Hiten Madhani, MD, PhD
Professor
Biochemistry and Biophysics
School of Medicine

Awards

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• Fellow of the American Association for the Advancement of Science (AAAS), UCSF, 2020
• Outstanding Faculty Mentor Award, UCSF (Graduate Division), 2015
• Fellow of the American Academy of Microbiology, UCSF, 2014
• Lymphoma and Leukemia Society Scholar Award, UCSF, 2005-2010
• David and Lucille Packard Foundation Fellowship, UCSF, 2000-2005
• Burroughs-Wellcome Career Award, UCSF, 1999-2002
• Helen Hay Whitney Postdoctoral Research Fellowship, Whitehead Institute, 1995-1999
• Dean's Prize for Student Research, UCSF, 1987
• Firestone Medal, Stanford University, 1986
• Fox Award for Outstanding Undergraduate in Biology, Stanford University, 1986

Education & Training

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• MD Medicine UCSF 06/1995
• PhD Genetics UCSF 12/1993
• BS Biological Sciences Stanford 06/1986

Interests

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• Molecular Biology
• Infectious Disease

Websites

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• @@hitenmadhani on Twitter (twitter.com)

Grants and Projects

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• Mechanisms of Gene Silencing, NIH, 2005-2022
• Cryptococcus knockout and tag resource, NIH, 2012-2022
• Intracellular Recognition of Fungi by the Innate Immune System, NIH, 2020-2021
• Epigenetic control of virulence in a fungal meningitis pathogen, NIH, 2015-2021
• Peptide-based signaling and virulence in Cryptococcus neoformans, NIH, 2017-2019
• Chemical-genetic functional annotation of the genome of a meningitis pathogen, NIH, 2012-2018
• Regulation of Virulence of Cryptococcus neoformans, NIH, 2011-2016
• Comprehensive Biology: Exploiting the Yeast Genome, NIH, 1996-2016
• Systems Biology of Molecular Noise in Yeast, NIH, 2009-2013
• Mechanisms of Signal Transduction Specificity in Yeast, NIH, 2001-2011
• Systematic Genetic Analysis of Fungal Virulence, NIH, 2005-2010

Publications (123)

Top publication keywords:
HistonesSchizosaccharomycesSaccharomyces cerevisiaeCryptococcus neoformansFungiSchizosaccharomyces pombe ProteinsGene Expression Regulation, FungalCryptococcosisRNA InterferenceVirulence FactorsFungal ProteinsRNA SplicingSpliceosomesSaccharomyces cerevisiae ProteinsHeterochromatin

