Jack Taunton, PhD
Professor
Cellular Molecular Pharmacology
School of Medicine

Websites

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• Welcome to the Taunton Lab! (tauntonlab.ucsf.edu)

Publications (105)

Top publication keywords:
AldehydesSEC Translocation ChannelsEukaryotic Initiation Factor-4ECysteineRibosomal Protein S6 Kinases, 90-kDaWiskott-Aldrich Syndrome Protein, NeuronalPeptide Elongation Factor 1Hydrogen BondingPeptides, CyclicSulfinic AcidsProtein KinasesProtein Sorting SignalsLysineProtein Kinase InhibitorsMolecular Probes

• Benzoxaboroles Are Structurally Unique Binders of Eukaryotic Translation Initiation Factor 4E.
  Journal of the American Chemical Society 2026 Combs JB, Peacock DM, Craven GB, Jung S, Chen Y, Le SM, Taunton J, Shokat KM
• Preclinical characterization of novel multi-client inhibitors of Sec61 with broad antitumor activity.
  The Journal of pharmacology and experimental therapeutics 2025 Lowe E, Anderl JL, Bade D, Delgado-Martin C, Dong C, Fan RA, Fang Y, Jiang J, Johnson HWB, Kempema A, McGilvray P, McMinn D, Millare B, Muchamuel T, Poweleit N, Qian Y, Rehan S, Scapin G, Sugahara A, …
• Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation.
  Nature 2024 Craven GB, Chu H, Sun JD, Carelli JD, Coyne B, Chen H, Chen Y, Ma X, Das S, Kong W, Zajdlik AD, Yang KS, Reisberg SH, Thompson PA, Lipford JR, Taunton J
• Aminomethyl Salicylaldehydes Lock onto a Surface Lysine by Forming an Extended Intramolecular Hydrogen Bond Network.
  Journal of the American Chemical Society 2024 Weaver J, Craven GB, Tram L, Chen H, Taunton J
• Global signal peptide profiling reveals principles of selective Sec61 inhibition.
  Nature chemical biology 2024 Wenzell NA, Tuch BB, McMinn DL, Lyons MJ, Kirk CJ, Taunton J

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• Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors.
  Protein science : a publication of the Protein Society 2023 Fink EA, Bardine C, Gahbauer S, Singh I, Detomasi TC, White K, Gu S, Wan X, Chen J, Ary B, Glenn I, O'Connell J, O'Donnell H, Fajtová P, Lyu J, Vigneron S, Young NJ, Kondratov IS, Alisoltani A, Simons…
• Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes.
  Nature chemistry 2023 Chen Y, Craven GB, Kamber RA, Cuesta A, Zhersh S, Moroz YS, Bassik MC, Taunton J
• Signal peptide mimicry primes Sec61 for client-selective inhibition.
  Nature chemical biology 2023 Rehan S, Tranter D, Sharp PP, Craven GB, Lowe E, Anderl JL, Muchamuel T, Abrishami V, Kuivanen S, Wenzell NA, Jennings A, Kalyanaraman C, Strandin T, Javanainen M, Vapalahti O, Jacobson MP, McMinn D, …
• An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.
  Cell 2023 Oltion K, Carelli JD, Yang T, See SK, Wang HY, Kampmann M, Taunton J
• IFITM proteins assist cellular uptake of diverse linked chemotypes.
  Science (New York, N.Y.) 2022 Lou K, Wassarman DR, Yang T, Paung Y, Zhang Z, O'Loughlin TA, Moore MK, Egan RK, Greninger P, Benes CH, Seeliger MA, Taunton J, Gilbert LA, Shokat KM
• Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes.
  eLife 2022 Juette MF, Carelli JD, Rundlet EJ, Brown A, Shao S, Ferguson A, Wasserman MR, Holm M, Taunton J, Blanchard SC
• Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3.
  Nature chemistry 2022 Wang HY, Yang H, Holm M, Tom H, Oltion K, Al-Khdhairawi AAQ, Weber JF, Blanchard SC, Ruggero D, Taunton J
• Reversible lysine-targeted probes reveal residence time-based kinase selectivity.
  Nature chemical biology 2022 Yang T, Cuesta A, Wan X, Craven GB, Hirakawa B, Khamphavong P, May JR, Kath JC, Lapek JD, Niessen S, Burlingame AL, Carelli JD, Taunton J
• Inhibition of the Sec61 translocon overcomes cytokine-induced glucocorticoid resistance in T-cell acute lymphoblastic leukaemia.
