Irfan Kathiriya, MD, PhD
Professor
Anesthesia
School of Medicine

Education & Training

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• Clinical fellow Pediatric Anesthesia University of California, San Francisco 2011
• Clinical fellow Pediatric Cardiac Anesthesia University of California, San Francisco 2010
• Residency Anesthesia & Perioperative Care University of California, San Francisco 2009
• Internship Pediatrics University of California, San Francisco 2006
• M.D., Ph.D. School of Medicine University of Texas Southwestern 2005
• B.A. Chemistry & International Relations Claremont McKenna College 1997

Websites

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• Clinical Profile at UCSF Medical Center (ucsfhealth.org)

Grants and Projects

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• Patterning Mechanisms for Ventricular Septation and Congenital Heart Defects, NIH, 2024-2026
• Genetic determinants of 4D genome folding in human cardiac development, NIH, 2020-2025
• Mechanisms for Ventricular Septation: Implications for Congenital Heart Disease, Saving tiny Hearts Society, 2023-2025
• Gene regulatory networks for heart development, NIH, 2021-2024
• Cell-Cell Signaling Mechanisms for Heart Development: A Pilot Project, Pediatric Heart Center, 2022-2024

Publications (27)

Top publication keywords:
HaploinsufficiencyBody PatterningHeart Septal Defects, AtrialHeartAtrial FibrillationMEF2 Transcription FactorsCell LineageGene Expression Regulation, DevelopmentalMyocytes, CardiacGene Regulatory NetworksT-Box Domain ProteinsHeart Defects, CongenitalHeart Septal Defects, VentricularHeart AtriaTranscription Factors

• Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease.
  Development (Cambridge, England) 2026 Kathiriya IS, Rao KS, Clark AP, Hu KM, Grant ZL, Matthews MN, Chen Z, Hota SK, Saucerman JJ, Bruneau BG
• A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects.
  Nature cardiovascular research 2025 Kathiriya IS, Dominguez MH, Rao KS, Muncie-Vasic JM, Devine WP, Hu KM, Hota SK, Garay BI, Quintero D, Goyal P, Matthews MN, Thomas R, Sukonnik T, Miguel-Perez D, Winchester S, Brower EF, Forjaz A, Wu …
• Author Correction: Brahma safeguards canalization of cardiac mesoderm differentiation.
  Nature 2025 Hota SK, Rao KS, Blair AP, Khalilimeybodi A, Hu KM, Thomas R, So K, Kameswaran V, Xu J, Polacco BJ, Desai RV, Chatterjee N, Hsu A, Muncie JM, Blotnick AM, Winchester SAB, Weinberger LS, Hüttenhain R, …
• Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease.
  bioRxiv : the preprint server for biology 2025 Kathiriya IS, Rao KS, Clark AP, Hu KM, Grant ZL, Matthews MN, Chen Z, Hota SK, Saucerman JJ, Bruneau BG
• Dose-dependent sensitivity of human 3D chromatin to a heart disease-linked transcription factor.
  bioRxiv : the preprint server for biology 2025 Grant ZL, Kuang S, Zhang S, Horrillo AJ, Rao KS, Kameswaran V, Joubran C, Lau PK, Dong K, Yang B, Bartosik WM, Zemke NR, Ren B, Kathiriya IS, Pollard KS, Bruneau BG

