Iona Cheng, PhD, MPH
Professor
Epidemiology & Biostatistics
School of Medicine

Dr. Cheng has an active program of research studies of nested case-control and cohort studies of the breast, lung, colorectal, and prostate cancer within the Multiethnic Cohort Study and is developing an electronic health record cohort of Asian Americans, Native Hawaiians, and Pacific Islanders through collaborations between Sutter Health and Kaiser Permanente Hawaii. In addition, she is conducting studies within Population Architecture Using Genomics and Epidemiology (PAGE) Study to discover novel genetic loci for complex traits among non-European ancestry populations. She is also Co-Investigator of Greater Bay Area Cancer Registry, a part of the California Cancer Registry and the NCI Surveillance Epidemiology End Results (SEER) Program, and the Colon Cancer Family Registry.

• Anti-Asian American Racism: A Wake-Up Call for Population-Based Cancer Research.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2021 Dee EC, Chen S, Santos PMG, Wu SZ, Cheng I, Gomez SL
• The association between ambient air pollutants and pancreatic cancer in the Multiethnic Cohort Study.
  Environmental research 2021 Bogumil D, Wu AH, Stram D, Yang J, Tseng CC, Le Marchand L, Wu J, Cheng I, Setiawan VW
• Association between Airport-Related Ultrafine Particles and Risk of Malignant Brain Cancer: A Multiethnic Cohort Study.
  Cancer research 2021 Wu AH, Fruin S, Larson TV, Tseng CC, Wu J, Yang J, Jain J, Shariff-Marco S, Inamdar PP, Setiawan VW, Porcel J, Stram DO, Le Marchand L, Ritz B, Cheng I
• Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals.
  HGG advances 2021 Chen H, Majumdar A, Wang L, Kar S, Brown KM, Feng H, Turman C, Dennis J, Easton D, Michailidou K, Simard J, Breast Cancer Association Consortium (BCAC), Bishop T, Cheng IC, Huyghe JR, Schmit SL, …
• Risk of breast cancer and prediagnostic urinary excretion of bisphenol A, triclosan and parabens: The Multiethnic Cohort Study.
  International journal of cancer 2021 Wu AH, Franke AA, Wilkens LR, Tseng C, Conroy SM, Li Y, Sangaramoorthy M, Polfus LM, DeRouen MC, Caberto C, Haiman C, Stram DO, Le Marchand L, Cheng I
• Recommended Definitions of Aggressive Prostate Cancer for Etiologic Epidemiologic Research.
  Journal of the National Cancer Institute 2021 Hurwitz LM, Agalliu I, Albanes D, Barry KH, Berndt SI, Cai Q, Chen C, Cheng I, Genkinger JM, Giles GG, Huang J, Joshu CE, Key TJ, Knutsen S, Koutros S, Langseth H, Li SX, MacInnis RJ, Markt SC, Penney…
• Integrating Electronic Health Record, Cancer Registry, and Geospatial Data to Study Lung Cancer in Asian American, Native Hawaiian, and Pacific Islander Ethnic Groups.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2021 DeRouen MC, Thompson CA, Canchola AJ, Jin A, Nie S, Wong C, Jain J, Lichtensztajn DY, Li Y, Allen L, Patel MI, Daida YG, Luft HS, Shariff-Marco S, Reynolds P, Wakelee HA, Liang SY, Waitzfelder BE, …
• BPA, Parabens, and Phthalates in Relation to Endometrial Cancer Risk: A Case-Control Study Nested in the Multiethnic Cohort.
  Environmental health perspectives 2021 Sarink D, Franke AA, White KK, Wu AH, Cheng I, Quon B, Le Marchand L, Wilkens LR, Yu H, Merritt MA
• Urinary phthalate exposures and risk of breast cancer: the Multiethnic Cohort study.
  Breast cancer research : BCR 2021 Wu AH, Franke AA, Wilkens LR, Tseng C, Conroy SM, Li Y, Polfus LM, De Rouen M, Caberto C, Haiman C, Stram DO, Le Marchand L, Cheng I
• Tobacco Smoking and Risk of Second Primary Lung Cancer.
  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2021 Aredo JV, Luo SJ, Gardner RM, Sanyal N, Choi E, Hickey TP, Riley TL, Huang WY, Kurian AW, Leung AN, Wilkens LR, Robbins HA, Riboli E, Kaaks R, Tjønneland A, Vermeulen RCH, Panico S, Le Marchand L, …
• The impact of global and local Polynesian genetic ancestry on complex traits in Native Hawaiians.
  PLoS genetics 2021 Sun H, Lin M, Russell EM, Minster RL, Chan TF, Dinh BL, Naseri T, Reupena MS, Lum-Jones A, Samoan Obesity, Lifestyle, and Genetic Adaptations (OLaGA) Study Group, Cheng I, Wilkens LR, Le Marchand L, …
• Racial and socioeconomic disparities in retroperitoneal lymph node dissection and survival in nonseminomatous germ cell tumor: A population-based study.
  Urologic oncology 2021 Bhambhvani HP, Greenberg DR, Kasman AM, DeRouen MC, Cheng I, Eisenberg ML, Shah SA
• Associations of the gut microbiome with hepatic adiposity in the Multiethnic Cohort Adiposity Phenotype Study.
  Gut microbes 2021 Hullar MAJ, Jenkins IC, Randolph TW, Curtis KR, Monroe KR, Ernst T, Shepherd JA, Stram DO, Cheng I, Kristal BS, Wilkens LR, Franke A, Le Marchand L, Lim U, Lampe JW
• Racial/Ethnic Disparities in Survival after Breast Cancer Diagnosis by Estrogen and Progesterone Receptor Status: A Pooled Analysis.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2020 John EM, McGuire V, Kurian AW, Koo J, Shariff-Marco S, Gomez SL, Cheng I, Keegan THM, Kwan ML, Bernstein L, Vigen C, Wu AH
• Monitoring Prostate Cancer Incidence Trends: Value of Multiple Imputation and Delay Adjustment to Discern Disparities in Stage-specific Trends.
