Izzy Charo, MD, PhD
Professor Emeritus
Cardiovascular Research Inst
School of Medicine

Grants and Projects

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• U.c.s.f. Multipurpose Arthritis Center, NIH, 1977-1988

Publications (81)

Top publication keywords:
Central Nervous SystemMonocytesMacrophagesHaploidyChemokine CCL7ChemokinesReceptors, ChemokineInflammationCell MovementMonocyte Chemoattractant ProteinsChemokine CX3CL1Mice, KnockoutChemokine CCL2ArteriosclerosisReceptors, CCR2

• CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity.
  PloS one 2023 Sullivan KMC, Vilalta M, Ertl LS, Wang Y, Dunlap C, Ebsworth K, Zhao BN, Li S, Zeng Y, Miao Z, Fan P, Mali V, Lange C, McMurtrie D, Yang J, Lui R, Scamp R, Chhina V, Kumamoto A, Yau S, Dang T, …
• Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis.
  bioRxiv : the preprint server for biology 2023 Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Lee CY, Sadagopan N, Huang Y, Pelonero A, Auclair K, Zhu A, Teran BG, Flanigan W, Kim CK, Lumbao-Conradson K, Costa M, Jain R, Charo I, Haldar …
• CCR2 deficiency alters activation of microglia subsets in traumatic brain injury.
  Cell reports 2021 Somebang K, Rudolph J, Imhof I, Li L, Niemi EC, Shigenaga J, Tran H, Gill TM, Lo I, Zabel BA, Schmajuk G, Wipke BT, Gyoneva S, Jandreski L, Craft M, Benedetto G, Plowey ED, Charo I, Campbell J, Ye CJ,…
• CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Flores-Toro JA, Luo D, Gopinath A, Sarkisian MR, Campbell JJ, Charo IF, Singh R, Schall TJ, Datta M, Jain RK, Mitchell DA, Harrison JK
• CCR2-Mediated Uptake of Constitutively Produced CCL2: A Mechanism for Regulating Chemokine Levels in the Blood.
  Journal of immunology (Baltimore, Md. : 1950) 2019 Zhao BN, Campbell JJ, Salanga CL, Ertl LS, Wang Y, Yau S, Dang T, Zeng Y, McMahon JP, Krasinski A, Zhang P, Kufareva I, Handel TM, Charo IF, Singh R, Schall TJ

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• Efficacy of Chemokine Receptor Inhibition in Treating IL-36α-Induced Psoriasiform Inflammation.
  Journal of immunology (Baltimore, Md. : 1950) 2019 Campbell JJ, Ebsworth K, Ertl LS, McMahon JP, Wang Y, Yau S, Mali VR, Chhina V, Kumamoto A, Liu S, Dang T, Newland D, Charo IF, Zhang P, Schall TJ, Singh R
• CCL7 Is a Negative Regulator of Cutaneous Inflammation Following Leishmania major Infection.
  Frontiers in immunology 2019 Ford J, Hughson A, Lim K, Bardina SV, Lu W, Charo IF, Lim JK, Fowell DJ
• Correction: Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study.
  PloS one 2019 Bekker P, Dairaghi D, Seitz L, Leleti M, Wang Y, Ertl L, Baumgart T, Shugarts S, Lohr L, Dang T, Miao S, Zeng Y, Fan P, Zhang P, Johnson D, Powers J, Jaen J, Charo I, Schall TJ
• CCR2 antagonism leads to marked reduction in proteinuria and glomerular injury in murine models of focal segmental glomerulosclerosis (FSGS).
  PloS one 2018 Miao Z, Ertl LS, Newland D, Zhao B, Wang Y, Zang X, Campbell JJ, Liu X, Dang T, Miao S, Krasinski A, Punna S, Zeng Y, McMahon J, Zhang P, Charo IF, Schall TJ, Singh R
• CC chemokine receptor 2 promotes recruitment of myeloid cells associated with insulin resistance in nonalcoholic fatty liver disease.
