Jacob McPhail, PhD
Professional Researcher
Institute for Neurodegenerative Diseases
School of Medicine

Publications (16)

Top publication keywords:
Parasitic DiseasesEnterovirusVirus DiseasesViral ProteinsProtein BindingAdaptor Proteins, Signal TransducingVirus ReplicationKobuvirusPhosphatidylinositol 3-KinasesDeuterium Exchange Measurementrab GTP-Binding ProteinsPhosphotransferases (Alcohol Group Acceptor)1-Phosphatidylinositol 4-KinaseImmune System DiseasesPhosphatidylinositols

• Microglia internalize tau monomers and fibrils using distinct receptors but similar mechanisms.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Falkon KF, Danford L, Gutierrez Kuri E, Esquinca-Moreno P, Peña Señeriz YL, Smith S, Wickline JL, Louwrier A, McPhail JA, Sayre NL, Hopp SC
• Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates.
  Science advances 2023 Saleeb RS, Leighton C, Lee JE, O'Shaughnessy J, Jeacock K, Chappard A, Cumberland R, Zhao T, Ball SR, Sunde M, Clarke DJ, Piché K, McPhail JA, Louwrier A, Angers R, Gandhi S, Downey P, Kunath T, …
• Molecular mechanisms of PI4K regulation and their involvement in viral replication.
  Traffic (Copenhagen, Denmark) 2022 McPhail JA, Burke JE
• Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα.
  Journal of the American Chemical Society 2022 Borsari C, Keles E, McPhail JA, Schaefer A, Sriramaratnam R, Goch W, Schaefer T, De Pascale M, Bal W, Gstaiger M, Burke JE, Wymann MP
• Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors.
  ACS infectious diseases 2020 Fienberg S, Eyermann CJ, Arendse LB, Basarab GS, McPhail JA, Burke JE, Chibale K

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• Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections.
  Advances in experimental medicine and biology 2020 McPhail JA, Burke JE
• Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication.
  EMBO reports 2019 McPhail JA, Lyoo H, Pemberton JG, Hoffmann RM, van Elst W, Strating JRPM, Jenkins ML, Stariha JTB, Powell CJ, Boulanger MJ, Balla T, van Kuppeveld FJM, Burke JE
• (S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase.
  Journal of medicinal chemistry 2019 Rageot D, Bohnacker T, Keles E, McPhail JA, Hoffmann RM, Melone A, Borsari C, Sriramaratnam R, Sele AM, Beaufils F, Hebeisen P, Fabbro D, Hillmann P, Burke JE, Wymann MP
• Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
  Antimicrobial agents and chemotherapy 2018 Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Gonzàlez Cabrera D, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini…
• Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.
  Nature communications 2018 Jenkins ML, Margaria JP, Stariha JTB, Hoffmann RM, McPhail JA, Hamelin DJ, Boulanger MJ, Hirsch E, Burke JE
• UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
  Antimicrobial agents and chemotherapy 2018 Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Cabrera DG, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, …
• The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIβ, PI4KB, through ACBD3.
  Structure (London, England : 1993) 2016 McPhail JA, Ottosen EH, Jenkins ML, Burke JE
• Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.
  Nature 2016 Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan GL, Duffy S, Eckley S, Itoe MA, Koolen KM, Lewis TA, Lui PS…
• Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ.
  Journal of medicinal chemistry 2016 Rutaganira FU, Fowler ML, McPhail JA, Gelman MA, Nguyen K, Xiong A, Dornan GL, Tavshanjian B, Glenn JS, Shokat KM, Burke JE
• Type III phosphatidylinositol 4 kinases: structure, function, regulation, signalling and involvement in disease.
  Biochemical Society transactions 2016 Dornan GL, McPhail JA, Burke JE
• Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11.
  Protein science : a publication of the Protein Society 2016 Fowler ML, McPhail JA, Jenkins ML, Masson GR, Rutaganira FU, Shokat KM, Williams RL, Burke JE