  European urology 2020 Gomez SL, Washington SL, Cheng I, Huang FW, Cooperberg MR
• Population-specific reference panels are crucial for genetic analyses: an example of the CREBRF locus in Native Hawaiians.
  Human molecular genetics 2020 Lin M, Caberto C, Wan P, Li Y, Lum-Jones A, Tiirikainen M, Pooler L, Nakamura B, Sheng X, Porcel J, Lim U, Setiawan VW, Le Marchand L, Wilkens LR, Haiman CA, Cheng I, Chiang CWK
• Genome-Wide Association Study of Liver Fat: The Multiethnic Cohort Adiposity Phenotype Study.
  Hepatology communications 2020 Park SL, Li Y, Sheng X, Hom V, Xia L, Zhao K, Pooler L, Setiawan VW, Lim U, Monroe KR, Wilkens LR, Kristal BS, Lampe JW, Hullar M, Shepherd J, Loo LLM, Ernst T, Franke AA, Tiirikainen M, Haiman CA, …
• Associations of plasma trimethylamine N-oxide, choline, carnitine, and betaine with inflammatory and cardiometabolic risk biomarkers and the fecal microbiome in the Multiethnic Cohort Adiposity Phenotype Study.
  The American journal of clinical nutrition 2020 Fu BC, Hullar MAJ, Randolph TW, Franke AA, Monroe KR, Cheng I, Wilkens LR, Shepherd JA, Madeleine MM, Le Marchand L, Lim U, Lampe JW
• Hospital Characteristics and Breast Cancer Survival in the California Breast Cancer Survivorship Consortium.
  JCO oncology practice 2020 Shariff-Marco S, Ellis L, Yang J, Koo J, John EM, Keegan THM, Cheng I, Monroe KR, Vigen C, Kwan ML, Lu Y, Bernstein L, Wu AH, Gomez SL, Kurian AW
• Testicular cancer in Hispanics: incidence of subtypes over time according to neighborhood sociodemographic factors in California.
  Cancer causes & control : CCC 2020 DeRouen MC, McKinley M, Shah SA, Borno HT, Aoki R, Lichtensztajn DY, Leppert JT, Brooks JD, Chung BI, Gomez SL, Cheng I
• Potential impact of family history-based screening guidelines on the detection of early-onset colorectal cancer.
  Cancer 2020 Gupta S, Bharti B, Ahnen DJ, Buchanan DD, Cheng IC, Cotterchio M, Figueiredo JC, Gallinger SJ, Haile RW, Jenkins MA, Lindor NM, Macrae FA, Le Marchand L, Newcomb PA, Thibodeau SN, Win AK, Martinez ME
• Minority-centric meta-analyses of blood lipid levels identify novel loci in the Population Architecture using Genomics and Epidemiology (PAGE) study.
  PLoS genetics 2020 Hu Y, Graff M, Haessler J, Buyske S, Bien SA, Tao R, Highland HM, Nishimura KK, Zubair N, Lu Y, Verbanck M, Hilliard AT, Klarin D, Damrauer SM, Ho YL, VA Million Veteran Program, Wilson PWF, Chang KM,…
• Circulating Biomarker Score for Visceral Fat and Risks of Incident Colorectal and Postmenopausal Breast Cancer: The Multiethnic Cohort Adiposity Phenotype Study.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2020 Le Marchand L, Wilkens LR, Castelfranco AM, Monroe KR, Kristal BS, Cheng I, Maskarinec G, Hullar MA, Lampe JW, Shepherd JA, Franke A, Ernst T, Lim U
• Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility.
  Nature communications 2020 Kachuri L, Johansson M, Rashkin SR, Graff RE, Bossé Y, Manem V, Caporaso NE, Landi MT, Christiani DC, Vineis P, Liu G, Scelo G, Zaridze D, Shete SS, Albanes D, Aldrich MC, Tardón A, Rennert G, Chen C,…
• Association Between Outdoor Air Pollution and Risk of Malignant and Benign Brain Tumors: The Multiethnic Cohort Study.
  JNCI cancer spectrum 2020 Wu AH, Wu J, Tseng C, Yang J, Shariff-Marco S, Fruin S, Larson T, Setiawan VW, Masri S, Porcel J, Jain J, Chen TC, Stram DO, Marchand LL, Ritz B, Cheng I
• Association of change in the neighborhood obesogenic environment with colorectal cancer risk: The Multiethnic Cohort Study.
  SSM - population health 2019 Shvetsov YB, Shariff-Marco S, Yang J, Conroy SM, Canchola AJ, Albright CL, Park SY, Monroe KR, Le Marchand L, Gomez SL, Wilkens LR, Cheng I
• Association between mitochondrial genetic variation and breast cancer risk: The Multiethnic Cohort.
  PloS one 2019 Li Y, Giorgi EE, Beckman KB, Caberto C, Kazma R, Lum-Jones A, Haiman CA, Marchand LL, Stram DO, Saxena R, Cheng I
• Genetic analyses of diverse populations improves discovery for complex traits.
  Nature 2019 Wojcik GL, Graff M, Nishimura KK, Tao R, Haessler J, Gignoux CR, Highland HM, Patel YM, Sorokin EP, Avery CL, Belbin GM, Bien SA, Cheng I, Cullina S, Hodonsky CJ, Hu Y, Huckins LM, Jeff J, Justice AE,…
• Association between ambient air pollution and breast cancer risk: The multiethnic cohort study.
