J. Michael Bishop, MD
Professor Emeritus
Microbiology and Immunology
School of Medicine

While serving as chancellor, Bishop continued to teach medical students and run his distinguished research lab.

Bishop and his colleague Harold Varmus, MD, shared the Nobel Prize in Physiology or Medicine in 1989 for cancer research. Bishop and Glenn Seaborg, who served as chancellor at UC Berkeley from 1958-61, are the only two Nobel laureates to have served as chancellors in the 10-campus UC system.

Dr. Bishop and his team research the genetic underpinnings of cancer, in particular the large group of cellular genes known as proto-oncogenes (see link to the Bishop Lab below).

• Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.
  Nature medicine 2007 Goga A, Yang D, Tward AD, Morgan DO, Bishop JM
• beta-Catenin/Wnt signaling regulates expression of the membrane type 3 matrix metalloproteinase in gastric cancer.
  Cancer research 2006 Lowy AM, Clements WM, Bishop J, Kong L, Bonney T, Sisco K, Aronow B, Fenoglio-Preiser C, Groden J
• Mary Lasker and her prizes: an appreciation.
  JAMA 2005 Bishop JM
• MET and MYC cooperate in mammary tumorigenesis.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Welm AL, Kim S, Welm BE, Bishop JM
• A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Kim S, Chin K, Gray JW, Bishop JM
• Cell division and cell survival in the absence of survivin.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Yang D, Welm A, Bishop JM
• Negative control of the Myc protein by the stress-responsive kinase Pak2.
  Molecular and cellular biology 2004 Huang Z, Traugh JA, Bishop JM
• Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Yang D, Buchholz F, Huang Z, Goga A, Chen CY, Brodsky FM, Bishop JM
• Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice.
  The Journal of cell biology 2001 Wang R, Ferrell LD, Faouzi S, Maher JJ, Bishop JM
• BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia.
  The Journal of experimental medicine 2001 Kogan SC, Brown DE, Shultz DB, Truong BT, Lallemand-Breitenbach V, Guillemin MC, Lagasse E, Weissman IL, Bishop JM
• Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse.
  EMBO reports 2000 Buchholz F, Refaeli Y, Trumpp A, Bishop JM
• Genome-wide screen for allelic imbalance in a mouse model for neuroblastoma.
  Cancer research 2000 Weiss WA, Godfrey T, Francisco C, Bishop JM
• Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch.
  Genes & development 1999 Trumpp A, Depew MJ, Rubenstein JL, Bishop JM, Martin GR
• Reversible tumorigenesis by MYC in hematopoietic lineages.
  Molecular cell 1999 Felsher DW, Bishop JM
• Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Smith-McCune K, Kalman D, Robbins C, Shivakumar S, Yuschenkoff L, Bishop JM
• Ras family GTPases control growth of astrocyte processes.
  Molecular biology of the cell 1999 Kalman D, Gomperts SN, Hardy S, Kitamura M, Bishop JM
• Transient excess of MYC activity can elicit genomic instability and tumorigenesis.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Felsher DW, Bishop JM
• Senescence of human fibroblasts induced by oncogenic Raf.
  Genes & development 1998 Zhu J, Woods D, McMahon M, Bishop JM
• Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.
  Molecular and cellular biology 1997 Capobianco AJ, Zagouras P, Blaumueller CM, Artavanis-Tsakonas S, Bishop JM
• Ethic of science.
  New scientist (1971) 1981 Bishop JM