Ivan Diamond, MD, PhD
Professor Emeritus
Neurology
School of Medicine

Websites

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• Dr. Diamond's CV (ivandiamond.com)

Publications (119)

Top publication keywords:
GTP-Binding Protein beta SubunitsAldehyde DehydrogenaseIsoflavonesAcetaldehyde Dehydrogenase InhibitorsAdenosineCocaine-Related DisordersEthanolCyclic AMP Response Element-Binding ProteinReceptor, Adenosine A2AMitochondrial ProteinsMedicine, Chinese TraditionalReceptors, Dopamine D2Nucleus AccumbensCyclic AMP-Dependent Protein KinasesCyclic AMP

• Aldehyde Dehydrogenase 2 Anti-Sense in the Ventral Tegmental Area Reduces Alcohol Drinking.
  Journal of Alcoholism and Drug Dependence 2019 Ivan Diamond, Peidong Fan, Maria P Arolfo, Lina Yao
• Inhibition of Aldehyde Dehydrogenase-2 (ALDH-2) Suppresses Nicotine Self-Administration in Rats.
  Journal of Drug and Alcohol Research 2016 Amir H. Rezvani, Edward D. Levin, Maria P. Arolfo, Corinne Wells, Michael Graupe, Ivan Diamond
• From Ancient Chinese Medicine to a Novel Approach to Treat Cocaine Addiction.
  CNS & neurological disorders drug targets 2015 Diamond I, Yao L
• CVT-10216 selectively suppresses binge eating of palatable foods and attenuates dopamine release in the accumbens of rats.
  The FASEB Journal 2012 Miriam E Bocarsly, Nicole M Avena, Bartley G Hoebel, Daniel Paredes, Maria P Arolfo, Lina Yao, Peidong Fan4, Ivan Diamond
• Ranolazine attenuates mechanical allodynia associated with demyelination injury.
  Journal of Pain 2012 H. Gould, R. Soignier, S. Cho, C. Hernandez, I. Diamond, B. Taylor, D. Paul

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• Addendum: Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use–dependent inhibitor of dopamine synthesis.
  Nature Medicine 2011 Lina Yao, Peidong Fan, Maria Arolfo, Zhang Jiang, M Foster Olive, Jeff Zablocki, Hai-Ling Sun, Nancy Chu, Jeongrim Lee, Hee-Yong Kim, Kwan Leung, John Shryock, Brent Blackburn, Ivan Diamond
• Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis.
  Nature medicine 2010 Yao L, Fan P, Arolfo M, Jiang Z, Olive MF, Zablocki J, Sun HL, Chu N, Lee J, Kim HY, Leung K, Shryock J, Blackburn B, Diamond I
• Ranolazine attenuation of CFA-induced mechanical hyperalgesia.
  Pain medicine (Malden, Mass.) 2010 Casey GP, Roberts JS, Paul D, Diamond I, Gould HJ
• Ranolazine attenuates behavioral signs of neuropathic pain.
  Behavioural pharmacology 2009 Gould HJ, Garrett C, Donahue RR, Paul D, Diamond I, Taylor BK
• A selective ALDH-2 inhibitor reduces anxiety in rats.
  Pharmacology, biochemistry, and behavior 2009 Overstreet DH, Knapp DJ, Breese GR, Diamond I
• Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor.
  Alcoholism, clinical and experimental research 2009 Arolfo MP, Overstreet DH, Yao L, Fan P, Lawrence AJ, Tao G, Keung WM, Vallee BL, Olive MF, Gass JT, Rubin E, Anni H, Hodge CW, Besheer J, Zablocki J, Leung K, Blackburn BK, Lange LG, Diamond I
• Up-regulation of AGS3 during morphine withdrawal promotes cAMP superactivation via adenylyl cyclase 5 and 7 in rat nucleus accumbens/striatal neurons.
  Molecular pharmacology 2009 Fan P, Jiang Z, Diamond I, Yao L
• Recognizing Dr. Ting-Kai Li for a Job Well Done.