  International journal of cancer 2019 Cheng I, Tseng C, Wu J, Yang J, Conroy SM, Shariff-Marco S, Li L, Hertz A, Gomez SL, Le Marchand L, Whittemore AS, Stram DO, Ritz B, Wu AH
• The Future of Genomic Studies Must Be Globally Representative: Perspectives from PAGE.
  Annual review of genomics and human genetics 2019 Bien SA, Wojcik GL, Hodonsky CJ, Gignoux CR, Cheng I, Matise TC, Peters U, Kenny EE, North KE
• Body mass index, comorbidities, and hormonal factors in relation to meningioma in an ethnically diverse population: the Multiethnic Cohort.
  Neuro-oncology 2019 Muskens IS, Wu AH, Porcel J, Cheng I, Le Marchand L, Wiemels JL, Setiawan VW
• Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
  Journal of the National Cancer Institute 2019 Schmit SL, Edlund CK, Schumacher FR, Gong J, Harrison TA, Huyghe JR, Qu C, Melas M, Van Den Berg DJ, Wang H, Tring S, Plummer SJ, Albanes D, Alonso MH, Amos CI, Anton K, Aragaki AK, Arndt V, Barry EL,…
• Propensity for Intra-abdominal and Hepatic Adiposity Varies Among Ethnic Groups.
  Gastroenterology 2018 Lim U, Monroe KR, Buchthal S, Fan B, Cheng I, Kristal BS, Lampe JW, Hullar MA, Franke AA, Stram DO, Wilkens LR, Shepherd J, Ernst T, Le Marchand L
• Undertreatment of High-Risk Localized Prostate Cancer in the California Latino Population.
  Journal of the National Comprehensive Cancer Network : JNCCN 2018 Lichtensztajn DY, Leppert JT, Brooks JD, Shah SA, Sieh W, Chung BI, Gomez SL, Cheng I
• Temporal Variability and Stability of the Fecal Microbiome: The Multiethnic Cohort Study.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2018 Fu BC, Randolph TW, Lim U, Monroe KR, Cheng I, Wilkens LR, Le Marchand L, Lampe JW, Hullar MAJ
• Impact of individual and neighborhood factors on socioeconomic disparities in localized and advanced prostate cancer risk.
  Cancer causes & control : CCC 2018 DeRouen MC, Schupp CW, Yang J, Koo J, Hertz A, Shariff-Marco S, Cockburn M, Nelson DO, Ingles SA, Cheng I, John EM, Gomez SL
• Colorectal Cancer Incidence Trends by Age, Stage, and Racial/Ethnic Group in California, 1990-2014.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2018 Ellis L, Abrahão R, McKinley M, Yang J, Somsouk M, Marchand LL, Cheng I, Gomez SL, Shariff-Marco S
• Discovery, fine-mapping, and conditional analyses of genetic variants associated with C-reactive protein in multiethnic populations using the Metabochip in the Population Architecture using Genomics and Epidemiology (PAGE) study.
  Human molecular genetics 2018 Kocarnik JM, Richard M, Graff M, Haessler J, Bien S, Carlson C, Carty CL, Reiner AP, Avery CL, Ballantyne CM, LaCroix AZ, Assimes TL, Barbalic M, Pankratz N, Tang W, Tao R, Chen D, Talavera GA, …
• The influence of neighborhood socioeconomic status and ethnic enclave on endometrial cancer mortality among Hispanics and Asian Americans/Pacific Islanders in California.
  Cancer causes & control : CCC 2018 Von Behren J, Abrahão R, Goldberg D, Gomez SL, Setiawan VW, Cheng I
• Factors Associated With Treatment of Clinical Stage I Non-Small-cell Lung Cancer: A Population-based Analysis.
  Clinical lung cancer 2018 Berry MF, Canchola AJ, Gensheimer MF, Gomez SL, Cheng I
• Incidence of lung cancer histologic cell-types according to neighborhood factors: A population based study in California.
  PloS one 2018 DeRouen MC, Hu L, McKinley M, Gali K, Patel M, Clarke C, Wakelee H, Haile R, Gomez SL, Cheng I
• An Analysis of Lung Cancer Screening Beliefs and Practice Patterns for Community Providers Compared to Academic Providers.
  Cancer control : journal of the Moffitt Cancer Center 2018 Khairy M, Duong DK, Shariff-Marco S, Cheng I, Jain J, Balakrishnan A, Liu L, Gupta A, Chandramouli R, Hsing A, Leung A, Singh B, Nair VS
• Characterizing the neighborhood obesogenic environment in the Multiethnic Cohort: a multi-level infrastructure for cancer health disparities research.
  Cancer causes & control : CCC 2017 Conroy SM, Shariff-Marco S, Yang J, Hertz A, Cockburn M, Shvetsov YB, Clarke CA, Abright CL, Haiman CA, Le Marchand L, Kolonel LN, Monroe KR, Wilkens LR, Gomez SL, Cheng I
• Association between the neighborhood obesogenic environment and colorectal cancer risk in the Multiethnic Cohort.
  Cancer epidemiology 2017 Canchola AJ, Shariff-Marco S, Yang J, Albright C, Hertz A, Park SY, Shvetsov YB, Monroe KR, Le Marchand L, Gomez SL, Wilkens LR, Cheng I
• Risk Stratification for Second Primary Lung Cancer.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2017 Han SS, Rivera GA, Tammemägi MC, Plevritis SK, Gomez SL, Cheng I, Wakelee HA
• Genome-Wide Association Studies of Cancer in Diverse Populations.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2017 Park SL, Cheng I, Haiman CA
• Impact of the environment on cancer: Seeing the forest for the trees.
