Hiroyuki Yoda, PhD
Specialist
Neurology
School of Medicine

Websites

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• Linkedin (linkedin.com)
• Weiss Lab (waweisslab.ucsf.edu)

Publications (18)

Top publication keywords:
ImidazolesAntineoplastic Agents, AlkylatingHuman Embryonic Stem CellsCore Binding Factor Alpha 1 SubunitPyrrolesNeuroblastomaDrug Delivery SystemsN-Myc Proto-Oncogene ProteinGene Expression Regulation, NeoplasticNylonsAntineoplastic AgentsReceptor-Like Protein Tyrosine Phosphatases, Class 2Gene AmplificationAC133 AntigenGenes, p53

• ALK upregulates POSTN and WNT signaling to drive neuroblastoma.
  Cell reports 2024 Huang M, Fang W, Farrel A, Li L, Chronopoulos A, Nasholm N, Cheng B, Zheng T, Yoda H, Barata MJ, Porras T, Miller ML, Zhen Q, Ghiglieri L, McHenry L, Wang L, Asgharzadeh S, Park J, Gustafson WC, …
• Use of DNA-alkylating pyrrole-imidazole polyamides for anti-cancer drug sensitivity screening in pancreatic ductal adenocarcinoma.
  Cancer medicine 2022 Tsujimoto A, Matsuo N, Lai X, Inoue T, Yoda H, Lin J, Shinozaki Y, Watanabe T, Koshikawa N, Takatori A, Nagase H
• CD55, a potential immunotherapeutic target for MYCN-amplified neuroblastoma.
  Neuro-oncology 2022 Yoda H, Weiss WA
• Targeting anaplastic lymphoma kinase (ALK) gene alterations in neuroblastoma by using alkylating pyrrole-imidazole polyamides.
  PloS one 2021 Ota Y, Yoda H, Inoue T, Watanabe T, Shinozaki Y, Takatori A, Nagase H
• CD133 prevents colon cancer cell death induced by serum deprivation through activation of Akt-mediated protein synthesis and inhibition of apoptosis.
  FEBS open bio 2021 Mori Y, Takeuchi A, Miyagawa K, Yoda H, Soda H, Nabeya Y, Watanabe N, Ozaki T, Shimozato O

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• An expanded universe of cancer targets.
  Cell 2021 Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, …
• Targeting the mutant PIK3CA gene by DNA-alkylating pyrrole-imidazole polyamide in cervical cancer.
  Cancer science 2021 Krishnamurthy S, Yoda H, Hiraoka K, Inoue T, Lin J, Shinozaki Y, Watanabe T, Koshikawa N, Takatori A, Nagase H
• Vitamin K3 derivative induces apoptotic cell death in neuroblastoma via downregulation of MYCN expression.
  Biochemistry and biophysics reports 2019 Yoda H, Nakayama T, Miura M, Toriyama M, Motohashi S, Suzuki T
• PTPRK suppresses progression and chemo-resistance of colon cancer cells via direct inhibition of pro-oncogenic CD133.
  FEBS open bio 2019 Matsushita M, Mori Y, Uchiumi K, Ogata T, Nakamura M, Yoda H, Soda H, Takiguchi N, Nabeya Y, Shimozato O, Ozaki T
• Estimating genome-wide off-target effects for pyrrole-imidazole polyamide binding by a pathway-based expression profiling approach.
  PloS one 2019 Lin J, Krishnamurthy S, Yoda H, Shinozaki Y, Watanabe T, Koshikawa N, Takatori A, Horton P, Nagase H
• Direct Targeting of MYCN Gene Amplification by Site-Specific DNA Alkylation in Neuroblastoma.
  Cancer research 2018 Yoda H, Inoue T, Shinozaki Y, Lin J, Watanabe T, Koshikawa N, Takatori A, Nagase H
• Depletion of runt-related transcription factor 2 (RUNX2) enhances SAHA sensitivity of p53-mutated pancreatic cancer cells through the regulation of mutant p53 and TAp63.
  PloS one 2017 Ogata T, Nakamura M, Sang M, Yoda H, Hiraoka K, Yin D, Sang M, Shimozato O, Ozaki T
• Depletion of pro-oncogenic RUNX2 enhances gemcitabine (GEM) sensitivity of p53-mutated pancreatic cancer Panc-1 cells through the induction of pro-apoptotic TAp63.
  Oncotarget 2016 Ozaki T, Nakamura M, Ogata T, Sang M, Yoda H, Hiraoka K, Sang M, Shimozato O
• Improvement of gemcitabine sensitivity of p53-mutated pancreatic cancer MiaPaCa-2 cells by RUNX2 depletion-mediated augmentation of TAp73-dependent cell death.
  Oncogenesis 2016 Nakamura M, Sugimoto H, Ogata T, Hiraoka K, Yoda H, Sang M, Sang M, Zhu Y, Yu M, Shimozato O, Ozaki T
• Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death.
  Cell death discovery 2015 Sugimoto H, Nakamura M, Yoda H, Hiraoka K, Shinohara K, Sang M, Fujiwara K, Shimozato O, Nagase H, Ozaki T
• Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate.
  Nature communications 2015 Hiraoka K, Inoue T, Taylor RD, Watanabe T, Koshikawa N, Yoda H, Shinohara K, Takatori A, Sugimoto H, Maru Y, Denda T, Fujiwara K, Balmain A, Ozaki T, Bando T, Sugiyama H, Nagase H
• Runt-related transcription factor 2 attenuates the transcriptional activity as well as DNA damage-mediated induction of pro-apoptotic TAp73 to regulate chemosensitivity.
  The FEBS journal 2014 Ozaki T, Sugimoto H, Nakamura M, Hiraoka K, Yoda H, Sang M, Fujiwara K, Nagase H
• Vitamin K3 analogs induce selective tumor cytotoxicity in neuroblastoma.
  Biological & pharmaceutical bulletin 2012 Kitano T, Yoda H, Tabata K, Miura M, Toriyama M, Motohashi S, Suzuki T