Ira Mellman, PhD
Professor
Biochemistry and Biophysics
School of Medicine

Education & Training

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• AB Oberlin College
• postdoc Immunology/Cell Biology The Rockefeller University
• PhD Genetics Yale University School of Medicine

Grants and Projects

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• Developmental Cell Biology of Dendritic Cells, NIH, 1993-2008
• Molecular Sorting During Intracellular Transport, NIH, 1981-2007
• Cell Biology of the Immune Response, NIH, 2003
• Cell Biology of Mhc Class Ii Antigen Presentation, NIH, 1984-1999
• Cell Biology of Fc Receptor Function, NIH, 1993-1998
• Gordon Research Conference on Molecular Membrane Biology, NIH, 1993-1994

Publications (172)

Top publication keywords:
EndosomesB7-H1 AntigenImmunotherapyCell PolarityT-LymphocytesHistocompatibility Antigens Class IICell MembraneCross-PrimingAntigen PresentationProtein TransportNeoplasmsDendritic CellsCD8-Positive T-LymphocytesEndocytosisLysosomes

• Elements of cancer immunity and the cancer-immune set point.
  Nature 2017 Chen DS, Mellman I
• MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade.
  Immunity 2016 Ebert PJR, Cheung J, Yang Y, McNamara E, Hong R, Moskalenko M, Gould SE, Maecker H, Irving BA, Kim JM, Belvin M, Mellman I
• Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing.
  Nature 2014 Yadav M, Jhunjhunwala S, Phung QT, Lupardus P, Tanguay J, Bumbaca S, Franci C, Cheung TK, Fritsche J, Weinschenk T, Modrusan Z, Mellman I, Lill JR, Delamarre L
• Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.
  Nature 2014 Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, Sosman JA, McDermott DF, Powderly JD, Gettinger SN, Kohrt HE, Horn L, Lawrence DP, Rost S, Leabman M, Xiao Y, Mokatrin A, Koeppen H, Hegde…
• Oncology meets immunology: the cancer-immunity cycle.
  Immunity 2013 Chen DS, Mellman I
• Cancer immunotherapy comes of age.
  Nature 2011 Mellman I, Coukos G, Dranoff G
• Ira Mellman: from endosomes to industry. Interview by William A Wells.
  The Journal of cell biology 2007 Mellman I
• Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination.
  Nature 2006 Shin JS, Ebersold M, Pypaert M, Delamarre L, Hartley A, Mellman I
• Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate.
  Science (New York, N.Y.) 2005 Delamarre L, Pack M, Chang H, Mellman I, Trombetta ES
• Old lysosomes, new tricks: MHC II dynamics in DCs.
  Trends in immunology 2005 Chow AY, Mellman I
• Cell biology of antigen processing in vitro and in vivo.
  Annual review of immunology 2005 Trombetta ES, Mellman I

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• The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity.
  Cancer immunology research 2024 Lim J, Rodriguez R, Williams K, Silva J, Gutierrez AG, Tyler P, Baharom F, Sun T, Lin E, Martin S, Kayser BD, Johnston RJ, Mellman I, Delamarre L, West NR, Müller S, Qu Y, Heger K
• Publisher Correction: Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells.
  Nature 2024 Guan X, Hu R, Choi Y, Srivats S, Nabet BY, Silva J, McGinnis L, Hendricks R, Nutsch K, Banta KL, Duong E, Dunkle A, Chang PS, Han CJ, Mittman S, Molden N, Daggumati P, Connolly W, Johnson M, Abreu DR,…
• Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells.
  Nature 2024 Guan X, Hu R, Choi Y, Srivats S, Nabet BY, Silva J, McGinnis L, Hendricks R, Nutsch K, Banta KL, Duong E, Dunkle A, Chang PS, Han CJ, Mittman S, Molden N, Daggumati P, Connolly W, Johnson M, Abreu DR,…
• Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer.
  Cell reports. Medicine 2024 Galsky MD, Guan X, Rishipathak D, Rapaport AS, Shehata HM, Banchereau R, Yuen K, Varfolomeev E, Hu R, Han CJ, Li H, Liang Y, Vucic D, Wang L, Zhu J, Yu H, Herbst RH, Hajaj E, Kiner E, Bamias A, De …
• Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage.
  The Journal of experimental medicine 2023 Tong AJ, Leylek R, Herzner AM, Rigas D, Wichner S, Blanchette C, Tahtinen S, Kemball CC, Mellman I, Haley B, Freund EC, Delamarre L
• The cancer-immunity cycle: Indication, genotype, and immunotype.
  Immunity 2023 Mellman I, Chen DS, Powles T, Turley SJ
• Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors.
  Nature communications 2023 Castiglioni A, Yang Y, Williams K, Gogineni A, Lane RS, Wang AW, Shyer JA, Zhang Z, Mittman S, Gutierrez A, Astarita JL, Thai M, Hung J, Yang YA, Pourmohamad T, Himmels P, De Simone M, Elstrott J, …
• In situ tumour arrays reveal early environmental control of cancer immunity.