  Cancer 2017 Gomez SL, Shariff-Marco S, Cheng I, Reynolds P
• Dietary Patterns Derived by Reduced Rank Regression Are Inversely Associated with Type 2 Diabetes Risk across 5 Ethnic Groups in the Multiethnic Cohort.
  Current developments in nutrition 2017 Jacobs S, Kroeger J, Schulze MB, Frank LK, Franke AA, Cheng I, Monroe KR, Haiman CA, Kolonel LN, Wilkens LR, Le Marchand L, Boushey CJ, Maskarinec G
• Breast cancer in Asian Americans in California, 1988-2013: increasing incidence trends and recent data on breast cancer subtypes.
  Breast cancer research and treatment 2017 Gomez SL, Von Behren J, McKinley M, Clarke CA, Shariff-Marco S, Cheng I, Reynolds P, Glaser SL
• Lung cancer incidence trends in California by race/ethnicity, histology, sex, and neighborhood socioeconomic status: An analysis spanning 28 years.
  Lung cancer (Amsterdam, Netherlands) 2017 Patel MI, McKinley M, Cheng I, Haile R, Wakelee H, Gomez SL
• Contextual Impact of Neighborhood Obesogenic Factors on Postmenopausal Breast Cancer: The Multiethnic Cohort.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2017 Conroy SM, Clarke CA, Yang J, Shariff-Marco S, Shvetsov YB, Park SY, Albright CL, Hertz A, Monroe KR, Kolonel LN, Marchand LL, Wilkens LR, Gomez SL, Cheng I
• Recent declines in cancer incidence: related to the Great Recession?
  Cancer causes & control : CCC 2017 Gomez SL, Canchola AJ, Nelson DO, Keegan TH, Clarke CA, Cheng I, Shariff-Marco S, DeRouen M, Catalano R, Satariano WA, Davidson-Allen K, Glaser SL
• Patient and primary care provider attitudes and adherence towards lung cancer screening at an academic medical center.
  Preventive medicine reports 2017 Duong DK, Shariff-Marco S, Cheng I, Naemi H, Moy LM, Haile R, Singh B, Leung A, Hsing A, Nair VS
• Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci.
  Human molecular genetics 2016 Zubair N, Graff M, Luis Ambite J, Bush WS, Kichaev G, Lu Y, Manichaikul A, Sheu WH, Absher D, Assimes TL, Bielinski SJ, Bottinger EP, Buzkova P, Chuang LM, Chung RH, Cochran B, Dumitrescu L, Gottesman…
• Strategies for Enriching Variant Coverage in Candidate Disease Loci on a Multiethnic Genotyping Array.
  PloS one 2016 Bien SA, Wojcik GL, Zubair N, Gignoux CR, Martin AR, Kocarnik JM, Martin LW, Buyske S, Haessler J, Walker RW, Cheng I, Graff M, Xia L, Franceschini N, Matise T, James R, Hindorff L, Le Marchand L, …
• PS01.77: Risk-Stratification for Second Primary Lung Cancer: Topic: Medical Oncology.
  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2016 Han S, Rivera GA, Cheng I, Gomez S, Plevritis SK, Wakelee H
• Telomere structure and maintenance gene variants and risk of five cancer types.
  International journal of cancer 2016 Karami S, Han Y, Pande M, Cheng I, Rudd J, Pierce BL, Nutter EL, Schumacher FR, Kote-Jarai Z, Lindstrom S, Witte JS, Fang S, Han J, Kraft P, Hunter DJ, Song F, Hung RJ, McKay J, Gruber SB, Chanock SJ,…
• Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes - A Meta-Analysis.
  EBioMedicine 2016 Chen LS, Baker T, Hung RJ, Horton A, Culverhouse R, Hartz S, Saccone N, Cheng I, Deng B, Han Y, Hansen HM, Horsman J, Kim C, Rosenberger A, Aben KK, Andrew AS, Chang SC, Saum KU, Dienemann H, …
• Reply to being a widower may be an indication for routine prostate-specific antigen screening above age 69 years, which the American Urological Association recommends as a cutoff point.
  Cancer 2016 Gomez SL, Martínez ME, Brooks JD, Cheng I, Lichtensztajn D, Murphy JD
• The Effect of Patient and Contextual Characteristics on Racial/Ethnic Disparity in Breast Cancer Mortality.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2016 Sposto R, Keegan TH, Vigen C, Kwan ML, Bernstein L, John EM, Cheng I, Yang J, Koo J, Kurian AW, Caan BJ, Lu Y, Monroe KR, Shariff-Marco S, Gomez SL, Wu AH
• Differences in marital status and mortality by race/ethnicity and nativity among California cancer patients.
  Cancer 2016 Martínez ME, Anderson K, Murphy JD, Hurley S, Canchola AJ, Keegan TH, Cheng I, Clarke CA, Glaser SL, Gomez SL
• Effects of marital status and economic resources on survival after cancer: A population-based study.
  Cancer 2016 Gomez SL, Hurley S, Canchola AJ, Keegan TH, Cheng I, Murphy JD, Clarke CA, Glaser SL, Martínez ME
• No Association between the Mitochondrial Genome and Prostate Cancer Risk: The Multiethnic Cohort.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2016 Giorgi EE, Li Y, Caberto CP, Beckman KB, Lum-Jones A, Haiman CA, Le Marchand L, Stram DO, Saxena R, Cheng I
• Characterization of the gut microbiome in epidemiologic studies: the multiethnic cohort experience.
