Igor Odintsov, MD
Assistant Professor
Pathology
School of Medicine

Publications (61)

Top publication keywords:
RhabdomyosarcomaHemangiosarcomaDNA Mismatch RepairBiomarkers, TumorTelomere-Binding ProteinsNeuregulin-1SarcomaVascular Endothelial Growth Factor Receptor-2Heart NeoplasmsLung NeoplasmsSarcoma, Clear CellCarcinoma, Non-Small-Cell LungGene FusionLeiomyosarcomaGene Rearrangement

• MITF Activation Is a Feature of Clear Cell and Conventional Fibrous Papule.
  Journal of cutaneous pathology 2026 Papke DJ, Pissaloux D, Odintsov I, Baranov E, Hornick JL, de la Fouchardiere A, Hanna J
• Secondary Renal Cell Carcinoma Bearing the Genomic Signature of Prior Temozolomide Therapy.
  JCO precision oncology 2026 Zhao T, Church AJ, Siegmund SE, Odintsov I
• Therapeutic targeting of RAS-mediated resistance in oncogene-driven lung cancer.
  Annals of oncology : official journal of the European Society for Medical Oncology 2026 Facchinetti F, Friboulet L, Liao L, Peroni M, Nakazawa S, Zullo L, Aldea M, Pecci F, Makarem M, Alonso Garcia I, Minari R, Tuladhar B, Ngo K, Da Silva A, Bigot L, Odintsov I, Koivu MKA, Leonetti A, …
• Undifferentiated and Dedifferentiated Melanoma of the Genitourinary Tract: A Case Series Demonstrating the Potential for Diagnostic Pitfalls.
  International journal of surgical pathology 2026 Repetto F, Russell-Goldman EE, Duncan L, Dias-Santagata D, Odintsov I, Acosta AM, Chebib I, Oliva E, Wu CL, Hirsch MS
• EML4-ALK mediates resistance to KRAS G12C inhibition and induces an oncogenic dependency by rewiring signaling through the wild-type RAS pathway.
  Cancer discovery 2026 Scaparone P, Mira A, Cheong TC, Patrucco E, Ricciuti B, Gribaudo R, Garbo E, Scardaci R, Savinelli I, Vietti Michelina S, Odintsov I, Brea EJ, Mignacco R, Blasco RB, Santamaría D, Voena C, Hofmann MH,…

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• Clinicopathological and molecular features of uterine smooth muscle tumours in patients with Li-Fraumeni syndrome.
  Histopathology 2026 Lin LH, Odintsov I, Towery EA, Quade BJ, Nucci MR, Ordulu Z, Kolin DL
• Clinicopathologic Study of 39 Mismatch Repair-deficient Sarcomas Demonstrates Recurrent Histologic Patterns and Supports Universal Screening of Pleomorphic Rhabdomyosarcoma, Uterine Leiomyosarcoma, and Undifferentiated and Unclassified Sarcomas.
  The American journal of surgical pathology 2026 Odintsov I, Nowak JA, Baranov E, Alcindor T, Haddox CL, Venkataraman V, Sholl LM, George S, Doyle LA, Redston M, Papke DJ
• Clinicopathologic characterization of renal tumors with Folliculin (FLCN) biallelic inactivation.
  Virchows Archiv : an international journal of pathology 2026 Siegmund SE, Wobker SE, Harik LR, Tretiakova M, Kandukuri S, Trpkov K, Maclean F, Odintsov I, Alchoueiry M, Aron M, Picken MM, Mahlow J, Adeniran AJ, Humphrey PA, Moch H, Tsai H, Henske EP, Hirsch MS
• Novel BRAF fusion in Erdheim-Chester disease with pulmonary manifestations: Importance of RNA-based testing and response to MEK inhibition.
  Histopathology 2026 Odintsov I, Tazelaar HD, Lee JC, Damon LE, Devine WP, Jones KD
• FOS and FOSB Immunohistochemistry and Molecular Testing Reveal Novel Patterns in Proliferative Fasciitis and Myositis, FOSB Rearrangement in Proliferative Funiculitis, and FOSL1 :: RELA Fusion in Pediatric Proliferative Fasciitis.
  The American journal of surgical pathology 2026 Yu S, Cordier F, Baranov E, Odintsov I, Magnusson L, Van der Meulen J, Loontiens S, Ferdinande L, Van Dorpe J, Haglund de Flon F, Mertens F, Fletcher CDM, Creytens D, Papke DJ
• MTAP loss is frequent in oncogene-driven NSCLC and may confer sensitivity to combined PRMT5 inhibitors and targeted therapies.