  Alcoholism Clinical and Experimental Research 2008 Ivan Diamond, Harriet De Wit, Jan B. Hoek
• Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Bowers MS, Hopf FW, Chou JK, Guillory AM, Chang SJ, Janak PH, Bonci A, Diamond I
• Ticku Memorial Introduction.
  Alcoholism Clinical and Experimental Research 2008 Ivan Diamond
• Dopamine and ethanol cause translocation of epsilonPKC associated with epsilonRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase C signaling pathways.
  Molecular pharmacology 2008 Yao L, Fan P, Jiang Z, Gordon A, Mochly-Rosen D, Diamond I
• Alcoholism.
  Van Nostrand\u0027s Scientific Encyclopedia 2007 Robert O. Messing, Ivan Diamond
• Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry implications for drug addiction, sleep and pain.
  Progress in neurobiology 2007 Ferré S, Diamond I, Goldberg SR, Yao L, Hourani SM, Huang ZL, Urade Y, Kitchen I
• Nicotine and ethanol activate protein kinase A synergistically via G(i) betagamma subunits in nucleus accumbens/ventral tegmental cocultures: the role of dopamine D(1)/D(2) and adenosine A(2A) receptors.
  The Journal of pharmacology and experimental therapeutics 2007 Inoue Y, Yao L, Hopf FW, Fan P, Jiang Z, Bonci A, Diamond I
• Characterization of the potency, selectivity, and pharmacokinetic profile for six adenosine A2A receptor antagonists.
  Naunyn-Schmiedeberg's archives of pharmacology 2007 Yang M, Soohoo D, Soelaiman S, Kalla R, Zablocki J, Chu N, Leung K, Yao L, Diamond I, Belardinelli L, Shryock JC
• Begleiter Memorial Introduction.
  Alcoholism Clinical and Experimental Research 2006 Ivan Diamond
• Ethanol activates cAMP response element-mediated gene expression in select regions of the mouse brain.
  Brain research 2006 Asyyed A, Storm D, Diamond I
• Adenosine A2a blockade prevents synergy between mu-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted rats.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Yao L, McFarland K, Fan P, Jiang Z, Ueda T, Diamond I
• Alcoholism.
  eLS 2005 Robert O Messing, Ivan Diamond
• Activator of G protein signaling 3 regulates opiate activation of protein kinase A signaling and relapse of heroin-seeking behavior.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Yao L, McFarland K, Fan P, Jiang Z, Inoue Y, Diamond I
• Atypical protein kinase C is a novel mediator of dopamine-enhanced firing in nucleus accumbens neurons.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Hopf FW, Mailliard WS, Gonzalez GF, Diamond I, Bonci A
• Ethanol Effects on Dopaminergic “Reward” Neurons in the Ventral Tegmental Area and the Mesolimbic Pathway.
  Alcoholism Clinical and Experimental Research 2004 Sarah B. Appel, William J. McBride, Marco Diana, Ivan Diamond, Antonello Bonci, Mark S. Brodie
• Ethanol operant self-administration in rats is regulated by adenosine A2 receptors.
  Alcoholism, clinical and experimental research 2004 Arolfo MP, Yao L, Gordon AS, Diamond I, Janak PH
• cAMP-dependent protein kinase type I regulates ethanol-induced cAMP response element-mediated gene expression via activation of CREB-binding protein and inhibition of MAPK.
  The Journal of biological chemistry 2004 Constantinescu A, Wu M, Asher O, Diamond I
• Long-term effects of and physiological responses to nitrous oxide gas treatment during alcohol withdrawal: a double-blind, placebo-controlled trial.
  Alcoholism, clinical and experimental research 2004 Diamond I
• The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference.
  Nature neuroscience 2004 Choi DS, Cascini MG, Mailliard W, Young H, Paredes P, McMahon T, Diamond I, Bonci A, Messing RO
• State-specific monoclonal antibodies identify an intermediate state in epsilon protein kinase C activation.
