Ingrid Chen, PhD, MS
Associate Professor
Epidemiology & Biostatistics
School of Medicine

Trained as an organic chemist, Ingrid has been conducting malaria research since 2011, with interdisciplinary expertise spanning from drug discovery and clinical trials (phase 1 and 2) to implementation, cost-effectiveness, antimalarial delivery within the informal private sector, and more.

Since joining the UCSF's Malaria Elimination Initiative (MEI) in 2013, Ingrid led the Primaquine Rollout Group, the Antiparasite Rollout Group (APROG), and the scientific sections of the Lancet Commission on Malaria Eradication. Her current research focuses on spatial repellents, a product class that can accelerate the trajectory to malaria eradication while addressing other vector-borne diseases.

• Efficacy of Single-Dose Primaquine With Artemisinin Combination Therapy on Plasmodium falciparum Gametocytes and Transmission: An Individual Patient Meta-Analysis.
  The Journal of infectious diseases 2022 Stepniewska K, Humphreys GS, Gonçalves BP, Craig E, Gosling R, Guerin PJ, Price RN, Barnes KI, Raman J, Smit MR, D'Alessandro U, Stone WJR, Bjorkman A, Samuels AM, Arroyo-Arroyo MI, Bastiaens GJH, …
• Triple artemisinin-based combination therapies for malaria: a timely solution to counter antimalarial drug resistance.
  The Lancet. Infectious diseases 2022 Chen I, Hsiang MS
• G6PD Polymorphisms and Hemolysis After Antimalarial Treatment With Low Single-Dose Primaquine: A Pooled Analysis of Six African Clinical Trials.
  Frontiers in genetics 2021 Sepúlveda N, Grignard L, Curry J, Mahey L, Bastiaens GJH, Tiono AB, Okebe J, Coulibaly SA, Gonçalves BP, Affara M, Ouédraogo A, Bougouma EC, Sanou GS, Nébié I, Lanke K, Sirima SB, Dicko A, d'…
• Persistence of mRNA indicative of Plasmodium falciparum ring-stage parasites 42 days after artemisinin and non-artemisinin combination therapy in naturally infected Malians.
  Malaria journal 2021 Mahamar A, Lanke K, Graumans W, Diawara H, Sanogo K, Diarra K, Niambele SM, Gosling R, Drakeley C, Chen I, Dicko A, Bousema T, Roh ME
• Malaria eradication - Authors' reply.
  Lancet (London, England) 2020 Chen I, Dondorp A, Gosling R, Harvard K, Tulloch J
• District-level approach for tailoring and targeting interventions: a new path for malaria control and elimination.
  Malaria journal 2020 Gosling R, Chimumbwa J, Uusiku P, Rossi S, Ntuku H, Harvard K, White C, Tatarsky A, Chandramohan D, Chen I
• Assessing the role of the private sector in surveillance for malaria elimination in Haiti and the Dominican Republic: a qualitative study.
  Malaria journal 2019 Sidibe A, Maglior A, Cueto C, Chen I, Le Menach A, Chang MA, Eisele TP, Andrinopolous K, Cherubin J, Lemoine JF, Bennett A
• CYP2D6 Polymorphisms and the Safety and Gametocytocidal Activity of Single-Dose Primaquine for Plasmodium falciparum.
  Antimicrobial agents and chemotherapy 2019 Pett H, Bradley J, Okebe J, Dicko A, Tiono AB, Gonçalves BP, Stone W, Chen I, Lanke K, Neuvonen M, Mustaniemi AL, Eziefula AC, Gosling R, D'Alessandro U, Drakeley C, Niemi M, Bousema T
• Malaria eradication within a generation: ambitious, achievable, and necessary.
  Lancet (London, England) 2019 Feachem RGA, Chen I, Akbari O, Bertozzi-Villa A, Bhatt S, Binka F, Boni MF, Buckee C, Dieleman J, Dondorp A, Eapen A, Sekhri Feachem N, Filler S, Gething P, Gosling R, Haakenstad A, Harvard K, Hatefi …
• What is community engagement and how can it drive malaria elimination? Case studies and stakeholder interviews.