  Annals of epidemiology 2016 Fu BC, Randolph TW, Lim U, Monroe KR, Cheng I, Wilkens LR, Le Marchand L, Hullar MA, Lampe JW
• Validation of self-reported comorbidity status of breast cancer patients with medical records: the California Breast Cancer Survivorship Consortium (CBCSC).
  Cancer causes & control : CCC 2016 Vigen C, Kwan ML, John EM, Gomez SL, Keegan TH, Lu Y, Shariff-Marco S, Monroe KR, Kurian AW, Cheng I, Caan BJ, Lee VS, Roh JM, Bernstein L, Sposto R, Wu AH
• Lung Cancer Survival Among Chinese Americans, 2000 to 2010.
  Journal of global oncology 2016 Gomez SL, Yang J, Lin SW, McCusker M, Sandler A, Patel M, Cheng I, Wakelee HA, Clarke CA
• Intersection of Race/Ethnicity and Socioeconomic Status in Mortality After Breast Cancer.
  Journal of community health 2015 Shariff-Marco S, Yang J, John EM, Kurian AW, Cheng I, Leung R, Koo J, Monroe KR, Henderson BE, Bernstein L, Lu Y, Kwan ML, Sposto R, Vigen CL, Wu AH, Keegan TH, Gomez SL
• Impact of neighborhoods and body size on survival after breast cancer diagnosis.
  Health & place 2015 Shariff-Marco S, Gomez SL, Sangaramoorthy M, Yang J, Koo J, Hertz A, John EM, Cheng I, Keegan TH
• Association of Genes, Pathways, and Haplogroups of the Mitochondrial Genome with the Risk of Colorectal Cancer: The Multiethnic Cohort.
  PloS one 2015 Li Y, Beckman KB, Caberto C, Kazma R, Lum-Jones A, Haiman CA, Le Marchand L, Stram DO, Saxena R, Cheng I
• Racial/ethnic differences in lifestyle-related factors and prostate cancer risk: the Multiethnic Cohort Study.
  Cancer causes & control : CCC 2015 Park SY, Haiman CA, Cheng I, Park SL, Wilkens LR, Kolonel LN, Le Marchand L, Henderson BE
• Methodological Considerations in Estimation of Phenotype Heritability Using Genome-Wide SNP Data, Illustrated by an Analysis of the Heritability of Height in a Large Sample of African Ancestry Adults.
  PloS one 2015 Chen F, He J, Zhang J, Chen GK, Thomas V, Ambrosone CB, Bandera EV, Berndt SI, Bernstein L, Blot WJ, Cai Q, Carpten J, Casey G, Chanock SJ, Cheng I, Chu L, Deming SL, Driver WR, Goodman P, Hayes RB, …
• Contribution of the neighborhood environment and obesity to breast cancer survival: the California Breast Cancer Survivorship Consortium.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2015 Cheng I, Shariff-Marco S, Koo J, Monroe KR, Yang J, John EM, Kurian AW, Kwan ML, Henderson BE, Bernstein L, Lu Y, Sposto R, Vigen C, Wu AH, Gomez SL, Keegan TH
• Re: Nationwide prevalence of lymph node metastases in Gleason score 3 + 3 = 6 prostate cancer: authors' reply.
  Pathology 2015 Sieh W, Lichtensztajn DY, Gomez SL, Liu JJ, Chung BI, Cheng I, Brooks JD
• PIK3CA Somatic Mutation Status in Relation to Patient and Tumor Factors in Racial/Ethnic Minorities with Colorectal Cancer.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2015 Phipps AI, Ahnen DJ, Cheng I, Newcomb PA, Win AK, Burnett T
• Incidence trends of lung cancer by immigration status among Chinese Americans.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2015 Gomez SL, Yang J, Lin SW, McCusker M, Sandler A, Cheng I, Wakelee HA, Patel M, Clarke CA
• History of Recreational Physical Activity and Survival After Breast Cancer: The California Breast Cancer Survivorship Consortium.
  American journal of epidemiology 2015 Lu Y, John EM, Sullivan-Halley J, Vigen C, Gomez SL, Kwan ML, Caan BJ, Lee VS, Roh JM, Shariff-Marco S, Keegan TH, Kurian AW, Monroe KR, Cheng I, Sposto R, Wu AH, Bernstein L
• CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis--a meta-analysis.
  Journal of the National Cancer Institute 2015 Chen LS, Hung RJ, Baker T, Horton A, Culverhouse R, Saccone N, Cheng I, Deng B, Han Y, Hansen HM, Horsman J, Kim C, Lutz S, Rosenberger A, Aben KK, Andrew AS, Breslau N, Chang SC, Dieffenbach AK, …
• Pleiotropic and sex-specific effects of cancer GWAS SNPs on melanoma risk in the population architecture using genomics and epidemiology (PAGE) study.
  PloS one 2015 Kocarnik JM, Park SL, Han J, Dumitrescu L, Cheng I, Wilkens LR, Schumacher FR, Kolonel L, Carlson CS, Crawford DC, Goodloe RJ, Dilks HH, Baker P, Richardson D, Matise TC, Ambite JL, Song F, Qureshi AA…
• In silico functional pathway annotation of 86 established prostate cancer risk variants.
  PloS one 2015 Loo LW, Fong AY, Cheng I, Le Marchand L
• US lung cancer trends by histologic type.
  Cancer 2014 Patel MI, Cheng I, Gomez SL
• Diabetes and other comorbidities in breast cancer survival by race/ethnicity: the California Breast Cancer Survivorship Consortium (CBCSC).
