Iris Otani, MD
Associate Professor
Medicine
School of Medicine

She is the associate program director for the UCSF Allergy/Immunology Fellowship Training Program. She has pursued further training in quality improvement and was selected to join the Learning Health System Coach program at UCSF Health, a faculty development program for faculty who lead continuous improvement in their clinical settings. She serves on the editorial board of the Annals of Allergy Asthma & Immunology.

• Predicting Penicillin Allergy from Patient-Reported Data: A Multi-Site Prospective Study from The United States Drug Allergy Registry.
  Journal of Allergy and Clinical Immunology 2024 Kimberly Blumenthal, Allison Ramsey, Elizabeth Phillips, Alexei Gonzalez-Estrada, John Accarino, Aleena Banerji, Cosby Stone, Iris Otani, David Khan, Timothy Chow, Anne Liu, Anna Arroyo, Andrew King, …
• From the pages of AllergyWatch.
  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2024 Fineman SM, Joshi SR, Otani I, Knox S
• Hereditary alpha tryptasemia presenting as recurrent chemotherapy hypersensitivity reactions.
  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2023 Monahan R, Alfaro E, Ho H, Otani IM, Tsao LR
• From the pages of AllergyWatch.
  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2023 Fineman SM, Chow T, Otani I
• From the Pages of AllergyWatch.
  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2023 Fineman S, Spriet S, Otani I, Lee GB
• United States Drug Allergy Registry (USDAR) grading scale for immediate drug reactions.
  The Journal of allergy and clinical immunology 2023 Khan DA, Phillips EJ, Accarino JJ, Gonzalez-Estrada A, Otani IM, Ramsey A, Arroyo AC, Banerji A, Chow T, Liu AY, Stone CA, Blumenthal KG
• Drug allergy in older adults: A study from the United States Drug Allergy Registry.
  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2023 Accarino JJO, Ramsey A, Samarakoon U, Phillips E, Gonzalez-Estrada A, Otani IM, Fu X, Banerji A, Stone CA, Khan DA, Blumenthal KG, United States Drug Allergy Registry Study Team
• Updated guidance regarding the risk of allergic reactions to COVID-19 vaccines and recommended evaluation and management: A GRADE assessment and international consensus approach.
  The Journal of allergy and clinical immunology 2023 Greenhawt M, Dribin TE, Abrams EM, Shaker M, Chu DK, Golden DBK, Akin C, Anagnostou A, ALMuhizi F, Alqurashi W, Arkwright P, Baldwin JL, Banerji A, Bégin P, Ben-Shoshan M, Bernstein J, Bingemann TA, …
• Impact of an Inpatient Allergy Guideline on β-Lactam and Alternative Antibiotic Use.
  The journal of allergy and clinical immunology. In practice 2023 Otani IM, Tang M, Wang L, Anstey KM, Hilts-Horeczko A, Li F, Le VP, Lee M, Bystritsky R, Mulliken JS, Wattier RL, Blumenthal KG, Doernberg SB
• IgG Replacement Therapy Use in Patients with Hypogammaglobulinemia after Lung Transplant.
  Clinical Immunology 2023 Rose Monahan, Alyssa Perez, Joey Lew, Megan Casey, Lorriana Leard, Steven Hays, Iris Otani
• Access To Outpatient Chemotherapy Desensitization Improved With Implementation Of A Multidisciplinary Pharmacy, Nursing, And Allergist Team.
  Journal of Allergy and Clinical Immunology 2023 Rose Monahan, Fernanda Young, Emely Alfaro, Carlo Legasto, Dorothy Wang, Jessica Zheng, Lulu Tsao, Hansen Ho, Iris Otani
• Drug Allergy Assessments in Older Adults: A Multi-Site Prospective Study from the United States Drug Allergy Registry.
  Journal of Allergy and Clinical Immunology 2023 John Accarino, Allison Ramsey, Upeka Samarakoon, Iris Otani, Alexei Gonzalez-Estrada, Xiaoqing Fu, Elizabeth Phillips, Cosby Stone, Aleena Banerji, Kimberly Blumenthal
• Medicine resident perceptions regarding β-lactam antibiotic prescribing in patients with penicillin allergy.