  American journal of physiology. Gastrointestinal and liver physiology 2018 Parker R, Weston CJ, Miao Z, Corbett C, Armstrong MJ, Ertl L, Ebsworth K, Walters MJ, Baumart T, Newland D, McMahon J, Zhang P, Singh R, Campbell J, Newsome PN, Charo I, Schall TJ, Adams DH
• IL-17-Secreting γδ T Cells Are Completely Dependent upon CCR6 for Homing to Inflamed Skin.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Campbell JJ, Ebsworth K, Ertl LS, McMahon JP, Newland D, Wang Y, Liu S, Miao Z, Dang T, Zhang P, Charo IF, Singh R, Schall TJ
• Correction: Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice.
  PloS one 2017 Saederup N, Cardona AE, Croft K, Mizutani M, Cotleur AC, Tsou CL, Ransohoff RM, Charo IF
• Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study.
  PloS one 2016 Bekker P, Dairaghi D, Seitz L, Leleti M, Wang Y, Ertl L, Baumgart T, Shugarts S, Lohr L, Dang T, Miao S, Zeng Y, Fan P, Zhang P, Johnson D, Powers J, Jaen J, Charo I, Schall TJ
• Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Bardina SV, Michlmayr D, Hoffman KW, Obara CJ, Sum J, Charo IF, Lu W, Pletnev AG, Lim JK
• Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation.
  Nature communications 2015 Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K
• A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury.
  The Journal of experimental medicine 2015 Dal-Secco D, Wang J, Zeng Z, Kolaczkowska E, Wong CH, Petri B, Ransohoff RM, Charo IF, Jenne CN, Kubes P
• CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury.
  Journal of neurotrauma 2014 Hsieh CL, Niemi EC, Wang SH, Lee CC, Bingham D, Zhang J, Cozen ML, Charo I, Huang EJ, Liu J, Nakamura MC
• Differential roles of microglia and monocytes in the inflamed central nervous system.
  The Journal of experimental medicine 2014 Yamasaki R, Lu H, Butovsky O, Ohno N, Rietsch AM, Cialic R, Wu PM, Doykan CE, Lin J, Cotleur AC, Kidd G, Zorlu MM, Sun N, Hu W, Liu L, Lee JC, Taylor SE, Uehlein L, Dixon D, Gu J, Floruta CM, Zhu M, …
• Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists.
  Bioorganic & medicinal chemistry letters 2014 Cherney RJ, Mo R, Yang MG, Xiao Z, Zhao Q, Mandlekar S, Cvijic ME, Charo IF, Barrish JC, Decicco CP, Carter PH
• The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8.
  Journal of immunology (Baltimore, Md. : 1950) 2014 Severa M, Islam SA, Waggoner SN, Jiang Z, Kim ND, Ryan G, Kurt-Jones E, Charo I, Caffrey DR, Boyartchuk VL, Luster AD, Fitzgerald KA
• CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice.
  EMBO molecular medicine 2013 Sennlaub F, Auvynet C, Calippe B, Lavalette S, Poupel L, Hu SJ, Dominguez E, Camelo S, Levy O, Guyon E, Saederup N, Charo IF, Rooijen NV, Nandrot E, Bourges JL, Behar-Cohen F, Sahel JA, Guillonneau X,…
• B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction.
  Nature medicine 2013 Zouggari Y, Ait-Oufella H, Bonnin P, Simon T, Sage AP, Guérin C, Vilar J, Caligiuri G, Tsiantoulas D, Laurans L, Dumeau E, Kotti S, Bruneval P, Charo IF, Binder CJ, Danchin N, Tedgui A, Tedder TF, …
• CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice.
  American journal of physiology. Renal physiology 2013 Sullivan T, Miao Z, Dairaghi DJ, Krasinski A, Wang Y, Zhao BN, Baumgart T, Ertl LS, Pennell A, Seitz L, Powers J, Zhao R, Ungashe S, Wei Z, Boring L, Tsou CL, Charo I, Berahovich RD, Schall TJ, Jaen …
• Dual effect of chemokine CCL7/MCP-3 in the development of renal tubulointerstitial fibrosis.