  British journal of haematology 2022 Meyer LK, Delgado-Martin C, Sharp PP, Huang BJ, McMinn D, Vincent TL, Ryan T, Horton TM, Wood BL, Teachey DT, Taunton J, Kirk CJ, Hermiston ML
• Identifying the Cellular Target of Cordyheptapeptide A and Synthetic Derivatives.
  ACS chemical biology 2021 Klein VG, Bray WM, Wang HY, Edmondson Q, Schwochert J, Ono S, Naylor MR, Turmon AC, Faris JH, Okada O, Taunton J, Lokey RS
• p90RSK-MAGI1 Module Controls Endothelial Permeability by Post-translational Modifications of MAGI1 and Hippo Pathway.
  Frontiers in cardiovascular medicine 2020 Abe RJ, Savage H, Imanishi M, Banerjee P, Kotla S, Paez-Mayorga J, Taunton J, Fujiwara K, Won JH, Yusuf SW, Palaskas NL, Banchs J, Lin SH, Schadler KL, Abe JI, Le NT
• CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma.
  Blood advances 2020 Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, Wiita AP, Kampmann M
• A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
  Nature 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, …
• Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking.
  Journal of the American Chemical Society 2020 Wan X, Yang T, Cuesta A, Pang X, Balius TE, Irwin JJ, Shoichet BK, Taunton J
• Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90.
  Journal of the American Chemical Society 2020 Cuesta A, Wan X, Burlingame AL, Taunton J
• Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting protein.
  JCI insight 2019 Kotla S, Vu HT, Ko KA, Wang Y, Imanishi M, Heo KS, Fujii Y, Thomas TN, Gi YJ, Mazhar H, Paez-Mayorga J, Shin JH, Tao Y, Giancursio CJ, Medina JL, Taunton J, Lusis AJ, Cooke JP, Fujiwara K, Le NT, Abe …
• MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis.
  JCI insight 2019 Abe JI, Ko KA, Kotla S, Wang Y, Paez-Mayorga J, Shin IJ, Imanishi M, Vu HT, Tao Y, Leiva-Juarez MM, Thomas TN, Medina JL, Won JH, Fujii Y, Giancursio CJ, McBeath E, Shin JH, Guzman L, Abe RJ, Taunton …
• Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals.
  Circulation 2019 Singh MV, Kotla S, Le NT, Ae Ko K, Heo KS, Wang Y, Fujii Y, Thi Vu H, McBeath E, Thomas TN, Jin Gi Y, Tao Y, Medina JL, Taunton J, Carson N, Dogra V, Doyley MM, Tyrell A, Lu W, Qiu X, Stirpe NE, Gates…
• Lysine-Targeted Inhibitors and Chemoproteomic Probes.
  Annual review of biochemistry 2019 Cuesta A, Taunton J
• Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.
  Cell 2018 Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E,…
• Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment.
  Haematologica 2018 Lam C, Ferguson ID, Mariano MC, Lin YT, Murnane M, Liu H, Smith GA, Wong SW, Taunton J, Liu JO, Mitsiades CS, Hann BC, Aftab BT, Wiita AP
• Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4.
  Cell death & disease 2018 Ogbechi J, Hall BS, Sbarrato T, Taunton J, Willis AE, Wek RC, Simmonds RE
• IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4+ and CD8+ T cells.
  Science signaling 2017 Smith GA, Taunton J, Weiss A
• JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias.
  Leukemia 2017 Delgado-Martin C, Meyer LK, Huang BJ, Shimano KA, Zinter MS, Nguyen JV, Smith GA, Taunton J, Winter SS, Roderick JR, Kelliher MA, Horton TM, Wood BL, Teachey DT, Hermiston ML
• Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes.
  Journal of the American Chemical Society 2017 Zhao Q, Ouyang X, Wan X, Gajiwala KS, Kath JC, Jones LH, Burlingame AL, Taunton J
• Regulation of B cell fate by chronic activity of the IgE B cell receptor.
  eLife 2016 Yang Z, Robinson MJ, Chen X, Smith GA, Taunton J, Liu W, Allen CD
• Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
  Cell 2016 Shao S, Murray J, Brown A, Taunton J, Ramakrishnan V, Hegde RS
• Mycolactone subverts immunity by selectively blocking the Sec61 translocon.
  The Journal of experimental medicine 2016 Baron L, Paatero AO, Morel JD, Impens F, Guenin-Macé L, Saint-Auret S, Blanchard N, Dillmann R, Niang F, Pellegrini S, Taunton J, Paavilainen VO, Demangel C
• Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription.
  Molecular cell 2016 Josefowicz SZ, Shimada M, Armache A, Li CH, Miller RM, Lin S, Yang A, Dill BD, Molina H, Park HS, Garcia BA, Taunton J, Roeder RG, Allis CD
• Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization.
