Hilde Schjerven, PhD
Associate Professor
Laboratory Medicine
School of Medicine

Member, UCSF Bakar ImmunoX Member and Education and Training Liaison, UCSF Helen Diller Family Comprehensive Cancer Center (Cancer Immunology & Immunotherapy Program) Member, UCSF Precision Medicine in Rheumatology (PREMIER) Center Member, BMS and DSCB Graduate programs

Awards

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• Pilot for Established Investigators, UCSF Research Evaluation and Allocation Committee (REAC), 2023-2024
• Pilot for Junior Investigators, UCSF Research Evaluation and Allocation Committee (REAC), 2021-2022
• Pilot for Junior Investigators, Academic Senate, UCSF, 2020-2021
• Research Award, Oncology Research Fund, 2018-2020

Websites

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• DSCB Graduate Program Faculty Page (dscb.ucsf.edu)
• BMS Graduate Program Faculty Page (bms.ucsf.edu)
• Schjerven Lab - UCSF (schjervenlab.ucsf.edu)
• Hilde Schjerven - HDFCCC (cancer.ucsf.edu)

Grants and Projects

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• Regulation of medullary thymic epithelial cells and thymic central tolerance by Ikaros, NIH, 2022-2027
• Understanding Ikaros molecular functions for targeted therapies of pre-B ALL, NIH, 2018-2023
• Role of the transcription factor Ikaros in development of autoimmune disease, NIH, 2018-2023
• Mechanism of Ikaros Tumor Suppression in progenitor B cell leukemia, NIH, 2016-2018

Publications (57)

Top publication keywords:
Precursor Cell Lymphoblastic Leukemia-LymphomaReceptors, Polymeric ImmunoglobulinIkaros Transcription FactorUp-RegulationPrecursor B-Cell Lymphoblastic Leukemia-LymphomaFusion Proteins, bcr-ablLymphopoiesisIntronsLeukemiaGene Expression Regulation, LeukemicTranscription FactorsInterleukin-4B-LymphocytesTumor Suppressor ProteinsReceptors, Aryl Hydrocarbon

• Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL.
  The Journal of experimental medicine 2017 Schjerven H, Ayongaba EF, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, Boyd JR, Eggesbø LM, Lindeman I, Heath JL, Park E, Witte ON, Smale ST, Frietze S, Müschen M
• Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros.
  Nature immunology 2013 Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST
• Azaindole 1, a selective Rock1/2 kinase inhibitor, induces G2/M arrest and cell death in B-cell acute lymphoblastic leukemia (B-ALL).
  Leukemia & lymphoma 2025 Podgorica M, Drivet E, Vestbøstad J, Kvam AK, Wik HS, Munthe L, Schjerven H
• Identification of High-Efficiency ß-Catenin Protein Degradation As Critical Vulnerability in B-Cell Malignancies.
  Blood 2024 Kadriye Nehir Cosgun, Mark E Robinson, Nikol Agadzhanian, Zhangliang Cheng, Salim Oulghazi, Philipp Berning, David Fonseca-Arce, Kohei Kume, Jake Fontaine, Lai N Chan, Jaewoong Lee, Fang Yu, Zhijian …
• Transcriptome analysis of primary adult B-cell lineage acute lymphoblastic leukemia identifies pathogenic variants and gene fusions, and predicts subtypes for in depth molecular diagnosis.
  European journal of haematology 2024 Podgorica M, Drivet E, Viken JK, Richman A, Vestbøstad J, Szodoray P, Kvam AK, Wik HS, Tjønnfjord GE, Munthe LA, Frietze S, Schjerven H

