Hubert Kim, MD, PhD
Professor
Orthopaedic Surgery
School of Medicine

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California, San Francisco 2019
• Orthopaedic Surgery Residency School of Medicine University of California, San Francisco 1998
• M.D., Ph.D School of Medicine Stanford University School of Medicine 1993

Websites

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• Clinical Profile at UCSF Medical Center (ucsfhealth.org)

Grants and Projects

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• ShEEP Equipment Request for BD FACSMelody Cell Sorter, NIH, 2019-2020
• TGFb and BMP signaling in muscle atrophy and degradation after massive RCT, NIH, 2015-2020
• ECM and MMPs in Muscle Atrophy and Rehabilitation, NIH, 2010-2014

Publications (56)

Top publication keywords:
Rotator Cuff InjuriesMatrix Metalloproteinase 2Tendon InjuriesMuscular AtrophyCartilage DiseasesApoptosisArthroplastyAdipogenesisBone CementsCartilage, ArticularMuscle, SkeletalRotator CuffChondrocytesBone TransplantationPolymethyl Methacrylate

• Defining Endogenous Mitochondrial Transfer in Muscle After Rotator Cuff Injury.
  The American journal of sports medicine 2024 Chi HM, Davies MR, Garcia SM, Montenegro C, Sharma S, Lizarraga M, Wang Z, Nuthalapati P, Kim HT, Liu X, Feeley BT
• Polarized macrophages regulate fibro/adipogenic progenitor (FAP) adipogenesis through exosomes.
  Stem cell research & therapy 2023 Liu M, Ng M, Phu T, Bouchareychas L, Feeley BT, Kim HT, Raffai RL, Liu X
• The Role of Matrix Metalloproteinase-13 (MMP13) in TGFβ/BMP Pathway Regulation of Fibro-Adipogenic Progenitor (FAP) Differentiation.
  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2022 Liu M, Feeley BT, Kim HT, Liu X
• Muscle-Derived Beige Adipose Precursors Secrete Promyogenic Exosomes That Treat Rotator Cuff Muscle Degeneration in Mice and Are Identified in Humans by Single-Cell RNA Sequencing.
  The American journal of sports medicine 2022 Davies MR, Garcia S, Liu M, Chi H, Kim HT, Raffai RL, Liu X, Feeley BT
• Rotator Cuff Tear Size Regulates Fibroadipogenic Progenitor Number and Gene Expression Profile in the Supraspinatus Independent of Patient Age.
  The American journal of sports medicine 2021 Davies MR, Chi H, Kaur G, Liu M, Ma CB, Kim HT, Liu X, Feeley BT