  Biochemical and biophysical research communications 2013 Gonzalez J, Mouttalib S, Delage C, Calise D, Maoret JJ, Pradère JP, Klein J, Buffin-Meyer B, Van der Veen B, Charo IF, Heeringa P, Duchene J, Bascands JL, Schanstra JP
• Regulation of adaptive immunity by the fractalkine receptor during autoimmune inflammation.
  Journal of immunology (Baltimore, Md. : 1950) 2013 Garcia JA, Pino PA, Mizutani M, Cardona SM, Charo IF, Ransohoff RM, Forsthuber TG, Cardona AE
• Blinding the monocytes to protect the heart.
  Circulation 2013 Charo IF
• Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Varvel NH, Grathwohl SA, Baumann F, Liebig C, Bosch A, Brawek B, Thal DR, Charo IF, Heppner FL, Aguzzi A, Garaschuk O, Ransohoff RM, Jucker M
• Characterization of CCX140-B, an orally bioavailable antagonist of the CCR2 chemokine receptor, for the treatment of type 2 diabetes and associated complications.
  The Journal of pharmacology and experimental therapeutics 2012 Sullivan TJ, Dairaghi DJ, Krasinski A, Miao Z, Wang Y, Zhao BN, Baumgart T, Berahovich R, Ertl LS, Pennell A, Seitz L, Miao S, Ungashe S, Wei Z, Johnson D, Boring L, Tsou CL, Charo IF, Bekker P, …
• Resolving postoperative neuroinflammation and cognitive decline.
  Annals of neurology 2011 Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M
• The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood.
  Journal of immunology (Baltimore, Md. : 1950) 2011 Mizutani M, Pino PA, Saederup N, Charo IF, Ransohoff RM, Cardona AE
• Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.
  Immunity 2011 Lewis KL, Caton ML, Bogunovic M, Greter M, Grajkowska LT, Ng D, Klinakis A, Charo IF, Jung S, Gommerman JL, Ivanov II, Liu K, Merad M, Reizis B
• Anti-inflammatory therapeutics for the treatment of atherosclerosis.
  Nature reviews. Drug discovery 2011 Charo IF, Taub R
• Neutrophil-dominant experimental autoimmune uveitis in CC-chemokine receptor 2 knockout mice.
  Acta ophthalmologica 2011 Sonoda KH, Yoshimura T, Egashira K, Charo IF, Ishibashi T
• Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells.
  Nature immunology 2011 Islam SA, Chang DS, Colvin RA, Byrne MH, McCully ML, Moser B, Lira SA, Charo IF, Luster AD
• Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice.
  PloS one 2010 Saederup N, Cardona AE, Croft K, Mizutani M, Cotleur AC, Tsou CL, Ransohoff RM, Charo IF
• Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Lu H, Huang D, Saederup N, Charo IF, Ransohoff RM, Zhou L
• Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility.
  The Journal of biological chemistry 2010 Yan W, Si Y, Slaymaker S, Li J, Zheng H, Young DL, Aslanian A, Saunders L, Verdin E, Charo IF
• Inhibition of chemokine-glycosaminoglycan interactions in donor tissue reduces mouse allograft vasculopathy and transplant rejection.
  PloS one 2010 Dai E, Liu LY, Wang H, McIvor D, Sun YM, Macaulay C, King E, Munuswamy-Ramanujam G, Bartee MY, Williams J, Davids J, Charo I, McFadden G, Esko JD, Lucas AR
• CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice.
  The Journal of clinical investigation 2010 Si Y, Tsou CL, Croft K, Charo IF
• Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice.
  Clinical science (London, England : 1979) 2010 Daugherty A, Rateri DL, Charo IF, Owens AP, Howatt DA, Cassis LA
• CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation.
  The Journal of experimental medicine 2009 Auffray C, Fogg DK, Narni-Mancinelli E, Senechal B, Trouillet C, Saederup N, Leemput J, Bigot K, Campisi L, Abitbol M, Molina T, Charo I, Hume DA, Cumano A, Lauvau G, Geissmann F
• Increased expression of CCL2 in insulin-producing cells of transgenic mice promotes mobilization of myeloid cells from the bone marrow, marked insulitis, and diabetes.
