• Facial pain and sensory outcomes following resection of tumors compressing the trigeminal nerve.
  Journal of neurosurgery 2021 Castro MRH, Magill ST, Morshed RA, Young JS, Braunstein SE, McDermott MW, Chang EF
• Resection of supplementary motor area gliomas: revisiting supplementary motor syndrome and the role of the frontal aslant tract.
  Journal of neurosurgery 2021 Young JS, Gogos AJ, Aabedi AA, Morshed RA, Pereira MP, Lashof-Regas S, Mansoori Z, Luks T, Hervey-Jumper SL, Villanueva-Meyer JE, Berger MS
• Comparison of Outcomes following Primary and Repeat Resection of Craniopharyngioma.
  Journal of neurological surgery. Part B, Skull base 2021 Aabedi AA, Young JS, Phelps RRL, Winkler EA, McDermott MW, Theodosopoulos PV
• Prosopagnosia following nonlanguage dominant inferior temporal lobe low-grade glioma resection in which the inferior longitudinal fasciculus was disrupted preoperatively: illustrative case.
  Journal of neurosurgery. Case lessons 2021 Young JS, Morshed RA, Andrews JP, Cha S, Berger MS
• A Review of Cortical and Subcortical Stimulation Mapping for Language.
  Neurosurgery 2021 Young JS, Lee AT, Chang EF
• Mouse models of glioblastoma for the evaluation of novel therapeutic strategies.
  Neuro-oncology advances 2021 Haddad AF, Young JS, Amara D, Berger MS, Raleigh DR, Aghi MK, Butowski NA
• Clinical Pearls and Methods for Intraoperative Awake Language Mapping.
  Neurosurgery 2021 Morshed RA, Young JS, Lee AT, Berger MS, Hervey-Jumper SL
• A Neurosurgeon's Guide to Cognitive Dysfunction in Adult Glioma.
  Neurosurgery 2021 Morshed RA, Young JS, Kroliczek AA, Berger MS, Brang D, Hervey-Jumper SL
• A single institution retrospective analysis on survival based on treatment paradigms for patients with anaplastic oligodendroglioma.
  Journal of neuro-oncology 2021 Bush NAO, Young JS, Zhang Y, Dalle Ore CL, Molinaro AM, Taylor J, Clarke J, Prados M, Braunstein SE, Raleigh DR, Chang SM, Berger MS, Butowski NA
• Detection of glioma infiltration at the tumor margin using quantitative stimulated Raman scattering histology.
  Scientific reports 2021 Pekmezci M, Morshed RA, Chunduru P, Pandian B, Young J, Villanueva-Meyer JE, Tihan T, Sloan EA, Aghi MK, Molinaro AM, Berger MS, Hervey-Jumper SL
• Balancing task sensitivity with reliability for multimodal language assessments.
  Journal of neurosurgery 2021 Aabedi AA, Kakaizada S, Young JS, Ahn E, Weissman DH, Berger MS, Brang D, Hervey-Jumper SL
• Oncology and Spinal Neurosurgeons Performing Resections of Intramedullary Ependymomas Compared with Single Neurosurgeons: A 13-Year Experience at a Single Institution.
  World neurosurgery 2021 Nichols NM, Young JS, Magill ST, Morshed RA, Aabedi AA, Chou D, Mummaneni PV, McDermott MW, Theodosopoulos PV
• Letter: COVID Conundrum: Postoperative COVID-19 Infections Following Endonasal Transsphenoidal Pituitary Surgery.
  Neurosurgery 2021 Young JS, Oh T, Arora T, Blevins LS, Aghi MK, El-Sayed IH, Kunwar S, Theodosopoulos PV
• The Relationship Between Stimulation Current and Functional Site Localization During Brain Mapping.
  Neurosurgery 2021 Muster RH, Young JS, Woo PYM, Morshed RA, Warrier G, Kakaizada S, Molinaro AM, Berger MS, Hervey-Jumper SL
• Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex.
  Scientific reports 2021 Aabedi AA, Kakaizada S, Young JS, Kaur J, Wiese O, Valdivia C, Krishna S, Weyer-Jamora C, Berger MS, Weissman DH, Brang D, Hervey-Jumper SL
• Commentary: Planning Brain Tumor Resection Using a Probabilistic Atlas of Cortical and Subcortical Structures Critical for Functional Processing: A Proof of Concept.
  Operative neurosurgery (Hagerstown, Md.) 2021 Morshed RA, Young JS, Hervey-Jumper SL
• Using viral vectors to deliver local immunotherapy to glioblastoma.
