Hong Sun, PhD
Postdoctoral Scholar
Surgery
School of Medicine

Publications (14)

Top publication keywords:
Mechanistic Target of Rapamycin Complex 1CD8-Positive T-LymphocytesMultiprotein ComplexesReceptor, Adenosine A2AT-Lymphocytes, RegulatoryMyxococcus xanthusMechanistic Target of Rapamycin Complex 2TOR Serine-Threonine KinasesMyeloid-Derived Suppressor CellsMelanoma, ExperimentalForkhead Transcription FactorsNeoplasms, ExperimentalCaproatesProgrammed Cell Death 1 ReceptorAdenosine A2 Receptor Antagonists

• mTORC1 Signaling Regulates Proinflammatory Macrophage Function and Metabolism.
  Journal of immunology (Baltimore, Md. : 1950) 2021 Collins SL, Oh MH, Sun IH, Chan-Li Y, Zhao L, Powell JD, Horton MR
• Metabolic programs define dysfunctional immune responses in severe COVID-19 patients.
  Cell reports 2021 Thompson EA, Cascino K, Ordonez AA, Zhou W, Vaghasia A, Hamacher-Brady A, Brady NR, Sun IH, Wang R, Rosenberg AZ, Delannoy M, Rothman R, Fenstermacher K, Sauer L, Shaw-Saliba K, Bloch EM, Redd AD, …
• Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells.
  The Journal of clinical investigation 2020 Oh MH, Sun IH, Zhao L, Leone RD, Sun IM, Xu W, Collins SL, Tam AJ, Blosser RL, Patel CH, Englert JM, Arwood ML, Wen J, Chan-Li Y, Tenora L, Majer P, Rais R, Slusher BS, Horton MR, Powell JD
• Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion.
  Science (New York, N.Y.) 2019 Leone RD, Zhao L, Englert JM, Sun IM, Oh MH, Sun IH, Arwood ML, Bettencourt IA, Patel CH, Wen J, Tam A, Blosser RL, Prchalova E, Alt J, Rais R, Slusher BS, Powell JD
• Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models.
  Cancer immunology, immunotherapy : CII 2018 Leone RD, Sun IM, Oh MH, Sun IH, Wen J, Englert J, Powell JD

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• mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells.
  Journal of immunology (Baltimore, Md. : 1950) 2018 Sun IH, Oh MH, Zhao L, Patel CH, Arwood ML, Xu W, Tam AJ, Blosser RL, Wen J, Powell JD
• mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages.
  Cell reports 2017 Oh MH, Collins SL, Sun IH, Tam AJ, Patel CH, Arwood ML, Chan-Li Y, Powell JD, Horton MR
• An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor.
  Chembiochem : a European journal of chemical biology 2016 Hsiao PY, Kalin JH, Sun IH, Amin MN, Lo YC, Chiang MJ, Giddens J, Sysa-Shah P, Gabrielson K, Wang LX, Powell JD, Cole PA
• Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation.
  Nature immunology 2016 Pollizzi KN, Sun IH, Patel CH, Lo YC, Oh MH, Waickman AT, Tam AJ, Blosser RL, Wen J, Delgoffe GM, Powell JD
• mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation.
  The Journal of clinical investigation 2015 Pollizzi KN, Patel CH, Sun IH, Oh MH, Waickman AT, Wen J, Delgoffe GM, Powell JD
• Cellular size as a means of tracking mTOR activity and cell fate of CD4+ T cells upon antigen recognition.
  PloS one 2015 Pollizzi KN, Waickman AT, Patel CH, Sun IH, Powell JD
• The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.
  Nature immunology 2014 Heikamp EB, Patel CH, Collins S, Waickman A, Oh MH, Sun IH, Illei P, Sharma A, Naray-Fejes-Toth A, Fejes-Toth G, Misra-Sen J, Horton MR, Powell JD
• Flagella stator homologs function as motors for myxobacterial gliding motility by moving in helical trajectories.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Nan B, Bandaria JN, Moghtaderi A, Sun IH, Yildiz A, Zusman DR
• A multi-protein complex from Myxococcus xanthus required for bacterial gliding motility.
  Molecular microbiology 2010 Nan B, Mauriello EM, Sun IH, Wong A, Zusman DR