Ian Seiple, PhD
Associate Professor
Cardiovascular Research Inst
School of Medicine

Education & Training

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• Postdoctoral Chemistry and Chemical Biology Harvard University 2015
• Ph.D. Chemistry The Scripps Research Institute 2011
• BS Chemistry UC Berkeley 2006

Websites

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• Seiple Group Website (seiplegroup.ucsf.edu)

Grants and Projects

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• Platforms for the Synthesis of Bacterial Protein Synthesis Inhibitors, NIH, 2018-2023
• Preparation of a Solid-Phase Polyketide Synthase Mimic, NIH, 2011-2014

Publications (36)

Top publication keywords:
Spiro CompoundsAlkaloidsChemistryStreptogramin Group AImidazolesAnti-Bacterial AgentsBacillus subtilisAuthorshipSiderophoresSerial PublicationsMacrolidesMolecular StructureGuanidinesPyrrolesMicrococcus

• Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.
  bioRxiv : the preprint server for biology 2024 Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken SJ, Locksley RM, Fraser JS
• Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice.
  Nature biotechnology 2022 Tolani B, Celli A, Yao Y, Tan YZ, Fetter R, Liem CR, de Smith AJ, Vasanthakumar T, Bisignano P, Cotton AD, Seiple IB, Rubinstein JL, Jost M, Weissman JS
• Roadmap for Optimizing and Broadening Antibody-Based PROTACs for Degradation of Cell Surface Proteins.
  ACS chemical biology 2022 Gramespacher JA, Cotton AD, Burroughs PWW, Seiple IB, Wells JA
• Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020.
  Antimicrobial agents and chemotherapy 2022 Prasad NK, Seiple IB, Cirz RT, Rosenberg OS
• Examining Gender Imbalance in Chemistry Authorship.
  ACS chemical biology 2021 Cotton AD, Seiple IB