• Convergent evolution of innate immune-modulating effectors in invasive fungal pathogens.
  Trends in microbiology 2023 Boucher MJ, Madhani HD
• Meet the authors: Irene Beusch and Hiten Madhani.
  Molecular cell 2023 Beusch I, Madhani H
• Platelets and mast cells promote pathogenic eosinophil recruitment during invasive fungal infection via the 5-HIAA-GPR35 ligand-receptor system.
  Immunity 2023 De Giovanni M, Dang EV, Chen KY, An J, Madhani HD, Cyster JG
• Intrinsic mesoscale properties of a Polycomb protein underpin heterochromatin fidelity.
  Nature structural & molecular biology 2023 Lee S, Abini-Agbomson S, Perry DS, Goodman A, Rao B, Huang MY, Diedrich JK, Moresco JJ, Yates JR, Armache KJ, Madhani HD
• Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response.
  Cell host & microbe 2022 Basso P, Dang EV, Urisman A, Cowen LE, Madhani HD, Noble SM
• Christine Guthrie (1945-2022): a tribute from her trainees.
  RNA (New York, N.Y.) 2022 Mayerle M, Madhani HD, Maeder C
• Telomere transposon takeover in Cryptococcus.
  Nature microbiology 2022 Huang MY, Madhani HD
• Secreted fungal virulence effector triggers allergic inflammation via TLR4.
  Nature 2022 Dang EV, Lei S, Radkov A, Volk RF, Zaro BW, Madhani HD
• Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance.
  Molecular cell 2022 Wang J, Catania S, Wang C, de la Cruz MJ, Rao B, Madhani HD, Patel DJ
• Short homology-directed repair using optimized Cas9 in the pathogen Cryptococcus neoformans enables rapid gene deletion and tagging.
  Genetics 2022 Huang MY, Joshi MB, Boucher MJ, Lee S, Loza LC, Gaylord EA, Doering TL, Madhani HD
• Model organism databases are in jeopardy.
  Development (Cambridge, England) 2021 Bellen HJ, Hubbard EJA, Lehmann R, Madhani HD, Solnica-Krezel L, Southard-Smith EM
• Unbelievable but True: Epigenetics and Chromatin in Fungi.
  Trends in genetics : TIG 2020 Madhani HD
• Coordinate genomic association of transcription factors controlled by an imported quorum sensing peptide in Cryptococcus neoformans.
  PLoS genetics 2020 Summers DK, Perry DS, Rao B, Madhani HD
• Cholesterol in quarantine.
  Nature immunology 2020 Dang EV, Madhani HD, Vance RE
• ATP Hydrolysis by the SNF2 Domain of Dnmt5 Is Coupled to Both Specific Recognition and Modification of Hemimethylated DNA.
  Molecular cell 2020 Dumesic PA, Stoddard CI, Catania S, Narlikar GJ, Madhani HD
• Quantitative global studies reveal differential translational control by start codon context across the fungal kingdom.
  Nucleic acids research 2020 Wallace EWJ, Maufrais C, Sales-Lee J, Tuck LR, de Oliveira L, Feuerbach F, Moyrand F, Natarajan P, Madhani HD, Janbon G
• Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase.
  Cell 2020 Catania S, Dumesic PA, Pimentel H, Nasif A, Stoddard CI, Burke JE, Diedrich JK, Cooke S, Shea T, Gienger E, Lintner R, Yates JR, Hajkova P, Narlikar GJ, Cuomo CA, Pritchard JK, Madhani HD
• Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase.
  Cell 2020 Catania S, Dumesic PA, Pimentel H, Nasif A, Stoddard CI, Burke JE, Diedrich JK, Cook S, Shea T, Geinger E, Lintner R, Yates JR, Hajkova P, Narlikar GJ, Cuomo CA, Pritchard JK, Madhani HD
• A Non-Dicer RNase III and Four Other Novel Factors Required for RNAi-Mediated Transposon Suppression in the Human Pathogenic Yeast Cryptococcus neoformans.
  G3 (Bethesda, Md.) 2019 Burke JE, Longhurst AD, Natarajan P, Rao B, Liu J, Sales-Lee J, Mortensen Y, Moresco JJ, Diedrich JK, Yates JR, Madhani HD
• A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.
  PLoS biology 2019 Brimacombe CA, Burke JE, Parsa JY, Catania S, O'Meara TR, Witchley JN, Burrack LS, Madhani HD, Noble SM
• Real-Time Genetic Compensation Defines the Dynamic Demands of Feedback Control.
  Cell 2018 Harrigan P, Madhani HD, El-Samad H
• Polymerase pausing induced by sequence-specific RNA-binding protein drives heterochromatin assembly.
  Genes & development 2018 Parsa JY, Boudoukha S, Burke J, Homer C, Madhani HD
• Spliceosome Profiling Visualizes Operations of a Dynamic RNP at Nucleotide Resolution.
  Cell 2018 Burke JE, Longhurst AD, Merkurjev D, Sales-Lee J, Rao B, Moresco JJ, Yates JR, Li JJ, Madhani HD
• Ten principles of heterochromatin formation and function.
  Nature reviews. Molecular cell biology 2017 Allshire RC, Madhani HD
• Intracellular Action of a Secreted Peptide Required for Fungal Virulence.
  Cell host & microbe 2016 Homer CM, Summers DK, Goranov AI, Clarke SC, Wiesner DL, Diedrich JK, Moresco JJ, Toffaletti D, Upadhya R, Caradonna I, Petnic S, Pessino V, Cuomo CA, Lodge JK, Perfect J, Yates JR, Nielsen K, Craik …