  Neurosurgical focus 2021 Haddad AF, Young JS, Aghi MK
• Preoperative Applications of Navigated Transcranial Magnetic Stimulation.
  Frontiers in neurology 2021 Haddad AF, Young JS, Berger MS, Tarapore PE
• Effects of ventricular entry on patient outcome during glioblastoma resection.
  Journal of neurosurgery 2021 Young JS, Gogos AJ, Pereira MP, Morshed RA, Li J, Barkovich MJ, Hervey-Jumper SL, Berger MS
• Immunologic aspects of viral therapy for glioblastoma and implications for interactions with immunotherapies.
  Journal of neuro-oncology 2021 Haddad AF, Young JS, Mummaneni NV, Kasahara N, Aghi MK
• Effects of Ventricular Entry During Glioblastoma Resection on Tumor Spread and Survival.
  Neurosurgery 2020 Jacob S Young, Andrew J Gogos, Matheus Pereira, Ramin Morshed, Matthew Barkovich, Jing Li, Shawn L Hervey-Jumper, Mitchel S Berger
• Functional Neurologic and Surgical Outcomes Among Patients Undergoing Reoperation for Craniopharyngioma Recurrence.
  Neurosurgery 2020 Alexander A Aabedi, Jacob S Young, Ryan R.L Phelps, Ethan A Winkler, Philip V Theodosopoulos
• Local Delivery of a Novel Combination Immunotherapy Increases T Cell Infiltration and Significantly Improves Survival in a Poorly Immunogenic Model of Glioblastoma.
  Neurosurgery 2020 Alexander F Haddad, Jordan Spatz, Sara Collins, Matheus P Pereira, Sabraj Gill, Megan Montoya, Pavlina Chuntova, Jacob S Young, Nikhil Mummaneni, Noriyuki Kasahara, Manish K Aghi
• Outcomes After Surgical Resection of Melanoma Brain Metastases in the Age of Checkpoint Inhibitor Treatment.
  Neurosurgery 2020 Ramin Morshed, Ramin A Morshed, Jason Chung, Vivek Sudhakar, Daniel Cummins, Jacob S Young, Mariza Daras, Manish K Aghi
• The Glioma-Network Interface: A Review of the Relationship Between Glioma Molecular Subtype and Intratumoral Function.
  Neurosurgery 2020 Young JS, Morshed RA, Gogos AJ, Amara D, Villanueva-Meyer JE, Berger MS, Hervey-Jumper SL
• Functional Mapping for Glioma Surgery, Part 2: Intraoperative Mapping Tools.
  Neurosurgery clinics of North America 2020 Morshed RA, Young JS, Lee AT, Hervey-Jumper SL
• Achieving efficacious immunotherapy for patients with glioblastoma.
  Expert review of anticancer therapy 2020 Young JS
• Surgical management of incidentally discovered low-grade gliomas.
  Journal of neurosurgery 2020 Gogos AJ, Young JS, Pereira MP, Morshed RA, Potts MB, Hervey-Jumper SL, Berger MS
• WHO Grade I Meningioma Recurrence: Identifying High Risk Patients Using Histopathological Features and the MIB-1 Index.
  Frontiers in oncology 2020 Haddad AF, Young JS, Kanungo I, Sudhir S, Chen JS, Raleigh DR, Magill ST, McDermott MW, Aghi MK
• Intraoperative Stereotactic Frame Registration Using a Three-Dimensional Imaging System with and without Preoperative Computed Tomography for Image Fusion.
  Stereotactic and functional neurosurgery 2020 Spatz JM, Conner AK, Young JS, Starr PA
• Triple motor mapping: transcranial, bipolar, and monopolar mapping for supratentorial glioma resection adjacent to motor pathways.
  Journal of neurosurgery 2020 Gogos AJ, Young JS, Morshed RA, Avalos LN, Noss RS, Villanueva-Meyer JE, Hervey-Jumper SL, Berger MS
• Abstract A056: A study of race and socioeconomic status impacting therapeutic clinical trial enrollment in adult gliomas patients.
  Cancer Epidemiology Biomarkers & Prevention 2020 Sheantel J Reihl, Ramin A Morshed, Sofia Kakaizada, Eric Zhang, Jacob S Young, Jennifer Clarke, Nicholas Butowski, Jennie Taylor, Nancy Ann Bush, Manish K Aghi, Mitchel S Berger, Susan Chang, Shawn L …
• Clinical characteristics and outcomes of null-cell versus silent gonadotroph adenomas in a series of 1166 pituitary adenomas from a single institution.