  Nature 2023 Ortiz-Muñoz G, Brown M, Carbone CB, Pechuan-Jorge X, Rouilly V, Lindberg H, Ritter AT, Raghupathi G, Sun Q, Nicotra T, Mantri SR, Yang A, Doerr J, Nagarkar D, Darmanis S, Haley B, Mariathasan S, Wang …
• Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer.
  Nature 2023 Rojas LA, Sethna Z, Soares KC, Olcese C, Pang N, Patterson E, Lihm J, Ceglia N, Guasp P, Chu A, Yu R, Chandra AK, Waters T, Ruan J, Amisaki M, Zebboudj A, Odgerel Z, Payne G, Derhovanessian E, Müller …
• CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy.
  Cell reports. Medicine 2023 Huseni MA, Wang L, Klementowicz JE, Yuen K, Breart B, Orr C, Liu LF, Li Y, Gupta V, Li C, Rishipathak D, Peng J, Senbabaoglu Y, Modrusan Z, Keerthivasan S, Madireddi S, Chen YJ, Fraser EJ, Leng N, …
• NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer.
  Cancer cell 2022 Salomé B, Sfakianos JP, Ranti D, Daza J, Bieber C, Charap A, Hammer C, Banchereau R, Farkas AM, Ruan DF, Izadmehr S, Geanon D, Kelly G, de Real RM, Lee B, Beaumont KG, Shroff S, Wang YA, Wang YC, Thin…
• Coming of Age: Human Genomics and the Cancer-Immune Set Point.
  Cancer immunology research 2022 Hammer C, Mellman I
• Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation.
  The Journal of cell biology 2022 Guttman O, Le Thomas A, Marsters S, Lawrence DA, Gutgesell L, Zuazo-Gaztelu I, Harnoss JM, Haag SM, Murthy A, Strasser G, Modrusan Z, Wu T, Mellman I, Ashkenazi A
• ESCRT-mediated membrane repair protects tumor-derived cells against T cell attack.
  Science (New York, N.Y.) 2022 Ritter AT, Shtengel G, Xu CS, Weigel A, Hoffman DP, Freeman M, Iyer N, Alivodej N, Ackerman D, Voskoboinik I, Trapani J, Hess HF, Mellman I
• Allelic variation in HLA-DRB1 is associated with development of antidrug antibodies in cancer patients treated with atezolizumab that are neutralizing in vitro.
  Clinical and translational science 2022 Hammer C, Ruppel J, Kamen L, Hunkapiller J, Mellman I, Quarmby V
• TIGIT-CD226-PVR axis: advancing immune checkpoint blockade for cancer immunotherapy.
  Journal for immunotherapy of cancer 2022 Chiang EY, Mellman I
• IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines.
  Nature immunology 2022 Tahtinen S, Tong AJ, Himmels P, Oh J, Paler-Martinez A, Kim L, Wichner S, Oei Y, McCarron MJ, Freund EC, Amir ZA, de la Cruz CC, Haley B, Blanchette C, Schartner JM, Ye W, Yadav M, Sahin U, Delamarre …
• Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity.
  Nature immunology 2022 Barreira da Silva R, Leitao RM, Pechuan-Jorge X, Werneke S, Oeh J, Javinal V, Wang Y, Phung W, Everett C, Nonomiya J, Arnott D, Lu C, Hsiao YC, Koerber JT, Hötzel I, Ziai J, Modrusan Z, Pillow TH, …
• Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses.
  Immunity 2022 Banta KL, Xu X, Chitre AS, Au-Yeung A, Takahashi C, O'Gorman WE, Wu TD, Mittman S, Cubas R, Comps-Agrar L, Fulzele A, Bennett EJ, Grogan JL, Hui E, Chiang EY, Mellman I
• Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification.
  Cancer cell 2021 Leader AM, Grout JA, Maier BB, Nabet BY, Park MD, Tabachnikova A, Chang C, Walker L, Lansky A, Le Berichel J, Troncoso L, Malissen N, Davila M, Martin JC, Magri G, Tuballes K, Zhao Z, Petralia F, …
• Publisher Correction: An open-access volume electron microscopy atlas of whole cells and tissues.
  Nature 2021 Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV, Lippincott-…
• An open-access volume electron microscopy atlas of whole cells and tissues.
  Nature 2021 Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV, Lippincott-…
• Molecular determinants of response to PD-L1 blockade across tumor types.
  Nature communications 2021 Banchereau R, Leng N, Zill O, Sokol E, Liu G, Pavlick D, Maund S, Liu LF, Kadel E, Baldwin N, Jhunjhunwala S, Nickles D, Assaf ZJ, Bower D, Patil N, McCleland M, Shames D, Molinero L, Huseni M, …
• Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade.
  Nature communications 2021 Khan Z, Hammer C, Carroll J, Di Nucci F, Acosta SL, Maiya V, Bhangale T, Hunkapiller J, Mellman I, Albert ML, McCarthy MI, Chandler GS
• Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues.