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• Mechanisms of Inheritance of Chromatin States: From Yeast to Human.
  Annual review of biophysics 2024 Madhani HD
• An auxin-inducible degron system for conditional mutation in the fungal meningitis pathogen Cryptococcus neoformans.
  bioRxiv : the preprint server for biology 2024 Huang MY, Nalley MJ, Hecht P, Madhani HD
• Phenotypic landscape of a fungal meningitis pathogen reveals its unique biology.
  bioRxiv : the preprint server for biology 2024 Boucher MJ, Banerjee S, Joshi MB, Wei AL, Huang MY, Lei S, Ciranni M, Condon A, Langen A, Goddard TD, Caradonna I, Goranov AI, Homer CM, Mortensen Y, Petnic S, Reilly MC, Xiong Y, Susa KJ, Pastore VP,…
• Deep learning meets histones at the replication fork.
  Cell 2024 Madhani HD
• Understanding the dynamic design of the spliceosome.
  Trends in biochemical sciences 2024 Beusch I, Madhani HD
• Abstract 2289 Understanding the dynamic design of the human spliceosome.
  Journal of Biological Chemistry 2024 Hiten Madhani
• Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles.
  Molecular cell 2023 Beusch I, Rao B, Studer MK, Luhovska T, Šukyte V, Lei S, Oses-Prieto J, SeGraves E, Burlingame A, Jonas S, Madhani HD
• Christine Guthrie (1945–2022).
  Cell 2022 David A. Brow, Hiten D. Madhani
• Coupling of spliceosome complexity to intron diversity.
  Current biology : CB 2021 Sales-Lee J, Perry DS, Bowser BA, Diedrich JK, Rao B, Beusch I, Yates JR, Roy SW, Madhani HD
• Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery.
  Journal of medicinal chemistry 2021 Kryštufek R, Šácha P, Starková J, Brynda J, Hradilek M, Tloušt'ová E, Grzymska J, Rut W, Boucher MJ, Drag M, Majer P, Hájek M, Rezácová P, Madhani HD, Craik CS, Konvalinka J
• Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance.
  Biology open 2018 Mavor D, Barlow KA, Asarnow D, Birman Y, Britain D, Chen W, Green EM, Kenner LR, Mensa B, Morinishi LS, Nelson CA, Poss EM, Suresh P, Tian R, Arhar T, Ary BE, Bauer DP, Bergman ID, Brunetti RM, Chio …
• Genome-wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans.
  Molecular microbiology 2018 Garcia-Santamarina S, Festa RA, Smith AD, Yu CH, Probst C, Ding C, Homer CM, Yin J, Noonan JP, Madhani H, Perfect JR, Thiele DJ
• Total RNA Isolation and Quantification of Specific RNAs in Fission Yeast.
  Methods in molecular biology (Clifton, N.J.) 2018 Roth R, Madhani HD, Garcia JF
• Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence.
  PLoS pathogens 2016 Clarke SC, Dumesic PA, Homer CM, O'Donoghue AJ, La Greca F, Pallova L, Majer P, Madhani HD, Craik CS
• Sensitive and Quantitative Three-Color Protein Imaging in Fission Yeast Using Spectrally Diverse, Recoded Fluorescent Proteins with Experimentally-Characterized In Vivo Maturation Kinetics.
  PloS one 2016 Al-Sady B, Greenstein RA, El-Samad HJ, Braun S, Madhani HD
• Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast.
  Nucleic acids research 2016 Inada M, Nichols RJ, Parsa JY, Homer CM, Benn RA, Hoxie RS, Madhani HD, Shuman S, Schwer B, Pleiss JA
• Noncanoncial signal recognition particle RNAs in a major eukaryotic phylum revealed by purification of SRP from the human pathogen Cryptococcus neoformans.
  Nucleic acids research 2015 Dumesic PA, Rosenblad MA, Samuelsson T, Nguyen T, Moresco JJ, Yates JR, Madhani HD
• Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes.
  Nature communications 2015 Desjardins CA, Sanscrainte ND, Goldberg JM, Heiman D, Young S, Zeng Q, Madhani HD, Becnel JJ, Cuomo CA
• Intrinsic Toxicity of Unchecked Heterochromatin Spread Is Suppressed by Redundant Chromatin Boundary Functions in Schizosacchromyces pombe.
  G3 (Bethesda, Md.) 2015 Garcia JF, Al-Sady B, Madhani HD
• Product binding enforces the genomic specificity of a yeast polycomb repressive complex.
  Cell 2014 Dumesic PA, Homer CM, Moresco JJ, Pack LR, Shanle EK, Coyle SM, Strahl BD, Fujimori DG, Yates JR, Madhani HD
• Unraveling the biology of a fungal meningitis pathogen using chemical genetics.
