Holly Ingraham, PhD
Professor
Cellular Molecular Pharmacology
School of Medicine

Through question-driven basic science, Ingraham seeks to uncover the molecular mechanisms underlying adaptive responses throughout the female lifespan and to understand how hormonal fluctuations affect women’s health beyond the reproductive system. Please visit our website at https://ingrahamlab.ucsf.edu for an overview of our current research efforts in the basic science of "Hormones and Nerves in Female Physiology," which aims to improve women's health.

During her postdoctoral work in the Rosenfeld lab at UCSD, she was the driving force behind identifying Pit-1, one of the first tissue-specific regulators and a founding member of the POU transcription factor family. At UCSF, Ingraham demonstrated that the nuclear receptor SF-1 is a key developmental factor in establishing gonadal sex differences by regulating the peptide hormone anti-Mullerian hormone (AMH). Using biochemical and structural studies, her lab identified phospholipids as ligands for SF-1 (LRH-1) and further demonstrated the in vivo impact of SUMOylation of these receptors in endocrine organs and metabolic tissues. Ingraham’s more recent work has defined molecular pathways that control female physiology. Her group provided a mechanistic understanding of the preovulatory activity spike, underscoring the impact of estrogen in counteracting metabolic decline. Her high-impact studies focused on brain-body physiology during distinct female life stages have been featured in The New York Times Science Section (October 26, 2021) and the NIH Director’s Blog (August 1, 2024). Ingraham has chaired and served on numerous NIH review panels and scientific advisory boards. Her long-standing dedication to understanding basic female physiology has led to numerous distinguished lectureships and public forums on women’s health. She is also the founder of a biotech venture focused on alleviating age-related frailty and skeletal decline. Ingraham is an elected fellow of the American Association for the Advancement of Science and a member of the National Academy of Sciences and the American Academy of Arts and Sciences. She earned her Ph.D. from Revelle College at the University of California, San Diego.

ABOUT ME: Those who devote their lives to creative pursuits are often inspired by a singular event. Mine came from my great-grandfather, whose 1890 Bausch & Lomb microscope, abandoned in a closet after being shipped west from Worcester, Massachusetts, came into my possession when I was 10. I picked it up and began exploring the biological world of Northern California, never to stop. However, sporadic events are insufficient to sustain a lifetime of curiosity and discovery. That support would come through the State of California via its amazing and accessible public education system, beginning at Revelle College at UCSD, and through the NIH, which has continuously supported my curiosity-based discovery research program for over 25 years. Unwavering support also comes from my family and mentors, who provide the personal strength and resiliency needed to overcome moments of disappointment, insecurity, and self-doubt. I thoroughly enjoy my life as a scientist and remain addicted to the rare experimental successes that are sprinkled among the many failures inherent in the scientific process.

ABOUT MENTORING: In partnership with San Francisco State University, I also direct the UCSF IRACDA Scholars Program, which aims to build our nation's biomedical workforce and faculty. Our efforts, along with generous funding from an NIGMS K12 grant and the UCSF School of Medicine, provide career development programming for a small cohort of postdoctoral fellows. Our local efforts today will make a national difference tomorrow.

• Gut enterochromaffin cells drive visceral pain and anxiety.
  Nature 2023 Bayrer JR, Castro J, Venkataraman A, Touhara KK, Rossen ND, Morrie RD, Maddern J, Hendry A, Braverman KN, Garcia-Caraballo S, Schober G, Brizuela M, Castro Navarro FM, Bueno-Silva C, Ingraham HA, …
• An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice.
  Science (New York, N.Y.) 2022 Nikkanen J, Leong YA, Krause WC, Dermadi D, Maschek JA, Van Ry T, Cox JE, Weiss EJ, Gokcumen O, Chawla A, Ingraham HA
• Running the Female Power Grid Across Lifespan Through Brain Estrogen Signaling.
  Annual review of physiology 2021 Ingraham HA, Herber CB, Krause WC
• Oestrogen engages brain MC4R signalling to drive physical activity in female mice.