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2014 Wu AH, Kurian AW, Kwan ML, John EM, Lu Y, Keegan TH, Gomez SL, Cheng I, Shariff-Marco S, Caan BJ, Lee VS, Sullivan-Halley J, Tseng CC, Bernstein L, Sposto R, Vigen C
• Cancer research in Asian American, Native Hawaiian, and Pacific Islander populations: accelerating cancer knowledge by acknowledging and leveraging heterogeneity.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2014 Gomez SL, Glaser SL, Horn-Ross PL, Cheng I, Quach T, Clarke CA, Reynolds P, Shariff-Marco S, Yang J, Lee MM, Satariano WA, Hsing AW
• Lung cancer incidence trends by histology type among Asian American, Native Hawaiian, and Pacific Islander populations in the United States, 1990-2010.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2014 Cheng I, Le GM, Noone AM, Gali K, Patel M, Haile RW, Wakelee HA, Gomez SL
• Response to Molakatalla and Kumar.
  The American journal of gastroenterology 2014 Ladabaum U, Clarke CA, Cheng I, Gomez SL
• Association of cancer susceptibility variants with risk of multiple primary cancers: The population architecture using genomics and epidemiology study.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2014 Park SL, Caberto CP, Lin Y, Goodloe RJ, Dumitrescu L, Love SA, Matise TC, Hindorff LA, Fowke JH, Schumacher FR, Beebe-Dimmer J, Chen C, Hou L, Thomas F, Deelman E, Han Y, Peters U, North KE, Heiss G, …
• Analysis of metabolic syndrome components in >15 000 african americans identifies pleiotropic variants: results from the population architecture using genomics and epidemiology study.
  Circulation. Cardiovascular genetics 2014 Carty CL, Bhattacharjee S, Haessler J, Cheng I, Hindorff LA, Aroda V, Carlson CS, Hsu CN, Wilkens L, Liu S, Selvin E, Jackson R, North KE, Peters U, Pankow JS, Chatterjee N, Kooperberg C
• Colorectal cancer mortality among Hispanics in California: differences by neighborhood socioeconomic status and nativity.
  Cancer 2014 Tao L, Ladabaum U, Gomez SL, Cheng I
• Fine-mapping IGF1 and prostate cancer risk in African Americans: the multiethnic cohort study.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2014 Giorgi EE, Stram DO, Taverna D, Turner SD, Schumacher F, Haiman CA, Lum-Jones A, Tirikainen M, Caberto C, Duggan D, Henderson BE, Le Marchand L, Cheng I
• Nationwide prevalence of lymph node metastases in Gleason score 3 + 3 = 6 prostate cancer.
  Pathology 2014 Liu JJ, Lichtensztajn DY, Gomez SL, Sieh W, Chung BI, Cheng I, Brooks JD
• Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia.
  Carcinogenesis 2014 Setiawan VW, Schumacher F, Prescott J, Haessler J, Malinowski J, Wentzensen N, Yang H, Chanock S, Brinton L, Hartge P, Lissowska J, Park SL, Cheng I, Bush WS, Crawford DC, Ursin G, Horn-Ross P, …
• Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia.
  Journal of the National Cancer Institute 2014 Park SL, Fesinmeyer MD, Timofeeva M, Caberto CP, Kocarnik JM, Han Y, Love SA, Young A, Dumitrescu L, Lin Y, Goodloe R, Wilkens LR, Hindorff L, Fowke JH, Carty C, Buyske S, Schumacher FR, Butler A, …
• Multiancestral analysis of inflammation-related genetic variants and C-reactive protein in the population architecture using genomics and epidemiology study.
  Circulation. Cardiovascular genetics 2014 Kocarnik JM, Pendergrass SA, Carty CL, Pankow JS, Schumacher FR, Cheng I, Durda P, Ambite JL, Deelman E, Cook NR, Liu S, Wactawski-Wende J, Hutter C, Brown-Gentry K, Wilson S, Best LG, Pankratz N, …
• Colorectal cancer incidence in Asian populations in California: effect of nativity and neighborhood-level factors.
  The American journal of gastroenterology 2014 Ladabaum U, Clarke CA, Press DJ, Mannalithara A, Myer PA, Cheng I, Gomez SL
• Replication of associations between GWAS SNPs and melanoma risk in the Population Architecture Using Genomics and Epidemiology (PAGE) Study.
  The Journal of investigative dermatology 2014 Kocarnik JM, Park SL, Han J, Dumitrescu L, Cheng I, Wilkens LR, Schumacher FR, Kolonel L, Carlson CS, Crawford DC, Goodloe RJ, Dilks H, Baker P, Richardson D, Ambite JL, Song F, Quresh AA, Zhang M, …
• Prostate cancer risk profiles of Asian-American men: disentangling the effects of immigration status and race/ethnicity.
  The Journal of urology 2013 Lichtensztajn DY, Gomez SL, Sieh W, Chung BI, Cheng I, Brooks JD
• Obesity and mortality after breast cancer by race/ethnicity: The California Breast Cancer Survivorship Consortium.
  American journal of epidemiology 2013 Kwan ML, John EM, Caan BJ, Lee VS, Bernstein L, Cheng I, Gomez SL, Henderson BE, Keegan TH, Kurian AW, Lu Y, Monroe KR, Roh JM, Shariff-Marco S, Sposto R, Vigen C, Wu AH
• No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population.
  Human genetics 2013 Dumitrescu L, Carty CL, Franceschini N, Hindorff LA, Cole SA, Bužková P, Schumacher FR, Eaton CB, Goodloe RJ, Duggan DJ, Haessler J, Cochran B, Henderson BE, Cheng I, Johnson KC, Carlson CS, Love SA, …
• Fine Mapping and Identification of BMI Loci in African Americans.