  The Journal of biological chemistry 2004 Souroujon MC, Yao L, Chen H, Endemann G, Khaner H, Geeraert V, Schechtman D, Gordon AS, Diamond I, Mochly-Rosen D
• Recent advances in the neurobiology of alcoholism: the role of adenosine.
  Pharmacology & therapeutics 2004 Mailliard WS, Diamond I
• Addicting drugs utilize a synergistic molecular mechanism in common requiring adenosine and Gi-beta gamma dimers.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Yao L, Fan P, Jiang Z, Mailliard WS, Gordon AS, Diamond I
• Cooperative activation of dopamine D1 and D2 receptors increases spike firing of nucleus accumbens neurons via G-protein betagamma subunits.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Hopf FW, Cascini MG, Gordon AS, Diamond I, Bonci A
• Outcome of pediatric live-donor liver transplantation-the Toronto experience.
  Journal of pediatric surgery 2003 Borenstein S, Diamond IR, Grant DR, Greig PD, Jones N, Ng V, Roberts E, Fecteau A
• Phospholipase C activation is required for cardioprotection by ethanol consumption.
  Experimental and clinical cardiology 2003 Miyamae M, Domae N, Zhou HZ, Sugioka S, Diamond I, Figueredo VM
• Alcohol neurotoxicity.
  2002 Ivan F. Diamond, Steven L. McIntire
• betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption.
  Cell 2002 Yao L, Arolfo MP, Dohrman DP, Jiang Z, Fan P, Fuchs S, Janak PH, Gordon AS, Diamond I
• Ethanol stimulates cAMP-responsive element (CRE)-mediated transcription via CRE-binding protein and cAMP-dependent protein kinase.
  The Journal of pharmacology and experimental therapeutics 2002 Asher O, Cunningham TD, Yao L, Gordon AS, Diamond I
• cAMP-dependent protein kinase types I and II differentially regulate cAMP response element-mediated gene expression: implications for neuronal responses to ethanol.
  The Journal of biological chemistry 2002 Constantinescu A, Gordon AS, Diamond I
• Ethanol-induced translocation of protein kinase A occurs in two phases: control by different molecular mechanisms.
  Alcoholism, clinical and experimental research 2002 Dohrman DP, Chen HM, Gordon AS, Diamond I
• Alcoholism.
  Encyclopedia of Life Sciences 2001 Robert O Messing, Ivan Diamond
• Chronic dipyridamole therapy produces sustained protection against cardiac ischemia-reperfusion injury.
  The American journal of physiology 1999 Figueredo VM, Diamond I, Zhou HZ, Camacho SA
• Protein kinase C translocation with chronic ethanol exposure: potential mechanism for a chronic cardioprotective effect against reperfusion injury.
  Journal of the American College of Cardiology 1998 M.M. Rodriguez, M. Miyamae, S.A. Camacho, I. Diamond, D. Mochly-Rason, V.M. Figuerado
• The role of adenosine in mediating cellular and molecular responses to ethanol.
  EXS 1994 Diamond I, Gordon AS
• Nucleoside Transport and Ethanol-Induced Heterologous Desensitization.
  Alcohol, Cell Membranes, and Signal Transduction in Brain 1993 Adrienne Gordon, Mohan K. Sapru, Sharon W. Krauss, Ivan Diamond
• Adenosine is required for ethanol-induced heterologous desensitization.
  Molecular pharmacology 1989 Nagy LE, Diamond I, Collier K, Lopez L, Ullman B, Gordon AS
• Alcoholic myopathy and cardiomyopathy.
  The New England journal of medicine 1989 Diamond I
• Studies of acute and chronic effects of ethanol on early evoked potentials.
  Alcohol (Fayetteville, N.Y.) 1987 Diamond I
• Basal and adenosine receptor-stimulated levels of cAMP are reduced in lymphocytes from alcoholic patients.
  Proceedings of the National Academy of Sciences of the United States of America 1987 Diamond I, Wrubel B, Estrin W, Gordon A
• Adaptation to ethanol in cultured neural cells and human lymphocytes from alcoholics.