  Cell 2014 Brown JCS, Nelson J, VanderSluis B, Deshpande R, Butts A, Kagan S, Polacheck I, Krysan DJ, Myers CL, Madhani HD
• Functional profiling of human fungal pathogen genomes.
  Cold Spring Harbor perspectives in medicine 2014 Goranov AI, Madhani HD
• Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo.
  mBio 2014 Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, DiDone L, Tabroff J, Childers WE, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ
• Using a Transcriptional Network to Approach the Mechanism of Fungal Meningitis.
  Biophysical Journal 2014 Christina M. Homer, Alexi Goranov, Dan Santos, Ippolito Caradonna, Sarah Petnic, Hiten D. Madhani
• snRNA catalysts in the spliceosome's ancient core.
  Cell 2013 Madhani HD
• Recognizing the enemy within: licensing RNA-guided genome defense.
  Trends in biochemical sciences 2013 Dumesic PA, Madhani HD
• The frustrated gene: origins of eukaryotic gene expression.
  Cell 2013 Madhani HD
• The spliceosome as a transposon sensor.
  RNA biology 2013 Dumesic PA, Madhani HD
• A conserved ncRNA-binding protein recruits silencing factors to heterochromatin through an RNAi-independent mechanism.
  Genes & development 2013 Marina DB, Shankar S, Natarajan P, Finn KJ, Madhani HD
• Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread.
  Molecular cell 2013 Al-Sady B, Madhani HD, Narlikar GJ
• Abstract IA23: Functional and structural studies of HP1 heterochromatin.
  DNA Methylation 2013 Daniele Canzio, Moafu Liang, Nariman Naber, Adam Larson, Diana Marina, Jennifer Garcia, Hiten Madhani, Roger Cooke, Peter Schuck, Yifan Cheng, Geeta J. Narlikar
• A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly.
  Nature 2013 Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ
• Stalled spliceosomes are a signal for RNAi-mediated genome defense.
  Cell 2013 Dumesic PA, Natarajan P, Chen C, Drinnenberg IA, Schiller BJ, Thompson J, Moresco JJ, Yates JR, Bartel DP, Madhani HD
• Approaching the functional annotation of fungal virulence factors using cross-species genetic interaction profiling.
  PLoS genetics 2012 Brown JC, Madhani HD
• Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin.
  EMBO Reports 2012 Sigurd Braun, Hiten D Madhani
• Timing of transcriptional quiescence during gametogenesis is controlled by global histone H3K4 demethylation.
  Developmental cell 2012 Xu M, Soloveychik M, Ranger M, Schertzberg M, Shah Z, Raisner R, Venkatasubrahmanyan S, Tsui K, Gebbia M, Hughes T, van Bakel H, Nislow C, Madhani HD, Meneghini MD
• Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin.
  EMBO reports 2012 Braun S, Madhani HD
• Ers1 links HP1 to RNAi.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Rougemaille M, Braun S, Coyle S, Dumesic PA, Garcia JF, Isaac RS, Libri D, Narlikar GJ, Madhani HD
• Quorum sensing in fungi: Q&A.
  PLoS pathogens 2011 Madhani HD
• Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe.
  Molecular and cellular biology 2011 Kiely CM, Marguerat S, Garcia JF, Madhani HD, Bähler J, Winston F
• Can a systems perspective help us appreciate the biological meaning of small effects?
  Developmental cell 2011 El-Samad H, Madhani HD
• Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Charles GM, Chen C, Shih SC, Collins SR, Beltrao P, Zhang X, Sharma T, Tan S, Burlingame AL, Krogan NJ, Madhani HD, Narlikar GJ
• A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans.
  Cell host & microbe 2011 Chun CD, Brown JCS, Madhani HD
• Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly.
  Molecular cell 2011 Canzio D, Chang EY, Shankar S, Kuchenbecker KM, Simon MD, Madhani HD, Narlikar GJ, Al-Sady B
• The Cul4-Ddb1(Cdt)² ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin.
  Cell 2011 Braun S, Garcia JF, Rowley M, Rougemaille M, Shankar S, Madhani HD
• Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway.
  Nature cell biology 2010 McCullagh E, Seshan A, El-Samad H, Madhani HD
• Ctr2 links copper homeostasis to polysaccharide capsule formation and phagocytosis inhibition in the human fungal pathogen Cryptococcus neoformans.