  Nature immunology 2021 Kapoor VN, Müller S, Keerthivasan S, Brown M, Chalouni C, Storm EE, Castiglioni A, Lane R, Nitschke M, Dominguez CX, Astarita JL, Krishnamurty AT, Carbone CB, Senbabaoglu Y, Wang AW, Wu X, Cremasco V,…
• Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade.
  Journal for immunotherapy of cancer 2021 Banchereau R, Chitre AS, Scherl A, Wu TD, Patil NS, de Almeida P, Kadel Iii EE, Madireddi S, Au-Yeung A, Takahashi C, Chen YJ, Modrusan Z, McBride J, Nersesian R, El-Gabry EA, Robida MD, Hung JC, …
• Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Zhou Y, Bastian IN, Long MD, Dow M, Li W, Liu T, Ngu RK, Antonucci L, Huang JY, Phung QT, Zhao XH, Banerjee S, Lin XJ, Wang H, Dang B, Choi S, Karin D, Su H, Ellisman MH, Jamieson C, Bosenberg M, …
• Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers.
  The Journal of experimental medicine 2021 Byrd AL, Liu M, Fujimura KE, Lyalina S, Nagarkar DR, Charbit B, Bergstedt J, Patin E, Harrison OJ, Quintana-Murci L, Mellman I, Duffy D, Albert ML, Milieu Intérieur Consortium
• Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation.
  PloS one 2020 Nalle SC, Barreira da Silva R, Zhang H, Decker M, Chalouni C, Xu M, Posthuma G, de Mazière A, Klumperman J, Baz Morelli A, Fleire SJ, Verkman AS, Trombetta ES, Albert ML, Mellman I
• PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer.
  Nature cancer 2020 Oh SA, Wu DC, Cheung J, Navarro A, Xiong H, Cubas R, Totpal K, Chiu H, Wu Y, Comps-Agrar L, Leader AM, Merad M, Roose-Germa M, Warming S, Yan M, Kim JM, Rutz S, Mellman I
• Polygenic risk for skin autoimmunity impacts immune checkpoint blockade in bladder cancer.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Khan Z, Di Nucci F, Kwan A, Hammer C, Mariathasan S, Rouilly V, Carroll J, Fontes M, Ley Acosta S, Guardino E, Chen-Harris H, Bhangale T, Mellman I, Rosenberg J, Powles T, Hunkapiller J, Chandler GS, …
• Dexamethasone premedication suppresses vaccine-induced immune responses against cancer.
  Oncoimmunology 2020 Vormehr M, Lehar S, Kranz LM, Tahtinen S, Oei Y, Javinal V, Delamarre L, Walzer KC, Diken M, Kreiter S, Mellman I, Sahin U, Schartner JM, Türeci Ö
• Mutation position is an important determinant for predicting cancer neoantigens.
  The Journal of experimental medicine 2020 Capietto AH, Jhunjhunwala S, Pollock SB, Lupardus P, Wong J, Hänsch L, Cevallos J, Chestnut Y, Fernandez A, Lounsbury N, Nozawa T, Singh M, Fan Z, de la Cruz CC, Phung QT, Taraborrelli L, Haley B, …
• Peripheral T cell expansion predicts tumour infiltration and clinical response.
  Nature 2020 Wu TD, Madireddi S, de Almeida PE, Banchereau R, Chen YJ, Chitre AS, Chiang EY, Iftikhar H, O'Gorman WE, Au-Yeung A, Takahashi C, Goldstein LD, Poon C, Keerthivasan S, de Almeida Nagata DE, Du X, Lee …
• Transposable element expression in tumors is associated with immune infiltration and increased antigenicity.
  Nature communications 2019 Kong Y, Rose CM, Cass AA, Williams AG, Darwish M, Lianoglou S, Haverty PM, Tong AJ, Blanchette C, Albert ML, Mellman I, Bourgon R, Greally J, Jhunjhunwala S, Chen-Harris H
• E-Cadherin is Dispensable to Maintain Langerhans Cells in the Epidermis.
  The Journal of investigative dermatology 2019 Brand A, Diener N, Zahner SP, Tripp C, Backer RA, Karram K, Jiang A, Mellman I, Stoitzner P, Clausen BE
• Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8+ T Cells in Murine Syngeneic Tumor Models.
  Cancer immunology research 2019 Xiong H, Mittman S, Rodriguez R, Pacheco-Sanchez P, Moskalenko M, Yang Y, Elstrott J, Ritter AT, Müller S, Nickles D, Arenzana TL, Capietto AH, Delamarre L, Modrusan Z, Rutz S, Mellman I, Cubas R
• The Dendritic Cell Strikes Back.
  Immunity 2019 Moussion C, Mellman I
• The Dendritic Cell Strikes Back.