  Annals of oncology : official journal of the European Society for Medical Oncology 2026 Aldea M, Lenahan SM, Locquet MA, Liao L, Gasparro M, Gokhale PC, Ghigna MR, Ionescu DN, Odintsov I, Ngo K, Wang X, Aziz S, Pecci F, Garbo E, Ivanova E, Nakazawa S, Kulesza J, Tsai JA, Zullo L, Lee J, …
• Ultramutated Colonic Adenocarcinoma With Mismatch Repair Deficiency and Distinctive Mutational Signature Following Solid Organ Transplantation.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2026 Ling-Lin Pai E, Halper-Stromberg E, Herzog C, Odintsov I, Baranov E
• Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer.
  Cancer cell 2026 Campisi M, Osaki T, Dryg I, Stornante C, Wolff J, Weirather J, Weaver N, Tarannum M, Gillanders I, Bers A, Bobilev E, Lineberry MS, Schol P, Chen M, Ota K, Park SR, Fahey CG, Thai TC, Li Y, Li Z, Li …
• Clinical Utility of Next-Generation Sequencing in Tumors Diagnosed as Lung Squamous Cell Carcinoma: Real-World Data of Diagnostic and Therapeutic Implications.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2026 Odintsov I, Siegmund SE, Pecci F, Ricciuti B, LoPiccolo J, Sands JM, Wang CI, Sholl LM, Dong F
• Spatial transcriptomics reveals coordinated endothelial and epithelial activator protein-1 activation in chronic lung allograft dysfunction.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2026 Goda Y, Naito T, Banday MM, Potter AS, Odintsov I, Patel K, Davis N, Lee S, Gaggar A, Rosas I, Loor G, Hayes D, Sharma NS
• Cardiac epithelioid hemangioendothelioma with WWTR1::ACTL6A fusion and atypical histology mimicking cardiac angiosarcoma.
  Histopathology 2026 Kwok A, Papke DJ, Odintsov I
• Mutational Signature in Cancers Following Solid Organ or Allogeneic Stem Cell Transplantation.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2025 Odintsov I, Siegmund SE, Mahadevan NR, Church AJ, Sholl LM, Nowak JA
• The Genomic Landscape of NSCLC in Systemic Sclerosis Reveals Frequent TP53 Mutations and a Paucity of Actionable Oncogenes.
  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2025 Odintsov I, Hammer MM, Ricciuti B, Pecci F, Awad MM, Dellaripa PF, Sholl LM
• Brief Report: Critical Role for DNA-Based Sequencing in Discriminating Distinct Primary Lung Cancers With Different MET Exon 14 Skipping Mutations.
  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2025 Pecci F, Agrawal P, Ross JS, Ricciuti B, Nakazawa S, Di Federico A, Aldea M, Garbo E, Santo V, Gariazzo E, Makarem M, Haradon D, Odintsov I, Baine M, Travis W, Yang SR, Ugalde Figueroa PA, Gray KD, …
• High-Grade Early-Onset Prostate Cancer: Assessment of TMPRSS2::ERG -Negative Tumors Suggests Low Frequency of Germline Alterations and a Pathogenic Role for HOXB13.
  The American journal of surgical pathology 2025 Maharjan D, Siegmund S, Michalova K, Odintsov I, Hornick JL, Nair V, Idrees MT, Collins K, Gordetsky JB, Osunkoya AO, Cheng L, Miyamoto H, Sangoi AR, Wu DJ, Ricci C, Mollica V, Raspollini MR, …
• MUC4-positive Fibroblastoma: A Distinctive Hyalinized Spindle Cell Neoplasm With Aberrant Nuclear Beta-catenin Expression and Frequent Biallelic Inactivation of APC.
  The American journal of surgical pathology 2025 Repetto F, Odintsov I, Sholl LM, Hornick JL, Anderson WJ
• Efficacy and Safety of Tarlatamab in a Patient With Advanced Delta-Like Ligand 3-Positive Large Cell Neuroendocrine Lung Carcinoma and Untreated Brain Metastases: A Case Report.
  JCO precision oncology 2025 Gariazzo E, Laaksonen S, Canty S, De Almeida GR, Odintsov I, Santo V, Garbo E, Pecci F, Aldea M, Oser MG, Sholl L, Sands JM, Ricciuti B
• Antitumor Activity of Vebreltinib and Characterization of Clinicogenomic Features in Solid Tumors with MET Rearrangements.