  Neurosurgical focus 2020 Haddad AF, Young JS, Oh T, Pereira MP, Joshi RS, Pereira KM, Osorio RC, Donohue KC, Peeran Z, Sudhir S, Jain S, Beniwal A, Chopra AS, Sandhu NS, Theodosopoulos PV, Kunwar S, El-Sayed IH, Gurrola J, …
• Molecular characteristics of diffuse lower grade gliomas: what neurosurgeons need to know.
  Acta neurochirurgica 2020 Young JS, Gogos AJ, Morshed RA, Hervey-Jumper SL, Berger MS
• A Safe Transitions Pathway for post-craniotomy neurological surgery patients: high-value care that bypasses the intensive care unit.
  Journal of neurosurgery 2020 Young JS, Chan AK, Viner JA, Sankaran S, Chan AY, Imershein S, Meary-Miller A, Theodosopoulos PV, Jacques L, Aghi MK, Chang EF, Hervey-Jumper SL, Ward T, Gibson L, Ward MM, Sanftner P, Wong S, Amara D…
• The influence of race and socioeconomic status on therapeutic clinical trial screening and enrollment.
  Journal of neuro-oncology 2020 Morshed RA, Reihl SJ, Molinaro AM, Kakaizada S, Young JS, Schulte JD, Butowski N, Taylor J, Bush NA, Aghi MK, Berger MS, Chang S, Clarke J, Hervey-Jumper SL
• Awake glioma surgery: technical evolution and nuances.
  Journal of neuro-oncology 2020 Gogos AJ, Young JS, Morshed RA, Hervey-Jumper SL, Berger MS
• The impact of high functional connectivity network hub resection on language task performance in adult low- and high-grade glioma.
  Journal of neurosurgery 2020 Lee AT, Faltermeier C, Morshed RA, Young JS, Kakaizada S, Valdivia C, Findlay AM, Tarapore PE, Nagarajan SS, Hervey-Jumper SL, Berger MS
• Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma.
  JAMA oncology 2020 Molinaro AM, Hervey-Jumper S, Morshed RA, Young J, Han SJ, Chunduru P, Zhang Y, Phillips JJ, Shai A, Lafontaine M, Crane J, Chandra A, Flanigan P, Jahangiri A, Cioffi G, Ostrom Q, Anderson JE, Badve C…
• Mesolimbic dopamine D2 receptors and neural representations of subjective value.
  Scientific reports 2019 Castrellon JJ, Young JS, Dang LC, Cowan RL, Zald DH, Samanez-Larkin GR
• Disruption of Frontal Aslant Tract Is Not Associated with Long-Term Postoperative Language Deficits.
  World neurosurgery 2019 Young JS, Morshed RA, Mansoori Z, Cha S, Berger MS
• Safe Transitions Pathway for Postcraniotomy Neurological Surgery Patients: High-Value Care That Bypasses the Intensive Care Unit.
  Neurosurgery 2019 Jacob S Young, Andrew Kai-Hong Chan, Jennifer Viner, Sujatha Sankaran, Alvin Y Chan, Dominic Amara, Stephen T Magill, Joseph A Osorio, Lizbeth Gibson, Peter Sanftner, Mariann Ward, Tracy Ward, Stacy …
• Management of Noncatastrophic Internal Carotid Artery Injury in Endoscopic Skull Base Surgery.
  Cureus 2019 Safaee M, Young JS, El-Sayed IH, Theodosopoulos PV
• Insurance type impacts the economic burden and survival of patients with newly diagnosed glioblastoma.
  Journal of neurosurgery 2019 Chandra A, Young JS, Dalle Ore C, Dayani F, Lau D, Wadhwa H, Rick JW, Nguyen AT, McDermott MW, Berger MS, Aghi MK
• Assessment of wakefulness during awake craniotomy to predict intraoperative language performance.
  Journal of neurosurgery 2019 Aabedi AA, Ahn E, Kakaizada S, Valdivia C, Young JS, Hervey-Jumper H, Zhang E, Sagher O, Weissman DH, Brang D, Hervey-Jumper SL
• The management of low-grade gliomas in adults.
  Journal of neurosurgical sciences 2019 Morshed RA, Young JS, Hervey-Jumper SL, Berger MS
• Delirium Risk Factors and Associated Outcomes in a Neurosurgical Cohort: A Case-Control Study.
  World neurosurgery 2019 Morshed RA, Young JS, Safaee M, Sankaran S, Berger MS, McDermott MW, Hervey-Jumper SL
• The transcortical equatorial approach for gliomas of the mesial temporal lobe: techniques and functional outcomes.