  PloS one 2010 Chun CD, Madhani HD
• Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions.
  Genes & development 2010 Garcia JF, Dumesic PA, Hartley PD, El-Samad H, Madhani HD
• Applying genetics and molecular biology to the study of the human pathogen Cryptococcus neoformans.
  Methods in enzymology 2010 Chun CD, Madhani HD
• Multisite phosphorylation of the Saccharomyces cerevisiae filamentous growth regulator Tec1 is required for its recognition by the E3 ubiquitin ligase adaptor Cdc4 and its subsequent destruction in vivo.
  Eukaryotic cell 2009 Bao MZ, Shock TR, Madhani HD
• Nonredundant requirement for multiple histone modifications for the early anaphase release of the mitotic exit regulator Cdc14 from nucleolar chromatin.
  PLoS genetics 2009 Hwang WW, Madhani HD
• “Pearls”: A New Type of Open-Access Educational Resource.
  PLoS Pathogens 2009 Hiten D. Madhani, Kasturi Haldar, Grant McFadden
• Mechanisms that specify promoter nucleosome location and identity.
  Cell 2009 Hartley PD, Madhani HD
• Hog1 mitogen-activated protein kinase (MAPK) interrupts signal transduction between the Kss1 MAPK and the Tec1 transcription factor to maintain pathway specificity.
  Eukaryotic cell 2009 Shock TR, Thompson J, Yates JR, Madhani HD
• Epigenomics: a roadmap, but to where?
  Science (New York, N.Y.) 2008 Madhani HD, Francis NJ, Kingston RE, Kornberg RD, Moazed D, Narlikar GJ, Panning B, Struhl K
• Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans.
  Cell 2008 Liu OW, Chun CD, Chow ED, Chen C, Madhani HD, Noble SM
• Genomewide screen for negative regulators of sirtuin activity in Saccharomyces cerevisiae reveals 40 loci and links to metabolism.
  Genetics 2008 Raisner RM, Madhani HD
• Ers1, a rapidly diverging protein essential for RNA interference-dependent heterochromatic silencing in Schizosaccharomyces pombe.
  The Journal of biological chemistry 2008 Rougemaille M, Shankar S, Braun S, Rowley M, Madhani HD
• A comprehensive strategy enabling high-resolution functional analysis of the yeast genome.
  Nature methods 2008 Breslow DK, Cameron DM, Collins SR, Schuldiner M, Stewart-Ornstein J, Newman HW, Braun S, Madhani HD, Krogan NJ, Weissman JS
• Histone Variant H2A.Z Marks the 5' Ends of Both Active and Inactive Genes in Euchromatin.
  Cell 2008 Ryan M. Raisner, Paul D. Hartley, Marc D. Meneghini, Marie Z. Bao, Chih Long Liu, Stuart L. Schreiber, Oliver J. Rando, Hiten D. Madhani
• Genome-wide, as opposed to local, antisilencing is mediated redundantly by the euchromatic factors Set1 and H2A.Z.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Venkatasubrahmanyam S, Hwang WW, Meneghini MD, Tong AH, Madhani HD
• Exploration of whole-genome responses of the human AIDS-associated yeast pathogen Cryptococcus neoformans var grubii: nitric oxide stress and body temperature.
  Current genetics 2007 Chow ED, Liu OW, O'Brien S, Madhani HD
• Optimizing TiO2-based phosphopeptide enrichment for automated multidimensional liquid chromatography coupled to tandem mass spectrometry.
  Analytical chemistry 2007 Cantin GT, Shock TR, Park SK, Madhani HD, Yates JR
• Parallel beta-helix proteins required for accurate capsule polysaccharide synthesis and virulence in the yeast Cryptococcus neoformans.
  Eukaryotic cell 2007 Liu OW, Kelly MJ, Chow ED, Madhani HD
• A link between virulence and homeostatic responses to hypoxia during infection by the human fungal pathogen Cryptococcus neoformans.
  PLoS pathogens 2007 Chun CD, Liu OW, Madhani HD
• Histone H3 lysine 36 methylation antagonizes silencing in Saccharomyces cerevisiae independently of the Rpd3S histone deacetylase complex.
  Genetics 2006 Tompa R, Madhani HD
• Functional analysis of protein kinase networks in living cells: beyond "knock-outs" and "knock-downs".
  Methods (San Diego, Calif.) 2006 Madhani HD
• Selective kinase inhibition by exploiting differential pathway sensitivity.
  Chemistry & biology 2006 Kung C, Kenski DM, Krukenberg K, Madhani HD, Shokat KM
• H2A.Z marks the 5' ends of both active and inactive genes in euchromatin.