  Nature 2021 Krause WC, Rodriguez R, Gegenhuber B, Matharu N, Rodriguez AN, Padilla-Roger AM, Toma K, Herber CB, Correa SM, Duan X, Ahituv N, Tollkuhn J, Ingraham HA
• Chronic Stimulation of Arcuate Kiss1 Neurons Decreases Bone Mass in Female Mice.
  Journal of the Endocrine Society 2021 Ruben Rodriguez, Candice B Herber, William C Krause, Holly A Ingraham
• SPARC - Mapping Gut-Spinal Cord Connections in Visceral Pain.
  The FASEB Journal 2020 Ryan David Morrie, James Bayrer, Stuart Brierley, Holly Ingraham, David Julius
• Should We Make More Bone or Not, As Told by Kisspeptin Neurons in the Arcuate Nucleus.
  Seminars in reproductive medicine 2019 Herber CB, Ingraham HA
• 948 – Nuclear Receptor Liver Receptor Homolog-1 Promotes Intestinal Notch Signaling and Enteroendocrine Cell Development.
  Gastroenterology 2019 Pervinder K. Choksi, Holly A. Ingraham, James Bayrer
• Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.
  Nature communications 2019 Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA
• LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.
  Nature communications 2018 Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA
• 273 - Nuclear Receptor LRH-1 Mitigates Intestinal Inflammatory Disease by Promoting Stem Cell Survival and Directing Normal Epithelial Composition.
  Gastroenterology 2018 James Bayrer, Hazel Escusa, Ophir D. Kein, Holly Ingraham
• LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity.
  JCI insight 2018 Miranda DA, Krause WC, Cazenave-Gassiot A, Suzawa M, Escusa H, Foo JC, Shihadih DS, Stahl A, Fitch M, Nyangau E, Hellerstein M, Wenk MR, Silver DL, Ingraham HA
• Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.
  Development (Cambridge, England) 2017 Xing Y, Morohashi KI, Ingraham HA, Hammer GD
• Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways.
  Cell 2017 Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O'Donnell TA, Brierley SM, Ingraham HA, Julius D
• Origins and Functions of the Ventrolateral VMH: A Complex Neuronal Cluster Orchestrating Sex Differences in Metabolism and Behavior.
  Advances in experimental medicine and biology 2017 Krause WC, Ingraham HA
• Testosterone Rapidly Augments Retrograde Endocannabinoid Signaling in Proopiomelanocortin Neurons to Suppress Glutamatergic Input from Steroidogenic Factor 1 Neurons via Upregulation of Diacylglycerol Lipase-α.
  Neuroendocrinology 2016 Conde K, Fabelo C, Krause WC, Propst R, Goethel J, Fischer D, Hur J, Meza C, Ingraham HA, Wagner EJ
• Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2).
  PloS one 2016 de Jesus Cortez F, Suzawa M, Irvy S, Bruning JM, Sablin E, Jacobson MP, Fletterick RJ, Ingraham HA, England PM
• A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver.
  eLife 2015 Suzawa M, Miranda DA, Ramos KA, Ang KK, Faivre EJ, Wilson CG, Caboni L, Arkin MR, Kim YS, Fletterick RJ, Diaz A, Schneekloth JS, Ingraham HA
• Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket.
  Journal of structural biology 2015 Sablin EP, Blind RD, Uthayaruban R, Chiu HJ, Deacon AM, Das D, Ingraham HA, Fletterick RJ
• Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output.
  Molecular metabolism 2015 Cheung CC, Krause WC, Edwards RH, Yang CF, Shah NM, Hnasko TS, Ingraham HA
• The Signaling Phospholipid PIP3 Functions As a Ligand Hormone For Nuclear Receptors.
  The FASEB Journal 2015 Holly Ingraham, Raymond Blind, Elena Sablin, Debanu Das, Robert Fletterick
• An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females.
  Cell reports 2014 Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein JL, Ingraham HA
• The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Blind RD, Sablin EP, Kuchenbecker KM, Chiu HJ, Deacon AM, Das D, Fletterick RJ, Ingraham HA
• Genetic labeling of steroidogenic factor-1 (SF-1) neurons in mice reveals ventromedial nucleus of the hypothalamus (VMH) circuitry beginning at neurogenesis and development of a separate non-SF-1 neuronal cluster in the ventrolateral VMH.