  Journal of neurosurgery 2019 Morshed RA, Young JS, Han SJ, Hervey-Jumper SL, Berger MS
• Immunotherapy for High-Grade Gliomas: A Clinical Update and Practical Considerations for Neurosurgeons.
  World neurosurgery 2019 Young JS, Dayani F, Morshed RA, Okada H, Aghi MK
• Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Castrellon JJ, Seaman KL, Crawford JL, Young JS, Smith CT, Dang LC, Hsu M, Cowan RL, Zald DH, Samanez-Larkin GR
• A Dendritic Cell-Targeted Adenoviral Vector Facilitates Adaptive Immune Response Against Human Glioma Antigen (CMV-IE) and Prolongs Survival in a Human Glioma Tumor Model.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2018 Kim JW, Kane JR, Panek WK, Young JS, Rashidi A, Yu D, Kanojia D, Hasan T, Miska J, Gómez-Lim MA, Ulasov IV, Balyasnikova IV, Ahmed AU, Wainwright DA, Lesniak MS
• Perioperative outcomes following reoperation for recurrent insular gliomas.
  Journal of neurosurgery 2018 Morshed RA, Young JS, Han SJ, Hervey-Jumper SL, Berger MS
• Using genomics to guide treatment for glioblastoma.
  Pharmacogenomics 2018 Young JS, Prados MD, Butowski N
• Gene Therapy and Virotherapy of Gliomas.
  Progress in neurological surgery 2018 Kim JW, Chang AL, Kane JR, Young JS, Qiao J, Lesniak MS
• Convection-Enhanced Delivery of Polymeric Nanoparticles Encapsulating Chemotherapy in Canines with Spontaneous Supratentorial Tumors.
  World neurosurgery 2018 Young JS, Bernal G, Polster SP, Nunez L, Larsen GF, Mansour N, Podell M, Yamini B
• Sharpening the Surgeon's Knife: Value of Extent of Resection for Glioma in Molecular Age.
  World neurosurgery 2018 Morshed RA, Young JS, Hervey-Jumper SL
• Safety and outcomes of resection of butterfly glioblastoma.
  Neurosurgical focus 2018 Dayani F, Young JS, Bonte A, Chang EF, Theodosopoulos P, McDermott MW, Berger MS, Aghi MK
• Relationship between tumor location, size, and WHO grade in meningioma.
  Neurosurgical focus 2018 Magill ST, Young JS, Chae R, Aghi MK, Theodosopoulos PV, McDermott MW
• Chapter 15 Gene/Viral Treatment Approaches for Malignant Brain Cancer.
  Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy 2018 Julius W. Kim, Katarzyna C. Pituch, Annie Xiao, Jacob S. Young, Wojciech K. Panek, Megan E. Muroski, Aida Rashidi, J. Robert Kane, Deepak Kanojia, Maciej S. Lesniak
• Large-Scale Network Coupling with the Fusiform Cortex Facilitates Future Social Motivation.
  eNeuro 2017 Utevsky AV, Smith DV, Young JS, Huettel SA
• Hitting the nail on the head: combining oncolytic adenovirus-mediated virotherapy and immunomodulation for the treatment of glioma.
  Oncotarget 2017 Panek WK, Kane JR, Young JS, Rashidi A, Kim JW, Kanojia D, Lesniak MS
• Management of glioblastoma in elderly patients.
  Journal of the neurological sciences 2017 Young JS, Chmura SJ, Wainwright DA, Yamini B, Peters KB, Lukas RV
• A Comparative Study of Replication-Incompetent and -Competent Adenoviral Therapy-Mediated Immune Response in a Murine Glioma Model.
  Molecular therapy oncolytics 2017 Kim JW, Miska J, Young JS, Rashidi A, Kane JR, Panek WK, Kanojia D, Han Y, Balyasnikova IV, Lesniak MS
• P08.46 Synergistic Therapeutic Efficacy via Immunomodulatory Platelet Rich Fibrin Patch (PRF-P) in Combination with Oncolytic Adenovirus for the Treatment of Glioma.
  Neuro-Oncology 2017 W. K. Panek, Julius W. Kim, Katarzyna C. Pituch, Joshua R. Kane, Deepak Kanojia, Alex Cordero, Jason Miska, Aida Rashidi, Jacob S. Young, Maciej S. Lesniak
• 19 All Aboard Mesenchymal Stem/Stromal Cells as Cell Carriers for Virotherapy.