  The journal of allergy and clinical immunology. In practice 2022 Jiang SY, Tang M, Desai K, Song P, Eng J, Otani IM
• Coronavirus disease 2019 vaccine administration in patients with reported reactions to polyethylene glycol- and polysorbate-containing therapeutics.
  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2022 Otani IM, Tsao LR, Tang M
• Practical guidance for the diagnosis and management of secondary hypogammaglobulinemia: A Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees.
  The Journal of allergy and clinical immunology 2022 Otani IM, Lehman HK, Jongco AM, Tsao LR, Azar AE, Tarrant TK, Engel E, Walter JE, Truong TQ, Khan DA, Ballow M, Cunningham-Rundles C, Lu H, Kwan M, Barmettler S
• Direct Rechallenges, Slowed Infusions, and Titrated Infusions following Platinum Hypersensitivity Reactions: Review of 5-Year Experience.
  Journal of Allergy and Clinical Immunology 2022 Fernanda Young, Karen Anstey, Hansen Ho, Emely Alfaro, Pelin Cinar, Iris Otani
• Implementing a Hospital-Wide Inpatient Beta-Lactam Allergy Guideline Leads to Consistent Increases in Beta-Lactam Use.
  Journal of Allergy and Clinical Immunology 2022 Iris Otani, Monica Tang, Karen Anstey, Lusha Wang, Alexandra Hilts-Horeczko, Fanny Li, Vincent Le, Melissa Lee, Jennifer Mulliken, Rachel Bystritsky, Sarah Doernberg
• The United States Drug Allergy Registry: A Prospective Longitudinal Cohort Study of Patients Tested for Drug Allergies.
  Journal of Allergy and Clinical Immunology 2022 Kimberly Blumenthal, Allison Ramsey, Upeka Samarakoon, Iris Otani, Alexei Gonzalez-Estrada, Aleena Banerji, Anne Liu, Paige Wickner, Cosby Stone, Miguel Park, Christian Mancini, Allen Judd, Catherine …
• Urticarial and Eczematous Eruptions Following mRNA COVID-19 Vaccination in Patients With and Without Chronic Urticaria and Atopic Dermatitis.
  Journal of Allergy and Clinical Immunology 2022 Ruchi Shah, Lulu Tsao, Jessica Zheng, Monica Tang, Iris Otani
• Drug Allergy Delabeling Programs: Recent Strategies and Targeted Populations.
  Clinical reviews in allergy & immunology 2022 Anstey KM, Tsao L, Otani IM
• M060 SUCCESSFUL REINTRODUCTION OF MOGAMULIZUMAB VIA OUTPATIENT ONE DILUTION DESENSITIZATION PROTOCOLS FOLLOWING RECURRENT DELAYED CUTANEOUS REACTIONS.
  Annals of Allergy Asthma & Immunology 2021 F. Young, L. Pincus, W. Ai, I. Otani
• One-Bag Desensitization Protocols in the Management of Chemotherapy Hypersensitivity.
  The journal of allergy and clinical immunology. In practice 2021 Tsao LR, Otani IM
• Perceptions Around Lung Transplant-Associated Hypogammaglobulinemia.
  Journal of clinical immunology 2021 Lew J, Casey M, Leard LE, Hays S, Otani IM
• Hypersensitivity Reactions to Platinum Agents and Taxanes.
  Clinical reviews in allergy & immunology 2021 Tsao LR, Young FD, Otani IM, Castells MC
• Enabling antibiotic allergy evaluations and reintroduction of first-line antibiotics for patients with cystic fibrosis.
  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2021 Anstey KM, Choi L, Dawson D, Kleinhenz ME, Otani IM
• Impact of Rapid Transition to Telemedicine-Based Delivery on Allergy/Immunology Care During COVID-19.
  The journal of allergy and clinical immunology. In practice 2021 Tsao LR, Villanueva SA, Pines DA, Pham MN, Choo EM, Tang MC, Otani IM
• Hypogammaglobulinemia Identification and Management in Lung Transplant Patients: Survey of Provider Practices.
