Hyun Jun Yang, PhD
Postdoctoral Scholar
Institute for Neurodegenerative Diseases
School of Medicine

Awards

Show all (5) Hide

• Sandler Program for Breakthrough Biomedical Research (PBBR), UCSF, 2021
• BrightFocus Alzheimer Postdoctoral Fellowship, BrightFocus Foundation, 2020-2022
• Faculty/Staff Morale Fund, UCSF, 2020
• The Peptide Science Poster Award, American Peptide Society, 2019
• Allergan Graduate Fellowship in Synthetic Organic Chemistry, University of California, Irvine, 2018

Education & Training

Show all (2) Hide

• Ph.D. Organic Chemistry University of California, Irvine 2019
• B.S. Biochemistry University of Wisconsin, Madison 2013

Websites

Show all (3) Hide

• DeGrado lab (pharm.ucsf.edu)
• PeptideLinks (peptidelinks.net)
• Condello lab (condellolab.ucsf.edu)

Grants and Projects

Show all (1) Hide

• Fingerprinting In Vivo and In Vitro Prion Strains, BrightFocus, 2020-2022

Publications (12)

Top publication keywords:
ChloridesDepsipeptidesProtein Conformation, alpha-HelicalHydrophobic and Hydrophilic InteractionsLactamsbcl-X ProteinStructure-Activity RelationshipIntegrin alpha5beta1Pick Disease of the BrainMicrobial Sensitivity TestsAnti-Bacterial AgentsGram-Positive BacteriaPeptidomimeticsCrystallography, X-Raybcl-2 Homologous Antagonist-Killer Protein

• De novo design of drug-binding proteins with predictable binding energy and specificity.
  Science (New York, N.Y.) 2024 Lu L, Gou X, Tan SK, Mann SI, Yang H, Zhong X, Gazgalis D, Valdiviezo J, Jo H, Wu Y, Diolaiti ME, Ashworth A, Polizzi NF, DeGrado WF
• EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Yang H, Yuan P, Wu Y, Shi M, Caro CD, Tengeiji A, Yamanoi S, Inoue M, DeGrado WF, Condello C
• Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides.
  Chemical science 2022 Zhang MY, Yang H, Ortiz G, Trnka MJ, Petronikolou N, Burlingame AL, DeGrado WF, Fujimori DG
• Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry.
  Advanced materials (Deerfield Beach, Fla.) 2022 Xu L, Li X, Li W, Chang KC, Yang H, Tao N, Zhang P, Payne EM, Modavi C, Humphries J, Lu CW, Abate AR
• Exploration of α/β/γ-peptidomimetics design for BH3 helical domains.
  Chemical communications (Cambridge, England) 2022 Shin YH, Yang H

Show all (7 more) Hide

• Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness.
  Bioorganic & medicinal chemistry letters 2020 Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H
• Design, Synthesis, and Study of Lactam and Ring-Expanded Analogues of Teixobactin.
  The Journal of organic chemistry 2019 Yang H, Pishenko AV, Li X, Nowick JS
• Antimicrobial Compositions
  Antimicrobial Compositions 2019 James S Nowick, Hyun Jun Yang
• X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-like Assembly.
  Journal of the American Chemical Society 2018 Yang H, Wierzbicki M, Du Bois DR, Nowick JS
• Antimicrobial compositions (WO2017181179A1)
  Antimicrobial compositions (WO2017181179A1) 2017
• X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore.
  Chemical communications (Cambridge, England) 2017 Yang H, Du Bois DR, Ziller JW, Nowick JS
• Elucidation of the Teixobactin Pharmacophore.
  ACS chemical biology 2016 Yang H, Chen KH, Nowick JS