  Mesenchymal Stromal Cells as Tumor Stromal Modulators 2017 J.W. Kim, J. Murphy, A.L. Chang, D.A. Spencer, J.R. Kane, D. Kanojia, A. Rashidi, J.S. Young, M.S. Lesniak
• The Impact of Traumatic Brain Injury on the Aging Brain.
  Current psychiatry reports 2016 Young JS, Hobbs JG, Bailes JE
• Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters.
  Journal of translational medicine 2016 Kim JW, Auffinger B, Spencer DA, Miska J, Chang AL, Kane JR, Young JS, Kanojia D, Qiao J, Mann JF, Zhang L, Wu M, Ahmed AU, Aboody KS, Strong TV, Hébert CD, Lesniak MS
• Sports-related concussions: diagnosis, complications, and current management strategies.
  Neurosurgical focus 2016 Hobbs JG, Young JS, Bailes JE
• A novel single-chain antibody redirects adenovirus to IL13Rα2-expressing brain tumors.
  Scientific reports 2015 Kim JW, Young JS, Solomaha E, Kanojia D, Lesniak MS, Balyasnikova IV
• ATPS-41DENDRITIC CELL BASED IMMUNOTHERAPY OF MALIGNANT GLIOMA VIA A NOVEL CD8a+ DC TARGETED ADENOVIRAL VECTOR.
  Neuro-Oncology 2015 Julius W. Kim, J. Robert Kane, Jacob S. Young, Dou Yu, Jason Miska, Alan L. Chang, Aida Rashidi, Atique Ahmed, Irina Balyasnikova, Maciej S. Lesniak
• A Genetically Modified Adenoviral Vector with a Phage Display-Derived Peptide Incorporated into Fiber Fibritin Chimera Prolongs Survival in Experimental Glioma.
  Human gene therapy 2015 Kim JW, Kane JR, Young JS, Chang AL, Kanojia D, Morshed RA, Miska J, Ahmed AU, Balyasnikova IV, Han Y, Zhang L, Curiel DT, Lesniak MS
• 22. A Novel Single-Chain Antibody for Selective Targeting of IL13Ra2-Expressing Brain Tumors.
  Molecular Therapy 2015 Julius W. Kim, Jacob S. Young, Maciej S. Lesniak, Irina V. Balyasnikova
• Neural stem cell-mediated delivery of oncolytic adenovirus.
  Current protocols in human genetics 2015 Kim JW, Kane JR, Young JS, Chang AL, Kanojia D, Qian S, Spencer DA, Ahmed AU, Lesniak MS
• Synchrony between sensory and cognitive networks is associated with subclinical variation in autistic traits.
  Frontiers in human neuroscience 2015 Young JS, Smith DV, Coutlee CG, Huettel SA
• Sui generis: gene therapy and delivery systems for the treatment of glioblastoma.
  Neuro-oncology 2015 Kane JR, Miska J, Young JS, Kanojia D, Kim JW, Lesniak MS
• Unlocking the promise of oncolytic virotherapy in glioma: combination with chemotherapy to enhance efficacy.
  Therapeutic delivery 2015 Spencer DA, Young JS, Kanojia D, Kim JW, Polster SP, Murphy JP, Lesniak MS
• ET-29AN OPTIMIZED ONCOLYTIC ADENOVIRUS FOR GLIOMA THERAPY: SPECIFIC TARGETING, EFFICIENT INFECTION, AND RESTRICTED REPLICATION IN GLIOMA.
  Neuro-Oncology 2014 Julius W. Kim, J. Robert Kane, Jacob S. Young, Ramin A. Morshed, Alan A. Chang, Atique U. Ahmed, Irina V. Balyasnikova, Maciej S. Lesniak
• Caudate asymmetry is related to attentional impulsivity and an objective measure of ADHD-like attentional problems in healthy adults.
  Brain structure & function 2014 Dang LC, Samanez-Larkin GR, Young JS, Cowan RL, Kessler RM, Zald DH
• Advances in stem cells, induced pluripotent stem cells, and engineered cells: delivery vehicles for anti-glioma therapy.
  Expert opinion on drug delivery 2014 Young JS, Morshed RA, Kim JW, Balyasnikova IV, Ahmed AU, Lesniak MS
• Therapeutic cell carriers: a potential road to cure glioma.
  Expert review of neurotherapeutics 2014 Young JS, Kim JW, Ahmed AU, Lesniak MS
• Radiation Dosimetry of (18)F-FPEB in Humans.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2014 Kessler RM, Seibyl J, Cowan RL, Zald D, Young JS, Ansari MS, Stabin MG