Hyunil Jo, PhD
Specialist
Pharmaceutical Chemistry
School of Pharmacy

Awards

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• Predoctoral Training Award for Prostate Cancer, Department of Defense, 2005-2008

Education & Training

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• Ph.D. Chemistry University of Pennsylvania 2008
• M.S. Pharmacy Seoul National University 2003
• B.S. Pharmacy Seoul National University 2001

Grants and Projects

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• Targeting Acid Ceramidase for Hepatic Fibrogenesis, NIH/NIDDK, 2023-2028
• Mitigation of Exaggerated Smooth Muscle Force with Inhibitors of Integrin Alpha2Beta1, NIH, 2022-2024

Publications (58)

Top publication keywords:
CysteineTryptophanIntegrin alpha2beta1Molecular StructureCalpainCalcium-Binding ProteinsCalmodulinIntegrin alpha5beta1Cysteine Proteinase InhibitorsFluorescent DyesAdamantaneReceptors, VitronectinNitrilesLipid BilayersRespiratory Hypersensitivity

• De novo design of drug-binding proteins with predictable binding energy and specificity.
  Science (New York, N.Y.) 2024 Lu L, Gou X, Tan SK, Mann SI, Yang H, Zhong X, Gazgalis D, Valdiviezo J, Jo H, Wu Y, Diolaiti ME, Ashworth A, Polizzi NF, DeGrado WF
• De novo-designed transmembrane proteins bind and regulate a cytokine receptor.
  Nature chemical biology 2024 Mravic M, He L, Kratochvil HT, Hu H, Nick SE, Bai W, Edwards A, Jo H, Wu Y, DiMaio D, DeGrado WF
• De novo design of drug-binding proteins with predictable binding energy and specificity.
  bioRxiv : the preprint server for biology 2023 Lu L, Gou X, Tan SK, Mann SI, Yang H, Zhong X, Gazgalis D, Valdiviezo J, Jo H, Wu Y, Diolaiti ME, Ashworth A, Polizzi NF, DeGrado WF
• De novo Design of Peptides that Bind Specific Conformers of α-Synuclein.
  bioRxiv : the preprint server for biology 2023 Wallace HM, Yang H, Tan S, Pan HS, Yang R, Xu J, Jo H, Condello C, Polizzi NF, DeGrado WF
• Gender differences in the upper airway, craniofacial morphological and polysomnographic parameters in patients with obstructive sleep apnoea.
  Journal of oral rehabilitation 2023 Udayakumar SIV, Jo HJ, Kim HY, Joo EY, Paeng JY