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• Repurposing GSK3B Small Molecule Inhibitors for Refractory Lymphoid Malignancies.
  Blood 2023 Kadriye Nehir Cosgun, Mark E Robinson, Salim Oulghazi, Liang Xu, Gang Xiao, Lai N Chan, Jaewoong Lee, Kohei Kume, Etienne Leveille, David Fonseca Arce, Dhruv Khanduja, Niklas Feldhahn, Joo Y. Song, …
• Ikaros is a principal regulator of Aire+ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance.
  Science immunology 2023 Sin JH, Sucharov J, Kashyap S, Wang Y, Proekt I, Liu X, Parent AV, Gupta A, Kastner P, Chan S, Gardner JM, Ntranos V, Miller CN, Anderson MS, Schjerven H, Waterfield MR
• ß-catenin engages IKZF factors to control lymphopoiesis.
  The Journal of Immunology 2023 Kadriye Nehir Cosgun, Huda Jumaa, Mark E. Robinson, Liang Xu, Gang Xiao, David Fonseca Arce, Dhruv Khanduja, Lai N. Chan, Jaewoong Lee, Hilde Schjerven, Julia Jellusova, Markus Müschen
• Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies.
  bioRxiv : the preprint server for biology 2023 Cosgun KN, Jumaa H, Robinson ME, Kistner KM, Xu L, Xiao G, Chan LN, Lee J, Kume K, Leveille E, Fonseca-Arce D, Khanduja D, Ng HL, Feldhahn N, Song J, Chan WC, Chen J, Taketo MM, Kothari S, Davids MS, …
• Ikaros Regulates microRNA Networks in Acute Lymphoblastic Leukemia
  Epigenomes 2022 Kogut S, Paculova H, Rodriguez P, Boyd J, Richman A, Palaria A, *Schjerven H, *Frietze S.
• Ikaros Regulates microRNA Networks in Acute Lymphoblastic Leukemia.
  Epigenomes 2022 Kogut S, Paculova H, Rodriguez P, Boyd J, Richman A, Palaria A, Schjerven H, Frietze S
• ssvQC: an integrated CUT&RUN quality control workflow for histone modifications and transcription factors.
  BMC research notes 2021 Boyd J, Rodriguez P, Schjerven H, Frietze S
• Individual zinc finger domains of Ikaros have specific roles in regulating murine myeloid hematopoietic development.
  The Journal of Immunology 2021 Johanne Vestbostad, Mirjam Podgorica, Matthew Strege, Douglas Pinheiro, Ludvig Munthe, Hilde Schjerven
• Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia
  (Review). 2021 Rodriguez PD, Paculova H, Kogut S, Heath J, Schjerven H, Frietze S.
• Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia.
  International journal of molecular sciences 2021 Rodriguez PD, Paculova H, Kogut S, Heath J, Schjerven H, Frietze S
• Abstract PO-62: Overcoming venetoclax resistance in B-cell malignancies by antagonism of stromal TGF-beta-mediated drug resistance.
  Blood Cancer Discovery 2020 Eugene Park, Jingyu Chen, Andrew Moore, Maurizio Mangolini, Joseph R. Byod, Hilde Schjerven, James C. Williamson, Paul J. Lehner, Michael Leitges, Alexander Egle, Marc Schmidt-Supprian, Seth Frietze, …
• Ikaros regulates gene expression programs required for proper BCR-activation in mature B cells.
  The Journal of Immunology 2020 Princess D Rodriguez, William Howell, Joseph Boyd, Seth Frietze, Hilde Schjerven
• Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance.
  Science translational medicine 2020 Park E, Chen J, Moore A, Mangolini M, Santoro A, Boyd JR, Schjerven H, Ecker V, Buchner M, Williamson JC, Lehner PJ, Gasparoli L, Williams O, Bloehdorn J, Stilgenbauer S, Leitges M, Egle A, Schmidt-…
• Ikaros mutations can bypass the requirement for second co-stimulatory signal and lead to break of B-cell tolerance.
  The Journal of Immunology 2019 Hilde Schjerven, Princess D Rodriguez, William Howell, Johanne Vestbostad, Seth Frietze, Hilde Schjerven
• Ikaros regulates chromatin landscape in mature B cells, and is critical for B cell tolerance.
  The Journal of Immunology 2019 Princess D Rodriguez, William Howell, Eyal Amiel, Seth Frietze, Hilde Schjerven
• Cell circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development.
