Idelisse Ortiz Torres, MD, PhD
Clinical Fellow
Neurology
School of Medicine

Education & Training

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• MD Icahn School of Medicine at Mount Sinai 2019
• PhD Chemistry and Chemical Biology UCSF 2015
• BS Chemistry University of Puerto Rico 2008

Publications (8)

Top publication keywords:
Mineral OilDNA MethylationMesalaminePlakortisNucleosomesHeterocyclic Compounds, 2-RingPeroxidesCatalytic DomainAlginatesZinc FingersSmall Molecule LibrariesRetinoblastoma-Binding Protein 2Gene Expression Regulation, NeoplasticHistonesJumonji Domain-Containing Histone Demethylases

• Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex.
  Nature neuroscience 2019 Lorsch ZS, Hamilton PJ, Ramakrishnan A, Parise EM, Salery M, Wright WJ, Lepack AE, Mews P, Issler O, McKenzie A, Zhou X, Parise LF, Pirpinias ST, Ortiz Torres I, Kronman HG, Montgomery SE, Loh YE, …
• Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling.
  Nature communications 2019 Longbotham JE, Chio CM, Dharmarajan V, Trnka MJ, Torres IO, Goswami D, Ruiz K, Burlingame AL, Griffin PR, Fujimori DG
• Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.
  Journal of medicinal chemistry 2015 Korczynska M, Le DD, Younger N, Gregori-Puigjané E, Tumber A, Krojer T, Velupillai S, Gileadi C, Nowak RP, Iwasa E, Pollock SB, Ortiz Torres I, Oppermann U, Shoichet BK, Fujimori DG
• Functional coupling between writers, erasers and readers of histone and DNA methylation.
  Current opinion in structural biology 2015 Torres IO, Fujimori DG
• Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism.
  Nature communications 2015 Torres IO, Kuchenbecker KM, Nnadi CI, Fletterick RJ, Kelly MJ, Fujimori DG
• Reconstitution of nucleosome demethylation and catalytic properties of a Jumonji histone demethylase.
  Chemistry & biology 2013 Shiau C, Trnka MJ, Bozicevic A, Ortiz Torres I, Al-Sady B, Burlingame AL, Narlikar GJ, Fujimori DG
• A microfluidic approach to encapsulate living cells in uniform alginate hydrogel microparticles.
  Macromolecular bioscience 2012 Martinez CJ, Kim JW, Ye C, Ortiz I, Rowat AC, Marquez M, Weitz D
• Bioactive Cycloperoxides Isolated from the Puerto Rican Sponge Plakortis halichondrioides.
  Journal of natural products 2010 Jiménez-Romero C, Ortiz I, Vicente J, Vera B, Rodríguez AD, Nam S, Jove R