Hong-Erh Liang, PhD, MS
Professor
Medicine
School of Medicine

Allergic immunologic diseases.

Education & Training

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• Postdoctoral Studies Graduate Division University of California, San Francisco

Websites

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• Profile at UCSF Immunology Program (immunology.ucsf.edu)

Publications (51)

Top publication keywords:
EosinophilsNippostrongylusChitinInterleukin-4BasophilsLymphocytesImmunity, InnateInterleukinsInterleukin-13Th2 CellsIntestine, SmallStrongylida InfectionsInterferon-gammaHypersensitivityLymphocyte Subsets

• Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Nguyen TTT, Lu W, Zhu WS, Ansel KM, Liang HE, Weiss A
• Innate type 2 immunity controls hair follicle commensalism by Demodex mites.
  Immunity 2022 Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, Díaz RE, Fraser JS, Ali N, …
• Innate type 2 immunity controls hair follicle commensalism by Demodex mites.
  The Journal of Immunology 2022 Roberto R Ricardo-Gonzalez, Maya E Kotas, Claire O’Leary, Iliana Tenvooren, Diana Marquez, Katelyn Singh, William Damsky, Chang Liao, Andrew Schroeder, Jarish Cohen, Marlys S Fassett, Jinwoo Lee, …
• Bile acid-sensitive tuft cells regulate biliary neutrophil influx.
  Science immunology 2022 O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM
• Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.
  Immunity 2022 Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, Molofsky AB

