Isha Jain, PhD
Assistant Professor
Biochemistry and Biophysics
School of Medicine

Awards

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• NIH Early Independence Award (DP5), 2018-2023
• UCSF Sandler Faculty Fellowship, 2018-2023
• American Federation for Aging Research Junior Faculty Grant, 2018-2020
• Glenn Award for Aging Research, 2018
• Harold Weintraub Graduate Student Award, 2017
• Philantropic Educational Organization National Scholar Award ($15K), 2016
• Department of Energy Computational Sciences Graduate Fellowship, 2013-2016
• Barry Goldwater Award, 2011
• Glamour Magazine's Top 10 College Women, 2009
• Discover Magazine's Top 5 Scientists Under 20, 2008
• Siemens Competition in Math, Science and Technology National Individual Winner ($100K), 2007

Education & Training

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• PhD Computer Science, Systems Biology Massachusetts Institute of Technology 09/2017
• AB Chemical and Physical Biology Harvard University 06/2012

Websites

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• Jain Lab Website (ishajainlab.com)

Grants and Projects

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• Redesigning a Neuron's Breath: A Modern Twist to Classical Oxygen Biology, NIH, 2018-2023

Publications (16)

Top publication keywords:
SynechococcusHyperoxiaOxygenMitochondriaHypoxiaElectron Transport Complex IChromosome SegregationCyanobacteriaLeigh DiseaseCarbon MonoxideMitochondrial DiseasesVon Hippel-Lindau Tumor Suppressor ProteinLipid MetabolismGlucoseChromosomes, Bacterial

• In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response.
  Science advances 2023 Chen X, Haribowo AG, Baik AH, Fossati A, Stevenson E, Chen YR, Reyes NS, Peng T, Matthay MA, Traglia M, Pico AR, Jarosz DF, Buchwalter A, Ghaemmaghami S, Swaney DL, Jain IH
• Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes.
  Molecular cell 2023 Baik AH, Haribowo AG, Chen X, Queliconi BB, Barrios AM, Garg A, Maishan M, Campos AR, Matthay MA, Jain IH
• Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism.
  Cell metabolism 2023 Midha AD, Zhou Y, Queliconi BB, Barrios AM, Haribowo AG, Chew BTL, Fong COY, Blecha JE, VanBrocklin H, Seo Y, Jain IH
• The Goldilocks Oxygen Principle: not too little and not too much.
  Nature cardiovascular research 2022 Flanigan WR, Jain IH
• Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS-MAPK Pathway Inhibition in Pancreatic Cancer.
  Cancer discovery 2022 Ravichandran M, Hu J, Cai C, Ward NP, Venida A, Foakes C, Kuljanin M, Yang A, Hennessey CJ, Yang Y, Desousa BR, Rademaker G, Staes AAL, Cakir Z, Jain IH, Aguirre AJ, Mancias JD, Shen Y, DeNicola GM, …

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• Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells.
  Science (New York, N.Y.) 2021 Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, Rajagopal J
• Turning the Oxygen Dial: Balancing the Highs and Lows.
  Trends in cell biology 2020 Baik AH, Jain IH
• Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism.
  Cell 2020 Jain IH, Calvo SE, Markhard AL, Skinner OS, To TL, Ast T, Mootha VK
• Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation.
  Cell metabolism 2019 Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK
• Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM
• Hypoxia as a therapy for mitochondrial disease.
  Science (New York, N.Y.) 2016 Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK
• Spatial ordering of chromosomes enhances the fidelity of chromosome partitioning in cyanobacteria.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Jain IH, Vijayan V, O'Shea EK
• A high resolution map of a cyanobacterial transcriptome.
  Genome biology 2011 Vijayan V, Jain IH, O'Shea EK
• The making of a young scientist.
  Developmental dynamics : an official publication of the American Association of Anatomists 2008 Jain I, Iovine K
• Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration.
  Developmental biology 2008 Hoptak-Solga AD, Nielsen S, Jain I, Thummel R, Hyde DR, Iovine MK
• Bone growth in zebrafish fins occurs via multiple pulses of cell proliferation.
  Developmental dynamics : an official publication of the American Association of Anatomists 2007 Jain I, Stroka C, Yan J, Huang WM, Iovine MK