  The Journal of Heart and Lung Transplantation 2021 M. Casey, J. Lew, S. Hays, L. Leard, I. Otani
• Screening for Severe Hypogammaglobulinemia in Lung Transplant Recipients.
  The Journal of Heart and Lung Transplantation 2021 I.M. Otani, J. Lew, M. Casey, A. Perez, L. Zhang, L. Leard, S. Hays
• Perioperative use and safety of cephalosporin antibiotics in patients with documented penicillin allergy.
  The journal of allergy and clinical immunology. In practice 2021 Anstey KM, Anstey JE, Doernberg SB, Chen LL, Otani IM
• Rapid Adoption of Video Visits and Return-to-Clinic Procedures to Maintain Access to Allergy/Immunology Care Delivery During COVID-19.
  Journal of Allergy and Clinical Immunology 2021 Lulu Tsao, Stephanie Anne Villanueva Ferraris, David Pines, Eugene Choo, Michele Pham, Monica Tang, Lorianna Leard, Andrew Gross, Cameron Ashbaugh, Lei Choi, Iris Otani
• Zoonotic coronavirus epidemics: Severe acute respiratory syndrome, Middle East respiratory syndrome, and coronavirus disease 2019.
  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2020 Fung M, Otani I, Pham M, Babik J
• A055 EXPANDING PENICILLIN ALLERGY EVALUATION FOR PRENATAL PATIENTS.
  Annals of Allergy Asthma & Immunology 2020 L. Tsao, R. Irani, G. Rosenbluth, L. Choi, I. Otani
• Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs.
  The journal of allergy and clinical immunology. In practice 2020 Broyles AD, Banerji A, Barmettler S, Biggs CM, Blumenthal K, Brennan PJ, Breslow RG, Brockow K, Buchheit KM, Cahill KN, Cernadas J, Chiriac AM, Crestani E, Demoly P, Dewachter P, Dilley M, Farmer JR, …
• Neurologic Conditions and Symptoms Reported Among Common Variable Immunodeficiency Patients in the USIDNET.
  Journal of clinical immunology 2020 Lee M, Nguyen J, Fuleihan R, Gundling K, Cunningham-Rundles C, Otani IM
• Patient Characteristics and Concerns about Drug Allergy: A Report from the United States Drug Allergy Registry.
  The journal of allergy and clinical immunology. In practice 2020 Blumenthal KG, Harkness T, Phillips EJ, Ramsey A, Banerji A, Samarakoon U, Stone C, Fu X, Khan DA, Otani I, Camargo CA, Zhang Y, Donelan K, USDAR Study Team
• Antibiotic adverse reactions in adult cystic fibrosis patients.
  The journal of allergy and clinical immunology. In practice 2020 Anstey KM, Lee M, Dawson D, Jue V, Budzik JM, Yu M, Kleinhenz ME, Otani IM
• Novel Roles for Platinum and Taxane Agent Skin Testing in Risk Stratification of Chemotherapy Hypersensitivity.
  The journal of allergy and clinical immunology. In practice 2020 Otani IM, Castells M
• Development of an Antibiotic Allergy Program to Address a Clinical Gap in the Antibiotic Stewardship of Cystic Fibrosis Patients.
  Journal of Allergy and Clinical Immunology 2020 Karen Anstey, Mary Ellen Kleinhenz, Iris Otani
• Hypogammaglobulinemia in Patients with Neuromyelitis Optica (NMO).
  Journal of Allergy and Clinical Immunology 2020 Lulu Tsao, Riley Bove, Tanya Krishnakumar, Iris Otani
• Primary Immunodeficiency Diagnoses seen in Patients with Chronic Lung Disease: Findings from the USIDNET Registry.
  Journal of Allergy and Clinical Immunology 2020 Michael Lee, John Routes, Rebecca Marsh, Ramsay Fuleihan, Patricia Lugar, Charlotte Cunningham-Rundles, Elizabeth Garabedian, Iris Otani
• A006 ADVERSE DRUG REACTIONS IN CYSTIC FIBROSIS PATIENTS: USING DATA TO DEVELOP AN ANTIBIOTIC EVALUATION PROGRAM.
