Jacob Ayers, PhD
Associate Professor
Institute for Neurodegenerative Diseases
School of Medicine

Publications (37)

Top publication keywords:
Amyotrophic Lateral SclerosisInclusion BodiesPrion DiseasesPrion ProteinsMotor Neuron DiseaseMultiple System AtrophySuperoxide DismutaseSuperoxide Dismutase-1Prionsalpha-SynucleinProtein FoldingLewy Body DiseaseProteostasis DeficienciesProtein Aggregation, PathologicalSpinal Cord

• Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice.
  Viruses 2023 Ayers JI, Xu G, Lu Q, Dillon K, Fromholt S, Borchelt DR
• Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Condello C, Ayers JI, Dalgard CL, Garcia Garcia MM, Rivera BM, Seeley WW, Perl DP, Prusiner SB
• Trans-channel fluorescence learning improves high-content screening for Alzheimer's disease therapeutics.
  Nature machine intelligence 2022 Wong DR, Conrad J, Johnson N, Ayers J, Laeremans A, Lee JC, Lee J, Prusiner SB, Bandyopadhyay S, Butte AJ, Paras NA, Keiser MJ
• Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Ayers JI, Lee J, Monteiro O, Woerman AL, Lazar AA, Condello C, Paras NA, Prusiner SB
• Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence.
  Acta neuropathologica communications 2021 Ayers JI, Xu G, Dillon K, Lu Q, Chen Z, Beckman J, Moreno-Romero AK, Zamora DL, Galaleldeen A, Borchelt DR

