Irina Proekt, PhD
Assistant Researcher
Diabetes Center
School of Medicine

Education & Training

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• PhD/Biomedical Sciences Microbiology/Immunology UCSF 2015
• B.S./Chemistry California Institute of Technology 2001

Publications (14)

Top publication keywords:
Autoantibodiessrc-Family KinasesCentral ToleranceThymus GlandAutoimmunityAutoantigensThymocytesAutoimmune DiseasesImmune ToleranceUveitis, PosteriorPolyendocrinopathies, AutoimmuneBacteriophagesTranscription FactorsRetinol-Binding ProteinsLymphoid Progenitor Cells

• Validation of a murine proteome-wide phage display library for identification of autoantibody specificities.
  JCI insight 2023 Rackaityte E, Proekt I, Miller HS, Ramesh A, Brooks JF, Kung AF, Mandel-Brehm C, Yu D, Zamecnik CR, Bair R, Vazquez SE, Sunshine S, Abram CL, Lowell CA, Rizzuto G, Wilson MR, Zikherman J, Anderson MS,…
• Ikaros is a principal regulator of Aire+ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance.
  Science immunology 2023 Sin JH, Sucharov J, Kashyap S, Wang Y, Proekt I, Liu X, Parent AV, Gupta A, Kastner P, Chan S, Gardner JM, Ntranos V, Miller CN, Anderson MS, Schjerven H, Waterfield MR
• Validation of a murine proteome-wide phage display library for the identification of autoantibody specificities.
  bioRxiv : the preprint server for biology 2023 Rackaityte E, Proekt I, Miller HS, Ramesh A, Brooks JF, Kung AF, Mandel-Brehm C, Yu D, Zamecnik C, Bair R, Vazquez SE, Sunshine S, Abram CL, Lowell CA, Rizzuto G, Wilson MR, Zikherman J, Anderson MS, …
• Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq.
  eLife 2022 Vazquez SE, Mann SA, Bodansky A, Kung AF, Quandt Z, Ferré EMN, Landegren N, Eriksson D, Bastard P, Zhang SY, Liu J, Mitchell A, Proekt I, Yu D, Mandel-Brehm C, Wang CY, Miao B, Sowa G, Zorn K, Chan AY…
• Thymic regulatory T cells arise via two distinct developmental programs.
  Nature immunology 2019 Owen DL, Mahmud SA, Sjaastad LE, Williams JB, Spanier JA, Simeonov DR, Ruscher R, Huang W, Proekt I, Miller CN, Hekim C, Jeschke JC, Aggarwal P, Broeckel U, LaRue RS, Henzler CM, Alegre ML, Anderson …

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• Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.
  Nature 2018 Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, …
• Insights into immune tolerance from AIRE deficiency.
  Current opinion in immunology 2017 Proekt I, Miller CN, Lionakis MS, Anderson MS
• LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.
  The Journal of clinical investigation 2016 Proekt I, Miller CN, Jeanne M, Fasano KJ, Moon JJ, Lowell CA, Gould DB, Anderson MS, DeFranco AL
• Identification of a novel cis-regulatory element essential for immune tolerance.
  The Journal of experimental medicine 2015 LaFlam TN, Seumois G, Miller CN, Lwin W, Fasano KJ, Waterfield M, Proekt I, Vijayanand P, Anderson MS
• Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Yoshida H, Bansal K, Schaefer U, Chapman T, Rioja I, Proekt I, Anderson MS, Prinjha RK, Tarakhovsky A, Benoist C, Mathis D
• Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells.
  European journal of immunology 2011 Gross AJ, Proekt I, DeFranco AL
• Natural killer cells in NOD.NK1.1 mice acquire cytolytic function during viral infection and provide protection against cytomegalovirus.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Orr MT, Beilke JN, Proekt I, Lanier LL
• Notch/Delta signaling constrains reengineering of pro-T cells by PU.1.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Franco CB, Scripture-Adams DD, Proekt I, Taghon T, Weiss AH, Yui MA, Adams SL, Diamond RA, Rothenberg EV
• Somatostatin receptor type 5 modulates somatostatin receptor type 2 regulation of adrenocorticotropin secretion.
  The Journal of biological chemistry 2005 Ben-Shlomo A, Wawrowsky KA, Proekt I, Wolkenfeld NM, Ren SG, Taylor J, Culler MD, Melmed S