  The Journal of comparative neurology 2013 Cheung CC, Kurrasch DM, Liang JK, Ingraham HA
• Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK.
  Science signaling 2012 Blind RD, Suzawa M, Ingraham HA
• Science Signaling Podcast: 19 June 2012.
  Science Signaling 2012 H. A. Ingraham, R. D. Blind, A. M. VanHook
• An affective disorder in zebrafish with mutation of the glucocorticoid receptor.
  Molecular psychiatry 2012 Ziv L, Muto A, Schoonheim PJ, Meijsing SH, Strasser D, Ingraham HA, Schaaf MJ, Yamamoto KR, Baier H
• Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development.
  Developmental cell 2011 Lee FY, Faivre EJ, Suzawa M, Lontok E, Ebert D, Cai F, Belsham DD, Ingraham HA
• Metabolism: A lipid for fat disorders.
  Nature 2011 Ingraham HA
• Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes.
  The Journal of steroid biochemistry and molecular biology 2011 Hayes TB, Anderson LL, Beasley VR, de Solla SR, Iguchi T, Ingraham H, Kestemont P, Kniewald J, Kniewald Z, Langlois VS, Luque EH, McCoy KA, Muñoz-de-Toro M, Oka T, Oliveira CA, Orton F, Ruby S, Suzawa…
• Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2).
  Journal of medicinal chemistry 2011 Whitby RJ, Stec J, Blind RD, Dixon S, Leesnitzer LM, Orband-Miller LA, Williams SP, Willson TM, Xu R, Zuercher WJ, Cai F, Ingraham HA
• Hypothalamic Fetal Programming of Energy Homeostasis.
  Obesity Before Birth 2011 Clement C. Cheung, Holly A. Ingraham
• Molecular pathways controlling development of thalamus and hypothalamus: from neural specification to circuit formation.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Blackshaw S, Scholpp S, Placzek M, Ingraham H, Simerly R, Shimogori T
• Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25.
  Cell metabolism 2010 Mullaney BC, Blind RD, Lemieux GA, Perez CL, Elle IC, Faergeman NJ, Van Gilst MR, Ingraham HA, Ashrafi K
• Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish.
  Neural development 2009 Kurrasch DM, Nevin LM, Wong JS, Baier H, Ingraham HA
• Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation.
  Cancer research 2009 Lin BC, Suzawa M, Blind RD, Tobias SC, Bulun SE, Scanlan TS, Ingraham HA
• The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ
• Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands.
  Molecular endocrinology (Baltimore, Md.) 2008 Sablin EP, Blind RD, Krylova IN, Ingraham JG, Cai F, Williams JD, Fletterick RJ, Ingraham HA
• Decreased recognition of SUMO-sensitive target genes following modification of SF-1 (NR5A1).
  Molecular and cellular biology 2008 Campbell LA, Faivre EJ, Show MD, Ingraham JG, Flinders J, Gross JD, Ingraham HA
• Nuclear Receptors, Chemistry of.
  Wiley Encyclopedia of Chemical Biology 2008 Lioudmila A. Campbell, Holly A. Ingraham
• The herbicide atrazine activates endocrine gene networks via non-steroidal NR5A nuclear receptors in fish and mammalian cells.
  PloS one 2008 Suzawa M, Ingraham HA
• The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Kurrasch DM, Cheung CC, Lee FY, Tran PV, Hata K, Ingraham HA
• International Union of Pharmacology. LXVI. Orphan nuclear receptors.
  Pharmacological reviews 2006 Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V
• Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage.
  The Journal of comparative neurology 2006 Tran PV, Akana SF, Malkovska I, Dallman MF, Parada LF, Ingraham HA
• Orphan nuclear receptors adopted by crystallography.
  Current opinion in structural biology 2005 Ingraham HA, Redinbo MR
• The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification.
  Molecular and cellular biology 2005 Lee MB, Lebedeva LA, Suzawa M, Wadekar SA, Desclozeaux M, Ingraham HA
• Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
  Cell 2005 Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM,…
• Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function.