  Annals of Allergy Asthma & Immunology 2019 K. Anstey, M. Kleinhenz, I. Otani
• 2543. Implementation of a Fellow-Driven ?-Lactam Allergy De-Labeling Initiative on an Inpatient ID Consult Service.
  Open Forum Infectious Diseases 2019 Jennifer S Mulliken, Rachel Bystritsky, Karen Anstey, Iris M Otani, Sarah B Doernberg
• Beta-lactam Administration Patterns at a Safety-net Hospital with Limited Access to Inpatient Penicillin Skin Testing.
  Journal of Allergy and Clinical Immunology 2019 Paula Song, Michael Hwa, Jen Eng, Iris M. Otani
• Hypogammaglobulinemia in Multiple Sclerosis Patients Receiving Disease-Modifying Immunomodulatory Agents.
  Journal of Allergy and Clinical Immunology 2019 Lulu Tsao, Iris M. Otani, Riley Bove
• Perioperative Use and Safety of Cephalosporin Antibiotics in Patients with Documented Penicillin Allergy.
  Journal of Allergy and Clinical Immunology 2019 Karen Anstey, James Anstey, Alexandra Hilts-Horeczko, Sarah B. Doernberg, Lee-Lynn Chen, Iris M. Otani
• Strategies for Discontinuing Omalizumab in Patients with Chronic Urticaria: Real-World Findings.
  Journal of Allergy and Clinical Immunology 2019 Sara Seghezzo, Lulu Tsao, Iris M. Otani
• Development of a health-related quality of life instrument for patients with hereditary angioedema living in the United States.
  The journal of allergy and clinical immunology. In practice 2018 Busse PJ, Christiansen SC, Birmingham JM, Overbey JR, Banerji A, Otani IM, Lumry W, Goryachkovsky A, Zuraw BL
• Diffuse cutaneous mastocytosis with novel somatic KIT mutation K509I and association with tuberous sclerosis.
  Clinical case reports 2018 Otani IM, Carroll RW, Yager P, Kroshinsky D, Murphy S, Hornick JL, Akin C, Castells M, Walter JE
• Cutaneous Manifestations of Reactions to Biologics.
  Current allergy and asthma reports 2018 Otani IM, Levin AS, Banerji A
• Documentation of Adverse Drug Reactions in Electronic Medical Records: Areas for Improvement and Impact on Clinical Outcomes.
  Journal of Allergy and Clinical Immunology 2018 Jenna T. Nguyen, Iris M. Otani
• Impact of a Novel Radiocontrast Media Reaction Treatment Algorithm in Simulation Settings of Anaphylaxis.
  Journal of Allergy and Clinical Immunology 2018 Iris M. Otani, Alexi Otrakji, Niki Holtzman, Matthew Iandoli, Kimberly G. Blumenthal, Aleena Banerji, Gloria Salazar
• Chapter 23 Corticosteroids.
  Drug Allergy Testing 2018 Iris M. Otani
• Utility of Risk Stratification for Paclitaxel Hypersensitivity Reactions.
  The journal of allergy and clinical immunology. In practice 2017 Otani IM, Lax T, Long AA, Slawski BR, Camargo CA, Banerji A
• Platinum Chemotherapy Hypersensitivity: Prevalence and Management.
  Immunology and allergy clinics of North America 2017 Otani IM, Wong J, Banerji A
• Acquired C1 Inhibitor Deficiency.
  Immunology and allergy clinics of North America 2017 Otani IM, Banerji A
• Biologic Therapies for Immunoglobulin E-mediated Food Allergy and Eosinophilic Esophagitis.
  Immunology and allergy clinics of North America 2017 Otani IM, Nadeau KC
• Gastrointestinal Manifestations in X-linked Agammaglobulinemia.
  Journal of clinical immunology 2017 Barmettler S, Otani IM, Minhas J, Abraham RS, Chang Y, Dorsey MJ, Ballas ZK, Bonilla FA, Ochs HD, Walter JE
• Subcutaneous Icatibant for the Treatment of Hereditary Angioedema Attacks: Comparison of Home Self-Administration with Administration at a Medical Facility.