  Immunity 2018 Moussion C, Mellman I
• Germline genetic polymorphisms influence tumor gene expression and immune cell infiltration.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Lim YW, Chen-Harris H, Mayba O, Lianoglou S, Wuster A, Bhangale T, Khan Z, Mariathasan S, Daemen A, Reeder J, Haverty PM, Forrest WF, Brauer M, Mellman I, Albert ML
• Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1).
  Proceedings of the National Academy of Sciences of the United States of America 2018 Kowanetz M, Zou W, Gettinger SN, Koeppen H, Kockx M, Schmid P, Kadel EE, Wistuba I, Chaft J, Rizvi NA, Spigel DR, Spira A, Hirsch FR, Cohen V, Smith D, Boyd Z, Miley N, Flynn S, Leveque V, Shames DS, …
• The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function.
  Cell reports 2018 Hernandez S, Qing J, Thibodeau RH, Du X, Park S, Lee HM, Xu M, Oh S, Navarro A, Roose-Girma M, Newman RJ, Warming S, Nannini M, Sampath D, Kim JM, Grogan JL, Mellman I
• TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.
  Nature 2018 Mariathasan S, Turley SJ, Nickles D, Castiglioni A, Yuen K, Wang Y, Kadel EE, Koeppen H, Astarita JL, Cubas R, Jhunjhunwala S, Banchereau R, Yang Y, Guan Y, Chalouni C, Ziai J, Senbabaoglu Y, Santoro …
• SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.
  The Journal of cell biology 2017 Viotti M, Wilson C, McCleland M, Koeppen H, Haley B, Jhunjhunwala S, Klijn C, Modrusan Z, Arnott D, Classon M, Stephan JP, Mellman I
• Visualization of early influenza A virus trafficking in human dendritic cells using STED microscopy.
  PloS one 2017 Baharom F, Thomas OS, Lepzien R, Mellman I, Chalouni C, Smed-Sörensen A
• T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.
  Science (New York, N.Y.) 2017 Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, Vale RD
• Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice.
  Nature communications 2017 Lau J, Cheung J, Navarro A, Lianoglou S, Haley B, Totpal K, Sanders L, Koeppen H, Caplazi P, McBride J, Chiu H, Hong R, Grogan J, Javinal V, Yauch R, Irving B, Belvin M, Mellman I, Kim JM, Schmidt M
• Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation.
  The Journal of cell biology 2017 Vander Lugt B, Riddell J, Khan AA, Hackney JA, Lesch J, DeVoss J, Weirauch MT, Singh H, Mellman I
• Natural killer cell granules converge to avoid collateral damage.
  The Journal of cell biology 2016 Ritter AT, Mellman I
• High cell-surface density of HER2 deforms cell membranes.
  Nature communications 2016 Chung I, Reichelt M, Shao L, Akita RW, Koeppen H, Rangell L, Schaefer G, Mellman I, Sliwkowski MX
• Society for immunotherapy of cancer (SITC) statement on the proposed changes to the common rule.
  Journal for immunotherapy of cancer 2016 Kaufman HL, Butterfield LH, Coulie PG, Demaria S, Ferris RL, Galon J, Khleif SN, Mellman I, Ohashi PS, Overwijk WW, Topalian SL, Marincola FM
• Immunomodulatory antibodies for the treatment of lymphoma: Report on the CALYM Workshop.
  Oncoimmunology 2016 Houot R, Gaulard P, Schreiber R, Mellman I, Lambotte O, Coulie PG, Fest T, Korman A, Levy R, Shipp M, Tarte K, Kohrt H, Marabelle A, Ansell S, Watier H, van Elsas A, Balakumaran A, Arce Vargas F, …
• The Human Vaccines Project: A roadmap for cancer vaccine development.
  Science translational medicine 2016 Romero P, Banchereau J, Bhardwaj N, Cockett M, Disis ML, Dranoff G, Gilboa E, Hammond SA, Hershberg R, Korman AJ, Kvistborg P, Melief C, Mellman I, Palucka AK, Redchenko I, Robins H, Sallusto F, …
• De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute.
  Cancer immunology research 2016 Mellman I, Hubbard-Lucey VM, Tontonoz MJ, Kalos MD, Chen DS, Allison JP, Drake CG, Levitsky H, Lonberg N, van der Burg SH, Fearon DT, Wherry EJ, Lowy I, Vonderheide RH, Hwu P
• Voices of biotech.
  Nature biotechnology 2016 Amit I, Baker D, Barker R, Berger B, Bertozzi C, Bhatia S, Biffi A, Demichelis F, Doudna J, Dowdy SF, Endy D, Helmstaedter M, Junca H, June C, Kamb S, Khvorova A, Kim DH, Kim JS, Krishnan Y, …
• Is all cancer therapy immunotherapy?
  Science translational medicine 2015 Belvin M, Mellman I
• Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Katakam AK, Brightbill H, Franci C, Kung C, Nunez V, Jones C, Peng I, Jeet S, Wu LC, Mellman I, Delamarre L, Austin CD
• Cancer immunotherapy. Neo approaches to cancer vaccines.