  The Journal of experimental medicine 2018 Fistonich C, Zehentmeier S, Bednarski JJ, Miao R, Schjerven H, Sleckman BP, Pereira JP
• Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors.
  Nature 2018 Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, …
• Ikaros establishes an epigenetic program required for proper two-signal activation of naive B cells.
  The Journal of Immunology 2018 Princess D. Rodriguez, Hilde Schjerven, Eyal Amiel, Seth Frietze
• Ikaros regulates B-cell tolerance.
  The Journal of Immunology 2018 Hilde Schjerven, Princess Rodriguez, Danielle Hagen, Marit Rasmussen, Etapong F. Ayongaba, Seth Frietze
• Ikaros regulates epigenetic and transcriptional programs in progenitor B cell leukemia.
  The Journal of Immunology 2018 Hilde Schjerven, Etapong F. Ayongaba, Princess Rodriguez, Seth Frietze
• A kindred with mutant IKAROS and autoimmunity.
  The Journal of allergy and clinical immunology 2018 Van Nieuwenhove E, Garcia-Perez JE, Helsen C, Rodriguez PD, van Schouwenburg PA, Dooley J, Schlenner S, van der Burg M, Verhoeyen E, Gijsbers R, Frietze S, Schjerven H, Meyts I, Claessens F, Humblet-…
• The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells.
  Cell reports 2017 Ye J, Qiu J, Bostick JW, Ueda A, Schjerven H, Li S, Jobin C, Chen ZE, Zhou L
• Abstract 93: Transcriptional control of glucocorticoid responses in leukemia.
  Experimental and Molecular Therapeutics 2017 Lai N. Chan, Zhengshan Chen, Gang Xiao, Jae Woong Lee, Kadriye Nehir Cosgun, Huimin Geng, Valeria Cazzaniga, Hilde Schjerven, Ross A. Dickins, Markus Muschen
• Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.
  Nature immunology 2017 Katerndahl CDS, Heltemes-Harris LM, Willette MJL, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KAT, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Müschen M, …
• Metabolic gatekeeper function of B-lymphoid transcription factors.
  Nature 2017 Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, …
• Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway.
  Immunity 2016 Li S, Heller JJ, Bostick JW, Lee A, Schjerven H, Kastner P, Chan S, Chen ZE, Zhou L
• Analysis of Ikaros tumor suppressor function in BCR-ABL1+ pre-B ALL reveals conserved target genes and biological pathways.
  The Journal of Immunology 2016 Hilde Schjerven, Etapong Fonabei Ayongaba, Jami McLaughlin, Donghui Cheng, Linn Margrethe Eggesbø, Ida Lindeman, Eugene Park, Owen N Witte, Stephen T Smale, Seth Frietze, Markus Muschen
• Role of the transcription factor Ikaros in development of autoimmune disease.
  The Journal of Immunology 2016 Hilde Schjerven, Seth Frietze, Si-Han Hai, Michelle Hermiston, Scott Kogan, Markus Muschen
• Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor.
  Genes & development 2015 Arenzana TL, Schjerven H, Smale ST
• Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.
  Blood 2015 Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S
• Ikaros tumor suppressor function in pre-B ALL: potential role of Ikaros target gene Ctnnd1 (IRM10P.621).
  The Journal of Immunology 2015 Hilde Schjerven, Linn Eggesbo, Ida Lindeman, Markus Muschen
• STAT5 antagonism of B cell superenhancer networks initiates progenitor B cell leukemia and predicts patient survival (HEM1P.222).
  The Journal of Immunology 2015 Michael Farrar, Casey Katerndahl, Lynn Heltemes Harris, Mark Willette, christine Henzler, Rendong Yang, Kevin Silverstein, Seth Frietze, Hilde Schjerven, Laura Ramsey, Gregory Hubbard, Markus Muschen,…
• Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia.
  Nature communications 2015 Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M
• Erk and Stat5 Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia.