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• In preprints: insights into human heart development and congenital heart defects.
  Development (Cambridge, England) 2024 Kathiriya IS
• A single institution anesthetic experience with catheterization of pediatric pulmonary hypertension patients.
  Pulmonary circulation 2024 Morell E, Colglazier E, Becerra J, Stevens L, Steurer MA, Sharma A, Nguyen H, Kathiriya IS, Weston S, Teitel D, Keller R, Amin EK, Nawaytou H, Fineman JR
• A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects.
  bioRxiv : the preprint server for biology 2024 Kathiriya IS, Dominguez MH, Rao KS, Muncie-Vasic JM, Devine WP, Hu KM, Hota SK, Garay BI, Quintero D, Goyal P, Matthews MN, Thomas R, Sukonnik T, Miguel-Perez D, Winchester S, Brower EF, Forjaz A, Wu …
• Cell Layers: uncovering clustering structure in unsupervised single-cell transcriptomic analysis.
  Bioinformatics advances 2022 Blair AP, Hu RK, Farah EN, Chi NC, Pollard KS, Przytycki PF, Kathiriya IS, Bruneau BG
• Brahma safeguards canalization of cardiac mesoderm differentiation.
  Nature 2022 Hota SK, Rao KS, Blair AP, Khalilimeybodi A, Hu KM, Thomas R, So K, Kameswaran V, Xu J, Polacco BJ, Desai RV, Chatterjee N, Hsu A, Muncie JM, Blotnick AM, Winchester SAB, Weinberger LS, Hüttenhain R, …
• Interactive anesthesiology educational program improves wellness for anesthesiologists and their children.
  Journal of clinical anesthesia 2021 Jung MJ, Libaw JS, Manuel SP, Kathiriya IS, Srejic U, Gandhi S
• Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease.
  Developmental cell 2020 Kathiriya IS, Rao KS, Iacono G, Devine WP, Blair AP, Hota SK, Lai MH, Garay BI, Thomas R, Gong HZ, Wasson LK, Goyal P, Sukonnik T, Hu KM, Akgun GA, Bernard LD, Akerberg BN, Gu F, Li K, Speir ML, …
• Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs.
  Development (Cambridge, England) 2019 George MR, Duan Q, Nagle A, Kathiriya IS, Huang Y, Rao K, Haldar SM, Bruneau BG
• A TBX5 dosage-sensitive gene regulatory network for human congenital heart disease.
  bioRxiv 2019 Irfan S. Kathiriya, Kavitha S. Rao, Giovanni Iacono, W. Patrick Devine, Swetansu K. Hota, Michael H. Lai, Bayardo I. Garay, Reuben Thomas, Andrew P. Blair, Henry Z. Gong, Lauren K. Wasson, Piyush …
• Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs.
  bioRxiv 2019 Matthew George, Qiming Duan, Abigail Nagle, Irfan Kathiriya, Yu Huang, Kavitha Rao, Saptarsi Haldar, Benoit Bruneau
• The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1.
  Development (Cambridge, England) 2017 Zhu JY, Heidersbach A, Kathiriya IS, Garay BI, Ivey KN, Srivastava D, Han Z, King IN
• Single-Cell Resolution of Temporal Gene Expression during Heart Development.
  Developmental cell 2016 DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J, Pu W, Bruneau BG, Seidman JG, Seidman CE
• Investigating the transcriptional control of cardiovascular development.
  Circulation research 2015 Kathiriya IS, Nora EP, Bruneau BG
• Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease.
  American journal of medical genetics. Part A 2007 Schluterman MK, Krysiak AE, Kathiriya IS, Abate N, Chandalia M, Srivastava D, Garg V
• Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa.
  Biochemical and biophysical research communications 2006 King IN, Kathiriya IS, Murakami M, Nakagawa M, Gardner KA, Srivastava D, Nakagawa O
• Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.
  Nature genetics 2005 Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau BG
• Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism.
  The Journal of biological chemistry 2004 Kathiriya IS, King IN, Murakami M, Nakagawa M, Astle JM, Gardner KA, Gerard RD, Olson EN, Srivastava D, Nakagawa O
• GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5.
  Nature 2003 Garg V, Kathiriya IS, Barnes R, Schluterman MK, King IN, Butler CA, Rothrock CR, Eapen RS, Hirayama-Yamada K, Joo K, Matsuoka R, Cohen JC, Srivastava D
• Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development.
  Developmental biology 2001 Garg V, Yamagishi C, Hu T, Kathiriya IS, Yamagishi H, Srivastava D
• Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway.
  Development (Cambridge, England) 2000 Fernandez-Teran M, Piedra ME, Kathiriya IS, Srivastava D, Rodriguez-Rey JC, Ros MA
• Left-right asymmetry and cardiac looping: implications for cardiac development and congenital heart disease.
  American journal of medical genetics 2000 Kathiriya IS, Srivastava D
• Cellular delivery of peptide nucleic acids and inhibition of human telomerase.
  Chemistry & biology 1999 Hamilton SE, Simmons CG, Kathiriya IS, Corey DR