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• Biotin as a Reactive Handle to Selectively Label Proteins and DNA with Small Molecules.
  ACS chemical biology 2021 Cotton AD, Wells JA, Seiple IB
• Label-retention expansion microscopy.
  The Journal of cell biology 2021 Shi X, Li Q, Dai Z, Tran AA, Feng S, Ramirez AD, Lin Z, Wang X, Chow TT, Chen J, Kumar D, McColloch AR, Reiter JF, Huang EJ, Seiple IB, Huang B
• Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division.
  Science advances 2021 Zhao X, Garcia JQ, Tong K, Chen X, Yang B, Li Q, Dai Z, Shi X, Seiple IB, Huang B, Guo S
• Modular Chemical Synthesis of Streptogramin and Lankacidin Antibiotics.
  Accounts of chemical research 2021 Cai L, Seiple IB, Li Q
• Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1.
  Journal of the American Chemical Society 2021 Cotton AD, Nguyen DP, Gramespacher JA, Seiple IB, Wells JA
• Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates.
  Journal of the American Chemical Society 2020 Boyce JH, Dang B, Ary B, Edmondson Q, Craik CS, DeGrado WF, Seiple IB
• Modular synthesis of streptogramin antibiotics.
  Synlett : accounts and rapid communications in synthetic organic chemistry 2020 Li Q, Seiple IB
• Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness.
  Bioorganic & medicinal chemistry letters 2020 Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H
• Synthetic group A streptogramin antibiotics that overcome Vat resistance.
  Nature 2020 Li Q, Pellegrino J, Lee DJ, Tran AA, Chaires HA, Wang R, Park JE, Ji K, Chow D, Zhang N, Brilot AF, Biel JT, van Zundert G, Borrelli K, Shinabarger D, Wolfe C, Murray B, Jacobson MP, Mühle E, Chesneau…
• Modular Approaches to Lankacidin Antibiotics.
  Journal of the American Chemical Society 2020 Cai L, Yao Y, Yeon SK, Seiple IB
• Photocaged Quinone Methide Crosslinkers for Light-Controlled Chemical Crosslinking of Protein-Protein and Protein-DNA Complexes.
  Angewandte Chemie (International ed. in English) 2019 Liu J, Cai L, Sun W, Cheng R, Wang N, Jin L, Rozovsky S, Seiple IB, Wang L
• A concise route to virginiamycin M2.
  Tetrahedron 2019 Li Q, Seiple IB
• Synthesis, Structural Reassignment, and Antibacterial Evaluation of 2,18-Seco-Lankacidinol B.
  Angewandte Chemie (International ed. in English) 2018 Yao Y, Cai L, Seiple IB
• Modular, Scalable Synthesis of Group A Streptogramin Antibiotics.
  Journal of the American Chemical Society 2017 Li Q, Seiple IB
• A platform for the discovery of new macrolide antibiotics.
  Nature 2016 Seiple IB, Zhang Z, Jakubec P, Langlois-Mercier A, Wright PM, Hog DT, Yabu K, Allu SR, Fukuzaki T, Carlsen PN, Kitamura Y, Zhou X, Condakes ML, Szczypinski FT, Green WD, Myers AG
• Practical Protocols for the Preparation of Highly Enantioenriched Silyl Ethers of (R)-3-Hydroxybutan-2-one, Building Blocks for the Synthesis of Macrolide Antibiotics
  Synlett 2015 Seiple, I. B.; Hog, D. T.; Myers, A. G.
• The evolving role of chemical synthesis in antibacterial drug discovery.
  Angewandte Chemie (International ed. in English) 2014 Wright PM, Seiple IB, Myers AG
• Stereocontrolled synthesis of syn-β-Hydroxy-α-amino acids by direct aldolization of pseudoephenamine glycinamide.
  Angewandte Chemie (International ed. in English) 2014 Seiple IB, Mercer JA, Sussman RJ, Zhang Z, Myers AG
• Palau'amine and related oroidin alkaloids dibromophakellin and dibromophakellstatin inhibit the human 20S proteasome.
  Journal of natural products 2012 Lansdell TA, Hewlett NM, Skoumbourdis AP, Fodor MD, Seiple IB, Su S, Baran PS, Feldman KS, Tepe JJ
• Configurational analysis of tetracyclic dimeric pyrrole-imidazole alkaloids using a floating chirality approach.
  Journal of natural products 2012 Köck M, Schmidt G, Seiple IB, Baran PS
• Enantioselective total syntheses of (-)-palau'amine, (-)-axinellamines, and (-)-massadines.
  Journal of the American Chemical Society 2011 Seiple IB, Su S, Young IS, Nakamura A, Yamaguchi J, Jørgensen L, Rodriguez RA, O'Malley DP, Gaich T, Köck M, Baran PS
• Innate C-H trifluoromethylation of heterocycles.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Ji Y, Brueckl T, Baxter RD, Fujiwara Y, Seiple IB, Su S, Blackmond DG, Baran PS
• Practical C-H functionalization of quinones with boronic acids.
  Journal of the American Chemical Society 2011 Fujiwara Y, Domingo V, Seiple IB, Gianatassio R, Del Bel M, Baran PS
• Direct C-H arylation of electron-deficient heterocycles with arylboronic acids.
  Journal of the American Chemical Society 2010 Seiple IB, Su S, Rodriguez RA, Gianatassio R, Fujiwara Y, Sobel AL, Baran PS
• Total synthesis of palau'amine.
  Angewandte Chemie (International ed. in English) 2010 Seiple IB, Su S, Young IS, Lewis CA, Yamaguchi J, Baran PS
• Total syntheses of (+/-)-massadine and massadine chloride.
  Journal of the American Chemical Society 2008 Su S, Seiple IB, Young IS, Baran PS
• Synthesis of 1,9-dideoxy-pre-axinellamine.
  Angewandte Chemie (International ed. in English) 2008 Yamaguchi J, Seiple IB, Young IS, O'Malley DP, Maue M, Baran PS
• Total synthesis of (+/-)-axinellamines A and B.
  Angewandte Chemie (International ed. in English) 2008 O'Malley DP, Yamaguchi J, Young IS, Seiple IB, Baran PS
• The pursuit of palau'amine.
  Angewandte Chemie (International ed. in English) 2007 Köck M, Grube A, Seiple IB, Baran PS
• Synthesis of taiwaniaquinoids via Nazarov triflation.
  Journal of the American Chemical Society 2006 Liang G, Xu Y, Seiple IB, Trauner D
• Stereoselective syntheses of the bioactive polypropionates aureothin, N-acetylaureothamine, and aureonitrile.
  Organic letters 2005 Liang G, Seiple IB, Trauner D