Imran Khan, MD, PhD
Adjunct Instructor
Office of the CEO
Chancellor/EVC/FAS

Education & Training

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• BA Molecular & Cell Biology, Immunology University of California, Berkeley
• PhD Immunology University of California, San Francisco
• MD Medicine University of California, San Francisco
• Fellowship Neonatology University of California, San Francisco
• Residency Pediatrics University of California, San Francisco

Publications (13)

Top publication keywords:
Thymus GlandT-LymphocytesAutoimmunityEndodeoxyribonucleasesCyclin-Dependent Kinase Inhibitor p16Transcription FactorsStem Cell NicheAntigens, NeoplasmMicroRNAsEpithelial CellsRANK LigandCentral ToleranceGene Expression RegulationImmune ToleranceThymocytes

• Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.
  Science (New York, N.Y.) 2022 Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T
• Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.
  Nature 2018 Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, …
• Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity.
  JCI insight 2017 Bakhru P, Zhu ML, Wang HH, Hong LK, Khan I, Mouchess M, Gulati AS, Starmer J, Hou Y, Sailer D, Lee S, Zhao F, Kirkwood JM, Moschos S, Fong L, Anderson MS, Su MA
• Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells.
  PloS one 2015 Khan IS, Park CY, Mavropoulos A, Shariat N, Pollack JL, Barczak AJ, Erle DJ, McManus MT, Anderson MS, Jeker LT
• Transglutaminase 4 as a prostate autoantigen in male subfertility.
  Science translational medicine 2015 Landegren N, Sharon D, Shum AK, Khan IS, Fasano KJ, Hallgren Å, Kampf C, Freyhult E, Ardesjö-Lundgren B, Alimohammadi M, Rathsman S, Ludvigsson JF, Lundh D, Motrich R, Rivero V, Fong L, Giwercman A, …

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• Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance.
  The Journal of experimental medicine 2014 Khan IS, Mouchess ML, Zhu ML, Conley B, Fasano KJ, Hou Y, Fong L, Su MA, Anderson MS
• Canonical microRNAs in thymic epithelial cells promote central tolerance.
  European journal of immunology 2014 Khan IS, Taniguchi RT, Fasano KJ, Anderson MS, Jeker LT
• The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
  Nature immunology 2014 Waterfield M, Khan IS, Cortez JT, Fan U, Metzger T, Greer A, Fasano K, Martinez-Llordella M, Pollack JL, Erle DJ, Su M, Anderson MS
• Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population.
  Cell reports 2013 Metzger TC, Khan IS, Gardner JM, Mouchess ML, Johannes KP, Krawisz AK, Skrzypczynska KM, Anderson MS
• Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development.
  Cell stem cell 2013 Parent AV, Russ HA, Khan IS, LaFlam TN, Metzger TC, Anderson MS, Hebrok M
• Restoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis.
  Nucleic acids research 2011 Mohapatra S, Kawahara M, Khan IS, Yannone SM, Povirk LF
• A non-leaky Artemis-deficient mouse that accurately models the human severe combined immune deficiency phenotype, including resistance to hematopoietic stem cell transplantation.
  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2009 Xiao Z, Dunn E, Singh K, Khan IS, Yannone SM, Cowan MJ
• Coordinate 5' and 3' endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase.
  Nucleic acids research 2008 Yannone SM, Khan IS, Zhou RZ, Zhou T, Valerie K, Povirk LF