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• Hexamethylene amiloride binds the SARS-CoV-2 envelope protein at the protein-lipid interface.
  Protein science : a publication of the Protein Society 2023 Somberg NH, Medeiros-Silva J, Jo H, Wang J, DeGrado WF, Hong M
• Patterning and folding of intestinal villi by active mesenchymal dewetting.
  bioRxiv : the preprint server for biology 2023 Huycke TR, Miyazaki H, Häkkinen TJ, Srivastava V, Barruet E, McGinnis CS, Kalantari A, Cornwall-Scoones J, Vaka D, Zhu Q, Jo H, DeGrado WF, Thomson M, Garikipati K, Boffelli D, Klein OD, Gartner ZJ
• A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi.
  Nature communications 2023 Dos Reis TF, de Castro PA, Bastos RW, Pinzan CF, Souza PFN, Ackloo S, Hossain MA, Drewry DH, Alkhazraji S, Ibrahim AS, Jo H, Lightfoot JD, Adams EM, Fuller KK, deGrado WF, Goldman GH
• Designed Transmembrane Proteins Inhibit the Erythropoietin Receptor in a Custom Binding Topology.
  bioRxiv : the preprint server for biology 2023 Mravic M, He L, Kratochvil H, Hu H, Nick SE, Bai W, Edwards A, Jo H, Wu Y, DiMaio D, DeGrado WF
• SARS-CoV-2 Envelope Protein Forms Clustered Pentamers in Lipid Bilayers.
  Biochemistry 2022 Somberg NH, Wu WW, Medeiros-Silva J, Dregni AJ, Jo H, DeGrado WF, Hong M
• Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Belsare KD, Wu H, Mondal D, Bond A, Castillo E, Jin J, Jo H, Roush AE, Pilla KB, Sali A, Condello C, DeGrado WF
• Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.
  The Journal of clinical investigation 2021 Liu S, Ngo U, Tang XZ, Ren X, Qiu W, Huang X, DeGrado W, Allen CD, Jo H, Sheppard D, Sundaram AB
• Visualization of Platelet Integrins via Two-Photon Microscopy Using Anti-transmembrane Domain Peptides Containing a Blue Fluorescent Amino Acid.
  Biochemistry 2021 Fong KP, Ahmed IA, Mravic M, Jo H, Kim OV, Litvinov RI, Weisel JW, DeGrado WF, Gai F, Bennett JS
• Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness.
  Bioorganic & medicinal chemistry letters 2020 Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H
• Direct visualization of platelet integrins using anti-transmembrane domain peptides containing a blue fluorescent amino acid.
  2020 Joel S. Bennett, MD, Ismail Ahmed, Karen Fong, Marco Mravic, Hyunil Jo, William F. DeGrado, Feng Gai, Joel S. Bennett
• Direct visualization of platelet integrins using anti-transmembrane domain peptides containing a blue fluorescent amino acid.
  2020 Joel S. Bennett, MD, Ismail Ahmed, Karen Fong, Marco Mravic, Hyunil Jo, William F. DeGrado, Feng Gai, Joel S. Bennett
• Direct visualization of platelet integrins using anti-transmembrane domain peptides containing a blue fluorescent amino acid.
  2020 Joel S. Bennett, MD, Ismail Ahmed, Karen Fong, marco mravic, Hyunil Jo, William F. DeGrado, Feng Gai, Joel S. Bennett
• Direct visualization of platelet integrins using anti-transmembrane domain peptides containing a blue fluorescent amino acid.
  2020 Joel S. Bennett, MD, Ismail Ahmed, Karen Fong, marco mravic, Hyunil Jo, William F. DeGrado, Feng Gai, Joel S. Bennett
• Direct Visualization of Platelet Integrins Using ANTI-Transmembrane Domain Peptides Containing a BLUE Fluorescent Amino Acid.
  Blood 2019 Karen Pei Yi Fong, Ismail A. Ahmed, Marco Mravic, Hyunil Jo, William F. DeGrado, Feng Gai, Joel S. Bennett
• Synthesis and application of the blue fluorescent amino acid l-4-cyanotryptophan to assess peptide-membrane interactions.
  Chemical communications (Cambridge, England) 2019 Zhang K, Ahmed IA, Kratochvil HT, DeGrado WF, Gai F, Jo H
• Glutamine Side Chain 13C═18O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly.
  Journal of the American Chemical Society 2019 Wu H, Saltzberg DJ, Kratochvil HT, Jo H, Sali A, DeGrado WF
• 4-Cyanoindole-2'-deoxyribonucleoside as a Dual Fluorescence and Infrared Probe of DNA Structure and Dynamics.