  Annals of the New York Academy of Sciences 1987 Gordon AS, Wrubel B, Collier K, Estrin W, Diamond I
• Ethanol regulates calcium channels in clonal neural cells.
  Proceedings of the National Academy of Sciences of the United States of America 1986 Messing RO, Carpenter CL, Diamond I, Greenberg DA
• Ethanol regulation of adenosine receptor-stimulated cAMP levels in a clonal neural cell line: an in vitro model of cellular tolerance to ethanol.
  Proceedings of the National Academy of Sciences of the United States of America 1986 Gordon AS, Collier K, Diamond I
• Ethanol increases the expression of functional delta-opioid receptors in neuroblastoma x glioma NG108-15 hybrid cells.
  The Journal of biological chemistry 1986 Charness ME, Querimit LA, Diamond I
• Phosphorylation of the nicotinic acetylcholine receptor.
  Progress in brain research 1986 Gordon AS, Diamond I
• Irreversible inhibition of phospholipid methylation and protein carboxymethylation does not alter acetylcholine receptor function in muscle cells.
  Experimental neurology 1984 Magilen G, Ziskind-Conhaim L, Diamond I, Gordon AS
• Ethanol and the gamma-aminobutyric acid-benzodiazepine receptor complex.
  Journal of neurochemistry 1984 Greenberg DA, Cooper EC, Gordon A, Diamond I
• Curious neurologic sequelae in galactosemia.
  Pediatrics 1984 Lo W, Packman S, Nash S, Schmidt K, Ireland S, Diamond I, Ng W, Donnell G
• Interaction of ethanol with neural cells in culture: a model of intoxication, tolerance and withdrawal.
  Ciba Foundation symposium 1984 Charness ME, Gordon AS, Diamond I
• Ethanol modulation of opiate receptors in cultured neural cells.
  Science (New York, N.Y.) 1983 Charness ME, Gordon AS, Diamond I
• Identification of a molecular weight 43,000 protein kinase in acetylcholine receptor-enriched membranes.
  Proceedings of the National Academy of Sciences of the United States of America 1983 Gordon AS, Milfay D, Diamond I
• Phospholipid methylation in myogenic cells.
  Biochemical and biophysical research communications 1983 Koch TK, Gordon AS, Diamond I
• Activation of acetylcholine receptors causes the partition of hydrophobic cations into postsynaptic membrane vesicles.
  Nature 1983 Davis CG, Hestrin S, Landahl H, Gordon AS, Diamond I, Korenbrot JI
• Specificity and localization of the acetylcholine receptor kinase.
  Proceedings of the National Academy of Sciences of the United States of America 1982 Davis CG, Gordon AS, Diamond I
• Identification of a mitochondrial phosphoprotein in brain synaptic membrane preparations.
  Journal of neurochemistry 1981 Magilen G, Gordon A, Au A, Diamond I
• Phosphoprotein phosphatase activity in normal and dystonic human fibroblast plasma membranes.
  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1981 Thomas RA, Gordon AS, Diamond I
• Membrane-bound protein kinase activity in acetylcholine receptor-enriched membranes.
  Biochimica et biophysica acta 1980 Gordon AS, Davis CG, Milfay D, Kaur J, Diamond I
• Regulation of acetylcholine receptor phosphorylation.
  Advances in biochemical psychopharmacology 1980 Gordon AS, Diamond I
• Reversible phosphorylation of the membrane-bound acetylcholine receptor.
  Journal of supramolecular structure 1980 Gordon AS, Diamond I
• ATP-binding proteins in acetylcholine receptor-enriched membranes.
  FEBS letters 1979 Gordon AS, Guillory RJ, Diamond I, Hucho F
• Dangers of mannitol in treatment of Reye's syndrome.
  The New England journal of medicine 1979 Schmidley J, Sander J, Diamond I, Fishman RA
• Protein phosphatase activity in acetylcholine receptor-enriched membranes.
  Biochemical and biophysical research communications 1979 Gordon AS, Milfay D, Davis CG, Diamond I
• Phosphorylation of the membrane-bound acetylcholine receptor: inhibition by diphenylhydantoin.