  Molecular cell 2016 Rodríguez-Molina JB, Tseng SC, Simonett SP, Taunton J, Ansari AZ
• Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel.
  Cell chemical biology 2016 Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO
• Phase separation of signaling molecules promotes T cell receptor signal transduction.
  Science (New York, N.Y.) 2016 Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD
• Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling.
  Nature chemical biology 2016 Smith GA, Uchida K, Weiss A, Taunton J
• Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.
  Immunity 2016 Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs D, Hamilton J, Leon PE, Chawdury A, Tripathi S, Melegari C, Campisi L, Hai R, …
• Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex.
  eLife 2015 Carelli JD, Sethofer SG, Smith GA, Miller HR, Simard JL, Merrick WC, Jain RK, Ross NT, Taunton J
• Allosteric N-WASP activation by an inter-SH3 domain linker in Nck.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Okrut J, Prakash S, Wu Q, Kelly MJ, Taunton J
• Prolonged and tunable residence time using reversible covalent kinase inhibitors.
  Nature chemical biology 2015 Bradshaw JM, McFarland JM, Paavilainen VO, Bisconte A, Tam D, Phan VT, Romanov S, Finkle D, Shu J, Patel V, Ton T, Li X, Loughhead DG, Nunn PA, Karr DE, Gerritsen ME, Funk JO, Owens TD, Verner E, …
• Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function.
  The Journal of clinical investigation 2015 Heo KS, Le NT, Cushman HJ, Giancursio CJ, Chang E, Woo CH, Sullivan MA, Taunton J, Yeh ET, Fujiwara K, Abe J
• Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum.
  Oncogene 2015 Ruiz-Saenz A, Sandhu M, Carrasco Y, Maglathlin RL, Taunton J, Moasser MM
• Covalent docking of large libraries for the discovery of chemical probes.
  Nature chemical biology 2014 London N, Miller RM, Krishnan S, Uchida K, Irwin JJ, Eidam O, Gibold L, Cimermancic P, Bonnet R, Shoichet BK, Taunton J
• Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.
  Journal of the American Chemical Society 2014 Krishnan S, Miller RM, Tian B, Mullins RD, Jacobson MP, Taunton J
• An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.
  eLife 2014 Mackinnon AL, Paavilainen VO, Sharma A, Hegde RS, Taunton J
• Targeting protein kinases with selective and semipromiscuous covalent inhibitors.
  Methods in enzymology 2014 Miller RM, Taunton J
• The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis.
  The Journal of biological chemistry 2013 Li D, Jin L, Alesi GN, Kim YM, Fan J, Seo JH, Wang D, Tucker M, Gu TL, Lee BH, Taunton J, Magliocca KR, Chen ZG, Shin DM, Khuri FR, Kang S
• Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected].
  eLife 2013 Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J
• p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms.
  Molecular and cellular biology 2013 Jin L, Li D, Lee JS, Elf S, Alesi GN, Fan J, Kang HB, Wang D, Fu H, Taunton J, Boggon TJ, Tucker M, Gu TL, Chen ZG, Shin DM, Khuri FR, Kang S
• Electrophilic fragment-based design of reversible covalent kinase inhibitors.
  Journal of the American Chemical Society 2013 Miller RM, Paavilainen VO, Krishnan S, Serafimova IM, Taunton J
• Proteostasis modulators with discriminating taste.
  Chemistry & biology 2013 Paavilainen VO, Taunton J
• Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.
  Beilstein journal of organic chemistry 2013 Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, McKerrow JM, Podust LM, Renslo AR
• A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.
  Circulation 2012 Le NT, Heo KS, Takei Y, Lee H, Woo CH, Chang E, McClain C, Hurley C, Wang X, Li F, Xu H, Morrell C, Sullivan MA, Cohen MS, Serafimova IM, Taunton J, Fujiwara K, Abe J
• Selective targeting of distinct active site nucleophiles by irreversible SRC-family kinase inhibitors.
  Journal of the American Chemical Society 2012 Gushwa NN, Kang S, Chen J, Taunton J
• Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation.
  Molecular biology of the cell 2012 Lakkaraju AK, Thankappan R, Mary C, Garrison JL, Taunton J, Strub K
• Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles.
  Nature chemical biology 2012 Serafimova IM, Pufall MA, Krishnan S, Duda K, Cohen MS, Maglathlin RL, McFarland JM, Miller RM, Frödin M, Taunton J
• Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Kapp GT, Liu S, Stein A, Wong DT, Reményi A, Yeh BJ, Fraser JS, Taunton J, Lim WA, Kortemme T
• p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.