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• Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components.
  Neuron 2021 Lester E, Ooi FK, Bakkar N, Ayers J, Woerman AL, Wheeler J, Bowser R, Carlson GA, Prusiner SB, Parker R
• Novel SOD1 monoclonal antibodies against the electrostatic loop preferentially detect misfolded SOD1 aggregates.
  Neuroscience letters 2020 Xia Y, Chen Z, Xu G, Borchelt DR, Ayers JI, Giasson BI
• Phenotypic diversity in ALS and the role of poly-conformational protein misfolding.
  Acta neuropathologica 2020 Ayers JI, Borchelt DR
• Expanding spectrum of prion diseases.
  Emerging topics in life sciences 2020 Ayers JI, Paras NA, Prusiner SB
• Prion protein - mediator of toxicity in multiple proteinopathies.
  Nature reviews. Neurology 2020 Ayers JI, Prusiner SB
• Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection.
  PloS one 2020 Crown A, McAlary L, Fagerli E, Brown H, Yerbury JJ, Galaleldeen A, Cashman NR, Borchelt DR, Ayers JI
• ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons.
  iScience 2019 Osking Z, Ayers JI, Hildebrandt R, Skruber K, Brown H, Ryu D, Eukovich AR, Golde TE, Borchelt DR, Read TA, Vitriol EA
• Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis.
  G3 (Bethesda, Md.) 2019 Crown AM, Roberts BL, Crosby K, Brown H, Ayers JI, Hart PJ, Borchelt DR
• ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons.
  iScience 2018 Osking Z, Ayers JI, Hildebrandt R, Skruber K, Brown H, Ryu D, Eukovich AR, Golde TE, Borchelt DR, Read TA, Vitriol EA
• Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models.
  PloS one 2018 Crosby K, Crown AM, Roberts BL, Brown H, Ayers JI, Borchelt DR
• Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts.
  Journal of virology 2018 Ayers JI, Riffe CJ, Sorrentino ZA, Diamond J, Fagerli E, Brooks M, Galaleldeen A, Hart PJ, Giasson BI
• Adsorption and decontamination of α-synuclein from medically and environmentally-relevant surfaces.
  Colloids and surfaces. B, Biointerfaces 2018 Phan HTM, Bartz JC, Ayers J, Giasson BI, Schubert M, Rodenhausen KB, Kananizadeh N, Li Y, Bartelt-Hunt SL
• Prion-like mechanisms in amyotrophic lateral sclerosis.
  Handbook of clinical neurology 2018 Ayers JI, Cashman NR
• Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding.
  The Journal of biological chemistry 2017 Rasouli S, Abdolvahabi A, Croom CM, Plewman DL, Shi Y, Ayers JI, Shaw BF
• Prion-like Spreading in Tauopathies.
  Biological psychiatry 2017 Ayers JI, Giasson BI, Borchelt DR
• Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils.
  Journal of virology 2017 Ayers JI, Brooks MM, Rutherford NJ, Howard JK, Sorrentino ZA, Riffe CJ, Giasson BI
• Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models.
  Journal of neurochemistry 2016 Ayers JI, McMahon B, Gill S, Lelie HL, Fromholt S, Brown H, Valentine JS, Whitelegge JP, Borchelt DR
• Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS.
  Acta neuropathologica 2016 Ayers JI, Diamond J, Sari A, Fromholt S, Galaleldeen A, Ostrow LW, Glass JD, Hart PJ, Borchelt DR
• Specificity, Size, and Frequency of Spaces That Characterize the Mechanism of Bulk Transepithelial Transport of Prions in the Nasal Cavities of Hamsters and Mice.
  Journal of virology 2016 Kincaid AE, Ayers JI, Bartz JC
• Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways.
  Acta neuropathologica 2015 Ayers JI, Fromholt SE, O'Neal VM, Diamond JH, Borchelt DR
• Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology.
  Acta neuropathologica 2015 Sacino AN, Ayers JI, Brooks MM, Chakrabarty P, Hudson VJ, Howard JK, Golde TE, Giasson BI, Borchelt DR
• Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation.
  Journal of neurochemistry 2015 Xu G, Fromholt S, Ayers JI, Brown H, Siemienski Z, Crosby KW, Mayer CA, Janus C, Borchelt DR
• Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice.
  Human molecular genetics 2014 Xu G, Ayers JI, Roberts BL, Brown H, Fromholt S, Green C, Borchelt DR
• Experimental transmissibility of mutant SOD1 motor neuron disease.
  Acta neuropathologica 2014 Ayers JI, Fromholt S, Koch M, DeBosier A, McMahon B, Xu G, Borchelt DR
• Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.
  Molecular therapy : the journal of the American Society of Gene Therapy 2014 Ayers JI, Fromholt S, Sinyavskaya O, Siemienski Z, Rosario AM, Li A, Crosby KW, Cruz PE, DiNunno NM, Janus C, Ceballos-Diaz C, Borchelt DR, Golde TE, Chakrabarty P, Levites Y
• Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Sacino AN, Brooks M, Thomas MA, McKinney AB, Lee S, Regenhardt RW, McGarvey NH, Ayers JI, Notterpek L, Borchelt DR, Golde TE, Giasson BI
• Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases.
  Acta neuropathologica communications 2014 Ayers JI, Xu G, Pletnikova O, Troncoso JC, Hart PJ, Borchelt DR
• Distinctive features of the D101N and D101G variants of superoxide dismutase 1; two mutations that produce rapidly progressing motor neuron disease.
  Journal of neurochemistry 2013 Ayers J, Lelie H, Workman A, Prudencio M, Brown H, Fromholt S, Valentine J, Whitelegge J, Borchelt D
• The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease.
  PLoS pathogens 2011 Ayers JI, Schutt CR, Shikiya RA, Aguzzi A, Kincaid AE, Bartz JC
• Coinfecting prion strains compete for a limiting cellular resource.
  Journal of virology 2010 Shikiya RA, Ayers JI, Schutt CR, Kincaid AE, Bartz JC
• Prion strain targeting independent of strain-specific neuronal tropism.
  Journal of virology 2008 Ayers JI, Kincaid AE, Bartz JC
• Prion interference is due to a reduction in strain-specific PrPSc levels.
  Journal of virology 2006 Bartz JC, Kramer ML, Sheehan MH, Hutter JA, Ayers JI, Bessen RA, Kincaid AE