  The FASEB Journal 2006 Hiten Madhani
• Patterning chromatin: form and function for H2A.Z variant nucleosomes.
  Current opinion in genetics & development 2006 Raisner RM, Madhani HD
• Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5.
  Current genetics 2006 Schwartz MA, Madhani HD
• Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin.
  Cell 2005 Raisner RM, Hartley PD, Meneghini MD, Bao MZ, Liu CL, Schreiber SL, Rando OJ, Madhani HD
• Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Kung C, Kenski DM, Dickerson SH, Howson RW, Kuyper LF, Madhani HD, Shokat KM
• Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast.
  Cell 2004 Bao MZ, Schwartz MA, Cantin GT, Yates JR, Madhani HD
• A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin.
  PLoS biology 2004 Kobor MS, Venkatasubrahmanyam S, Meneghini MD, Gin JW, Jennings JL, Link AJ, Madhani HD, Rine J
• Principles of MAP kinase signaling specificity in Saccharomyces cerevisiae.
  Annual review of genetics 2004 Schwartz MA, Madhani HD
• Conserved histone variant H2A.Z protects euchromatin from the ectopic spread of silent heterochromatin.
  Cell 2003 Meneghini MD, Wu M, Madhani HD
• A conserved RING finger protein required for histone H2B monoubiquitination and cell size control.
  Molecular cell 2003 Hwang WW, Venkatasubrahmanyam S, Ianculescu AG, Tong A, Boone C, Madhani HD
• Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex.
  Nature cell biology 2002 Brugnera E, Haney L, Grimsley C, Lu M, Walk SF, Tosello-Trampont AC, Macara IG, Madhani H, Fink GR, Ravichandran KS
• Accounting for specificity in receptor tyrosine kinase signaling.
  Cell 2001 Madhani HD
• Interplay of intrinsic and extrinsic signals in yeast differentiation.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Madhani HD
• Effectors of a developmental mitogen-activated protein kinase cascade revealed by expression signatures of signaling mutants.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Madhani HD, Galitski T, Lander ES, Fink GR
• Fungi take shape Fungal Morphogenesis, by David Moore.
  Trends in Cell Biology 1999 Laura Robertson, Hiten Madhani
• MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene.
  The EMBO journal 1999 Rupp S, Summers E, Lo HJ, Madhani H, Fink G
• The control of filamentous differentiation and virulence in fungi.
  Trends in cell biology 1998 Madhani HD, Fink GR
• The riddle of MAP kinase signaling specificity.
  Trends in genetics : TIG 1998 Madhani HD, Fink GR
• MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation.
  Cell 1997 Madhani HD, Styles CA, Fink GR
• Genetic abnormalities in Friedreich's ataxia.
  The New England journal of medicine 1997 Madhani HD
• Combinatorial control required for the specificity of yeast MAPK signaling.
  Science (New York, N.Y.) 1997 Madhani HD, Fink GR
• Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase.
  Genetics 1994 Madhani HD, Guthrie C
• Randomization-selection analysis of snRNAs in vivo: evidence for a tertiary interaction in the spliceosome.
  Genes & development 1994 Madhani HD, Guthrie C
• Dynamic RNA-RNA interactions in the spliceosome.
  Annual review of genetics 1994 Madhani HD, Guthrie C
• A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome.
  Cell 1992 Madhani HD, Guthrie C
• Multiple roles for U6 snRNA in the splicing pathway.
  Genes & development 1990 Madhani HD, Bordonné R, Guthrie C
• Greetings from the RNA world. RNA Processing sponsored by the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA, May 16-20, 1990.
  The New biologist 1990 Guthrie C, Madhani HD
• Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region.
  Cell 1988 Jacks T, Madhani HD, Masiarz FR, Varmus HE
• Differential DNA repair in transcriptionally active and inactive proto-oncogenes: c-abl and c-mos.
  Cell 1986 Madhani HD, Bohr VA, Hanawalt PC
• alpha DNA in African green monkey cells is organized into extremely long tandem arrays.
  The Journal of biological chemistry 1986 Madhani HD, Leadon SA, Smith CA, Hanawalt PC