  Circulation research 2012 Le NT, Takei Y, Shishido T, Woo CH, Chang E, Heo KS, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina CA, Taunton J, Yan C, Fujiwara K, Patterson C, Yang J, Abe J
• Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators.
  Chemistry & biology 2011 Maifeld SV, MacKinnon AL, Garrison JL, Sharma A, Kunkel EJ, Hegde RS, Taunton J
• High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases.
  Nature methods 2011 Chen F, Pruett-Miller SM, Huang Y, Gjoka M, Duda K, Taunton J, Collingwood TN, Frodin M, Davis GD
• Irreversible Nek2 kinase inhibitors with cellular activity.
  Journal of medicinal chemistry 2011 Henise JC, Taunton J
• p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.
  Blood 2011 Elf S, Blevins D, Jin L, Chung TW, Williams IR, Lee BH, Lin JX, Leonard WJ, Taunton J, Khoury HJ, Kang S
• Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains.
  Cell 2010 Puthenveedu MA, Lauffer B, Temkin P, Vistein R, Carlton P, Thorn K, Taunton J, Weiner OD, Parton RG, von Zastrow M
• ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1.
  The Journal of biological chemistry 2010 Oh YT, Liu X, Yue P, Kang S, Chen J, Taunton J, Khuri FR, Sun SY
• Excessive Na+/H+ exchange in disruption of dendritic Na+ and Ca2+ homeostasis and mitochondrial dysfunction following in vitro ischemia.
  The Journal of biological chemistry 2010 Kintner DB, Chen X, Currie J, Chanana V, Ferrazzano P, Baba A, Matsuda T, Cohen M, Orlowski J, Chiu SY, Taunton J, Sun D
• p90 activation contributes to cerebral ischemic damage via phosphorylation of Na+/H+ exchanger isoform 1.
  Journal of neurochemistry 2010 Manhas N, Shi Y, Taunton J, Sun D
• RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity.
  Molecular and cellular biology 2010 Lee S, Shuman JD, Guszczynski T, Sakchaisri K, Sebastian T, Copeland TD, Miller M, Cohen MS, Taunton J, Smart RC, Xiao Z, Yu LR, Veenstra TD, Johnson PF
• p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.
  The Journal of clinical investigation 2010 Kang S, Elf S, Lythgoe K, Hitosugi T, Taunton J, Zhou W, Xiong L, Wang D, Muller S, Fan S, Sun SY, Marcus AI, Gu TL, Polakiewicz RD, Chen ZG, Khuri FR, Shin DM, Chen J
• Target Identification by Diazirine Photo-Cross-linking and Click Chemistry.
  Current protocols in chemical biology 2009 Mackinnon AL, Taunton J
• RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.
  Molecular cell 2009 Doehn U, Hauge C, Frank SR, Jensen CJ, Duda K, Nielsen JV, Cohen MS, Johansen JV, Winther BR, Lund LR, Winther O, Taunton J, Hansen SH, Frödin M
• The PKARIalpha subunit of protein kinase A modulates the activation of p90RSK1 and its function.
  The Journal of biological chemistry 2009 Chaturvedi D, Cohen MS, Taunton J, Patel TB
• Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation.
  Molecular and cellular biology 2009 Kang S, Elf S, Dong S, Hitosugi T, Lythgoe K, Guo A, Ruan H, Lonial S, Khoury HJ, Williams IR, Lee BH, Roesel JL, Karsenty G, Hanauer A, Taunton J, Boggon TJ, Gu TL, Chen J
• Rapamycin induces transactivation of the EGFR and increases cell survival.
  Oncogene 2009 Chaturvedi D, Gao X, Cohen MS, Taunton J, Patel TB
• betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.
  Molecular cell 2009 Dehan E, Bassermann F, Guardavaccaro D, Vasiliver-Shamis G, Cohen M, Lowes KN, Dustin M, Huang DC, Taunton J, Pagano M
• Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.
  Journal of the American Chemical Society 2008 Bowers A, West N, Taunton J, Schreiber SL, Bradner JE, Williams RM
• Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity.
  Circulation research 2008 Lu Z, Abe J, Taunton J, Lu Y, Shishido T, McClain C, Yan C, Xu SP, Spangenberg TM, Xu H
• APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus.
  Genes & development 2008 Visintin C, Tomson BN, Rahal R, Paulson J, Cohen M, Taunton J, Amon A, Visintin R
• Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation.
  Journal of the American Chemical Society 2007 MacKinnon AL, Garrison JL, Hegde RS, Taunton J
• A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration.
  Chemistry & biology 2007 Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM
• FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.