  Blood 2014 Shojaee Seyedmehdi, Zhengshan Chen, Maike Buchner, Christian Hurtz, Huimin Geng, Hilde Schjerven, Lai N Chan, Phillip Koeffler, Cheryl L. Willman, Stephen Hunger, Sinisa Dovat, Elisabeth Paietta, Wolf…
• PTEN Is Essential for Normal Cytokine Signaling and Oncogenic Transformation of Pre-B Cells.
  Blood 2014 Seyedmehdi Shojaee, Valeria Cazzaniga, Hilde Schjerven, Maike Buchner, Christian Hurtz, Huimin Geng, Andreas Hochhaus, Giovanni Cazzaniga, Ari M Melnick, Steven M. Kornblau, Thomas G Graeber, Markus …
• Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor Ikaros.
  Journal of immunology (Baltimore, Md. : 1950) 2014 Heller JJ, Schjerven H, Li S, Lee A, Qiu J, Chen ZM, Smale ST, Zhou L
• 118 Modulation of Treg and Th17 fate decision by selective ikaros zinc fingers.
  Cytokine 2013 Jennifer Heller, Hilde Schjerven, Ju Qiu, Aileen Lee, Stephen Smale, Liang Zhou
• Selective requirement of Ikaros zinc fingers in Treg and Th17 fate decision. (P1137).
  The Journal of Immunology 2013 Jennifer Heller, Hilde Schjerven, Ju Qiu, Aileen Lee, Stephen Smale, Liang Zhou
• Role of Ikaros in hematopoiesis and tumor suppression: Selective functions of individual zinc fingers within the DNA-binding domain of Ikaros. (42.3).
  The Journal of Immunology 2012 Hilde Schjerven, Seth Frietze, Jami McLaughlin, Donghui Cheng, Peggy Farnham, Owen Witte, Stephen Smale
• Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros.
  Nature immunology 2008 Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H
• Regulation of B cell fate specification and VH gene rearrangements by Ikaros.
  The FASEB Journal 2008 Damien REYNAUD, Karen REDDY, Hilde SCHJERVEN, Chauncey SPOONER, Eric BERTOLINO, Stephen T SMALE, Susan WINANDY, Harinder SINGH
• Regulation of the Mucosal IgA System.
  Mucosal Immune Defense: Immunoglobulin A 2007 Finn-Eirik Johansen, Ranveig Braathen, Else Munthe, Hilde Schjerven, Per Brandtzaeg
• Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Schneeman TA, Bruno ME, Schjerven H, Johansen FE, Chady L, Kaetzel CS
• De novo synthesized RelB mediates TNF-induced up-regulation of the human polymeric Ig receptor.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Schjerven H, Tran TN, Brandtzaeg P, Johansen FE
• Proinflammatory cytokines upregulate expression of calprotectin (L1 protein, MRP-8/MRP-14) in cultured human keratinocytes.
  The British journal of dermatology 2003 Mørk G, Schjerven H, Mangschau L, Søyland E, Brandtzaeg P
• Hepatocyte NF-1 and STAT6 cooperate with additional DNA-binding factors to activate transcription of the human polymeric Ig receptor gene in response to IL-4.
  Journal of immunology (Baltimore, Md. : 1950) 2003 Schjerven H, Brandtzaeg P, Johansen FE
• A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptor.
  Journal of immunology (Baltimore, Md. : 1950) 2001 Schjerven H, Brandtzaeg P, Johansen FE
• Mechanism of IL-4-mediated up-regulation of the polymeric Ig receptor: role of STAT6 in cell type-specific delayed transcriptional response.
  Journal of immunology (Baltimore, Md. : 1950) 2000 Schjerven H, Brandtzaeg P, Johansen FE
• Mannuronan C-5-epimerases and their application for in vitro and in vivo design of new alginates useful in biotechnology.
  Metabolic engineering 1999 Ertesvåg H, Høidal HK, Schjerven H, Svanem BI, Valla S
• Regulation of the Formation and External Transport of Secretory Immunoglobulins.
  Critical Reviews in Immunology 1999 F.-E. Johansen, H. Schjerven, I. N. Norderhaug, P. Brandtzaeg
• Regulation of the formation and external transport of secretory immunoglobulins.
  Critical reviews in immunology 1999 Norderhaug IN, Johansen FE, Schjerven H, Brandtzaeg P
• E2F-mediated growth regulation requires transcription factor cooperation.
  The Journal of biological chemistry 1997 van Ginkel PR, Hsiao KM, Schjerven H, Farnham PJ