  Annals of neurology 1979 Gordon AS, Milfay D, Diamond I
• Inhibition of the evoked release of acetylcholine by the porphyrin precursor delta-aminolevulinic acid.
  Annals of neurology 1979 Bornstein JC, Pickett JB, Diamond I
• Phosphorylation of the acetylcholine receptor.
  Advances in experimental medicine and biology 1979 Gordon AS, Diamond I
• Glycolysis in quiescent cultures of 3T3 cells. Stimulation by serum, epidermal growth factor, and insulin in intact cells and persistence of the stimulation after cell homogenization.
  The Journal of biological chemistry 1978 Diamond I, Legg A, Schneider JA, Rozengurt E
• Glycolysis of quiescent cultures of 3T3 cells. Addition of serum, epidermal growth factor, and insulin increases the activity of phosphofructokinase in a protein synthesis-independent manner.
  The Journal of biological chemistry 1978 Schneider JA, Diamond I, Rozengurt E
• The high rate of aerobic glycolysis of transformed 3T3 cells persists after cell homogenization.
  Biochemical and biophysical research communications 1977 Rozengurt E, Schneider JA, Diamond I, Legg A
• Phosphorylation of acetylcholine receptor by endogenous membrane protein kinase in receptor-enriched membranes of Torpedo californica.
  Nature 1977 Gordon AS, Davis CG, Milfay D, Diamond I
• Separation of lactate dehydrogenase isoenzymes in rat brain by acrylamide--gel electrophoresis.
  Analytical biochemistry 1977 Simon K, Chaplin ER, Diamond I
• Carrier mediated glucose transport in capillaries isolated from rat brain.
  Journal of neurochemistry 1977 Goldstein GW, Csejtey J, Diamond I
• Photochemotherapy and photodynamic toxicity: simple methods for identifying potentially active agents.
  Biochemical medicine 1977 Diamond I, Granelli SG, McDonagh AF
• Phosphorylation of membrane proteins at a cholinergic synapse.
  Proceedings of the National Academy of Sciences of the United States of America 1977 Gordon AS, Davis CG, Diamond I
• LEUCINE OXIDATION IN BRAIN SLICES AND NERVE ENDINGS1.
  Journal of Neurochemistry 1976 E. R. Chaplin, A. L. Goldberg, I. Diamond
• Leucine oxidation in brain slices and nerve endings.
  Journal of neurochemistry 1976 Chaplin ER, Goldberg AL, Diamond I
• Isolation of metabolically active capillaries from rat brain.
  Journal of neurochemistry 1975 Goldstein GW, Wolinsky JS, Csejtey J, Diamond I
• Extraction of D-beta-hydroxybutyrate by brain in diabetic rats.
  Archives of neurology 1975 Openshaw H, Diamond I
• Photochemotherapy of glioma cells by visible light and hematoporphyrin.
  Cancer research 1975 Granelli SG, Diamond I, McDonagh AF, Wilson CB, Nielsen SL
• The albumin binding of unconjugated bilirubin in serum.
  Clinical biochemistry 1975 Griffiths WC, Diamond I, Dextraze P
• Photodynamic therapy of experimental gliomas.
  Transactions of the American Neurological Association 1975 Diamond I, Granelli SG, McDonagh SF, Crafts D, Wilson CB
• Pathogenesis of lead encephalopathy. Uptake of lead and reaction of brain capillaries.
  Archives of neurology 1974 Goldstein GW, Asbury AK, Diamond I
• THE IMPORTANCE OF LEUCINE OXIDATION IN ADULT AND DEVELOPING BRAIN.
  Pediatric Research 1974 Edward R Chaplin, Ivan Diamond, M Grumbach
• Metabolic basis of lead encephalopathy.
  Research publications - Association for Research in Nervous and Mental Disease 1974 Goldstein GW, Diamond I
• The relationship of choline acetyltransferase activity at the neuromuscular junction to changes in muscle mass and function.
