Hiroyu Hatano, MD, MHS
Assistant Adjunct Professor
Cio
Chancellor/EVC/FAS

Publications (47)

Top publication keywords:
Antiretroviral Therapy, Highly ActiveViral LoadHIVPyrrolidinonesDNA, ViralHIV-1ViremiaAnti-Retroviral AgentsHIV Integrase InhibitorsHIV Long Terminal RepeatCD4-Positive T-LymphocytesHIV InfectionsDrug Resistance, ViralRNA, ViralFibrin Fibrinogen Degradation Products

• Rapid biphasic decay of intact and defective HIV DNA reservoir during acute treated HIV disease.
  Nature communications 2024 Barbehenn A, Shi L, Shao J, Hoh R, Hartig HM, Pae V, Sarvadhavabhatla S, Donaire S, Sheikhzadeh C, Milush J, Laird GM, Mathias M, Ritter K, Peluso MJ, Martin J, Hecht F, Pilcher C, Cohen SE, …
• Rapid Biphasic Decay of Intact and Defective HIV DNA Reservoir During Acute Treated HIV Disease.
  medRxiv : the preprint server for health sciences 2024 Barbehenn A, Shi L, Shao J, Hoh R, Hartig HM, Pae V, Sarvadhavabhatla S, Donaire S, Sheikhzadeh C, Milush J, Laird GM, Mathias M, Ritter K, Peluso MJ, Martin J, Hecht F, Pilcher C, Cohen SE, …
• An Improved Backoff Scheme and Its Performance Analysis for Full Duplex MAC Protocols in VLC Networks.
  Sensors (Basel, Switzerland) 2021 Sawa Y, Sanada K, Hatano H, Mori K
• Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates With Immune Response.
  The Journal of infectious diseases 2021 Wu G, Zuck P, Goh SL, Milush JM, Vohra P, Wong JK, Somsouk M, Yukl SA, Shacklett BL, Chomont N, Haase AT, Hatano H, Schacker TW, Deeks SG, Hazuda DJ, Hunt PW, Howell BJ
• Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay.
  Journal of acquired immune deficiency syndromes (1999) 2020 Lee SA, Telwatte S, Hatano H, Kashuba ADM, Cottrell ML, Hoh R, Liegler TJ, Stephenson S, Somsouk M, Hunt PW, Deeks SG, Yukl S, Savic RM

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• Impact of Antiretroviral Therapy Duration on HIV-1 Infection of T Cells within Anatomic Sites.
  Journal of virology 2020 Lee E, von Stockenstrom S, Morcilla V, Odevall L, Hiener B, Shao W, Hartogensis W, Bacchetti P, Milush J, Liegler T, Sinclair E, Hatano H, Hoh R, Somsouk M, Hunt P, Boritz E, Douek D, Fromentin R, …
• Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency.
  PLoS pathogens 2018 Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA
• Anti-Human Immunodeficiency Virus Antibodies in the Cerebrospinal Fluid: Evidence of Early Treatment Impact on Central Nervous System Reservoir?
  The Journal of infectious diseases 2018 Burbelo PD, Price RW, Hagberg L, Hatano H, Spudich S, Deeks SG, Gisslén M
• HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.
  PLoS medicine 2017 Henrich TJ, Hatano H, Bacon O, Hogan LE, Rutishauser R, Hill A, Kearney MF, Anderson EM, Buchbinder SP, Cohen SE, Abdel-Mohsen M, Pohlmeyer CW, Fromentin R, Hoh R, Liu AY, McCune JM, Spindler J, …
• A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals.
  Pathogens & immunity 2017 Cockerham LR, Yukl SA, Harvill K, Somsouk M, Joshi SK, Sinclair E, Liegler T, Hoh R, Lyons S, Hunt PW, Rupert A, Sereti I, Morcock DR, Rhodes A, Emson C, Hellerstein MK, Estes JD, Lewin S, Deeks SG, …
• Corrigendum: Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection.
  Nature 2017 Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Muñoz-Arias I, Greene WC
• The Effect of Same-Day Observed Initiation of Antiretroviral Therapy on HIV Viral Load and Treatment Outcomes in a US Public Health Setting.