  Science (New York, N.Y.) 2015 Delamarre L, Mellman I, Yadav M
• Immunotherapy: The path to win the war on cancer?
  Cell 2015 Topalian SL, Wolchok JD, Chan TA, Mellman I, Palucka K, Banchereau J, Rosenberg SA, Dane Wittrup K
• Protection of human myeloid dendritic cell subsets against influenza A virus infection is differentially regulated upon TLR stimulation.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Baharom F, Thomas S, Bieder A, Hellmér M, Volz J, Sandgren KJ, McInerney GM, Karlsson Hedestam GB, Mellman I, Smed-Sörensen A
• β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Fu C, Liang X, Cui W, Ober-Blöbaum JL, Vazzana J, Shrikant PA, Lee KP, Clausen BE, Mellman I, Jiang A
• Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse.
  Molecular biology of the cell 2015 Reversat A, Yuseff MI, Lankar D, Malbec O, Obino D, Maurin M, Penmatcha NV, Amoroso A, Sengmanivong L, Gundersen GG, Mellman I, Darchen F, Desnos C, Pierobon P, Lennon-Duménil AM
• Single-molecule optical methods analyzing receptor tyrosine kinase activation in living cells.
  Methods in molecular biology (Clifton, N.J.) 2015 Chung I, Mellman I
• Endosomes are specialized platforms for bacterial sensing and NOD2 signalling.
  Nature 2014 Nakamura N, Lill JR, Phung Q, Jiang Z, Bakalarski C, de Mazière A, Klumperman J, Schlatter M, Delamarre L, Mellman I
• Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation.
  Nature immunology 2013 Vander Lugt B, Khan AA, Hackney JA, Agrawal S, Lesch J, Zhou M, Lee WP, Park S, Xu M, DeVoss J, Spooner CJ, Chalouni C, Delamarre L, Mellman I, Singh H
• Endocytosis and cancer.
  Cold Spring Harbor perspectives in biology 2013 Mellman I, Yarden Y
• A Nobel Prize for membrane traffic: vesicles find their journey's end.
  The Journal of cell biology 2013 Mellman I, Emr SD
• Antibody therapeutics in cancer.
  Science (New York, N.Y.) 2013 Sliwkowski MX, Mellman I
• β-catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8⁺ T cells.
  Journal of leukocyte biology 2013 Liang X, Fu C, Cui W, Ober-Blöbaum JL, Zahner SP, Shrikant PA, Clausen BE, Flavell RA, Mellman I, Jiang A
• Dendritic cells: master regulators of the immune response.
  Cancer immunology research 2013 Mellman I
• MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells.
  The Journal of experimental medicine 2013 Oh J, Wu N, Baravalle G, Cohn B, Ma J, Lo B, Mellman I, Ishido S, Anderson M, Shin JS
• Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation.
  The Journal of experimental medicine 2013 Cohn L, Chatterjee B, Esselborn F, Smed-Sörensen A, Nakamura N, Chalouni C, Lee BC, Vandlen R, Keler T, Lauer P, Brockstedt D, Mellman I, Delamarre L
• Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways.
  The Journal of cell biology 2012 Lo B, Strasser G, Sagolla M, Austin CD, Junttila M, Mellman I
• Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells.
  Blood 2012 Chatterjee B, Smed-Sörensen A, Cohn L, Chalouni C, Vandlen R, Lee BC, Widger J, Keler T, Delamarre L, Mellman I
• Profile of Ira Mellman. Interview by Prashant Nair.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Mellman I
• MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Ma JK, Platt MY, Eastham-Anderson J, Shin JS, Mellman I
• Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Maurer T, Garrenton LS, Oh A, Pitts K, Anderson DJ, Skelton NJ, Fauber BP, Pan B, Malek S, Stokoe D, Ludlam MJ, Bowman KK, Wu J, Giannetti AM, Starovasnik MA, Mellman I, Jackson PK, Rudolph J, Wang W,…
• Influenza A virus infection of human primary dendritic cells impairs their ability to cross-present antigen to CD8 T cells.
  PLoS pathogens 2012 Smed-Sörensen A, Chalouni C, Chatterjee B, Cohn L, Blattmann P, Nakamura N, Delamarre L, Mellman I
• Remembering Ralph Steinman.
  The Journal of experimental medicine 2011 Banchereau J, Cohn F, Inaba K, Muller B, Mellman I, Nathan C, Nussenzweig M, O'Garra A, Seder B, Schuler G, Sher A
• Retrospective. Ralph M. Steinman (1943-2011).
  Science (New York, N.Y.) 2011 Mellman I, Nussenzweig M
• Ralph Steinman (1943-2011).
  Nature 2011 Nussenzweig MC, Mellman I
• A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells.
  The Journal of cell biology 2011 Francis SS, Sfakianos J, Lo B, Mellman I
• AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β (GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane.
  The Journal of biological chemistry 2011 Zhang L, Jouret F, Rinehart J, Sfakianos J, Mellman I, Lifton RP, Young LH, Caplan MJ
• Harnessing dendritic cells for immunotherapy.