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• Microenergy acoustic pulses promotes muscle regeneration through in situ activation of muscle stem cells.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2021 Zhang H, Kim HT, Feeley BT, Lin G, Lue TF, Liu M, Banie L, Liu X
• Preconditioning improves muscle regeneration after ischemia-reperfusion injury.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2020 Zhang H, Liu M, Kim HT, Feeley BT, Liu X
• Rotator cuff tear degeneration and the role of fibro-adipogenic progenitors.
  Annals of the New York Academy of Sciences 2020 Agha O, Diaz A, Davies M, Kim HT, Liu X, Feeley BT
• Intervertebral disc herniation effects on multifidus muscle composition and resident stem cell populations.
  JOR spine 2020 Agha O, Mueller-Immergluck A, Liu M, Zhang H, Theologis AA, Clark A, Kim HT, Liu X, Feeley BT, Bailey JF
• Beige FAPs Transplantation Improves Muscle Quality and Shoulder Function After Massive Rotator Cuff Tears.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2019 Lee C, Liu M, Agha O, Kim HT, Feeley BT, Liu X
• Rotator Cuff Fibro-Adipogenic Progenitors Demonstrate Highest Concentration, Proliferative Capacity, and Adipogenic Potential Across Muscle Groups.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2019 Lee C, Agha O, Liu M, Davies M, Bertoy L, Kim HT, Liu X, Feeley BT
• Beige fibro-adipogenic progenitor transplantation reduces muscle degeneration and improves function in a mouse model of delayed repair of rotator cuff tears.
  Journal of shoulder and elbow surgery 2019 Lee C, Liu M, Agha O, Kim HT, Liu X, Feeley BT
• Reversal of Fatty Infiltration After Suprascapular Nerve Compression Release Is Dependent on UCP1 Expression in Mice.
  Clinical orthopaedics and related research 2018 Wang Z, Feeley BT, Kim HT, Liu X
• Knocking-out matrix metalloproteinase-13 exacerbates rotator cuff muscle fatty infiltration.
  Muscles, ligaments and tendons journal 2017 Liu X, Ravishankar B, Ning A, Liu M, Kim HT, Feeley BT
• Lysophosphatidic acid-induced RhoA signaling and prolonged macrophage infiltration worsens fibrosis and fatty infiltration following rotator cuff tears.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2016 Davies MR, Lee L, Feeley BT, Kim HT, Liu X
• TGF-β Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis.
  PloS one 2016 Davies MR, Liu X, Lee L, Laron D, Ning AY, Kim HT, Feeley BT
• Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes.
  Tissue engineering. Part A 2016 Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC
• Costs and Complications of Short Versus Long Cephalomedullary Nailing of OTA 31-A2 Proximal Femur Fractures in U.S. Veterans.
  Journal of orthopaedic trauma 2016 Krigbaum H, Takemoto S, Kim HT, Kuo AC
• Novel intracellular N-terminal truncated matrix metalloproteinase-2 isoform in skeletal muscle ischemia-reperfusion injury.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2015 Joshi SK, Lee L, Lovett DH, Kang H, Kim HT, Delgado C, Liu X
• Bone morphogenetic protein signaling in rotator cuff muscle atrophy and fatty infiltration.
  Muscles, ligaments and tendons journal 2015 Liu X, Joshi S, Ravishankar B, Laron D, Kim HT, Feeley BT
• Rat rotator cuff muscle responds differently from hindlimb muscle to a combined tendon-nerve injury.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2015 Davies MR, Ravishankar B, Laron D, Kim HT, Liu X, Feeley BT
• Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy.
  Muscles, ligaments and tendons journal 2015 Zhang Q, Joshi SK, Lovett DH, Zhang B, Bodine S, Kim HT, Liu X
• Upregulation of transforming growth factor-β signaling in a rat model of rotator cuff tears.
  Journal of shoulder and elbow surgery 2014 Liu X, Joshi SK, Ravishankar B, Laron D, Kim HT, Feeley BT
• Novel mouse model of spinal cord injury-induced heterotopic ossification.
  Journal of rehabilitation research and development 2014 Kang H, Dang AB, Joshi SK, Halloran B, Nissenson R, Zhang X, Li J, Kim HT, Liu X
• Joint instability and cartilage compression in a mouse model of posttraumatic osteoarthritis.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2013 Onur TS, Wu R, Chu S, Chang W, Kim HT, Dang AB
• Differential ubiquitin-proteasome and autophagy signaling following rotator cuff tears and suprascapular nerve injury.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2013 Joshi SK, Kim HT, Feeley BT, Liu X
• Trophic stimulation of articular chondrocytes by late-passage mesenchymal stem cells in coculture.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2013 Wang M, Rahnama R, Cheng T, Grotkopp E, Jacobs L, Limburg S, Kim HT, Kuo AC
• Original article Muscle extracellular matrix degradation and contractibility following tendon rupture and disuse.
  Muscles, ligaments and tendons journal 2013 Zhang Q, Joshi SK, Manzano G, Lovett DH, Kim HT, Liu X
• Evaluation of cartilage degeneration in a rat model of rotator cuff tear arthropathy.