  Diabetes 2008 Martin AP, Rankin S, Pitchford S, Charo IF, Furtado GC, Lira SA
• Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Jia T, Serbina NV, Brandl K, Zhong MX, Leiner IM, Charo IF, Pamer EG
• Inhibition of MCP-1/CCR2 signaling does not inhibit intimal proliferation in a mouse aortic transplant model.
  Journal of vascular research 2008 Alexis JD, Pyo RT, Chereshnev I, Katz J, Rollins BJ, Charo IF, Taubman MB
• Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis.
  Circulation 2007 Saederup N, Chan L, Lira SA, Charo IF
• Macrophage polarization and insulin resistance: PPARgamma in control.
  Cell metabolism 2007 Charo IF
• Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites.
  The Journal of clinical investigation 2007 Tsou CL, Peters W, Si Y, Slaymaker S, Aslanian AM, Weisberg SP, Mack M, Charo IF
• CCR2 regulates development of Theiler's murine encephalomyelitis virus-induced demyelinating disease.
  Viral immunology 2007 Bennett JL, Elhofy A, Charo I, Miller SD, Dal Canto MC, Karpus WJ
• Chemokine regulation of the inflammatory response to a low-dose influenza infection in CCR2-/- mice.
  Journal of leukocyte biology 2006 Wareing MD, Lyon A, Inglis C, Giannoni F, Charo I, Sarawar SR
• CC chemokine receptor 2 is protective against noise-induced hair cell death: studies in CX3CR1(+/GFP) mice.
  Journal of the Association for Research in Otolaryngology : JARO 2006 Sautter NB, Shick EH, Ransohoff RM, Charo IF, Hirose K
• Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Ragozzino D, Di Angelantonio S, Trettel F, Bertollini C, Maggi L, Gross C, Charo IF, Limatola C, Eusebi F
• Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosis.
  Circulation 2006 Aslanian AM, Charo IF
• The CC chemokine MCP-1 stimulates surface expression of CX3CR1 and enhances the adhesion of monocytes to fractalkine/CX3CL1 via p38 MAPK.
  Journal of immunology (Baltimore, Md. : 1950) 2006 Green SR, Han KH, Chen Y, Almazan F, Charo IF, Miller YI, Quehenberger O
• Monocyte recruitment in venous thrombus resolution.
  Journal of vascular surgery 2006 Ali T, Humphries J, Burnand K, Sawyer B, Bursill C, Channon K, Greaves D, Rollins B, Charo IF, Smith A
• The many roles of chemokines and chemokine receptors in inflammation.
  The New England journal of medicine 2006 Charo IF, Ransohoff RM
• CCR2 modulates inflammatory and metabolic effects of high-fat feeding.
  The Journal of clinical investigation 2005 Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, Charo I, Leibel RL, Ferrante AW
• Differential influence of chemokine receptors CCR2 and CXCR3 in development of atherosclerosis in vivo.
  Circulation 2005 Veillard NR, Steffens S, Pelli G, Lu B, Kwak BR, Gerard C, Charo IF, Mach F
• Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005 Huang D, Wujek J, Kidd G, He TT, Cardona A, Sasse ME, Stein EJ, Kish J, Tani M, Charo IF, Proudfoot AE, Rollins BJ, Handel T, Ransohoff RM
• Transient role for CD1d-restricted natural killer T cells in the formation of atherosclerotic lesions.
  Arteriosclerosis, thrombosis, and vascular biology 2004 Aslanian AM, Chapman HA, Charo IF
• Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes.
  The Journal of experimental medicine 2004 Qu C, Edwards EW, Tacke F, Angeli V, Llodrá J, Sanchez-Schmitz G, Garin A, Haque NS, Peters W, van Rooijen N, Sanchez-Torres C, Bromberg J, Charo IF, Jung S, Lira SA, Randolph GJ
• Chemokines in the pathogenesis of vascular disease.
  Circulation research 2004 Charo IF, Taubman MB
• CCR2-/- knockout mice revascularize normally in response to severe hindlimb ischemia.
  Journal of vascular surgery 2004 Tang G, Charo DN, Wang R, Charo IF, Messina L
• Impaired lung dendritic cell activation in CCR2 knockout mice.