  Cancer discovery 2025 Nakazawa S, Pecci F, Odintsov I, Gazgalis D, Gottlieb FH, Ricciuti B, Zullo L, Alessi JV, Di Federico A, Aldea M, Garbo E, Gandhi MM, Saini A, Feng WW, Jiang J, Baldacci S, Facchinetti F, Makarem M, …
• Genetic correlates of malignancy in TFE3-rearranged PEComa: a series of 14 cases.
  Histopathology 2025 Papke DJ, Odintsov I, Mahadevan NR, Fletcher CD, Hanna J
• Pan-Cancer Analysis of Oncogenic MET Fusions Reveals Distinct Pathogenomic Subsets with Differential Sensitivity to MET-Targeted Therapy.
  Cancer discovery 2025 Febres-Aldana CA, Vojnic M, Odintsov I, Zhang T, Cheng R, Beach CZ, Lu D, Mattar MS, Gazzo AM, Gili L, Harshan M, Ameri A, Machnicki S, Xiao X, Lockwood WW, Zhou XY, Yao Q, Drilon A, Rekhtman N, Shah …
• Genomic Profiling of Cardiac Angiosarcoma Reveals Novel Targetable KDR Variants, Recurrent MED12 Mutations, and a High Burden of Germline POT1 Alterations.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2025 Odintsov I, Papke DJ, George S, Padera RF, Hornick JL, Siegmund SE
• Malignant Giant Cell Tumor of Bone: A Clinicopathologic Series of 28 Cases Highlighting Genetic Differences Compared With Conventional, Atypical, and Metastasizing Conventional Tumors.
  The American journal of surgical pathology 2025 Papke DJ, Kovacs SK, Odintsov I, Hornick JL, Raskin KA, Newman ET, Lozano-Calderón S, Chebib I, Hung YP, Nielsen GP
• Odontogenic Myxoma Harbors Widespread Loss of Heterozygosity and Not Trisomies.
  The American journal of surgical pathology 2025 Odintsov I, Kleijn TG, Ryall ST, Ameline B, Dong F, Szuhai K, Baumhoer D, Dal Cin P, Cleven AHG, Papke DJ
• BRAF Gene Fusions in Melanoma: First Kinase Domain Duplication, New Fusion Partners, and Clinical Outcomes.
  The American journal of surgical pathology 2025 Odintsov I, Davis D, Pissaloux D, Tirode F, de la Fouchardiere A, Hanna J
• Clear Cell Stromal Tumor of the Lung: Clinicopathologic, Immunohistochemical, and Molecular Characterization of Eight Cases.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2024 Odintsov I, Isaacson A, Fritchie KJ, Hung YP, Khoshnoodi P, Sholl LM, Fletcher CDM, Anderson WJ
• HER2 Antibody-Drug Conjugates Are Active against Desmoplastic Small Round Cell Tumor.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Zhang T, Febres-Aldana CA, Liu Z, Dix JM, Cheng R, Dematteo RG, Lui AJW, Khodos I, Gili L, Mattar MS, Lisanti J, Kwong C, Linkov I, Tipping MJ, de Stanchina E, Odintsov I, Ladanyi M, Somwar R
• Epithelioid Fibrous Histiocytoma Is on a Continuum With Superficial ALK -rearranged Myxoid Spindle Cell Neoplasm : A Clinicopathologic Series of 35 Cases Including Alternate RET and NTRK3 Fusions.
  The American journal of surgical pathology 2024 DeSimone MS, Odintsov I, Tsai HK, Dickson BC, Alomari AK, Hornick JL, Fletcher CDM, Papke DJ
• Combination of MDM2 and Targeted Kinase Inhibitors Results in Prolonged Tumor Control in Lung Adenocarcinomas With Oncogenic Tyrosine Kinase Drivers and MDM2 Amplification.
  JCO precision oncology 2024 Elkrief A, Odintsov I, Smith RS, Vojnic M, Hayashi T, Khodos I, Markov V, Liu Z, Lui AJW, Bloom JL, Offin MD, Rudin CM, de Stanchina E, Riely GJ, Somwar R, Ladanyi M
• Preclinical evaluation of targeted therapies for central nervous system metastases.
  Disease models & mechanisms 2024 Pfeil AJ, Hale JD, Zhang TS, Wakayama K, Miyazaki I, Odintsov I, Somwar R
• Myxoid Inflammatory Myofibroblastic Sarcoma: Clinicopathologic Analysis of 25 Cases of a Distinctive Sarcoma With Deceptively Bland Morphology and Aggressive Clinical Behavior.
  The American journal of surgical pathology 2024 Papke DJ, Odintsov I, Dickson BC, Nucci MR, Agaimy A, Fletcher CDM
• A visual-language foundation model for computational pathology.