  Journal of shoulder and elbow surgery 2013 Kramer EJ, Bodendorfer BM, Laron D, Wong J, Kim HT, Liu X, Feeley BT
• Cytotoxicity of local anesthetics on human mesenchymal stem cells.
  The Journal of bone and joint surgery. American volume 2013 Rahnama R, Wang M, Dang AC, Kim HT, Kuo AC
• mTOR regulates fatty infiltration through SREBP-1 and PPARγ after a combined massive rotator cuff tear and suprascapular nerve injury in rats.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2012 Joshi SK, Liu X, Samagh SP, Lovett DH, Bodine SC, Kim HT, Feeley BT
• Functional motor recovery after peripheral nerve repair with an aligned nanofiber tubular conduit in a rat model.
  Regenerative medicine 2012 Jin J, Park M, Rengarajan A, Zhang Q, Limburg S, Joshi SK, Patel S, Kim HT, Kuo AC
• MRI quantification of fatty infiltration and muscle atrophy in a mouse model of rotator cuff tears.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2012 Samagh SP, Kramer EJ, Melkus G, Laron D, Bodendorfer BM, Natsuhara K, Kim HT, Liu X, Feeley BT
• Fibroblast growth factor 2 enhances the kinetics of mesenchymal stem cell chondrogenesis.
  Biochemical and biophysical research communications 2012 Cheng T, Yang C, Weber N, Kim HT, Kuo AC
• Inducible immortality in hTERT-human mesenchymal stem cells.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2012 Piper SL, Wang M, Yamamoto A, Malek F, Luu A, Kuo AC, Kim HT
• Thermal stress potentiates bupivacaine chondrotoxicity.
  Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2012 Piper SL, Kim HT
• A mouse model of massive rotator cuff tears.
  The Journal of bone and joint surgery. American volume 2012 Liu X, Laron D, Natsuhara K, Manzano G, Kim HT, Feeley BT
• Evaluation of Akt/mTOR activity in muscle atrophy after rotator cuff tears in a rat model.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2012 Liu X, Joshi SK, Samagh SP, Dang YX, Laron D, Lovett DH, Bodine SC, Kim HT, Feeley BT
• Muscle degeneration in rotator cuff tears.
  Journal of shoulder and elbow surgery 2012 Laron D, Samagh SP, Liu X, Kim HT, Feeley BT
• Minocycline reduces articular cartilage damage following osteochondral injury.
  The Knee 2012 Yamamoto A, Warren AP, Kim HT
• The in vitro elution characteristics of antifungal-loaded PMMA bone cement and calcium sulfate bone substitute.
  Orthopedics 2011 Grimsrud C, Raven R, Fothergill AW, Kim HT
• Effects of local anesthetics on articular cartilage.
  The American journal of sports medicine 2011 Piper SL, Kramer JD, Kim HT, Feeley BT
• Effects of mixing techniques on vancomycin-impregnated polymethylmethacrylate.
  The Journal of arthroplasty 2011 Laine JC, Nguyen TQ, Buckley JM, Kim HT
• A rat model of massive rotator cuff tears.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2010 Liu X, Manzano G, Kim HT, Feeley BT
• Role of AP-1 and RE-1 binding sites in matrix metalloproteinase-2 transcriptional regulation in skeletal muscle atrophy.
  Biochemical and biophysical research communications 2010 Liu X, Manzano G, Lovett DH, Kim HT
• Role of gelatinases in disuse-induced skeletal muscle atrophy.
  Muscle & nerve 2010 Liu X, Lee DJ, Skittone LK, Natsuhara K, Kim HT
• Chondrocyte apoptosis after simulated intraarticular fracture: a comparison of histologic detection methods.
  Clinical orthopaedics and related research 2009 Dang AC, Kim HT
• Inhibition of MMP2/MMP9 after spinal cord trauma reduces apoptosis.
  Spine 2008 Dang AB, Tay BK, Kim HT, Nauth A, Alfonso-Jaume MA, Lovett DH
• Chondrocyte apoptosis: implications for osteochondral allograft transplantation.
  Clinical orthopaedics and related research 2008 Kim HT, Teng MS, Dang AC
• Enhancing osteochondral allograft viability: effects of storage media composition.
  Clinical orthopaedics and related research 2008 Teng MS, Yuen AS, Kim HT
• Matrix metalloproteinase-2 expression and promoter/enhancer activity in skeletal muscle atrophy.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2008 Skittone LK, Liu X, Tseng A, Kim HT
• Preventing chondrocyte programmed cell death caused by iatrogenic injury.
  The Knee 2006 Costouros JG, Kim HT
• A peek into the possible future of management of articular cartilage injuries: gene therapy and scaffolds for cartilage repair.
  The Journal of orthopaedic and sports physical therapy 2006 Kim HT, Zaffagnini S, Mizuno S, Abelow S, Safran MR
• Chondrocyte apoptosis induced by hydrogen peroxide requires caspase activation but not mitochondrial pore transition.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2004 Lo MY, Kim HT
• Comparison of chondrocyte apoptosis in vivo and in vitro following acute osteochondral injury.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2004 Costouros JG, Dang AC, Kim HT
• Chondrocyte apoptosis induced by collagen degradation: inhibition by caspase inhibitors and IGF-1.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2004 Lo MY, Kim HT