  Seminars in immunology 2011 Delamarre L, Mellman I
• Cell biology redux.
  Molecular biology of the cell 2010 Mellman I
• Designing vaccines based on biology of human dendritic cell subsets.
  Immunity 2010 Palucka K, Banchereau J, Mellman I
• Hepatocyte Growth Factor stimulated cell scattering requires ERK and Cdc42-dependent tight junction disassembly.
  Biochemical and biophysical research communications 2010 Togawa A, Sfakianos J, Ishibe S, Suzuki S, Fujigaki Y, Kitagawa M, Mellman I, Cantley LG
• Immunology. Beta-catenin balances immunity.
  Science (New York, N.Y.) 2010 Mellman I, Clausen BE
• Monocyte-derived dendritic cells exhibit increased levels of lysosomal proteolysis as compared to other human dendritic cell populations.
  PloS one 2010 McCurley N, Mellman I
• Trafficking guidance receptors.
  Cold Spring Harbor perspectives in biology 2010 Winckler B, Mellman I
• Spatial control of EGF receptor activation by reversible dimerization on living cells.
  Nature 2010 Chung I, Akita R, Vandlen R, Toomre D, Schlessinger J, Mellman I
• Antigen processing and presentation.
  Current opinion in immunology 2010 Mellman I, Cresswell P
• Mature dendritic cells use endocytic receptors to capture and present antigens.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Platt CD, Ma JK, Chalouni C, Ebersold M, Bou-Reslan H, Carano RA, Mellman I, Delamarre L
• Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism.
  Developmental cell 2010 Zovein AC, Luque A, Turlo KA, Hofmann JJ, Yee KM, Becker MS, Fassler R, Mellman I, Lane TF, Iruela-Arispe ML
• The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Cheever MA, Allison JP, Ferris AS, Finn OJ, Hastings BM, Hecht TT, Mellman I, Prindiville SA, Viner JL, Weiner LM, Matrisian LM
• Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells.
  The Journal of cell biology 2009 Farr GA, Hull M, Mellman I, Caplan MJ
• Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy.
  Vaccine 2009 Demento SL, Eisenbarth SC, Foellmer HG, Platt C, Caplan MJ, Mark Saltzman W, Mellman I, Ledizet M, Fikrig E, Flavell RA, Fahmy TM
• Differential role of the Ca(2+) sensor synaptotagmin VII in macrophages and dendritic cells.
  Immunobiology 2009 Becker SM, Delamarre L, Mellman I, Andrews NW
• Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis.
  The Journal of cell biology 2009 Mao YS, Yamaga M, Zhu X, Wei Y, Sun HQ, Wang J, Yun M, Wang Y, Di Paolo G, Bennett M, Mellman I, Abrams CS, De Camilli P, Lu CY, Yin HL
• Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells.
  The Journal of experimental medicine 2009 Goldszmid RS, Coppens I, Lev A, Caspar P, Mellman I, Sher A
• By the scientists, for the scientists.
  The Journal of cell biology 2009 Mellman I
• Coordinated protein sorting, targeting and distribution in polarized cells.
  Nature reviews. Molecular cell biology 2008 Mellman I, Nelson WJ
• A PDZ-binding motif controls basolateral targeting of syndecan-1 along the biosynthetic pathway in polarized epithelial cells.
  Traffic (Copenhagen, Denmark) 2008 Maday S, Anderson E, Chang HC, Shorter J, Satoh A, Sfakianos J, Fölsch H, Anderson JM, Walther Z, Mellman I
• A33 antigen displays persistent surface expression.
  Cancer immunology, immunotherapy : CII 2008 Ackerman ME, Chalouni C, Schmidt MM, Raman VV, Ritter G, Old LJ, Mellman I, Wittrup KD
• Design opportunities for actively targeted nanoparticle vaccines.
  Nanomedicine (London, England) 2008 Fahmy TM, Demento SL, Caplan MJ, Mellman I, Saltzman WM
• Spinophilin participates in information transfer at immunological synapses.
  The Journal of cell biology 2008 Bloom O, Unternaehrer JJ, Jiang A, Shin JS, Delamarre L, Allen P, Mellman I
• Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I.
  Nature immunology 2008 Di Pucchio T, Chatterjee B, Smed-Sörensen A, Clayton S, Palazzo A, Montes M, Xue Y, Mellman I, Banchereau J, Connolly JE
• Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin.
  Cellular microbiology 2008 Reig N, Jiang A, Couture R, Sutterwala FS, Ogura Y, Flavell RA, Mellman I, van der Goot FG
• Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells.
  The Journal of cell biology 2007 Sfakianos J, Togawa A, Maday S, Hull M, Pypaert M, Cantley L, Toomre D, Mellman I
• Internalization, intracellular trafficking, and biodistribution of monoclonal antibody 806: a novel anti-epidermal growth factor receptor antibody.