  Malaria journal 2019 Baltzell K, Harvard K, Hanley M, Gosling R, Chen I
• Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density.
  eLife 2018 Bradley J, Stone W, Da DF, Morlais I, Dicko A, Cohuet A, Guelbeogo WM, Mahamar A, Nsango S, Soumaré HM, Diawara H, Lanke K, Graumans W, Siebelink-Stoter R, van de Vegte-Bolmer M, Chen I, Tiono A, …
• The Lancet Commission on malaria eradication.
  Lancet (London, England) 2018 Chen I, Cooney R, Feachem RGA, Lal A, Mpanju-Shumbusho W
• Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial.
  The Journal of infectious diseases 2018 Chen I, Diawara H, Mahamar A, Sanogo K, Keita S, Kone D, Diarra K, Djimde M, Keita M, Brown J, Roh ME, Hwang J, Pett H, Murphy M, Niemi M, Greenhouse B, Bousema T, Gosling R, Dicko A
• Low risk of recurrence following artesunate-Sulphadoxine-pyrimethamine plus primaquine for uncomplicated Plasmodium falciparum and Plasmodium vivax infections in the Republic of the Sudan.
  Malaria journal 2018 Hamid MMA, Thriemer K, Elobied ME, Mahgoub NS, Boshara SA, Elsafi HMH, Gumaa SA, Hamid T, Abdelbagi H, Basheir HM, Marfurt J, Chen I, Gosling R, Price RN, Ley B
• Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial.
  The Lancet. Infectious diseases 2018 Dicko A, Roh ME, Diawara H, Mahamar A, Soumare HM, Lanke K, Bradley J, Sanogo K, Kone DT, Diarra K, Keita S, Issiaka D, Traore SF, McCulloch C, Stone WJR, Hwang J, Müller O, Brown JM, Srinivasan V, …
• Malaria risk factors and care-seeking behaviour within the private sector among high-risk populations in Vietnam: a qualitative study.
  Malaria journal 2017 Chen I, Thanh HNT, Lover A, Thao PT, Luu TV, Thang HN, Thang ND, Neukom J, Bennett A
• A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte Clearance.
  The Journal of infectious diseases 2017 Stone W, Sawa P, Lanke K, Rijpma S, Oriango R, Nyaurah M, Osodo P, Osoti V, Mahamar A, Diawara H, Woestenenk R, Graumans W, van de Vegte-Bolmer M, Bradley J, Chen I, Brown J, Siciliano G, Alano P, …
• Barriers to routine G6PD testing prior to treatment with primaquine.
  Malaria journal 2017 Ley B, Thriemer K, Jaswal J, Poirot E, Alam MS, Phru CS, Khan WA, Dysoley L, Qi G, Kheong CC, Shamsudin UK, Chen I, Hwang J, Gosling R, Price RN
• Mass Drug Administration for Malaria: A Means to What end?
  The Journal of infectious diseases 2016 Chen I, Gosling R, Drakeley C, Bousema T
• Comparison of molecular quantification of Plasmodium falciparum gametocytes by Pfs25 qRT-PCR and QT-NASBA in relation to mosquito infectivity.
  Malaria journal 2016 Pett H, Gonçalves BP, Dicko A, Nébié I, Tiono AB, Lanke K, Bradley J, Chen I, Diawara H, Mahamar A, Soumare HM, Traore SF, Baber I, Sirima SB, Sauerwein R, Brown J, Gosling R, Felger I, Drakeley C, …
• Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial.
  The Lancet. Infectious diseases 2016 Dicko A, Brown JM, Diawara H, Baber I, Mahamar A, Soumare HM, Sanogo K, Koita F, Keita S, Traore SF, Chen I, Poirot E, Hwang J, McCulloch C, Lanke K, Pett H, Niemi M, Nosten F, Bousema T, Gosling R
• "Asymptomatic" Malaria: A Chronic and Debilitating Infection That Should Be Treated.