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• Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice.
  Neuro-oncology 2022 Chuntova P, Hou Y, Naka R, Yamamichi A, Chen T, Goretsky Y, Hatae R, Nejo T, Kohanbash G, Mende AL, Montoya M, Downey KM, Diebold D, Skinner J, Liang HE, Schwer B, Okada H
• Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1.
  Science immunology 2021 Castellanos CA, Ren X, Gonzalez SL, Li HK, Schroeder AW, Liang HE, Laidlaw BJ, Hu D, Mak ACY, Eng C, Rodríguez-Santana JR, LeNoir M, Yan Q, Celedón JC, Burchard EG, Zamvil SS, Ishido S, Locksley RM, …
• CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone.
  Mucosal immunology 2021 Kotas ME, Mroz NM, Koga S, Liang HE, Schroeder AW, Ricardo-Gonzalez RR, Schneider C, Locksley RM
• Development of allergic airway immunity depends on MARCH1-mediated ubiquitination of MHCII and CD86 in dendritic cells.
  The Journal of Immunology 2020 Carlos A Castellanos, Xin Ren, Hong-Erh Liang, Brian J Laidlaw, Andrea Barczak, Joshua Rudolph, Walter L Eckalbar, Xiaozhu Huang, Jason G Cyster, Richard M Locksley, David J Erle, Satoshi Ishido, …
• Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity.
  The Journal of experimental medicine 2020 Ricardo-Gonzalez RR, Schneider C, Liao C, Lee J, Liang HE, Locksley RM
• Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming.
  Immunity 2019 Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM
• Tissue signals imprint ILC2 identity with anticipatory function.
  Nature immunology 2018 Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM
• A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling.
  Cell 2018 Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM
• 1021 Origin of type 2 innate lymphoid cells in the skin.
  Journal of Investigative Dermatology 2018 J. Lee, C. Schneider, H. Liang, R. Ricardo-Gonzalez, J. Nussbaum, L. Smith, S. Villeda, R. Locksley
• The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Savage AK, Liang HE, Locksley RM
• Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.
  Cell 2017 Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM
• Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness.
  The Journal of experimental medicine 2017 Hsu LY, Cheng DA, Chen Y, Liang HE, Weiss A
• A tissue checkpoint regulates type 2 immunity.
  Nature immunology 2016 Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM
• Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit.
  Nature 2015 von Moltke J, Ji M, Liang HE, Locksley RM
• Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation.
  Immunity 2015 Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM
• IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function.
  The Journal of Cell Biology 2015 Laurence E. Cheng, Brandon M. Sullivan, Lizett E. Retana, Christopher D.C. Allen, Hong-Erh Liang, Richard M. Locksley
• IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function.
  The Journal of experimental medicine 2015 Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM
• A novel model for IFN-γ-mediated autoinflammatory syndromes.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Reinhardt RL, Liang HE, Bao K, Price AE, Mohrs M, Kelly BL, Locksley RM
• Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine.
  Nature immunology 2014 Bando JK, Liang HE, Locksley RM
• Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.
  Immunity 2014 Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM
• Type 2 innate lymphoid cells control eosinophil homeostasis.
  Nature 2013 Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM
• 265 Cooperative activation of innate lymphoid type 2 cells (ILC2) by epithelial cytokines in response to chitin.
  Cytokine 2013 Steven J. Van Dyken, Alexander Mohapatra, Jesse C. Nussbaum, Hong-Erh Liang, Richard M. Locksley
• Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung.
  Journal of leukocyte biology 2013 Bando JK, Nussbaum JC, Liang HE, Locksley RM
• Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.
  The Journal of experimental medicine 2013 Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM
• Marking and quantifying IL-17A-producing cells in vivo.
  PloS one 2012 Price AE, Reinhardt RL, Liang HE, Locksley RM
• Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity.
  Nature immunology 2011 Liang HE, Reinhardt RL, Bando JK, Sullivan BM, Ho IC, Locksley RM
• Genetic analysis of basophil function in vivo.
  Nature immunology 2011 Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM
• Adipose eosinophils promote alternatively activated macrophages that maintain metabolic homeostasis (151.21).
  The Journal of Immunology 2011 Ari Molofsky, Davina Wu, Hong-Erh Liang, Jennifer Bando, Hani Jouihan, Robert Ricardo-Gonzalez, Ajay Chawla, Richard Locksley
• Arginase-I is expressed by ckit+IL-7Ra+ populations in cryptopatches (166.11).
  The Journal of Immunology 2011 Jennifer Bando, Hong-Erh Liang, Richard Locksley
• Divergent expression patterns of IL-4 and IL-13 define unique functions in type 2 immunity (56.22).
  The Journal of Immunology 2011 Richard Reinhardt, Hong-Erh Liang, Brandon Sullivan, Richard Locksley
• Genetic analysis of basophil function in vivo (151.22).
  The Journal of Immunology 2011 Brandon Sullivan, Hong-Erh Liang, Jennifer Bando, Davina Wu, Laurence Cheng, James McKerrow, Chris Allen, Richard Locksley
• Innate and adaptive Type 2 cytokines drive mucosal eosinophilia (58.2).
  The Journal of Immunology 2011 Jesse Nussbaum, Hong-Erh Liang, Brandon Sullivan, April Price, Richard Locksley
• Tracking in vivo IL-17A production during infection and autoimmunity (114.11).
  The Journal of Immunology 2011 April Price, Hong-Erh Liang, R. Lee Reinhardt, Richard Locksley
• Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.
  Science (New York, N.Y.) 2011 Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM
• Systemically dispersed innate IL-13-expressing cells in type 2 immunity.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Price AE, Liang HE, Sullivan BM, Reinhardt RL, Eisley CJ, Erle DJ, Locksley RM
• Tracking cytokine expression in vivo.
  Cytokine 2009 Richard M. Locksley, Brandon Sullivan, R. Lee Reinhardt, Davina Wu, Steve Van Dyken, Suk-Jo Kang, April Price, Jennifer Bando, Hong-Erh Liang
• Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates.
  BMC biotechnology 2009 Voehringer D, Wu D, Liang HE, Locksley RM
• Cytokine-secreting follicular T cells shape the antibody repertoire (34.19).
  The Journal of Immunology 2009 Richard Lee Reinhardt, Hong-Erh Liang, Richard M. Locksley
• Generation of IL-17A reporter mice to track IL-17A expression in vivo (38.19).
  The Journal of Immunology 2009 April E Price, Hong-Erh Liang, Richard M Locksley
• Tissue restricted activation of basophils mediates primary immunity against helminthes (79.22).
  The Journal of Immunology 2009 Brandon M Sullivan, Davina Wu, Hong-Erh Liang, P'ng Loke, James H McKerrow, David Voehringer, Richard M Locksley
• Cytokine-secreting follicular T cells shape the antibody repertoire.
  Nature immunology 2009 Reinhardt RL, Liang HE, Locksley RM
• Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells.
  Immunity 2008 Kang SJ, Liang HE, Reizis B, Locksley RM
• Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Voehringer D, Liang HE, Locksley RM
• Chitin induces accumulation in tissue of innate immune cells associated with allergy.
  Nature 2007 Reese TA, Liang HE, Tager AM, Luster AD, Van Rooijen N, Voehringer D, Locksley RM
• T helper cell effector fates--who, how and where?
  Current opinion in immunology 2006 Reinhardt RL, Kang SJ, Liang HE, Locksley RM
• Generation and characterization of a cell line with inducible expression of Ca(v)3.2 (T-type) channels.
  Assay and drug development technologies 2003 Xia M, Imredy JP, Santarelli VP, Liang HA, Condra CL, Bennett P, Koblan KS, Connolly TM