Huat Chye Lim, MD, MS
Assistant Professor
Medicine
School of Medicine

Awards

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• Rachel Pearline Award, UCSF Hematology/Oncology Fellowship, 2023
• Scholar-in-Training Award, American Association for Cancer Research, 2022
• Chief Fellow, UCSF Hematology/Oncology Fellowship, 2021
• Exceptional Physician Award nominee, UCSF, 2019
• Alpha Omega Alpha, University of Washington School of Medicine, 2014
• Gold Humanism Honor Society, University of Washington School of Medicine, 2014

Education & Training

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• Fellowship Hematology/Oncology UCSF 2023
• Residency Internal Medicine UCSF 2018
• MD University of Washington School of Medicine 2015
• MS Computer Science Stanford University 2002
• BS Computer Science Stanford University 2001

Publications (12)

Top publication keywords:
Cyclic AMP-Dependent Protein KinasesDrug-Related Side Effects and Adverse ReactionsCarcinoma, HepatocellularLiver NeoplasmsDNA Copy Number VariationsCholangiocarcinomaRNA, ViralProto-Oncogene Proteins B-rafSoftwareHepatitis B virusCyclin-Dependent Kinase Inhibitor p16Abdominal PainPrincipal Component AnalysisKelch-Like ECH-Associated Protein 1BRCA1 Protein

• Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma.
  Cell reports 2024 Lauer SM, Omar MH, Golkowski MG, Kenerson HL, Lee KS, Pascual BC, Lim HC, Forbush K, Smith FD, Gordan JD, Ong SE, Yeung RS, Scott JD
• New Opportunities to Individualize Frontline Therapy in Advanced Stages of Hepatocellular Carcinoma.
  Drugs 2023 Gordan JD, Keenan BP, Lim HC, Yarchoan M, Kelley RK
• Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms.
  eLife 2023 Chan GKL, Maisel S, Hwang YC, Pascual BC, Wolber RRB, Vu P, Patra KC, Bouhaddou M, Kenerson HL, Lim HC, Long D, Yeung RS, Sethupathy P, Swaney DL, Krogan NJ, Turnham RE, Riehle KJ, Scott JD, Bardeesy …
• Abstract PO017: HBV alters YAP regulation in liver cancer by remodeling PP2A complexes.
  Clinical Cancer Research 2022 John Gordan, Adriana Pitea, Rigney E Turnham, Manon Eckhardt, Gwendolyn M Jang, Huat Lim, Alex L Choi, Sourav Bandyopadhyay, Danielle Swaney, Kevan Shokat, Trey Ideker, Nevan Krogan
• Abstract PO023: Uncovering hepatitis B virus-induced signaling changes in hepatocellular carcinoma.
  Clinical Cancer Research 2022 Rigney E Turnham, Huat Chye Lim, Lucille Ferret, Katherine Lo, LeeAnn Wang, Alex Choi, John D Gordan

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• Abstract PR01: Computational identification of targetable dependencies in hepatocellular carcinoma (HCC) associated with hepatitis B virus (HBV) replication.
  Clinical Cancer Research 2022 Huat Chye Lim, Rigney Turnham, Katherine Lo, Yeonjoo Hwang, John Gordan
• Tumor hepatitis B virus RNA identifies a clinically and molecularly distinct subset of hepatocellular carcinoma.
  PLoS computational biology 2021 Lim HC, Gordan JD
• Abstract 4891: Hepatitis B virus remodels host protein interaction networks to generate distinct cellular dependencies.
  Cancer Research 2020 John D. Gordan, Adriana Pitea, Manon Eckhardt, Gwendolyn Jang, Rigney E. Turnham, Alex L M. Choi, John Von Dollen, Huat C. Lim, Elizabeth F. Thayer, R. Katie Kelley, Danielle L. Swaney, Wei Zhang, …
• Geriatric 'Crohn-ic' Abdominal Pain: An Unusual Presentation of a Common Disease.
  The American journal of medicine 2019 Narasimmaraj P, Lim HC, Beck KR, Lai AR
• Genomic analysis of hepatocellular carcinoma (HCC) with active hepatitis B virus (HBV) replication.
  Journal of Clinical Oncology 2019 Huat Chye Lim, John Dozier Gordan
• Hybrid Capture-Based Tumor Sequencing and Copy Number Analysis to Confirm Origin of Metachronous Metastases in BRCA1-Mutant Cholangiocarcinoma Harboring a Novel YWHAZ-BRAF Fusion.
  The oncologist 2018 Lim HC, Montesion M, Botton T, Collisson EA, Umetsu SE, Behr SC, Gordan JD, Stephens PJ, Kelley RK
• HIV Therapy Simulator: a graphical user interface for comparing the effectiveness of novel therapy regimens.
  Bioinformatics (Oxford, England) 2011 Lim HC, Curlin ME, Mittler JE