  PLoS medicine 2016 Chen I, Clarke SE, Gosling R, Hamainza B, Killeen G, Magill A, O'Meara W, Price RN, Riley EM
• Availability and quality of anti-malarials among private sector outlets in Myanmar in 2012: results from a large, community-based, cross-sectional survey before a large-scale intervention.
  Malaria journal 2015 Khin HS, Chen I, White C, Sudhinaraset M, McFarland W, Littrell M, Montagu D, Aung T
• Review of mass drug administration for malaria and its operational challenges.
  The American journal of tropical medicine and hygiene 2015 Newby G, Hwang J, Koita K, Chen I, Greenwood B, von Seidlein L, Shanks GD, Slutsker L, Kachur SP, Wegbreit J, Ippolito MM, Poirot E, Gosling R
• An assessment of the supply, programmatic use, and regulatory issues of single low-dose primaquine as a Plasmodium falciparum gametocytocide for sub-Saharan Africa.
  Malaria journal 2015 Chen I, Poirot E, Newman M, Kandula D, Shah R, Hwang J, Cohen JM, Gosling R, Rooney L
• Improving uptake and use of malaria rapid diagnostic tests in the context of artemisinin drug resistance containment in eastern Myanmar: an evaluation of incentive schemes among informal private healthcare providers.
  Malaria journal 2015 Aung T, White C, Montagu D, McFarland W, Hlaing T, Khin HS, San AK, Briegleb C, Chen I, Sudhinaraset M
• Cost-effectiveness analysis of malaria rapid diagnostic test incentive schemes for informal private healthcare providers in Myanmar.
  Malaria journal 2015 Chen IT, Aung T, Thant HN, Sudhinaraset M, Kahn JG
• Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria.
  Malaria journal 2014 White NJ, Ashley EA, Recht J, Delves MJ, Ruecker A, Smithuis FM, Eziefula AC, Bousema T, Drakeley C, Chotivanich K, Imwong M, Pukrittayakamee S, Prachumsri J, Chu C, Andolina C, Bancone G, Hien TT, …
• Low-dose primaquine to reduce the transmission of P. falciparum malaria: a roadmap update.
  Malaria Journal 2014 Ingrid Chen, Chris Drakeley, Eugenie Poirot, Jimee Hwang, Roly Gosling
• Pharmacovigilance for single low-dose primaquine: a practical approach.
  Malaria Journal 2014 Eugenie Poirot, Andy Stergachis, Feiko ter Kuile, Philippe J Guerin, Ingrid Chen, Roland Gosling
• Targeting Plasmodium falciparum transmission with primaquine: same efficacy, improved safety with a lower dose?
  Expert review of clinical pharmacology 2014 Chen IT, Gosling RD
• Total synthesis of sandresolide B and amphilectolide.
  Organic letters 2013 Chen IT, Baitinger I, Schreyer L, Trauner D
• Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Deu E, Chen IT, Lauterwasser EM, Valderramos J, Li H, Edgington LE, Renslo AR, Bogyo M
• Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant.
  Bioorganic & medicinal chemistry letters 2011 Thomas M, Huang WS, Wen D, Zhu X, Wang Y, Metcalf CA, Liu S, Chen I, Romero J, Zou D, Sundaramoorthi R, Li F, Qi J, Cai L, Zhou T, Commodore L, Xu Q, Keats J, Wang F, Wardwell S, Ning Y, Snodgrass JT,…
• Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant.
  Journal of medicinal chemistry 2010 Huang WS, Metcalf CA, Sundaramoorthi R, Wang Y, Zou D, Thomas RM, Zhu X, Cai L, Wen D, Liu S, Romero J, Qi J, Chen I, Banda G, Lentini SP, Das S, Xu Q, Keats J, Wang F, Wardwell S, Ning Y, Snodgrass …
• Total synthesis of (-)-archazolid B.
  Journal of the American Chemical Society 2007 Roethle PA, Chen IT, Trauner D