  Neoplasia (New York, N.Y.) 2007 Perera RM, Zoncu R, Johns TG, Pypaert M, Lee FT, Mellman I, Old LJ, Toomre DK, Scott AM
• Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation.
  Immunity 2007 Jiang A, Bloom O, Ono S, Cui W, Unternaehrer J, Jiang S, Whitney JA, Connolly J, Banchereau J, Mellman I
• Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.
  Nature 2007 Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, Cao W, Wang YH, Su B, Nestle FO, Zal T, Mellman I, Schröder JM, Liu YJ, Gilliet M
• Private lives: reflections and challenges in understanding the cell biology of the immune system.
  Science (New York, N.Y.) 2007 Mellman I
• How the rich get richer.
  The Journal of experimental medicine 2007 Rossner M, Mellman I
• How the rich get richer.
  The Journal of cell biology 2007 Rossner M, Mellman I
• Incomplete screening?
  Nature immunology 2007 Mellman I
• The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Unternaehrer JJ, Chow A, Pypaert M, Inaba K, Mellman I
• Bringing science to cancer therapy.
  The Yale journal of biology and medicine 2006 Mellman I
• Rab10 is involved in basolateral transport in polarized Madin-Darby canine kidney cells.
  Traffic (Copenhagen, Denmark) 2006 Schuck S, Gerl MJ, Ang A, Manninen A, Keller P, Mellman I, Simons K
• Modulation of cell adhesion and motility in the immune system by Myo1f.
  Science (New York, N.Y.) 2006 Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA
• Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis.
  The Journal of experimental medicine 2006 Delamarre L, Couture R, Mellman I, Trombetta ES
• CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis.
  The Journal of cell biology 2006 Shim JH, Xiao C, Hayden MS, Lee KY, Trombetta ES, Pypaert M, Nara A, Yoshimori T, Wilm B, Erdjument-Bromage H, Tempst P, Hogan BL, Mellman I, Ghosh S
• Vectorial insertion of apical and basolateral membrane proteins in polarized epithelial cells revealed by quantitative 3D live cell imaging.
  The Journal of cell biology 2006 Hua W, Sheff D, Toomre D, Mellman I
• Presentation of self-antigens on MHC class II molecules during dendritic cell maturation.
  International immunology 2005 Zwickey HL, Unternaehrer JJ, Mellman I
• Quantitative and dynamic assessment of the contribution of the ER to phagosome formation.
  Cell 2005 Touret N, Paroutis P, Terebiznik M, Harrison RE, Trombetta S, Pypaert M, Chow A, Jiang A, Shaw J, Yip C, Moore HP, van der Wel N, Houben D, Peters PJ, de Chastellier C, Mellman I, Grinstein S
• Transcytosis of NgCAM in epithelial cells reflects differential signal recognition on the endocytic and secretory pathways.
  The Journal of cell biology 2005 Anderson E, Maday S, Sfakianos J, Hull M, Winckler B, Sheff D, Fölsch H, Mellman I
• Targeting antigen to CD19 on B cells efficiently activates T cells.
  International immunology 2005 Yan J, Wolff MJ, Unternaehrer J, Mellman I, Mamula MJ
• The antitumor monoclonal antibody 806 recognizes a high-mannose form of the EGF receptor that reaches the cell surface when cells over-express the receptor.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005 Johns TG, Mellman I, Cartwright GA, Ritter G, Old LJ, Burgess AW, Scott AM
• Antigen processing and presentation by dendritic cells: cell biological mechanisms.
  Advances in experimental medicine and biology 2005 Mellman I
• Regulated recruitment of MHC class II and costimulatory molecules to lipid rafts in dendritic cells.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Meyer zum Bueschenfelde CO, Unternaehrer J, Mellman I, Bottomly K
• Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells.
  The Journal of cell biology 2004 Ang AL, Taguchi T, Francis S, Fölsch H, Murrells LJ, Pypaert M, Warren G, Mellman I
• IFN-gamma enables cross-presentation of exogenous protein antigen in human Langerhans cells by potentiating maturation.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Matsuo M, Nagata Y, Sato E, Atanackovic D, Valmori D, Chen YT, Ritter G, Mellman I, Old LJ, Gnjatic S
• The JEM and the JCB: a synergistic partnership.
  The Journal of cell biology 2004 Steinman RM, Mellman I
• Immunotherapy: bewitched, bothered, and bewildered no more.
  Science (New York, N.Y.) 2004 Steinman RM, Mellman I
• Sorting of H,K-ATPase beta-subunit in MDCK and LLC-PK cells is independent of mu 1B adaptin expression.
  Traffic (Copenhagen, Denmark) 2004 Duffield A, Fölsch H, Mellman I, Caplan MJ
• The J-domain protein Rme-8 interacts with Hsc70 to control clathrin-dependent endocytosis in Drosophila.
  The Journal of cell biology 2004 Chang HC, Hull M, Mellman I
• Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network.