  Journal of acquired immune deficiency syndromes (1999) 2017 Pilcher CD, Ospina-Norvell C, Dasgupta A, Jones D, Hartogensis W, Torres S, Calderon F, Demicco E, Geng E, Gandhi M, Havlir DV, Hatano H
• Immunologic profiles distinguish aviremic HIV-infected adults.
  AIDS (London, England) 2016 Ramirez CM, Sinclair E, Epling L, Lee SA, Jain V, Hsue PY, Hatano H, Conn D, Hecht FM, Martin JN, McCune JM, Deeks SG, Hunt PW
• Post-Treatment Controllers: Role in HIV "Cure" Research.
  Current HIV/AIDS reports 2016 Cockerham LR, Hatano H, Deeks SG
• Clinical outcomes and antiretroviral therapy in 'elite' controllers: a review of the literature.
  Journal of virus eradication 2015 Crowell TA, Hatano H
• Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy.
  The Journal of infectious diseases 2015 von Stockenstrom S, Odevall L, Lee E, Sinclair E, Bacchetti P, Killian M, Epling L, Shao W, Hoh R, Ho T, Faria NR, Lemey P, Albert J, Hunt P, Loeb L, Pilcher C, Poole L, Hatano H, Somsouk M, Douek D, …
• Elite control of HIV: is this the right model for a functional cure?
  Trends in microbiology 2014 Cockerham LR, Hatano H
• Lymphoid fibrosis occurs in long-term nonprogressors and persists with antiretroviral therapy but may be reversible with curative interventions.
  The Journal of infectious diseases 2014 Sanchez JL, Hunt PW, Reilly CS, Hatano H, Beilman GJ, Khoruts A, Jasurda JS, Somsouk M, Thorkelson A, Russ S, Anderson J, Deeks SG, Schacker TW
• Programmed death-1 expression on CD4⁺ and CD8⁺ T cells in treated and untreated HIV disease.
  AIDS (London, England) 2014 Cockerham LR, Jain V, Sinclair E, Glidden DV, Hartogenesis W, Hatano H, Hunt PW, Martin JN, Pilcher CD, Sekaly R, McCune JM, Hecht FM, Deeks SG
• HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.
  PLoS pathogens 2014 Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, …
• Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging.
  PloS one 2014 Lee SA, Sinclair E, Hatano H, Hsue PY, Epling L, Hecht FM, Bangsberg DR, Martin JN, McCune JM, Deeks SG, Hunt PW
• A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells.
  AIDS (London, England) 2014 Yukl SA, Sinclair E, Somsouk M, Hunt PW, Epling L, Killian M, Girling V, Li P, Havlir DV, Deeks SG, Wong JK, Hatano H
• Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection.
  Nature 2014 Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Muñoz-Arias I, Greene WC
• Reply to Karch et al.
  The Journal of infectious diseases 2014 Hatano H, Bacchetti P, Hsue PY, Deeks SG
• Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers.
  PLoS pathogens 2013 Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, …
• Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers.
  AIDS (London, England) 2013 Hatano H, Somsouk M, Sinclair E, Harvill K, Gilman L, Cohen M, Hoh R, Hunt PW, Martin JN, Wong JK, Deeks SG, Yukl SA
• Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: a randomized, placebo-controlled trial.
  The Journal of infectious diseases 2013 Hatano H, Strain MC, Scherzer R, Bacchetti P, Wentworth D, Hoh R, Martin JN, McCune JM, Neaton JD, Tracy RP, Hsue PY, Richman DD, Deeks SG
• Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size.
  The Journal of infectious diseases 2013 Jain V, Hartogensis W, Bacchetti P, Hunt PW, Hatano H, Sinclair E, Epling L, Lee TH, Busch MP, McCune JM, Pilcher CD, Hecht FM, Deeks SG
• Immune activation and HIV persistence: considerations for novel therapeutic interventions.
  Current opinion in HIV and AIDS 2013 Hatano H
• A randomized controlled trial assessing the effects of raltegravir intensification on endothelial function in treated HIV infection.
  Journal of acquired immune deficiency syndromes (1999) 2012 Hatano H, Scherzer R, Wu Y, Harvill K, Maka K, Hoh R, Sinclair E, Palmer S, Martin JN, Busch MP, Deeks SG, Hsue PY
• Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells.