  Molecular endocrinology (Baltimore, Md.) 2004 Bland ML, Fowkes RC, Ingraham HA
• 128 UPREGULATION OF WNT4 DISRUPTS TESTICULAR VASCULOGENESIS AND INHIBITS TESTOSTERONE SYNTHESIS.
  Journal of Investigative Medicine 2004 E. Vilain, J.H.-C. Shen, R. Olaso, H. A. Ingraham, B. K. Jordan
• UPREGULATION OF WNT4 DISRUPTS TESTICULAR VASCULOGENESIS AND INHIBITS TESTOSTERONE SYNTHESIS.: 128.
  Journal of Investigative Medicine 2004 E. Vilain, J.H.-C. Shen, R. Olaso, H. A. Ingraham, B. K. Jordan
• Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Jordan BK, Shen JH, Olaso R, Ingraham HA, Vilain E
• Steroidogenic factor-1 and the gonadotrope-specific element enhance basal and pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein hormone alpha-subunit gene in gonadotropes.
  Molecular endocrinology (Baltimore, Md.) 2003 Fowkes RC, Desclozeaux M, Patel MV, Aylwin SJ, King P, Ingraham HA, Burrin JM
• Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1.
  Molecular cell 2003 Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA
• Tissue growth and remodeling of the embryonic and adult adrenal gland.
  Annals of the New York Academy of Sciences 2003 Bland ML, Desclozeaux M, Ingraham HA
• Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons.
  Molecular and cellular neurosciences 2003 Tran PV, Lee MB, Marín O, Xu B, Jones KR, Reichardt LF, Rubenstein JR, Ingraham HA
• Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain.
  Molecular endocrinology (Baltimore, Md.) 2003 Huber BR, Desclozeaux M, West BL, Cunha-Lima ST, Nguyen HT, Baxter JD, Ingraham HA, Fletterick RJ
• Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1.
  Molecular and cellular biology 2002 Desclozeaux M, Krylova IN, Horn F, Fletterick RJ, Ingraham HA
• Anti-Müllerian Hormone Inhibits Initiation of Primordial Follicle Growth in the Mouse Ovary.
  Endocrinology 2002 Alexandra L. L. Durlinger, Maria J. G. Gruijters, Piet Kramer, Bas Karels, Holly A. Ingraham, Mark W. Nachtigal, Jan Th. J. Uilenbroek, J. Anton Grootegoed, Axel P. N. Themmen
• Anti-Müllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary.
  Endocrinology 2002 Durlinger AL, Gruijters MJ, Kramer P, Karels B, Ingraham HA, Nachtigal MW, Uilenbroek JT, Grootegoed JA, Themmen AP
• Involvement of a matrix metalloproteinase in MIS-induced cell death during urogenital development.
  Development (Cambridge, England) 2002 Roberts LM, Visser JA, Ingraham HA
• Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins.
  Molecular endocrinology (Baltimore, Md.) 2002 Shen JH, Ingraham HA
• The serine/threonine transmembrane receptor ALK2 mediates Müllerian inhibiting substance signaling.
  Molecular endocrinology (Baltimore, Md.) 2001 Visser JA, Olaso R, Verhoef-Post M, Kramer P, Themmen AP, Ingraham HA
• Müllerian inhibitory substance induces growth of rat preantral ovarian follicles.
  Biology of reproduction 2001 McGee EA, Smith R, Spears N, Nachtigal MW, Ingraham H, Hsueh AJ
• Upregulation of Wnt4 Disrupts Testicular Vasculogenesis and Inhibits Testosterone Synthesis.
  Journal of Investigative Medicine 2001 E. Vilain, J.H.-C. Shen, R. Olaso, H.A. Ingraham, B.K. Jordan
• Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Bland ML, Jamieson CA, Akana SF, Bornstein SR, Eisenhofer G, Dallman MF, Ingraham HA
• Gene dosage effects of steroidogenic factor 1 (SF-1) in adrenal development and the stress.
  Endocrine research 2000 Bland ML, Jamieson C, Akana S, Dallman M, Ingraham HA
• SF-1 and DAX-1: A Dynamic Duo in Endocrine Development Mark W. Nachtigal,.