  Nature medicine 2024 Lu MY, Chen B, Williamson DFK, Chen RJ, Liang I, Ding T, Jaume G, Odintsov I, Le LP, Gerber G, Parwani AV, Zhang A, Mahmood F
• Prevalence and Therapeutic Targeting of High-Level ERBB2 Amplification in NSCLC.
  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2023 Odintsov I, Makarem M, Nishino M, Bachert SE, Zhang T, LoPiccolo J, Paweletz CP, Gokhale PC, Ivanova E, Saldanha A, Rudin CM, Lockwood WW, Ladanyi M, Somwar R, Jänne PA, Sholl LM
• Prognostic and predictive biomarkers in non-small cell lung carcinoma.
  Pathology 2023 Odintsov I, Sholl LM
• Author Correction: Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations.
  Nature cancer 2023 Miyazaki I, Odintsov I, Ishida K, Lui AJW, Kato M, Suzuki T, Zhang T, Wakayama K, Kurth RI, Cheng R, Fujita H, Delasos L, Vojnic M, Khodos I, Yamada Y, Ishizawa K, Mattar MS, Funabashi K, Chang Q, …
• Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations.
  Nature cancer 2023 Miyazaki I, Odintsov I, Ishida K, Lui AJW, Kato M, Suzuki T, Zhang T, Wakayama K, Kurth RI, Cheng R, Fujita H, Delasos L, Vojnic M, Khodos I, Yamada Y, Ishizawa K, Mattar MS, Funabashi K, Chang Q, …
• HER4 and EGFR Activate Cell Signaling in NRG1 Fusion-Driven Cancers: Implications for HER2-HER3-specific Versus Pan-HER Targeting Strategies.
  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2023 Udagawa H, Nilsson MB, Robichaux JP, He J, Poteete A, Jiang H, Heeke S, Elamin YY, Shibata Y, Matsumoto S, Yoh K, Okazaki S, Masuko T, Odintsov I, Somwar R, Ladanyi M, Goto K, Heymach JV
• Infantile Sinonasal Myxoma Is Clinically and Genetically Distinct From Other Myxomas of the Craniofacial Bones and From Desmoid Fibromatosis.
  The American journal of surgical pathology 2023 Odintsov I, Dong F, Guenette JP, Fritchie KJ, Jo VY, Fletcher CDM, Papke DJ
• Combination Therapy With MDM2 and MEK Inhibitors Is Effective in Patient-Derived Models of Lung Adenocarcinoma With Concurrent Oncogenic Drivers and MDM2 Amplification.
  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2023 Elkrief A, Odintsov I, Markov V, Caeser R, Sobczuk P, Tischfield SE, Bhanot U, Vanderbilt CM, Cheng EH, Drilon A, Riely GJ, Lockwood WW, de Stanchina E, Tirunagaru VG, Doebele RC, Quintanal-Villalonga…
• Integrating Molecular Sequencing Into the Pathological Diagnosis of Clinically Suspected Non-Small Cell Lung Carcinomas.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2023 Lo YC, Bauer AH, Odintsov I, Siegmund SE, Sholl LM, Dong F
• Primary Clear Cell Sarcoma of Bone: Clinicopathologic Study of a Rare Presentation.
  The American journal of surgical pathology 2022 Odintsov I, Jagannathan JP, Al-Ibraheemi A, Selig MK, Newman ET, Fletcher CDM, Nielsen GP, Hornick JL
• MYC Promotes Tyrosine Kinase Inhibitor Resistance in ROS1-Fusion-Positive Lung Cancer.
  Molecular cancer research : MCR 2022 Iyer SR, Odintsov I, Schoenfeld AJ, Siau E, Mattar MS, de Stanchina E, Khodos I, Drilon A, Riely GJ, Ladanyi M, Somwar R, Davare MA
• Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements.
  Cancer discovery 2022 Schram AM, Odintsov I, Espinosa-Cotton M, Khodos I, Sisso WJ, Mattar MS, Lui AJW, Vojnic M, Shameem SH, Chauhan T, Torrisi J, Ford J, O'Connor MN, Geuijen CAW, Schackmann RCJ, Lammerts van Bueren JJ, …
• Corrigendum: Functional impact and targetability of PI3KCA, GNAS, and PTEN mutations in a spindle cell rhabdomyosarcoma with MYOD1 L122R mutation.
  Cold Spring Harbor molecular case studies 2022 Choo F, Odintsov I, Nusser K, Nicholson K, Davis L, Corless CL, Stork L, Somwar R, Ladanyi M, Davis JL, Davare MA
• CIC-Mediated Modulation of MAPK Signaling Opposes Receptor Tyrosine Kinase Inhibitor Response in Kinase-Addicted Sarcoma.