  The Journal of infectious diseases 2012 Hatano H, Jain V, Hunt PW, Lee TH, Sinclair E, Do TD, Hoh R, Martin JN, McCune JM, Hecht F, Busch MP, Deeks SG
• Prolonged and substantial discordance in prevalence of raltegravir-resistant HIV-1 in plasma versus PBMC samples revealed by 454 "deep" sequencing.
  PloS one 2012 Lee GQ, Swenson LC, Poon AF, Martin JN, Hatano H, Deeks SG, Harrigan PR
• Prevalence and significance of HIV-1 drug resistance mutations among patients on antiretroviral therapy with detectable low-level viremia.
  Antimicrobial agents and chemotherapy 2012 Li JZ, Gallien S, Do TD, Martin JN, Deeks S, Kuritzkes DR, Hatano H
• A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response.
  The Journal of infectious diseases 2011 Hatano H, Hayes TL, Dahl V, Sinclair E, Lee TH, Hoh R, Lampiris H, Hunt PW, Palmer S, McCune JM, Martin JN, Busch MP, Shacklett BL, Deeks SG
• A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers.
  PloS one 2011 Hunt PW, Landay AL, Sinclair E, Martinson JA, Hatano H, Emu B, Norris PJ, Busch MP, Martin JN, Brooks C, McCune JM, Deeks SG
• HIV-specific CD4+ T cells may contribute to viral persistence in HIV controllers.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011 Hunt PW, Hatano H, Sinclair E, Lee TH, Busch MP, Martin JN, McCune JM, Deeks SG
• Evidence of persistent low-level viremia in long-term HAART-suppressed, HIV-infected individuals.
  AIDS (London, England) 2010 Hatano H, Delwart EL, Norris PJ, Lee TH, Neilands TB, Kelley CF, Hunt PW, Hoh R, Linnen JM, Martin JN, Busch MP, Deeks SG
• Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypes.
  Journal of virological methods 2010 Li P, Ruel T, Fujimoto K, Hatano H, Yukl S, Eller LA, Liegler T, Kamya M, Gassasira A, Dorsey G, Rosenthal PJ, Havlir DV, Wong JK
• Evolution of integrase resistance during failure of integrase inhibitor-based antiretroviral therapy.
  Journal of acquired immune deficiency syndromes (1999) 2010 Hatano H, Lampiris H, Fransen S, Gupta S, Huang W, Hoh R, Martin JN, Lalezari J, Bangsberg D, Petropoulos C, Deeks SG
• Association of abacavir and impaired endothelial function in treated and suppressed HIV-infected patients.
  AIDS (London, England) 2009 Hsue PY, Hunt PW, Wu Y, Schnell A, Ho JE, Hatano H, Xie Y, Martin JN, Ganz P, Deeks SG
• Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy.
  Journal of virology 2008 Hatano H, Delwart EL, Norris PJ, Lee TH, Dunn-Williams J, Hunt PW, Hoh R, Stramer SL, Linnen JM, McCune JM, Martin JN, Busch MP, Deeks SG
• HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control.
  Journal of virology 2008 Emu B, Sinclair E, Hatano H, Ferre A, Shacklett B, Martin JN, McCune JM, Deeks SG
• Virologic characterization of HIV type 1 with a codon 70 deletion in reverse transcriptase.
  Journal of acquired immune deficiency syndromes (1999) 2007 Hu Z, Hatano H, Hammond SP, Smith D, Wild M, Gupta S, Whitcomb J, Kalayjian RC, Gripshover B, Kuritzkes DR
• Drug resistant HIV.
  BMJ (Clinical research ed.) 2007 Hatano H, Deeks SG
• Vibrational relaxation of O2(X3 Sigma g-, v = 9-13) by collisions with O2.
  Physical chemistry chemical physics : PCCP 2007 Watanabe S, Usuda SY, Fujii H, Hatano H, Tokue I, Yamasaki K
• Rate of viral evolution and risk of losing future drug options in heavily pretreated, HIV-infected patients who continue to receive a stable, partially suppressive treatment regimen.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006 Hatano H, Hunt P, Weidler J, Coakley E, Hoh R, Liegler T, Martin JN, Deeks SG
• Fitness comparison of thymidine analog resistance pathways in human immunodeficiency virus type 1.
  Journal of virology 2006 Hu Z, Giguel F, Hatano H, Reid P, Lu J, Kuritzkes DR