  Cancer cell 2007 Kang S, Dong S, Gu TL, Guo A, Cohen MS, Lonial S, Khoury HJ, Fabbro D, Gilliland DG, Bergsagel PL, Taunton J, Polakiewicz RD, Chen J
• The role of p58IPK in protecting the stressed endoplasmic reticulum.
  Molecular biology of the cell 2007 Rutkowski DT, Kang SW, Goodman AG, Garrison JL, Taunton J, Katze MG, Kaufman RJ, Hegde RS
• RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.
  The Journal of biological chemistry 2007 Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N, Blenis J
• Mechanism of actin network attachment to moving membranes: barbed end capture by N-WASP WH2 domains.
  Cell 2007 Co C, Wong DT, Gierke S, Chang V, Taunton J
• A clickable inhibitor reveals context-dependent autoactivation of p90 RSK.
  Nature chemical biology 2007 Cohen MS, Hadjivassiliou H, Taunton J
• Recruitment and activation of RSK2 by HIV-1 Tat.
  PloS one 2007 Hetzer C, Bisgrove D, Cohen MS, Pedal A, Kaehlcke K, Speyerer A, Bartscherer K, Taunton J, Ott M
• Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK): effects of the novel and specific RSK inhibitor fmk on responses to alpha1-adrenergic stimulation.
  Molecular pharmacology 2006 Cuello F, Snabaitis AK, Cohen MS, Taunton J, Avkiran M
• Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload.
  Cell 2006 Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding HP, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, Ron D
• The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.
  The EMBO journal 2006 Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, Hershey JW, Blenis J, Pende M, Sonenberg N
• A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum.
  Nature 2005 Garrison JL, Kunkel EJ, Hegde RS, Taunton J
• Structural bioinformatics-based design of selective, irreversible kinase inhibitors.
  Science (New York, N.Y.) 2005 Cohen MS, Zhang C, Shokat KM, Taunton J
• A polybasic motif allows N-WASP to act as a sensor of PIP(2) density.
  Molecular cell 2005 Papayannopoulos V, Co C, Prehoda KE, Snapper S, Taunton J, Lim WA
• Organolithium-mediated diversification of peptide thiazoles.
  Organic letters 2005 Deng S, Taunton J
• Kinetic control of proline amide rotamers: total synthesis of trans,trans- and cis,cis-ceratospongamide.
  Journal of the American Chemical Society 2002 Deng S, Taunton J
• Actin filament nucleation by endosomes, lysosomes and secretory vesicles.
  Current opinion in cell biology 2001 Taunton J
• How to starve a tumor.
  Chemistry & biology 1997 Taunton J
• A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p
  Science 1996 Taunton, J., Hassig, C.A. and Schreiber, S.L.
• Synthesis of natural and modified trapoxins, useful reagents for exploring histone deacetylase function
  J. Am. Chem. Soc. 1996 Taunton, J., Collins, J.L. and Schreiber, S.L.
• Total syntheses of di- and tri-O-methyl dynemicin A methyl esters
  J. Am. Chem. Soc. 1993 Taunton, J., Wood, J.L. and Schreiber, S.L.
• Application of the Allylic Diazene Rearrangement: Synthesis of the enediyne-bridged tricyclic core of dynemicin A
  J. Am. Chem. Soc. 1992 Wood, J.L., Porco, J.A., Taunton, J., Lee, A.Y., Clardy, J. and Schreiber, S.L.
• Synthesis of nitrogen-containing polycycles via rhodium(II)-induced cyclization-cycloaddition and insertion reactions of N-(diazoacetoacetyl)amides. Conformational control of reaction selectivity
  J. Org. Chem. 1991 Doyle, M.P., Pieters, R.J., Taunton, J., Pho, H.Q., Padwa, A., Hertzog, D.L. and Precedo, L.
• Conformational and electronic preferences in rhodium(II) carboxylate and rhodium(II) carboxamide catalyzed carbon-hydrogen insertion reactions of N,N-disubstituted diazoacetoacetamides
  Tetrahedron Lett. 1989 Doyle, M.P., Taunton, J. and Pho, H.Q.
• A new and general synthesis of a-silyl carbonyl compounds by silicon-hydrogen insertion from transition metal-catalyzed reactions of diazo esters and diazo ketones
  J. Org. Chem. 1988 Bagheri, V., Doyle, M.P., Taunton, J. and Claxton, E.E.
• Reactivity and selectivity in intermolecular insertion reactions of chlorophenylcarbene
  Tetrahedron Lett. 1988 Doyle, M.P., Taunton, J., Oon, S.M., Liu, M.T., Soundararajan, N., Platz, M.S. and Jackson, J.E.