  Cancer research 2022 Odintsov I, Ortiz MV, Khodos I, Mattar MS, Lui AJW, Kohsaka S, de Stanchina E, Bender JLG, Ladanyi M, Somwar R
• Functional impact and targetability of PI3KCA, GNAS, and PTEN mutations in a spindle cell rhabdomyosarcoma with MYOD1 L122R mutation.
  Cold Spring Harbor molecular case studies 2022 Choo F, Odintsov I, Nusser K, Nicholson KS, Davis L, Corless CL, Stork L, Somwar R, Ladanyi M, Davis JL, Davare MA
• Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling.
  Disease models & mechanisms 2022 Smith RS, Odintsov I, Liu Z, Lui AJ, Hayashi T, Vojnic M, Suehara Y, Delasos L, Mattar MS, Hmeljak J, Ramirez HA, Shaw M, Bui G, Hartono AB, Gladstone E, Kunte S, Magnan H, Khodos I, De Stanchina E, …
• Determination of biological behavior of solitary fibrous tumors: correlation of expression of Ki-67, TPX2 and TERT mRNA subunit level and NAB2-STAT6 fusion compared to morphological aspects of SFTs.
  Neoplasma 2021 Krsková L, Odintsov I, Fabián O, Hroudová P, Mrhalová M
• Novel Preclinical Patient-Derived Lung Cancer Models Reveal Inhibition of HER3 and MTOR Signaling as Therapeutic Strategies for NRG1 Fusion-Positive Cancers.
  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2021 Odintsov I, Mattar MS, Lui AJW, Offin M, Kurzatkowski C, Delasos L, Khodos I, Asher M, Daly RM, Rekhtman N, de Stanchina E, Ganji G, Ladanyi M, Somwar R
• The Anti-HER3 mAb Seribantumab Effectively Inhibits Growth of Patient-Derived and Isogenic Cell Line and Xenograft Models with Oncogenic NRG1 Fusions.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2021 Odintsov I, Lui AJW, Sisso WJ, Gladstone E, Liu Z, Delasos L, Kurth RI, Sisso EM, Vojnic M, Khodos I, Mattar MS, de Stanchina E, Leland SM, Ladanyi M, Somwar R
• ROS1 at the Crossroads of Clinical Oncology, Molecular Diagnostics, and Drug Development.
  JCO oncology practice 2021 Odintsov I, Somwar R, Ladanyi M, Drilon A
• NTRK kinase domain mutations in cancer variably impact sensitivity to type I and type II inhibitors.
  Communications biology 2020 Somwar R, Hofmann NE, Smith B, Odintsov I, Vojnic M, Linkov I, Tam A, Khodos I, Mattar MS, de Stanchina E, Flynn D, Ladanyi M, Drilon A, Shinde U, Davare MA
• RET inhibition in novel patient-derived models of RET-fusion positive lung adenocarcinoma reveals a role for MYC upregulation.
  Disease models & mechanisms 2020 Hayashi T, Odintsov I, Smith RS, Ishizawa K, Liu AJW, Delasos L, Kurzatkowski C, Tai H, Gladstone E, Vojnic M, Kohsaka S, Suzawa K, Liu Z, Kunte S, Mattar MS, Khodos I, Davare MA, Drilon A, Cheng E, …
• Therapeutic Potential of NTRK3 Inhibition in Desmoplastic Small Round Cell Tumor.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Ogura K, Somwar R, Hmeljak J, Magnan H, Benayed R, Momeni Boroujeni A, Bowman AS, Mattar MS, Khodos I, de Stanchina E, Jungbluth A, Asher M, Odintsov I, Hartono AB, LaQuaglia MP, Slotkin E, Pratilas …
• Expression of molecules of the Wnt pathway and of E-cadherin in the etiopathogenesis of human thymomas.
  Oncology letters 2020 Vodicka P, Krskova L, Odintsov I, Krizova L, Sedlackova E, Schutzner J, Zamecnik J
• Acquired MET Exon 14 Alteration Drives Secondary Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in EGFR-Mutated Lung Cancer.
  JCO precision oncology 2019 Suzawa K, Offin M, Schoenfeld AJ, Plodkowski AJ, Odintsov I, Lu D, Lockwood WW, Arcila ME, Rudin CM, Drilon A, Yu HA, Riely GJ, Somwar R, Ladanyi M
• A blast from the past: ROS1 on the brain.
  Oncotarget 2019 Odintsov I, Somwar R, Davare MA