  American journal of human genetics 2013 Gong J, Schumacher F, Lim U, Hindorff LA, Haessler J, Buyske S, Carlson CS, Rosse S, Bužková P, Fornage M, Gross M, Pankratz N, Pankow JS, Schreiner PJ, Cooper R, Ehret G, Gu CC, Houston D, Irvin MR, …
• Variations in bitter-taste receptor genes, dietary intake, and colorectal adenoma risk.
  Nutrition and cancer 2013 Schembre SM, Cheng I, Wilkens LR, Albright CL, Marchand le L
• Genetic variation in the inflammation and innate immunity pathways and colorectal cancer risk.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2013 Wang H, Taverna D, Stram DO, Fortini BK, Cheng I, Wilkens LR, Burnett T, Makar KW, Lindor NM, Hopper JL, Gallinger S, Baron JA, Haile R, Kolonel LN, Henderson BE, Newcomb PA, Casey G, Duggan D, Ulrich…
• Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia.
  Gut 2013 Cheng I, Kocarnik JM, Dumitrescu L, Lindor NM, Chang-Claude J, Avery CL, Caberto CP, Love SA, Slattery ML, Chan AT, Baron JA, Hindorff LA, Park SL, Schumacher FR, Hoffmeister M, Kraft P, Butler AM, …
• The California Breast Cancer Survivorship Consortium (CBCSC): prognostic factors associated with racial/ethnic differences in breast cancer survival.
  Cancer causes & control : CCC 2013 Wu AH, Gomez SL, Vigen C, Kwan ML, Keegan TH, Lu Y, Shariff-Marco S, Monroe KR, Kurian AW, Cheng I, Caan BJ, Lee VS, Roh JM, Sullivan-Halley J, Henderson BE, Bernstein L, John EM, Sposto R
• Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study.
  American journal of epidemiology 2013 Park SL, Cheng I, Pendergrass SA, Kucharska-Newton AM, Lim U, Ambite JL, Caberto CP, Monroe KR, Schumacher F, Hindorff LA, Oetjens MT, Wilson S, Goodloe RJ, Love SA, Henderson BE, Kolonel LN, Haiman …
• Post-genome-wide association study challenges for lipid traits: describing age as a modifier of gene-lipid associations in the Population Architecture using Genomics and Epidemiology (PAGE) study.
  Annals of human genetics 2013 Dumitrescu L, Carty CL, Franceschini N, Hindorff LA, Cole SA, Bužková P, Schumacher FR, Eaton CB, Goodloe RJ, Duggan DJ, Haessler J, Cochran B, Henderson BE, Cheng I, Johnson KC, Carlson CS, Love SA, …
• Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study.
  BMC genetics 2013 Taylor KC, Carty CL, Dumitrescu L, Bužková P, Cole SA, Hindorff L, Schumacher FR, Wilkens LR, Shohet RV, Quibrera PM, Johnson KC, Henderson BE, Haessler J, Franceschini N, Eaton CB, Duggan DJ, Cochran…
• Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained.
  PLoS genetics 2013 Wu Y, Waite LL, Jackson AU, Sheu WH, Buyske S, Absher D, Arnett DK, Boerwinkle E, Bonnycastle LL, Carty CL, Cheng I, Cochran B, Croteau-Chonka DC, Dumitrescu L, Eaton CB, Franceschini N, Guo X, …
• Global patterns of prostate cancer incidence, aggressiveness, and mortality in men of african descent.
  Prostate cancer 2013 Rebbeck TR, Devesa SS, Chang BL, Bunker CH, Cheng I, Cooney K, Eeles R, Fernandez P, Giri VN, Gueye SM, Haiman CA, Henderson BE, Heyns CF, Hu JJ, Ingles SA, Isaacs W, Jalloh M, John EM, Kibel AS, Kidd…
• Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study.
  PloS one 2013 Spencer KL, Malinowski J, Carty CL, Franceschini N, Fernández-Rhodes L, Young A, Cheng I, Ritchie MD, Haiman CA, Wilkens L, Matise TC, Carlson CS, Brennan K, Park A, Rajkovic A, Hindorff LA, Buyske S,…
• HOXB13 mutation and prostate cancer: studies of siblings and aggressive disease.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2013 Witte JS, Mefford J, Plummer SJ, Liu J, Cheng I, Klein EA, Rybicki BA, Casey G
• Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer.
  Genes, chromosomes & cancer 2013 Loo LW, Tiirikainen M, Cheng I, Lum-Jones A, Seifried A, Church JM, Gryfe R, Weisenberger DJ, Lindor NM, Gallinger S, Haile RW, Duggan DJ, Thibodeau SN, Casey G, Le Marchand L
• A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study.
  PLoS genetics 2013 Peters U, North KE, Sethupathy P, Buyske S, Haessler J, Jiao S, Fesinmeyer MD, Jackson RD, Kuller LH, Rajkovic A, Lim U, Cheng I, Schumacher F, Wilkens L, Li R, Monda K, Ehret G, Nguyen KD, Cooper R, …
• Association of the innate immunity and inflammation pathway with advanced prostate cancer risk.
  PloS one 2012 Kazma R, Mefford JA, Cheng I, Plummer SJ, Levin AM, Rybicki BA, Casey G, Witte JS
• Population genetic structure and origins of Native Hawaiians in the multiethnic cohort study.