  The Journal of physiology 1974 Diamond I, Franklin GM, Milfay D
• Development of Na+-stimulated glucose oxidation in synaptosomes.
  Journal of neurochemistry 1973 Diamond I, Fishman RA
• Preferential phosphorylation of recently transported 2-deoxy-D-glucose in isolated nerve endings.
  Brain research 1973 Diamond I, Fishman RA
• Development of glucose oxidation in isolated nerve endings.
  Nature 1973 Diamond I, Fishman RA
• High-affinity transport and phosphorylation of 2-deoxy-D-glucose in synaptosomes.
  Journal of neurochemistry 1973 Diamond I, Fishman RA
• Photodynamic therapy of malignant tumours.
  Lancet (London, England) 1972 Diamond I, Granelli SG, McDonagh AF, Nielsen S, Wilson CB, Jaenicke R
• Experimental brain ischemia: protection from irreversible damage with a rapid-acting barbiturate (methohexital).
  Stroke 1972 Yatsu FM, Diamond I, Graziano C, Lindquist P
• The formation of cerebrospinal fluid xanthochromia after subarachnoid hemorrhage. Enzymatic conversion of hemoglobin to bilirubin by the arachnoid and choroid plexus.
  Neurology 1972 Roost KT, Pimstone NR, Diamond I, Schmid R
• Uptake of ( 3 H-methyl)choline by microsomal, synaptosomal, mitochondrial and synaptic vesicle fractions of rat brain. The effects of hemicholinium.
  Journal of neurochemistry 1972 Diamond I, Milfay D
• Uptake and release of 45Ca by brain microsomes, synaptosomes and synaptic vesicles.
  Journal of neurochemistry 1971 Diamond I, Goldberg AL
• Choline metabolism in brain. The role of choline transport and the effects of phenobarbital.
  Archives of neurology 1971 Diamond I
• Studies on the neurotoxicity of bilirubin and the distribution of its derivatives.
  Birth defects original article series 1970 Diamond IF
• Choline metabolism in the central nervous system: the role of choline transport from plasma to brain.
  Neurology 1970 Diamond I
• Carrier-mediated transport of choline into synaptic nerve endings.
  The Journal of biological chemistry 1969 Diamond I, Kennedy EP
• Bilirubin binding and kernicterus.
  Advances in pediatrics 1969 Diamond I
• A sensitive radiochemical assay for choline acetylase.
  Analytical biochemistry 1968 Diamond I, Kennedy EP
• Neonatal hyperbilirubinemia and kernicterus. Experimental support for treatment by exposure to visible light.
  Archives of neurology 1968 Diamond I, Schmid R
• Prevention of hyperbilirubinemia and kernicterus by exposure to light: studies in newborn guinea pigs and premature infants.
  Transactions of the American Neurological Association 1968 Diamond I, Lucey J, Schmid R
• Oxidative phosphorylation in experimental bilirubin encephalopathy.
  Science (New York, N.Y.) 1967 Diamond I, Schmid R
• Kernicterus: revised concepts of pathogenesis and management.
  Pediatrics 1966 Diamond I, Odell GB, Johnson L, Boggs TR, Lucey JF
• Bilirubin encephalopathy: experimental models in newborn and adult animals.
  The Proceedings of the Institute of Medicine of Chicago 1966 Diamond I
• Experimental bilirubin encephalopathy. The mode of entry of bilirubin-14C into the central nervous system.
  The Journal of clinical investigation 1966 Diamond I, Schmid R
• Interaction of bilirubin with albumin.
  Nature 1965 Schmid R, Diamond I, Hammaker L, Gundersen CB
• MYOGLOBINURIA FOLLOWING UNILATERAL STATUS EPILEPTICUS AND IPSILATERAL RHABDOMYOLYSIS: A CLINICOPATHOLOGICAL REPORT.
  The New England journal of medicine 1965 DIAMOND I, AQUINO TI
• The pathogenesis of bilirubin encephalopathy: experimental models in newborn and adult animals.
  Transactions of the American Neurological Association 1965 Diamond I, Schmid R