  The journal of allergy and clinical immunology. In practice 2016 Otani IM, Lumry WR, Hurwitz S, Li HH, Craig TJ, Holtzman NS, Iandoli MI, Tucker J, Riedl MA, Zuraw BL, Banerji A
• Emergency Department Management of Hereditary Angioedema Attacks: Patient Perspectives.
  The journal of allergy and clinical immunology. In practice 2016 Otani IM, Christiansen SC, Busse P, Camargo CA, Zuraw BL, Riedl MA, Banerji A
• Reactions to Rituximab in an Outpatient Infusion Center: A 5-Year Review.
  The journal of allergy and clinical immunology. In practice 2016 Levin AS, Otani IM, Lax T, Hochberg E, Banerji A
• Immediate and Delayed Hypersensitivity Reactions to Corticosteroids: Evaluation and Management.
  Current allergy and asthma reports 2016 Otani IM, Banerji A
• Immediate and Delayed Hypersensitivity Reactions to Proton Pump Inhibitors: Evaluation and Management.
  Current allergy and asthma reports 2016 Otani IM, Banerji A
• Subcutaneous Icatibant for the Treatment of Acute Attacks of Hereditary Angioedema: Comparison of Self-Administration to Administration at a Medical Facility.
  Journal of Allergy and Clinical Immunology 2016 Iris Otani, William R. Lumry, Huamin Henry Li, Chevy Chase, Timothy J. Craig, Marc A. Riedl, Bruce L. Zuraw, Aleena Banerji
• A role for vancomycin epicutaneous skin testing in the evaluation of perioperative anaphylaxis.
  The journal of allergy and clinical immunology. In practice 2015 Otani IM, Kuhlen JL, Blumenthal KG, Guyer A, Banerji A
• Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies.
  Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2014 Arasi S, Otani IM, Klingbeil E, Bégin P, Kearney C, Dominguez TL, Block WM, O'Riordan G, Nadeau KC
• Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects.
  Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2014 Otani IM, Bégin P, Kearney C, Dominguez TL, Mehrotra A, Bacal LR, Wilson S, Nadeau K
• Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis.
  The Journal of allergy and clinical immunology 2013 Otani IM, Anilkumar AA, Newbury RO, Bhagat M, Beppu LY, Dohil R, Broide DH, Aceves SS
• Multi-Allergen Oral Immunotherapy Improves Quality of Life in Subjects with Food Allergies.
  Journal of Allergy and Clinical Immunology 2013 Iris Otani, Tina L.R. Dominguez, Alicia Sciancalepore, Anjuli Mehrotra, Daniela Pineda, Kari Nadeau
• The Effect of Anti-IL-5 Therapy on Esophageal Mastocytosis in Pediatric Eosinophilic Esophagitis.
  Journal of Allergy and Clinical Immunology 2012 I.M. Otani, M. Bhagat, R.O. Newbury, R. Dohil, D.H. Broide, S.S. Aceves
• Monomeric IgE and mast cell development, survival and function.
  Advances in experimental medicine and biology 2011 Kashiwakura J, Otani IM, Kawakami T
• A multicenter study of the frequency and distribution of GJB2 and GJB6 mutations in a large North American cohort.
  Genetics in medicine : official journal of the American College of Medical Genetics 2007 Putcha GV, Bejjani BA, Bleoo S, Booker JK, Carey JC, Carson N, Das S, Dempsey MA, Gastier-Foster JM, Greinwald JH, Hoffmann ML, Jeng LJ, Kenna MA, Khababa I, Lilley M, Mao R, Muralidharan K, Otani IM,…
• Enhancement of IGE-induced mediator release from rat peritoneal mast cells by serum-treated zymosan.
  Cellular immunology 1984 Otani I, Conrad DH, Ruddy S
• [Renal disease in the nail-patella syndrome: report of an affected family and studies of renal disease susceptibility and HLA (author's transl)].
  Nihon Jinzo Gakkai shi 1978 Kuroda M, Akiyama T, Otani I, Kusunoki N, Tohfuku Y, Imura M, Tamai T, Takeda R