  Molecules (Basel, Switzerland) 2019 Ahmed IA, Acharyya A, Eng CM, Rodgers JM, DeGrado WF, Jo H, Gai F
• Inhibitor binding mode and allosteric regulation of Na+-glucose symporters.
  Nature communications 2018 Bisignano P, Ghezzi C, Jo H, Polizzi NF, Althoff T, Kalyanaraman C, Friemann R, Jacobson MP, Wright EM, Grabe M
• Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule.
  Biochemistry 2018 Bokoch MP, Jo H, Valcourt JR, Srinivasan Y, Pan AC, Capponi S, Grabe M, Dror RO, Shaw DE, DeGrado WF, Coughlin SR
• Cover Feature: Design of a Short Thermally Stable a-Helix Embedded in a Macrocycle (ChemBioChem 9/2018).
  ChemBioChem 2018 Haifan Wu, Arusha Acharyya, Yibing Wu, Lijun Liu, Hyunil Jo, Feng Gai, William F. DeGrado
• Design of a Short Thermally Stable α-Helix Embedded in a Macrocycle.
  Chembiochem : a European journal of chemical biology 2018 Wu H, Acharyya A, Wu Y, Liu L, Jo H, Gai F, DeGrado WF
• Blue fluorescent amino acid for biological spectroscopy and microscopy.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Hilaire MR, Ahmed IA, Lin CW, Jo H, DeGrado WF, Gai F
• Water Distribution, Dynamics, and Interactions with Alzheimer's β-Amyloid Fibrils Investigated by Solid-State NMR.
  Journal of the American Chemical Society 2017 Wang T, Jo H, DeGrado WF, Hong M
• Stapled Voltage-Gated Calcium Channel (CaV) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.
  ACS chemical neuroscience 2017 Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf CH, Pope L, Rossen ND, Flucher BE, DeGrado WF, Minor DL
• Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo.
  Journal of the American Society of Nephrology : JASN 2017 Chang Y, Lau WL, Jo H, Tsujino K, Gewin L, Reed NI, Atakilit A, Nunes ACF, DeGrado WF, Sheppard D
• Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma.
  The Journal of clinical investigation 2016 Sundaram A, Chen C, Khalifeh-Soltani A, Atakilit A, Ren X, Qiu W, Jo H, DeGrado W, Huang X, Sheppard D
• Infrared and fluorescence assessment of the hydration status of the tryptophan gate in the influenza A M2 proton channel.
  Physical chemistry chemical physics : PCCP 2016 Markiewicz BN, Lemmin T, Zhang W, Ahmed IA, Jo H, Fiorin G, Troxler T, DeGrado WF, Gai F
• Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors.
  ACS medicinal chemistry letters 2016 Reed NI, Tang YZ, McIntosh J, Wu Y, Molnar KS, Civitavecchia A, Sheppard D, DeGrado WF, Jo H
• Structural Polymorphism of Alzheimer's β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study.
  Journal of the American Chemical Society 2016 Elkins MR, Wang T, Nick M, Jo H, Lemmin T, Prusiner SB, DeGrado WF, Stöhr J, Hong M
• Photoactivatable protein labeling by singlet oxygen mediated reactions.
  Bioorganic & medicinal chemistry letters 2016 To TL, Medzihradszky KF, Burlingame AL, DeGrado WF, Jo H, Shu X
• The αvβ1 integrin plays a critical in vivo role in tissue fibrosis.
  Science translational medicine 2015 Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D
• Entry from the Lipid Bilayer: A Novel Pathway for Inhibition of a Peptide G-Protein Coupled Receptor by a Lipophilic Small Molecule.
  Biophysical Journal 2015 Michael P. Bokoch, Hyunil I. Jo, James R. Valcourt, Yoga Srinivasan, Kazuma Yasuhara, Albert C. Pan, Ron O. Dror, David E. Shaw, William F. DeGrado, Shaun R. Coughlin
• Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel.
  Journal of the American Chemical Society 2014 Wu Y, Canturk B, Jo H, Ma C, Gianti E, Klein ML, Pinto LH, Lamb RA, Fiorin G, Wang J, DeGrado WF
• Differential Stability of CaVß2a and CaVß3 in a CaV1.2 Calcium Channel Complex.
  Biophysical Journal 2014 Marta Campiglio, Felix Findeisen, Hyunil Jo, William F. DeGrado, Daniel L. Minor, Bernhard E. Flucher
• Assessment of local friction in protein folding dynamics using a helix cross-linker.