  PloS one 2012 Kim SK, Gignoux CR, Wall JD, Lum-Jones A, Wang H, Haiman CA, Chen GK, Henderson BE, Kolonel LN, Le Marchand L, Stram DO, Saxena R, Cheng I
• Evaluating genetic risk for prostate cancer among Japanese and Latinos.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2012 Cheng I, Chen GK, Nakagawa H, He J, Wan P, Laurie CC, Shen J, Sheng X, Pooler LC, Crenshaw AT, Mirel DB, Takahashi A, Kubo M, Nakamura Y, Al Olama AA, Benlloch S, Donovan JL, Guy M, Hamdy FC, Kote-…
• Examining the association between socioeconomic status and invasive colorectal cancer incidence and mortality in California.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2012 Steinbrecher A, Fish K, Clarke CA, West DW, Gomez SL, Cheng I
• Susceptibility variants for waist size in relation to abdominal, visceral, and hepatic adiposity in postmenopausal women.
  Journal of the Academy of Nutrition and Dietetics 2012 Lim U, Ernst T, Wilkens LR, Albright CL, Lum-Jones A, Seifried A, Buchthal SD, Novotny R, Kolonel LN, Chang L, Cheng I, Le Marchand L
• Susceptibility variants for obesity and colorectal cancer risk: the multiethnic cohort and PAGE studies.
  International journal of cancer 2012 Lim U, Wilkens LR, Monroe KR, Caberto C, Tiirikainen M, Cheng I, Park SL, Stram DO, Henderson BE, Kolonel LN, Haiman CA, Le Marchand L
• Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study.
  PloS one 2012 Buyske S, Wu Y, Carty CL, Cheng I, Assimes TL, Dumitrescu L, Hindorff LA, Mitchell S, Ambite JL, Boerwinkle E, Buzkova P, Carlson CS, Cochran B, Duggan D, Eaton CB, Fesinmeyer MD, Franceschini N, …
• Measurement of circulating cell-free DNA in relation to 18F-fluorocholine PET/CT imaging in chemotherapy-treated advanced prostate cancer.
  Clinical and translational science 2012 Kwee S, Song MA, Cheng I, Loo L, Tiirikainen M
• Genetic variants, prediagnostic circulating levels of insulin-like growth factors, insulin, and glucose and the risk of colorectal cancer: the Multiethnic Cohort study.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2012 Ollberding NJ, Cheng I, Wilkens LR, Henderson BE, Pollak MN, Kolonel LN, Le Marchand L
• cis-Expression QTL analysis of established colorectal cancer risk variants in colon tumors and adjacent normal tissue.
  PloS one 2012 Loo LW, Cheng I, Tiirikainen M, Lum-Jones A, Seifried A, Dunklee LM, Church JM, Gryfe R, Weisenberger DJ, Haile RW, Gallinger S, Duggan DJ, Thibodeau SN, Casey G, Le Marchand L
• Impact of meat consumption, preparation, and mutagens on aggressive prostate cancer.
  PloS one 2011 Punnen S, Hardin J, Cheng I, Klein EA, Witte JS
• Copy number alterations in prostate tumors and disease aggressiveness.
  Genes, chromosomes & cancer 2011 Cheng I, Levin AM, Tai YC, Plummer S, Chen GK, Neslund-Dudas C, Casey G, Rybicki BA, Witte JS
• Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk.
  Nutrition and cancer 2011 Hardin J, Cheng I, Witte JS
• Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.
  Nature genetics 2011 Haiman CA, Chen GK, Blot WJ, Strom SS, Berndt SI, Kittles RA, Rybicki BA, Isaacs WB, Ingles SA, Stanford JL, Diver WR, Witte JS, Hsing AW, Nemesure B, Rebbeck TR, Cooney KA, Xu J, Kibel AS, Hu JJ, …
• Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies.
  Gut 2011 Cheng I, Caberto CP, Lum-Jones A, Seifried A, Wilkens LR, Schumacher FR, Monroe KR, Lim U, Tiirikainen M, Kolonel LN, Henderson BE, Stram DO, Haiman CA, Le Marchand L
• Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35.
  The Prostate 2010 Liu X, Cheng I, Plummer SJ, Suarez BK, Casey G, Catalona WJ, Witte JS
• Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer.
  Pharmaceuticals (Basel, Switzerland) 2010 Reese AC, Hardin J, Cheng I, Casey G, Witte JS
• Genome-wide association studies and cancer.
  Hawaii medical journal 2010 Jorgenson E, Cheng I
• IGF1, IGFBP1, and IGFBP3 genes and mammographic density: the Multiethnic Cohort.
  International journal of cancer 2010 Verheus M, Maskarinec G, Woolcott CG, Haiman CA, Le Marchand L, Henderson BE, Cheng I, Kolonel LN
• Prostate cancer susceptibility variants confer increased risk of disease progression.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010 Cheng I, Plummer SJ, Neslund-Dudas C, Klein EA, Casey G, Rybicki BA, Witte JS
• A comprehensive analysis of common IGF1, IGFBP1 and IGFBP3 genetic variation with prospective IGF-I and IGFBP-3 blood levels and prostate cancer risk among Caucasians.
  Human molecular genetics 2010 Schumacher FR, Cheng I, Freedman ML, Mucci L, Allen NE, Pollak MN, Hayes RB, Stram DO, Canzian F, Henderson BE, Hunter DJ, Virtamo J, Manjer J, Gaziano JM, Kolonel LN, Tjønneland A, Albanes D, Calle …
• Prostatitis, sexually transmitted diseases, and prostate cancer: the California Men's Health Study.
  PloS one 2010 Cheng I, Witte JS, Jacobsen SJ, Haque R, Quinn VP, Quesenberry CP, Caan BJ, Van Den Eeden SK
• Editorial comment.
  The Journal of urology 2009 Cheng I
• Socioeconomic status and prostate cancer incidence and mortality rates among the diverse population of California.
  Cancer causes & control : CCC 2009 Cheng I, Witte JS, McClure LA, Shema SJ, Cockburn MG, John EM, Clarke CA