  Gene Engineering in Endocrinology 2000 Debra Enyeart-VanHouten, Holly A. Ingraham
• Autocrine and paracrine Müllerian inhibiting substance hormone signaling in reproduction.
  Recent progress in hormone research 2000 Ingraham HA, Hirokawa Y, Roberts LM, Mellon SH, McGee E, Nachtigal MW, Visser JA
• SF-1 and DAX-1.
  Gene Engineering in Endocrinology 2000 Mark W. Nachtigal, Debra Enyeart-VanHouten, Holly A. Ingraham
• New solutions to an ancient riddle: defining the differences between Adam and Eve.
  American journal of human genetics 1999 Roberts LM, Shen J, Ingraham HA
• Steroidogenic factor-1: its role in endocrine organ development and differentiation.
  Frontiers in neuroendocrinology 1999 Hammer GD, Ingraham HA
• Paracrine-mediated apoptosis in reproductive tract development.
  Developmental biology 1999 Roberts LM, Hirokawa Y, Nachtigal MW, Ingraham HA
• Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress.
  Molecular cell 1999 Hammer GD, Krylova I, Zhang Y, Darimont BD, Simpson K, Weigel NL, Ingraham HA
• Raging Hormones in Development and Cancer Hormones and Growth Factors in Development and Neoplasia By Robert B. Dickson and David S. Salomon New York: Wiley (1998). 461 pp. $125.00.
  Cell 1999 Holly A Ingraham, Gary D Hammer
• Neuronal expression of the 5HT3 serotonin receptor gene requires nuclear factor 1 complexes.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Bedford FK, Julius D, Ingraham HA
• Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression.
  Cell 1998 Nachtigal MW, Hirokawa Y, Enyeart-VanHouten DL, Flanagan JN, Hammer GD, Ingraham HA
• The nuclear receptor SF-1 mediates sexually dimorphic expression of Mullerian Inhibiting Substance, in vivo.
  Development (Cambridge, England) 1997 Giuili G, Shen WH, Ingraham HA
• Bioactivation of Müllerian inhibiting substance during gonadal development by a kex2/subtilisin-like endoprotease.
  Proceedings of the National Academy of Sciences of the United States of America 1996 Nachtigal MW, Ingraham HA
• Molecular biology of pituitary development and disease.
  Hormone research 1996 Bedford FK, Christopherson K, Nachtigal MW, Shen WH, Julius DJ, Ingraham HA
• The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis.
  Genes & development 1994 Ingraham HA, Lala DS, Ikeda Y, Luo X, Shen WH, Nachtigal MW, Abbud R, Nilson JH, Parker KL
• Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: a link to the sex determination cascade.
  Cell 1994 Shen WH, Moore CC, Ikeda Y, Parker KL, Ingraham HA
• Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases.
  Molecular endocrinology (Baltimore, Md.) 1994 Ikeda Y, Shen WH, Ingraham HA, Parker KL
• PIT-1 AND ITS NATURALLY OCCURRING GENETIC MUTATIONS; ANSWERS AND QUESTIONS ABOUT THE MOLECULAR BIOLOGY OF PITUITARY DEVELOPMENT AND DISEASE.
  Pediatric Research 1993 Holly A Ingraham
• Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia.
  Science (New York, N.Y.) 1992 Pfäffle RW, DiMattia GE, Parks JS, Brown MR, Wit JM, Jansen M, Van der Nat H, Van den Brande JL, Rosenfeld MG, Ingraham HA
• Structural analysis of the transmembrane domain of the epidermal growth factor receptor.
  The Journal of biological chemistry 1991 Carpenter CD, Ingraham HA, Cochet C, Walton GM, Lazar CS, Sowadski JM, Rosenfeld MG, Gill GN
• Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements.
  Nature 1990 Chen RP, Ingraham HA, Treacy MN, Albert VR, Wilson L, Rosenfeld MG
• Mutational removal of the Thr669 and Ser671 phosphorylation sites alters substrate specificity and ligand-induced internalization of the epidermal growth factor receptor.