  The journal of physical chemistry. B 2013 Markiewicz BN, Jo H, Culik RM, DeGrado WF, Gai F
• Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus.
  Journal of medicinal chemistry 2013 Wang J, Ma C, Wang J, Jo H, Canturk B, Fiorin G, Pinto LH, Lamb RA, Klein ML, DeGrado WF
• Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials.
  Cell host & microbe 2012 Love MS, Millholland MG, Mishra S, Kulkarni S, Freeman KB, Pan W, Kavash RW, Costanzo MJ, Jo H, Daly TM, Williams DR, Kowalska MA, Bergman LW, Poncz M, DeGrado WF, Sinnis P, Scott RW, Greenbaum DC
• Erratum: Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins.
  Nature Chemistry 2012 Amanda J. Reig, Marcos M. Pires, Rae Ana Snyder, Yibing Wu, Hyunil Jo, Daniel W. Kulp, Susan E. Butch, Jennifer R. Calhoun, Thomas Szyperski, Edward I. Solomon, William F. DeGrado
• Development of α-helical calpain probes by mimicking a natural protein-protein interaction.
  Journal of the American Chemical Society 2012 Jo H, Meinhardt N, Wu Y, Kulkarni S, Hu X, Low KE, Davies PL, DeGrado WF, Greenbaum DC
• Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins.
  Nature chemistry 2012 Reig AJ, Pires MM, Snyder RA, Wu Y, Jo H, Kulp DW, Butch SE, Calhoun JR, Szyperski T, Szyperski TG, Solomon EI, DeGrado WF
• Cysteine-linked aromatic nitriles as UV resonance Raman probes of protein structure.
  Journal of Raman Spectroscopy 2012 Colin L. Weeks, Hyunil Jo, Brandon Kier, William F. DeGrado, Thomas G. Spiro
• Using thioamides to site-specifically interrogate the dynamics of hydrogen bond formation in β-sheet folding.
  Journal of the American Chemical Society 2012 Culik RM, Jo H, DeGrado WF, Gai F
• Inhibition of integrin α2β1 ameliorates glomerular injury.
  Journal of the American Society of Nephrology : JASN 2012 Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A
• Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Moore DT, Nygren P, Jo H, Boesze-Battaglia K, Bennett JS, DeGrado WF
• Selective incorporation of nitrile-based infrared probes into proteins via cysteine alkylation.
  Biochemistry 2010 Jo H, Culik RM, Korendovych IV, Degrado WF, Gai F
• Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.
  Antimicrobial agents and chemotherapy 2010 Lucumi E, Darling C, Jo H, Napper AD, Chandramohanadas R, Fisher N, Shone AE, Jing H, Ward SA, Biagini GA, DeGrado WF, Diamond SL, Greenbaum DC
• An unusual pathway to cyclobutane formation via desulfurative intramolecular photocycloaddition of an enone benzothiazoline pair.
  Organic letters 2009 Jo H, Fitzgerald ME, Winkler JD
• Highly Stereoselective and Efficient Total Synthesis of (+)-Laurencin.
  ChemInform 2005 Seungyoup Beak, Hyunil Jo, Hansoo Kim, Hyoungsu Kim, Sanghee Kim, Deukjoon Kim
• Highly stereoselective and efficient total synthesis of (+)-laurencin.
  Organic letters 2005 Baek S, Jo H, Kim H, Kim H, Kim S, Kim D
• Efficient Construction of Bicyclic Systems by an Internal SN2' Enolate Alkylation/Ring-Closing Metathesis (RCM) Strategy: A Concise Synthesis of the trans-Hydrindane Nucleus.
  ChemInform 2003 Hyunil Jo, Jongkook Lee, Hyoungsu Kim, Sanghee Kim, Deukjoon Kim
• Efficient construction of bicyclic systems by an internal SN2' enolate alkylation/ring-closing metathesis (RCM) strategy: a concise synthesis of the trans-hydrindane nucleus.
  Tetrahedron Letters 2003 Hyunil Jo, Jongkook Lee, Hyoungsu Kim, Sanghee Kim, Deukjoon Kim
• ChemInform Abstract: Asymmetric Total Synthesis of (+)-Brefeldin A from (S)-Lactate by Triple Chirality Transfer Process and Nitrile Oxide Cycloaddition.
  ChemInform 2002 Deukjoon Kim, Jongkook Lee, Phil Jong Shim, Joong Inn Lim, Hyunil Jo, Sanghee Kim
• Asymmetric total synthesis of (+)-brefeldin A from (S)-lactate by triple chirality transfer process and nitrile oxide cycloaddition.
  The Journal of organic chemistry 2002 Kim D, Lee J, Shim PJ, Lim JI, Jo H, Kim S