  The American journal of pathology 2004 Chiu BC, Freeman CM, Stolberg VR, Hu JS, Zeibecoglou K, Lu B, Gerard C, Charo IF, Lira SA, Chensue SW
• Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2.
  Respiratory research 2004 Koth LL, Rodriguez MW, Bernstein XL, Chan S, Huang X, Charo IF, Rollins BJ, Erle DJ
• Bone marrow-derived monocyte chemoattractant protein-1 receptor CCR2 is critical in angiotensin II-induced acceleration of atherosclerosis and aneurysm formation in hypercholesterolemic mice.
  Arteriosclerosis, thrombosis, and vascular biology 2004 Ishibashi M, Egashira K, Zhao Q, Hiasa K, Ohtani K, Ihara Y, Charo IF, Kura S, Tsuzuki T, Takeshita A, Sunagawa K
• CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Peters W, Cyster JG, Mack M, Schlöndorff D, Wolf AJ, Ernst JD, Charo IF
• Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease.
  Nature medicine 2004 Merad M, Hoffmann P, Ranheim E, Slaymaker S, Manz MG, Lira SA, Charo I, Cook DN, Weissman IL, Strober S, Engleman EG
• Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling.
  Circulation research 2004 Ishibashi M, Hiasa K, Zhao Q, Inoue S, Ohtani K, Kitamoto S, Tsuchihashi M, Sugaya T, Charo IF, Kura S, Tsuzuki T, Ishibashi T, Takeshita A, Egashira K
• MCP-1-dependent signaling in CCR2(-/-) aortic smooth muscle cells.
  Journal of leukocyte biology 2004 Schecter AD, Berman AB, Yi L, Ma H, Daly CM, Soejima K, Rollins BJ, Charo IF, Taubman MB
• Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Abdi R, Means TK, Ito T, Smith RN, Najafian N, Jurewicz M, Tchipachvili V, Charo I, Auchincloss H, Sayegh MH, Luster AD
• CC-chemokine receptor 2 required for bleomycin-induced pulmonary fibrosis.
  Cytokine 2003 Gharaee-Kermani M, McCullumsmith RE, Charo IF, Kunkel SL, Phan SH
• Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells.
  American journal of physiology. Lung cellular and molecular physiology 2003 Panoskaltsis-Mortari A, Hermanson JR, Taras E, Wangensteen OD, Charo IF, Rollins BJ, Blazar BR
• The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization.
  Journal of leukocyte biology 2003 Tsutsumi C, Sonoda KH, Egashira K, Qiao H, Hisatomi T, Nakao S, Ishibashi M, Charo IF, Sakamoto T, Murata T, Ishibashi T
• Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarization.
  Microcirculation (New York, N.Y. : 1994) 2003 Charo IF, Peters W
• Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis.
  The Journal of clinical investigation 2003 Lesnik P, Haskell CA, Charo IF
• In CCR2-/- mice monocyte recruitment and egress of LDL cholesterol in vivo is impaired.
  Biochemical and biophysical research communications 2003 Stein O, Dabach Y, Ben-Naim M, Halperin G, Charo IF, Stein Y
• Pertussis toxin-induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Huang D, Tani M, Wang J, Han Y, He TT, Weaver J, Charo IF, Tuohy VK, Rollins BJ, Ransohoff RM
• Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion.
  Journal of neuroscience research 2002 Ma M, Wei T, Boring L, Charo IF, Ransohoff RM, Jakeman LB
• Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1.
  The Journal of experimental medicine 2002 Keppler OT, Welte FJ, Ngo TA, Chin PS, Patton KS, Tsou CL, Abbey NW, Sharkey ME, Grant RM, You Y, Scarborough JD, Ellmeier W, Littman DR, Stevenson M, Charo IF, Herndier BG, Speck RF, Goldsmith MA
• IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling.
  Journal of immunology (Baltimore, Md. : 1950) 2002 Zhu Z, Ma B, Zheng T, Homer RJ, Lee CG, Charo IF, Noble P, Elias JA
• CCR2: from cloning to the creation of knockout mice.
  Chemical immunology 1999 Charo IF