  The Journal of biological chemistry 1990 Heisermann GJ, Wiley HS, Walsh BJ, Ingraham HA, Fiol CJ, Gill GN
• The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions.
  Cell 1990 Ingraham HA, Flynn SE, Voss JW, Albert VR, Kapiloff MS, Wilson L, Rosenfeld MG
• Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors.
  Genes & development 1990 Simmons DM, Voss JW, Ingraham HA, Holloway JM, Broide RS, Rosenfeld MG, Swanson LW
• A family of POU-domain and Pit-1 tissue-specific transcription factors in pituitary and neuroendocrine development.
  Annual review of physiology 1990 Ingraham HA, Albert VR, Chen RP, Crenshaw 3d EB, Elsholtz HP, He X, Kapiloff MS, Mangalam HJ, Swanson LW, Treacy MN
• Expression of a large family of POU-domain regulatory genes in mammalian brain development.
  Nature 1989 He X, Treacy MN, Simmons DM, Ingraham HA, Swanson LW, Rosenfeld MG
• A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally.
  Genes & development 1989 Mangalam HJ, Albert VR, Ingraham HA, Kapiloff M, Wilson L, Nelson C, Elsholtz H, Rosenfeld MG
• The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.
  Genes & development 1988 Herr W, Sturm RA, Clerc RG, Corcoran LM, Baltimore D, Sharp PA, Ingraham HA, Rosenfeld MG, Finney M, Ruvkun G
• A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype.
  Cell 1988 Ingraham HA, Chen RP, Mangalam HJ, Elsholtz HP, Flynn SE, Lin CR, Simmons DM, Swanson L, Rosenfeld MG
• Role of intrinsic protein tyrosine kinase in function and metabolism of the epidermal growth factor receptor.
  Cold Spring Harbor symposia on quantitative biology 1988 Gill GN, Chen WS, Lazar CS, Glenney JR, Wiley HS, Ingraham HA, Rosenfeld MG
• Characterization of Two Atypical Promoters and Alternate mRNA Processing in the Mouse Thy-1.2 Glycoprotein Gene.
  Molecular and Cellular Biology 1986 Holly A. Ingraham, Glen A. Evans
• Characterization of two atypical promoters and alternate mRNA processing in the mouse Thy-1.2 glycoprotein gene.
  Molecular and cellular biology 1986 Ingraham HA, Evans GA
• The mouse Thy-1.2 glycoprotein gene: complete sequence and identification of an unusual promoter.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Ingraham HA, Lawless GM, Evans GA
• Mechanism of thymineless death.
  Advances in experimental medicine and biology 1986 Goulian M, Bleile BM, Dickey LM, Grafstrom RH, Ingraham HA, Neynaber SA, Peterson MS, Tseng BY
• MECHANISM OF THYMINELESS DEATH: 73.
  Pediatric Research 1985 M Goulian, H Ingraham, B Tseng, L Dickey, B Bleile, S Neynaber
• Expression of the Thy-1 glycoprotein gene by DNA-mediated gene transfer.
  Proceedings of the National Academy of Sciences of the United States of America 1984 Evans GA, Ingraham HA, Lewis K, Cunningham K, Seki T, Moriuchi T, Chang HC, Silver J, Hyman R
• Molecular cloning of the acetylcholine receptor.
  Cold Spring Harbor symposia on quantitative biology 1983 Patrick J, Ballivet M, Boas L, Claudio T, Forrest J, Ingraham H, Mason P, Stengelin S, Ueno S, Heinemann S
• Mechanism for exclusion of 5-fluorouracil from DNA.
  Cancer research 1980 Ingraham HA, Tseng BY, Goulian M
• Characterization of Sialyltransferase in Noncancerous and Neoplastic Human Liver Tissue2.
  Journal of the National Cancer Institute 1978 Holly A. Ingraham, Jack A. Alhadeff
• Characterization of the association of specific proteins with messenger ribonucleic acid.
  Biochemistry 1976 Barrieux A, Ingraham HA, Nystul S, Rosenfeld MG
• Isolation of messenger-like ribonucleoproteins.
  Biochemistry 1975 Barrieux A, Ingraham HA, David DN, Rosenfeld MG