  Nature cell biology 2004 Yeaman C, Ayala MI, Wright JR, Bard F, Bossard C, Ang A, Maeda Y, Seufferlein T, Mellman I, Nelson WJ, Malhotra V
• The AP-1A and AP-1B clathrin adaptor complexes define biochemically and functionally distinct membrane domains.
  The Journal of cell biology 2003 Fölsch H, Pypaert M, Maday S, Pelletier L, Mellman I
• The Rab8 GTPase selectively regulates AP-1B-dependent basolateral transport in polarized Madin-Darby canine kidney cells.
  The Journal of cell biology 2003 Ang AL, Fölsch H, Koivisto UM, Pypaert M, Mellman I
• Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation.
  The Journal of experimental medicine 2003 Delamarre L, Holcombe H, Mellman I
• Computational cell biology.
  The Journal of cell biology 2003 Mellman I, Misteli T
• Activation of lysosomal function during dendritic cell maturation.
  Science (New York, N.Y.) 2003 Trombetta ES, Ebersold M, Garrett W, Pypaert M, Mellman I
• Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane.
  Nature 2002 Chow A, Toomre D, Garrett W, Mellman I
• Differential presentation of a soluble exogenous tumor antigen, NY-ESO-1, by distinct human dendritic cell populations.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Nagata Y, Ono S, Matsuo M, Gnjatic S, Valmori D, Ritter G, Garrett W, Old LJ, Mellman I
• Regulation and functional insights in cellular polarity, Madrid, Spain June 3-5, 2002.
  The Journal of cell biology 2002 Mellman I, Ridley A
• Differential recognition of tyrosine-based basolateral signals by AP-1B subunit mu1B in polarized epithelial cells.
  Molecular biology of the cell 2002 Sugimoto H, Sugahara M, Fölsch H, Koide Y, Nakatsu F, Tanaka N, Nishimura T, Furukawa M, Mullins C, Nakamura N, Mellman I, Ohno H
• Transferrin receptor recycling in the absence of perinuclear recycling endosomes.
  The Journal of cell biology 2002 Sheff D, Pelletier L, O'Connell CB, Warren G, Mellman I
• Actin dependence of polarized receptor recycling in Madin-Darby canine kidney cell endosomes.
  Molecular biology of the cell 2002 Sheff DR, Kroschewski R, Mellman I
• Expression of amplified DNA sequences for ornithine transcarbamylase in HeLa cells: arginine residues may be required for mitochondrial import of enzyme precursor.
  The Journal of cell biology 1985 Horwich AL, Fenton WA, Firgaira FA, Fox JE, Kolansky D, Mellman IS, Rosenberg LE
• Internalization and degradation of macrophage Fc receptors during receptor-mediated phagocytosis.
  The Journal of cell biology 1983 Mellman IS, Plutner H, Steinman RM, Unkeless JC, Cohn ZA
• Endocytosis and the recycling of plasma membrane.
  The Journal of cell biology 1983 Steinman RM, Mellman IS, Muller WA, Cohn ZA
• Interferon action: effects of mouse alpha and beta interferons on rosette formation, phagocytosis, and surface-antigen expression of cells of the macrophage-type line RAW 309Cr.1.
  Cellular immunology 1982 Yoshie O, Mellman IS, Broeze RJ, Garcia-Blanco M, Lengyel P
• Endocytosis, membrane recycling and Fc receptor function.
  Ciba Foundation symposium 1982 Mellman IS
• Structural Aspects and Heterogeneity of Immunoglobulin Fc Receptors.
  Advances in immunology 1981 Unkeless JC, Fleit H, Mellman IS
• Transmembrane transport of cobalamin in prokaryotic and eukaryotic cells.
  Annual review of biochemistry 1981 Sennett C, Rosenberg LE, Mellman IS
• Lymphokine enhances the expression and synthesis of Ia antigens on cultured mouse peritoneal macrophages.
  The Journal of experimental medicine 1980 Steinman RM, Nogueira N, Witmer MD, Tydings JD, Mellman IS
• Purificaton of a functional mouse Fc receptor through the use of a monoclonal antibody.
  The Journal of experimental medicine 1980 Mellman IS, Unkeless JC
• Selective iodination and polypeptide composition of pinocytic vesicles.
  The Journal of cell biology 1980 Mellman IS, Steinman RM, Unkeless JC, Cohn ZA
• Genetic control of cobalamin binding in normal and mutant cells: assignment of the gene for 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase to human chromosome 1.
  Proceedings of the National Academy of Sciences of the United States of America 1979 Mellman IS, Lin PF, Ruddle FH, Rosenberg LE
• Protein mediated vitamin uptake. Adsorptive endocytosis of the transcobalamin II-cobalamin complex by cultured human fibroblasts.
  Experimental cell research 1979 Youngdahl-Turner P, Mellman IS, Allen RH, Rosenberg LE
• The chemical composition of the cell wall of Chlamydomonas gymnogama and the concept of a plant cell wall protein.
  The Journal of cell biology 1974 Miller DH, Mellman IS, Lamport DT, Miller M